• 대한영상의학회지
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• 제83권1호
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• pp.112-126
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• 2022

목적 연조직 육종의 종양 가장자리 침윤을 예측하기 위한 3T 자기공명영상 텍스처 분석의 가치를 규명한다. 대상과 방법 3T 자기공명영상을 시행하고, 병리학적으로 연조직 육종으로 확인된 31명의 환자를 대상으로 하고, 병리학적인 가장자리 침윤을 표준으로 사용하였다. 연조직 육종에 대한 텍스처 분석은 축상 T1 강조영상, T2 강조영상, 지방억제 조영증강 T1 강조영상, 확산강조영상(b = 800 sec/mm²) 및 현성확산계수 지도 영상에서 이루어졌다. 텍스처 분석에서 얻어진 정량적 변수가 침윤성(infiltrative) 육종과 국한성(circumscribed) 육종에서 차이가 있는지 비교하였다. 결과 총 23명의 연조직 육종에서 병리학적인 가장자리 침윤을 보였다. 침윤성 육종과 국한성 육종은, T1 강조영상 공간 스케일 인자(spatial scaling factor; 이하 SSF) 0, 6에서의 첨도(kurtosis), 조영증강 T1 강조영상(SSF, 0)에서의 첨도, 확산강조영상(SSF, 0)에서의 왜도(skewness), 현성확산계수 지도(SSF 2, 4)에서의 왜도에서 유의한 차이가 있었다(p ≤ 0.046). 자기공명영상 텍스처 소견을 이용한 종양 가장자리 침윤을 예측하는 정확도는 수신자운영특성곡선(receiver operating characteristic; 이하 ROC)의 곡선하 면적(area under the ROC curve) 0.951 (p < 0.001)이었다. 결론 자기공명영상 텍스처 분석은 연조직 육종의 침윤성 가장자리를 예측하는 데 있어 신뢰 할 수 있으며 정확하다.

• Journal of Acupuncture Research
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• 제21권4호
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• pp.75-84
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• 2004

Objective: To evaluate the treatment effect of Bee-venom Acupuncture on Neck Pain, which is well known for anti-inflammatory effect and function of activating immune system. Methods : We investigated 22 cases of patients with Neck Pain induced by soft tissue injury. One group was treated by Bee-venom Acupuncture therapy (Bee-venom Acupuncture Group :BA), the other group was treated by General Acupuncture therapy (None Bee-venom Acupuncture Group :GA). We evaluated the treatment effect of each group by few statistical analysis such as frequency analysis, Mann Whitney U test and spearman correlation analysis. Results : 1. In the age distribution of both groups, we found the highest frequency at the interval 35 to 45 years old. And in the number of medical treatment, Both groups show the highest frequency at the interval of less than four times. 2. BA was significantly decreased in VAS and clinical grade compared with GA. 3. We found significant correlation between period and number of treatment. So did we between VAS and clinical grade. Conclusion : As a result of thorough investigation, we could come to a conclusion that Bee-venom Acupuncture Group might have a notable effect on VAS and clinic grade.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2004년도 추계학술대회 논문집
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• pp.389-392
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• 2004

It is clinically well known that pre-tension of wires increases the fracture stability in ring or hybrid external fixation. In some cases, additional half pin should be necessary to increase the stability when soft tissue impalement occurs during fixation. In this paper, the fracture stability of a hybrid external fixator system with different pre-tension effects and additional half-pins was analysed using FEM to investigate the effects of these pre-tension and half pin on the system stability quantitatively. 3-D finite element models of five different fixator frames were developed using by beam elements. In axial compression analysis, the fracture stiffness was increased maximally 62％ as the pre-tension increased. In torsion analysis, in the other hand, there is little variations in the fracture stiffness. Additional half pin increased the system stiffness about 200 ％. From the results, proper pre-tension and additional half pin would provide good methods to increase the fracture stability of the hybrid external fixator and provide more surgical options to minimize soft tissue damage at the fracture site.

• 대한치과교정학회지
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• 제30권3호
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• pp.343-355
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• 2000

본 연구는 과도한 하안면 고경을 동반하는 하악전돌증 환자의 악교정수술시 하악골후퇴 술과 이부 감소 성형술을 동시에 시행한 경우의 경조직과 연조직의 변화에 대해 살펴보고, 그 상관성을 평가하여 향후 진단시 보조자료로서 사용하고자 시행되었다. 골격성 III급 부정 교합으로 진단되어 술전 교정치료를 받고 하악골 후퇴술만을 시행한 성인 환자 20명을 대조군(A군)으로, 안모의 수평적 및 수직적 부조화가 심한 골격성 III급 부정교합으로 진단되어 술전 교정치료를 받고 하악골 후퇴술과 이부 감소 성형술을 함께 시행한 성인 환자 20명을 실험군(B군)으로 하였다. 두 군의 경조직 변화에 대한 연조직 변화 양상과, 경조직 변화에 따른 연조직의 이동 비율을 비교 분석하여 다음과 같은 결론을 얻었다. 1. A, B군 모두에서 경조직의 후방 이동과 하안면 하부 2/3의 연조직(Ils, Pog', Me')의 수평적 변화는 높은 상관성을 보였으며, B군에서는 A군에서보다 Ls, Stm, Li의 수평적 변화에도 중등도 이상의 상관성을 보였다. 2. B군의 경조직의 수직 이동에 따른 연조직의 수직적 변화의 상관성은 Point B-Ils, Me-Me'을 제외하고는 A군보다 적은 것으로 나타났다. 3. 경조직의 변화에 대한 연조직의 변화율을 비교해 보면, B군의 경우Pog'의 후방이동 비율이 A군에서보다 적게 나타났고, B군의 Ils, Pog', Me'의 상방이동 비율은 각각 32%, 54%, 60%로 나타났다. 4. 안면의 수직 고경에 대해서는 A, B군 모두에서 하안면 고경의 유의한 감소로 전안면 고경에 대한 하안면 고경의 비율이 감소하였으나, B군에서는 하안면 상부 1/3(Sn-Stm)의 비율은 변화 양상이 유의성있게 나타나지 않았다. 5. 이부 감소 성형술은 하악후퇴술과 함께 시행시 하안면 상부 1/3(Sn-Stm)의 안모비율에 대한 변화가 적고, 하안면 하부 2/3(St-Me')의 고경을 감소시킬 수 있는 술식이다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제41권
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• pp.32.1-32.7
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• 2019

Background: Tooth extraction commonly leads to loss of residual alveolar ridge, thus compromising the room available for the implant placement. To combat the post-extraction alveolar loss, alveolar ridge preservation is practiced, with the advent of the biomaterial available. The purpose of this study was to assess the efficiency of calcium phosphosilicate biomaterial in alveolar ridge preservation. Twenty patients indicated for extraction were selected followed by socket grafting using calcium phosphosilicate. Implant placement was done 6 months postoperatively during which a core was harvested from the preserved sockets. Clinico-radiographic measurements of hard and soft tissues were taken at baseline and 6 months post-grafting. Results: There were no significant changes in the radiographic and soft tissue parameters while significant changes in hard tissue parameters with 1.9 mm (p = 0.013) gain in mid-buccal aspect and 1.1 mm (p = 0.019) loss in horizontal bone width were observed. The histomorphometric evaluation depicted the vital bone volume of 54.5 ± 16.76%, non-mineralized tissue 43.50 ± 15.80%, and residual material 2.00 ± 3.37%. Conclusion: The implants placed in these preserved ridges presented 100% success rate with acceptable stability after a 1-year follow-up, concluding calcium phosphosilicate is a predictable biomaterial in alveolar ridge preservation.

• Journal of Periodontal and Implant Science
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• 제50권6호
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• pp.406-417
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• 2020

Purpose: This study investigated whether the placement of ribose cross-linked collagen (RCLC) membranes without primary soft tissue closure predictably resulted in sufficient alveolar ridge preservation in contained and non-contained extraction sockets. Methods: Membranes were positioned across extraction sockets, undermining full-thickness flaps, and the gingival margins were fixed by double-interrupted sutures without crossed horizontal mattress sutures for 1 week. In non-contained sockets, a bone substitute was used to support the membrane within the bony envelope. Radiographs and clinical images obtained 4 months later were analyzed by ImageJ software using non-parametric tests. Results: In 18 patients, 20 extraction sockets healed uneventfully and all sites received standard-diameter implants (4.1, 4.8, or 5.0 mm) without additional bone augmentation. Soft tissues and the muco-gingival border were well maintained. A retrospective analysis of X-rays and clinical photographs showed non-significant shrinkage in the vertical and horizontal dimensions (P=0.575 and P=0.444, respectively). The new bone contained vital bone cells embedded in mineralized tissues. Conclusions: Within the limitations of this pilot study, open healing of RCLC membranes may result in sufficient bone volume for implant placement without additional bone augmentation in contained and non-contained extraction sockets.

• 대한치과교정학회지
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• 제30권5호
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• pp.657-668
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• 2000

본 연구는 골격성 III급 부정교합 환자에서 상악골 전방이동 수술 후 야기되는 코의 형태변화에 대해 연구하고 이를 예측할 수 있는 요소를 찾아 교정-악교정 수술 복합 치료계획의 수립과 결과의 예측에 이용하고자 시행되었다. 부산대학교병원 치과진료처 교정과에 내원하여 골격성 III급 부정교합으로 진단되어 술전 교정치료를 받고 Le Fort I 골절단술로 상악골의 전방 이동시키는 동시에 하악골을 후방 이동시킨 남녀 성인 환자 25명을 대상으로 하였다. 이들의 수술전, 후 측모두부규격방사선사진과 정모 및 측모 안면사진을 계측, 분석하여 다음과 같은 결과를 얻었다. 1. 상악골 전방이동에 따른 비첨의 수직적 위치 변화는 상관성이 높았으며 ANt, SNt에서 A point의 전방이동에 의해 ${\beta}_0$는 각각 0.228, 0.257로 나타났다. 2. 상악골 전방이동에 따른 비첨의 수평적 위치변화는 상관성이 높았으며 ANt, SNt, Sn point에서 A point의 전방이류에 의해 ${\beta}_0$는 각각 0.484, 0.431, 0.806으로 나타났다. 3. 상악골의 전방이동에 따른 비익부의 확장정도는A point의 전방이동에 의해 0.002의 ${\beta}_0$를 나타내었으나, 임상적으로 유의한 변화는 없었다. 4. 수술 후 비첨의 수직적 및 전후방적 위치변화를 예측하는 지표로 사용된 ADV, DRI, Prominence of nose, Pre-Op CA 중 ADV 만이 설명변수로서 유의성이 있었다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제27권3호
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• pp.231-238
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• 2001

This study was performed to evaluate soft tissue cephalometric norms for Korean adults which can be implemented in surgical orthodontic treatment planning using selected horizontal reference plane especially for Koreans (Male: $SN-7.5^{\circ}$, Female: $SN-9.0^{\circ}$) and a simplified analytical method. 70 males and 70 females consisting of freshmen of Yonsei University from 1996 to 1997 and students from the Dental College of Yonsei University were chosen according to clinical examination and cephalometric analysis. The samples had normal profiles, normal anteroposterior skeletal relationship(ANB angle of $0^{\circ}\;to\;4^{\circ}$ and Wits appraisal of -4.0mm to 0mm), and Class I molar and canine relationship. They had no missing or supernumerary teeth and had no experience of orthodontic or prosthetic treatment. After the selection of 15 soft tissue landmarks and the construction of horizontal and vertical reference lines, 25 measurements were taken. These consisted of vertical and horizontal linear measurements and angular measurements. The results were as follows. 1. Mean and standard deviation of the measurements were calculated in males and females. 2. Vertical measurements were comparably bigger in males than females whereas anterior facial height ratio(sN-Sn/Sn-sMe) and lower anterior facial height ratio(Sn-Stms/Stmi-sMe) showed no significant difference between sexes. 3. Most of the horizontal measurements in relation to the vertical reference line(G-perpendicular) showed no significant difference between sexes. 4. Nasofacial angle, columellar angle, nasolabial angle and facial contour angle showed no significant difference between sexes. 5. The upper and lower lip were positioned about $-1.0{\pm}2.0mm$ and $+1.0{\pm}2.0mm$ in relation to the Ricketts' esthetic line in both sexes. In this study, soft tissue cephalometric norms of Korean adults for orthognathic surgery were obtained.

• Journal of Periodontal and Implant Science
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• 제30권2호
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• pp.483-490
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• 2000

The aim of this study was to analyze the reliability of an ultrasonic device(SDM) measuring soft tissue thickness in relation to tooth position, and to find factors which can influence the reliability. The results showed that 1. measurement error was the largest in the maxillary second molar position and the smallest in the mandibular central incisor position. 2. in a box whisker plot, the difference between two measurements was most widely distributed in molar positions. 3. in Pearson correlation analysis, the relationship between two measurements was the highest in the maxillary lateral incisor position and, the lowest in the maxillary second molar, mandibular first and second premolar position. 4. a stepwise multiple regression analysis could explain the difference of two measurements with various independent variables in 29.7% (P<0.0001). Gingival thickness was the only variable influencing the measurement difference in a statistically significant level(P<0.0001). It can be concluded that its high reliability, ease to use and patient comfort justified the application of the SDM in measurement of soft tissue thickness.

• Journal of Microbiology and Biotechnology
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• 제34권3호
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• pp.681-688
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• 2024

The accurate and rapid detection of methicillin-resistance of Staphylococcus aureus (SA) holds significant clinical importance. However, the methicillin-resistance detection strategies commonly require complicated cell lysis and gene extraction. Herein, we devised a novel colorimetric approach for the sensitive and accurate identification of methicillin-resistance of SA by combining allosteric probe-based target recognition with self-primer elongation-based target recycling. The PBP2a aptamer in the allosteric probe successfully identified the target MRSA, leading to the initiation of self-primer elongation based-cascade signal amplification. The peroxidase-like hemin/G-quadruplex undergo an isothermal autonomous process that effectively catalyzes the oxidation of ABTS2- and produces a distinct blue color, enabling the visual identification of MRSA at low concentrations. The method offers a shorter duration for bacteria cultivation compared to traditional susceptibility testing methods, as well as simplified manual procedures for gene analysis. The overall amplification time for this test is 60 min, and it has a detection limit of 3 CFU/ml. In addition, the approach has exceptional selectivity and reproducibility, demonstrating commendable performance when tested with real samples. Due to its advantages, this colorimetric assay exhibits considerable potential for integration into a sensor kit, thereby offering a viable and convenient alternative for the prompt and on-site detection of MRSA in patients with skin and soft tissue infections.