• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.463-467
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• 2012

Purpose: To assess the safety and efficacy of a gemcitabine plus docetaxel regimen as a second line therapy for patients with advanced soft tissue sarcoma (STS) resistant to doxorubicin and ifosfamide-based therapy. Patients and Methods: Medical records of 64 patients with advanced STS who received gemcitabine plus docetaxel regimen as a second line treatment between May 2006 and June 2011 were examined. All patients had been previously treated with doxorubicin plus ifosfamide-based regimen at first line setting. Patients received gemcitabine 900 $mg/m^2$ on days one and eight intravenously over 90 minutes, followed by docetaxel 75 $mg/m^2$ on day eight intravenously over one hour. Cycles were repeated every 3 weeks. Results: The male-to-female ratio was 37/27 and the median age was 44 years (range; 19-67 years). Objective responses were observed in 13 (20.3 %) patients (2 CR, 11 PR) and stable disease in 21 (32.8 %). Total clinical benefit (CR+PR+SD) was observed in 34 (53.1 %). Median overall survival (OS) was 18 months (95% confidence interval (CI):12.1-23.9) and Median time to progression (TTP) was 4.8 months (95% CI: 3.6-6). A total of 243 cycles of chemotherapy were administered. The median number of cycle was 3 (range;1-11). The most common grade 3-4 hematologic toxicity was neutropenia (35.9 %). The most common nonhematologic toxicities consisted of nausea/vomiting (37.5 %), mucositis (32.8 %), peripheral neuropathy (29.7%), and fatigue (26 %). There was no toxicity-related death. Conclusion: The combination of gemcitabine plus docetaxel is an active and tolerable regimen as a second line therapy for patients with advanced soft tissue sarcoma who have failed doxorubicin and ifosfamide-based therapy.

• Journal of Digital Convergence
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• v.12 no.6
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• pp.55-68
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• 2014

In this study, we performed an empirical research on how cultural power affects soft power as one of the elements of National Power. To fully exert the force of cultural power, appropriate level of "resources for power" need to be disseminated into cultural elements. Utilization of these resources need to appropriately developed and produced in quality and quantity when needed. This activity should be ensured with "composite support competence"; which is the combination of support organizations and their potentials. Indicators of cultural power includes society favorability rating, cultural favorability rating, E&D industry competitiveness index, and T&T competitiveness index. According to analysis of cultural power by each country, cultural industry (E&D) competitiveness index and travel and tourism (T&T) competitiveness index shows relatively high correlation. This research aims to analyze the "cultural power as soft power" of South Korea, China and US, and how they are different and how their resources of power are represented in their E&D and T&T competitiveness.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38C no.11
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• pp.1051-1059
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• 2013

This paper proposes a complexity reduced list sphere decoding (LSD) scheme for joint iterative soft detection scheme for coded MIMO system. The conventional LSD scheme is based on searching the candidates with a fixed radius. However, once the candidate list is full, it is highly probable that the radius can be reduced. By reducing the radius, the complexity can be also reduced. We propose a simple and efficient radius update method for complexity reduction of list version sphere decoding and its application to iterative soft MIMO detection. We evaluate the performance of the proposed scheme with a joint soft-input-soft-ouput iterative MIMO detection in combination with turbo codes. Simulation results show that the proposed methods provide substantial complexity reduction while achieving similar bit error rate (BER) performance as the conventional LSD scheme.

• Journal of The Korean Society of Integrative Medicine
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• v.8 no.2
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• pp.53-61
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• 2020

Purpose : We investigated the correlation between body composition and lung function in healthy adults. Methods : This study included 204 healthy adults in whom all measurements were obtained once, and all data were analyzed using the SPSS software for Windows, version 22.0. Pearson's correlation analysis was performed to determine the correlation between body composition (represented by the total body water, protein mass, soft lean mass, mineral mass, basal metabolic rate, fat-free mass, skeletal muscle mass, and body fat percentage) and lung function (represented by the forced vital capacity [FVC], forced expiratory volume in 1 second [FEV₁], the FEV₁/FVC ratio, maximum voluntary ventilation [MVV], maximum expiratory pressure [MEP], and the maximum inspiratory pressure [MIP]). All measurements were obtained by two investigators to improve reliability. A significance level of α=.05 was used to verify statistical significance. Results : Among the lung function measurements obtained in both men and women, the FVC, FEV₁, MVV, and MIP were positively correlated with the total body water, protein mass, soft lean mass, mineral mass, basal metabolic rate, fat-free mass, and skeletal muscle mass in men (p<.05). The FEV₁/FVC ratio was negatively correlated with the total body water, soft lean mass, mineral mass, basal metabolic rate, fat-free mass and the body fat percentage (p<.05). Notably, the FVC, FEV₁, and MVV were positively correlated with the total body water, protein mass, soft lean mass, mineral mass, basal metabolic rate, fat-free mass, and skeletal muscle mass in women (p<.05). Conclusion : This study showed a significant correlation between body composition and lung function in healthy adults. In combination with future studies on lung function, our results can provide objective evidence regarding the importance of prevention of lung disease, and our data can be utilized in rehabilitation programs for patients with respiratory diseases.

• Journal of the Korean Geotechnical Society
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• v.33 no.11
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• pp.45-57
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• 2017

Temperature change affects consolidation behavior of soft clays. The increase of temperature in soft clays induces the increase of pore water pressure. The dissipation of the excess pore water pressure decreases volume and void ratio. Also, the consolidation rate is accelerated by high temperature which induces the decrease of viscosity of pore fluid. The effects of temperature on the consolidation behavior such as consolidation settlement, consolidation time, and pore water pressure were investigated in this study. A numerical analysis of hydro-mechanical (HM) and thermo-hydro-mechanical (THM) behavior was performed. The combination of heat injection and sand drain for consolidating the soft ground, with varying temperature (40 and $60^{\circ}C$) and sand drain diameter (40, 60, and 80 mm), was considered. The results show that the temperature inside soil specimen increases with the increase of the temperature of heating source and the diameter of sand drain. Moreover, the heat injection increases the excess pore water pressure and, accordingly, induces additional settlement in overconsolidated (OC) state and reduces the consolidation time in normally consolidated (NC) state.

• Journal of KIISE:Computing Practices and Letters
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• v.16 no.1
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• pp.17-22
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• 2010

As deployments of Flash memory are spreading out rapidly from tiny USB storages to large DB servers, interoperability become an indispensable requirement for Flash memory software architecture. For the purpose, many systems make use of the conventional FAT file system and FTL (Flash Translation Layer) software as a de facto standard. However, the tactless combination of the FAT file system and FTL does not satisfy diverse other requirements of a variety of systems. In this paper, we propose a novel reconfigurable integrated Flash memory software architecture, named INFLAWARE (INtegrated FLAsh softWARE) that supports not only interoperability but also reconfigurability and performance enhancement. Real implementation based experimental results have shown that INFLAWARE can achieve improvements of memory footprint up to 27% with an average of 19%, compared with the conventional FAT and FTL combination. Also, by using map_destroy technique, it can reduce response times of various applications up to 21% with an average of 10%.

• Journal of Periodontal and Implant Science
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• v.26 no.2
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• pp.396-413
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• 1996

Current acceptable methods for promoting periodontal regeneration are based on removal of diseased soft tissue. root treatment, guided tissue regeneration, introduction of new graft materials and biological mediators. Insulin-like growth factor-I(IGF-I) and Platelet-derived growth factor-BB(PDGF-BB), the members of the polypeptuyde growth factor family have been reported as the biological mediators which regulate a variety cellular matrix biologic activities of wound healing process including the cell proliferation, migration and extracellular matrix synthesis.The purposes of this study is to evaluate the combination effects of IGF-I and PDGF-BB on the cellular activity of the periodontal ligament cells to act as a regeneration promoting agent of periodontal tissue. Human periodontal ligament cells were prepared from the first premolar tooth extracted for the orthodontic treatment and were cultured in DMEM containing 10% FBS at the $37^{\circ}C$, 5% CO2 incubator. Author measured the DNA synthetic activity, and total protein, collagen and noncollagenous protein synthetic activities according to the concentration of 10,100ng/ml IGF-I and1,10 ng/ml PDGF-BB in combination. The results were as follows: Significantly increased in the 1 ng/ml PDGF-BB alone compared to the 10 ng/ml PDGF-BB alone(P<0.01) and in the 1 ng/ml PDGF-BB and 10, 100ng/ml IGF-I in combination compared to the 1 ng/ml PDGF-BB alone(P<0.05, P<0.0l). The synthetic activity of the total protein and collagen is significantly increased like to the synthetic activity of the DNA(P<0.05). The synthetic activity of the noncollagenous protein is increased according to the concentration of IGF_I, but not statistically statistically significant(P>0.05). The percent of the collagen is significantly in the 1ng/ml PDGF-BB and 10ng/ml IGF-I in combination compared to the 1ng/ml PDGF-BB alone(P<0.05) and in the 10ng/ml IGF-I in combination compared to the 10ng/ml PDGF-BB alone(P<0.05). The synthetic activity of the DNA is In conclusions, the percent study shows that PDGF-BB and IGF-I in combination have a potentiality to enhance the DNA synthesis and the total protein and collagen synthesis of The periodontal ligament cells, especially it is more significant in the low concentration of PDGF-BB compared to the high one. Thus, the PDGF-BB and IGF-I in combination may have important roles in promotion of periodontal litgment healing, and consequently, may useful for clinical application in periodontal regenerative procedures.

• Journal of Photoscience
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• v.9 no.2
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• pp.460-462
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• 2002

Absorption spectra of biological specimens in the soft X-ray region have been presented with special reference to the XANES (X-ray absorption Near Edge Structure) of constituent elements. Absorption spectrum in this wavelength region is characterized by the absorption edges from which elemental content could be derived. In addition, XANES has a characteristic profile for chemical environment around the element such as chemical bond. Using the specific absorption peak we can assign not only the chemical bond but also molecules having such a chemical bond. In the present paper, absorption spectrum of DNA was measured in the wavelength range from 1.5nm to 5nm. Spectrum of Chinese Hamster Ovary (CHO) cells was compared with the DNA spectrum. XANES were distinct at the K absorption edges of major elements, C, N and O. In the spectrum of the cells prominent peaks at the L absorption edge of minor element Ca were also detectable. XANES profiles in small local areas in a cell could also be measured in combination with X-ray microscopy. These give information about local chemical environment in a cell. XANES at the phosphorus K absorption edge in a human HeLa cell was successfully obtained corresponding to a sharp and intensive XANES peak of DNA.

• Publications of The Korean Astronomical Society
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• v.12 no.1
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• pp.35-45
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• 1997

SOFT($\underline{So}lar\;\underline{F}lare\;\underline{T}elescope$) installed at BOAO(Bohyunsan Optical Astronomy Observatory) is purposed for observing solar active regions using four refractors on single mount with a $400"\times300"$ field of view: Two refractors with a diameter of 15cm(f15) are observe the white light and $H\alpha$, and the other two refractors with a diameter of 20cm(f8) are observe the magnetic field distribution and Doppler shifts at the solar chromosphere. Three Lyot filters, one of the most important observational instruments, are installed on the optical rails for VMG, LMG, and $H\alpha$ that possible to very narrow pass band observation under high precision stability of temperature. From the combination of KD*P and quarter wave plate in the Lyot filter possible observe the magnetic fields strength and doppler shifts by using the characteristics of polarization components. In this paper, we introduce the basic characteristics, optical system, and monitor system of the SOFT.

• Geomechanics and Engineering
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• v.10 no.4
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• pp.405-422
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• 2016

The paper deals with the results of the laboratory cyclic plate load tests performed on the reinforced soft clay beds. The performances of the clay bed reinforced with geocells and geocells with additional basal geogrid cases are compared with the performance of the unreinforced clay beds. From the cyclic plate load test results, the coefficient of elastic uniform compression ($C_u$) was calculated for the different cases. The $C_u$ value was found to increase in the presence of geocell reinforcement. The maximum increase in the $C_u$ value was observed in the case of the clay bed reinforced with the combination of geocell and geogrid. In addition, 3 times increase in the strain modulus, 10 times increase in the bearing capacity, 8 times increase in the stiffness and 90% reduction in the settlement was observed in the presence of the geocell and geogrid. Based on the laboratory test results, a hypothetical case of a prototype foundation subjected to cyclic load was analyzed. The results revealed that the natural frequency of the foundation-soil system increases by 4 times and the amplitude of the vibration reduces by 92% in the presence of the geocells and the geogrids.