• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2001.09a
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• pp.29-29
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• 2001

Well bordered solid enlarged 16.7x9.7x8 cm in the size neoplasma was found in a 7-year-old lioness without any clinical signs of diseases in Chonju city zoo and surgically removed. Simple lobes were separated by pale gray yellowish fibrous tissue. The tumor parenchyma was yellowish with numerous cysts, necrotic foci and hemorrhages. Histologically neoplasma was composed of cell nests different in the size and shape with high mitotic activity. Slow invasive spreading on the border was observed. Formation of the narrow ductular lumina bordered the flattened cells leading to keratinization was seen in some places. It was noted by supplemental clinical investigations, that the tumor did not metastasized to other organs. This tumor is considered to be a sample of a malignant tumor without metastatic spreading and was note described in literature yet.

• Korean Journal of Veterinary Service
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• v.37 no.4
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• pp.313-317
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• 2014

A bitch was presented for investigation of the mass in left 5th mammary gland. The partial mastectomy was performed and submitted for the histopathological diagnosis. The mammary mass was firm and white colored. The cut surface was separated with several lobules and developed vessels. The central area of the mass formed the cavity filled with inflammatory exudates. The dominant component of the tumor was the bundles of spindle-shaped cells. Some tumor cells possessed atypical nuclei and were arranged in a solid nest. Cysts were microscopically composed of hemorrhage, necrosis, and exudates, partially surrounded by tumor cells and granulation tissues. Histopathologically, the mammary mass revealed spindle cell carcinoma. The bitch made a complete recovery following the mastectomy. This case was a rare mammary spindle cell carcinoma in a dog.

• Journal of Chest Surgery
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• v.33 no.2
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• pp.199-202
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• 2000

Primary pulmonary meningioma is an extremely rare disease. It is mostly benign and asymptomatic. This tumor shows the same cytohigstologic appearance as brain or spinal cord meninioma. It can be diagnosed as a primary pulmonary meningioma only if there is no evidence of metastasis from the brain or spinal cord meningioma. We experienced a case of primary pulmonary meningioma in a 60-year-old woman who had asymptomatic 2 cm-sized solitary pulmonary tumor in the right lower lobe. It is rather peripherally located. Fine needle aspiration cytology has suggested the possibility of either well-differentiated epithelial malignancy such as papillary adenocarcinoma or mucoepidermoid carcinoma or metastatic carcinoma such as from ductal carcinoma of the breast. Right lower lobectomy was performed. The tumor was bilobated and soild with yellowish color. pathologically it proved to be a primary pulmonary and solid with yellowish color. Pathologically it proved to be a primary pulmonary meningioma because there was no evidance of brain or spinal cord tumor. To the best of our knowledge this is the first case reported in Korea. We report this case with review of the literature.

• Archives of Plastic Surgery
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• v.49 no.4
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• pp.523-526
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• 2022

Salivary duct carcinoma is a rare malignant salivary gland tumor that mainly has solid features. When it occurs in the parotid gland, it can invade the facial nerve and cause facial nerve paralysis. However, in our case, the salivary duct carcinoma exhibited cystic features on computed tomographic imaging, and the facial nerve passed through the cyst. Total parotidectomy with level-I to -III dissections was performed and nerve passing through the tumor was sacrificed. The patient received postoperative radiotherapy and was clinically and radiologically followed-up for every 3 months. Recurrence or distant metastasis was not reported. To the best of our knowledge, this is the first case involving a salivary duct carcinoma with cystic features and facial nerve invasion. Here, we report a first case of cystic salivary duct carcinoma of the parotid gland which uncommonly undergo cystic change and penetrated by facial nerve and successfully resected without causing facial nerve injury.

• Archives of Pharmacal Research
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• v.14 no.1
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• pp.68-72
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• 1991

The polysaccharide fraction from Taraxii Herba showed potent immunopotentiating activities with antitumor activities. The fraction having small amount of protein inhibited the growth of solid tumor and increased peritoneal exudate cells and immunoorgan weights in normal mice, and also increased hypersensitivities in tumor bearing mice.

• Journal of Chest Surgery
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• v.22 no.2
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• pp.357-363
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• 1989

We experienced very rare case of pulmonary blastoma in a 5 year old girl. She complained of right chest pain and productive cough for 3 months. With computerized tomography and echocardiography it is disclosed that huge mediastinal solid tumor is occupied to whole right thoracic cavity and compressed mediastinal structures to left and extended to left atrium. We removed the thoracic tumor and its extended intracardiac portion completely using the technique of intrapericardial pneumonectomy with cardiopulmonary bypass. Postoperatively the patient recovered without any problem and received adjuvant chemotherapy and radiotherapy. But she was succumbed 2 months later because of opportunistic pulmonary infection with pneumocystis carinii.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.167-168
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• 1998

Swainsonine is a toxic indolizidine alkaloid found in the plant, Swainsona species (Dorling, 1978; Colgate, 1979). It is a potent inhibitor of the glycoprotein processing pathway in the Golgi apparatus. Specifically, it inhibits mannosicase II resulting in abherrant high mannose glycans. Recent studies showed that swainsonine prevents metastasis of tumor cells and it inhibits solid growth tumor, at least partially (Goss et al., 1994; Baptista et al, 1994).

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.39-39
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• 1993

To find out the novel anticancer agent for the treatment of solid tumors, 1-arylsulfonyl-2-alkoxy-4-arylimidazolines were designed and prepared from substituted styrenes through three steps. Compared to 5-fluorouracil, these analogues exhibit moderate cytotoxicity against human solid tumor cell lines, A-549(lung carcinoma) and SK-Mel-2(malignant melanoma). The structure-activity relationship indicates the high potential of this series for the development of novel antineoplastic agent.

• Journal of Korean Neurosurgical Society
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• v.45 no.1
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• pp.39-42
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• 2009

We report a supratentorial primitive neuroectodermal tumor (sPNET) in 17-year-old primipara in the second trimester her pregnancy. Magnetic resonance imaging revealed a left frontoparietal mass with solid and cystic component. Gross-total resection was achieved via a left frontoparietal craniotomy. It was decided to suspend the radiotherapy and chemotherapy until the 30 weeks of gestation. But, a sudden uncal herniation was developed due to the reccurrence of the tumor and bleeding into the tumor at the 25 weeks of gestation and the patient died after urgent decompressive surgery. sPNETs is an extremely rare brain tumor in pregnancy and only two cases were reported in the literature to date. There is no universally agreed treatment protocol for sPNETs during pregnancy and a multidisciplinary approach is required in treatment. In the present study, the clinical, histopathological features and therapeutical difficulties of sPNETs diagnosed during pregnancy was discussed with the literature review.

• The Journal of Korean Medicine
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• v.24 no.3
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• pp.138-144
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• 2003

Objective : Though modern medicine has made various studies in cancer treatment, the results of the treatments are not satisfactory. Considering this, Oriental medicine can be a breakthrough in treatment of cancer, and therefore, its constant research eagerly needed. According to preceding studies, Hangamjedoktang (Kangaizhidu-tang) with Hagocho appeared to be statistically significant against cancer, and therefore to seek a better medication for cancer, Holotrichia which seemed to be effective against cancer was added to the formula, and herbs which showed an anti-tumor effect in preceding studies composed Hangamyagjaebang. The efficacy of both Hangamjedoktang with Holotrichia (HJJ) and Hangamyagjaebang (Kangaiyaocaijang) (HM) was compared. Methods : To examine the anti-cancer effect of HJJ and HM, inhibitory effect on solid tumor growth in mice induced by Sarcoma-180 (s-180), change of body and organ weight in tumor bearing mice and the activity of machrophages and lymphocytes in the spleen were examined. Results : 1. In the HJJ and HM treated groups, tumor growth was markedly decreased. 2. HJJ and HM increased the activity of ALP which is produced from the splenocytes transplanted with S-180. 3. HJJ and HM increased the ACP activity of the macrophages of the mice transplanted with S-180. Conclusion : These results suggest that HJJ and HM are good candidates for new drugs for cancer therapy.