• BMB Reports
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• v.42 no.6
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• pp.373-379
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• 2009

5-Hydroxyuridine (5-OHU) is a major lesion of uridine and cytosine produced in RNA by various chemical oxidants. To elucidate its biochemical and biophysical effects on RNA replication, the site-specifically modified oligoribonucleotides containing 5-OHU were synthesized with C5-hydroxy-5'-ODMTr-2'-TBDMS-uridine phosphoramidite using automated solid phase synthesis. The base-pairing properties of nucleotides opposite 5-OHU in 24 mer oligoribonulcleotides with dNTP were studied using three reverse transcriptases (Super-$Script^{TM}II$-, AMV-, MMLV-RT) in cDNA synthesis. Adenine as well as guanine was incorporated preferentially by all reverse transcriptases. In the UV-melting temperature experiment, the results from the relative stabilities of the base pairs were A : 5-OHU > G : 5-OHU > T : 5-OHU $\approx$ C : 5-OHU. Circular Dichroism (CD) studies showed that DNA-RNA containing 5- OHU heteroduplexes exhibit a similar conformation between the A-type RNA and B-type DNA. These results suggest that 5- OHU from oxidative damage was mainly influenced by adenine mismatch.

• Journal of Pharmaceutical Investigation
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• v.4 no.1_2
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• pp.39-45
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• 1974

According to previous paper, the hardness of semi-solid as ointments and suppositories causes the tough or skin, the pain and connected with absorption, the state of spread or the efficiency of drug. When the hardening agent or the softening agent is added to ointment whid, is registered on the pharmacopeia of the republic of Korea, the experimertal data by apparent logarithmic hardness are shown is Table 1. The results are as the folloring. 1) In case of the softening agent which is added to ointment base, each has shown two different equation with differnented slope as $K_1$ and $K_2$ value determined (Fig. 1,2). 2) When the hardening agent is added to same ointment base, these studies indicated that there is a direct correlation between $K_1$ and $K_2$. However, in case of softening agent $K_1$ and $K_1$ are not correlated as indicated in Fig. $3{\sim}8$. 3) On condition of same ointment base, the critical poit is proportional to $K_1$ 4) The second effect is at least $3{\sim}17$ times more. sensitive than the first effect or in average 8.3 times more sensitive, Therefore, the results presented in this paper. Suggest that, when the drug is added to a certain ointment base, it should be added within this first effect before the critical point is reached.

• Polymer(Korea)
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• v.39 no.2
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• pp.225-234
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• 2015

In this study, we proposed to synthesize thermally stable, soluble and conjugated Schiff base polymer (SbP). For this reason, a specific molecule namely 4,4'-thiodiphenol which has sulfur and oxygen bridge in its structure was used to synthesize bi-functional monomers. Bi-functional amino and carbonyl monomers namely 4,4'-[thio-bis(4,1-phenyleneoxy)] dianiline (DIA) and 4,4'-[thiobis(4,1-phenyleneoxy)]dibenzaldehyde (DIB) were prepared from the elimination reaction of 4,4'-thiodiphenol with 4-iodonitrobenzene and 4-iodobenzaldehyde, respectively. The structures of products were confirmed by elemental analysis, FTIR, $^1H$ NMR and $^{13}C$ NMR techniques. The molecular weight distribution parameters of SbP were determined by size exclusion chromatography (SEC). The synthesized SbP was characterized by solubility tests, TG-DTA and DSC. Also, conductivity values of SbP and SbP-iodine complex were determined from their solid conductivity measurements. The conductivity measurements of doped and undoped SbP were carried out by Keithley 2400 electrometer at room temperature and atmospheric pressure, which were calculated via four-point probe technique. When iodine was used as a doping agent, the conductivity of SbP was observed to be increased. Optical band gap ($E_g$) of SbP was also calculated by using UV-Vis spectroscopy. It should be stressed that SbP was a semiconductor which had a potential in electronic and optoelectronic applications, with fairly low band gap. SbP was found to be thermally stable up to $300^{\circ}C$. The char of SbP was observed 29.86% at $1000^{\circ}C$.

• Journal of Korean Society for Geospatial Information Science
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• v.18 no.1
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• pp.135-143
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• 2010

The national base map has its value sand roles as the basic spatial information of the nation. The current national base map that is a 1/5,000 digital map, however, has failed to perform its roles as basic spatial information due to the limitations with its quality and accuracy and requires measures to complement them. Thus this study set out to suggest ways to advance the current 1/5,000 national base map, selected topography and natural features of a digital map that could be made with GSD 0.25m digital aerial photographs, and set up the optimal ways to make a digital map by conducting an experiment of making an optimal digital map with such photographs. It also analyzed the map made with GSD 0.25m digital aerial photographs for accuracy and usability. In order to establish a set of criteria of making a digital map with GSD 0.25m digital aerial photographs, the investigator carried out analyses and picked topography and natural features items, which include 9 large categories, 31 medium categories, and 509 small categories. Then an experiment of making a digital map was conducted according to the digital map making method. As a result, solid drawing was selected as the optimal way to making a digital map, and the optimal process was established. Using the research achievements, a model digital map was made with GSD 0.25mm digital aerial photographs. The map recorded about two times horizontal and vertical location accuracy than the old 1/5,000 digital map and was capable of detailed descriptions of topography and natural features. A new national base map made with GSD 0.25m digital aerial photographs will provide reliable spatial data, thus increasing the level of satisfaction among people and the level of advancement of national base maps.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.10
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• pp.56-62
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• 2000

A fast and precise technique to make 3-dimensional object which is called direct metal shaping process is processed. It is very useful technique in design and inspection. Using this developed system, a solid object is made. In experiment, test parts are built by varying three factors, laser power, scan path, scan speed. This process used device, which is different from the widely used in rapid prototyping in that powder feeding device is used. Spraying powder directly at the focused laser beam and then three dimensional object is made by the deposit of melted metal powder. The optimum scanning path is found to be zigzag path, which had little thermal affection on base metal. As a result of these experiments, it was found that optimum scanning speed is 15mm/sec laser power is 50W. This constructed 3-dimensional object could be used in mold manufacturing directly.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.42 no.1
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• pp.26-34
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• 2010

Effects of drying condition (IR radiation) on the optical properties and the printability of coated paper were elucidated at various latex sizes and low and high coating color concentrations. It was found that the smaller latex provided better rheology and higher dry and wet pick strength than the larger one. The high solids coating resulted in higher paper gloss and smaller roughness than the low solids coating, even though the clay addition was reduced by 20 parts in the high solids coating. Increasing IR radiation prohibited binder migration into the base paper. Thus it improved binder distribution and decreased pores in the coated layer, resulting in the increased dry and wet pick strength and the improved printing gloss. On the other hand, the color trapping and ink set-off was impaired with increasing IR radiation. Print mottle index passed through a maximum with increasing IR radiation.

• Journal of Environmental Health Sciences
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• v.31 no.1
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• pp.86-93
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• 2005

Because generally large amount of sludges are generated from the process of sewage and wastewater treatment, the management and controlment of those sludge has become a important issue in many researches. In this dissertation, we conducted the research to see the physico-chemical characteristics of sludges generated from various sources. Moisture of sludges were 81.5% in textile industries, 81.4% in frame metal industries, 80.7% in 1st metal industries. Volatile solid were 22.1% in hide · rubber industries, 21.9% in coke · petroleum industries. Fixed solid were 18.5% and 17.7% in the 1st metal industries and frame metal industries. High heating value by wet base were 1,850 kcal/kg in coke · petroleum industries, 1,220 kcal/kg in hide · rubber industries, but sludges from the 1st metal industries and frame metal industries were impossible to incinerate because most of those sludges were inorganic. The leaching test showed that hazardous materials was detected in nearly every kinds of sludges. Some of sludges from hide · rubber industries and frame metal industries exceeded the leaching criteria and so they were classified as specific wastes. And other sludges generated in sewage treatment plants or other industries was below the leaching criteria.

• Bulletin of the Korean Chemical Society
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• v.35 no.8
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• pp.2381-2384
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• 2014

A solid-phase synthetic approach is reported for the synthesis of an ascorbic acid (ASA)-dipeptide conjugate that exhibited enhanced antioxidant activity. The N-terminal amino group of dipeptide (Ala-Ala) on a resin support was first activated by 1,1'-carbonyldiimidazole (CDI), and then reacted with an ASA derivative. The addition of a base, triethylamine (TEA), promoted nucleophilic acylation of ASA derivative and yielded a desired product (ASA-Ala-Ala) with enhanced purity, when cleaved from the resin. Compared to the approach where a C3 hydroxyl group of ASA was first activated with CDI and then reacted with the amino group of dipeptide on the resin, this new approach allowed a significant reduction of a total reaction time from 120 h to 8 h at $25^{\circ}C$. As-prepared ASA-dipeptide conjugate (ASA-Ala-Ala) showed improved antioxidant activity compared to ASA.

• Journal of the Korean institute of surface engineering
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• v.42 no.1
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• pp.13-20
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• 2009

Friction stir welding(FSW) was developed as a new solid state welding technique by The Welding Institute (TWI). On the basis of FSW, a new processing technique, friction stir processing (FSP), has recently been developed. FSP has been applied to cast aluminum alloy to modify the microstructure to enhance mechanical characteristic. FSP is a new solid state processing technique for microstructural modification in metallic materials. FSP has been applied to aluminum alloy to modify the microstructure to enhance mechanical characteristic. In this study, we investigated optimum condition friction stir processing with the evaluation of mechanical characteristic for 5456-H116 Al alloy. The mechanical characteristics of base metal similar with in 15 mm/min, 250 RPM with full screw probe. This condition is concluded that optimum friction stir processing condition. The result of this investigation will be able to application for repair of welding part for aluminum ship.

• Current Optics and Photonics
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• v.4 no.5
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• pp.441-445
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• 2020

A novel design for a Fresnel lens for a solar end-pumped laser is demonstrated in this paper. The new hybrid Fresnel lens includes two parts, inner and outer. The inner part is a twice-total-internal-reflection and vertical-transmission lens. The outer part is a once-total-reflection and vertical-transmission lens. The radius of the Fresnel lens is 600 mm, and its focal length is 750 mm. The concentrating performance of the Fresnel lens is examined using TracePro. The results show that the concentration efficiency has been greatly improved. The total concentration efficiency of the hybrid Fresnel lens reaches 73.2% when the radius of the laser rod is 3 mm. This design can simplify the concentration system of a solar end-pumped solid-state laser.