• 한국시뮬레이션학회논문지
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• 제17권3호
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• pp.1-8
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• 2008

멀티미디어 서비스의 QoS가 전송 지연 및 패킷 손실에 의하여 현저히 저하될 수 있으므로, 멀티미디어 데이터의 전송 동안 셀 부하와 무선 링크의 에러에도 불구하고 연속적인 QoS를 유지하는 것이 필요하다. 본 논문은 이종 망상에서 멀티미디어 서비스의 QoS를 지원하기 위한 셀 선정 방법을 다룬다. 제안된 방식은 사용자 시스템 선호도, 통신비용, 셀 부하 그리고 전송지연과 같은 다수의 부정확한 요소가 퍼지 집합 함수를 사용한 의사 결정에 사용되는 다기준 의사 결정 방법에 근거한다. 이 방법은 이진 논리를 사용하는 경우보다 의사 결정 시 평가 항목의 오차가 총체화된 평가치에 완만한 변화를 유발하고 최종적인 기준치를 변화시켜 셀 선정의 유연선을 증가시킬 수 있다. 시뮬레이션을 통하여 평균 지연과 패킷 손실률을 평가하고, 제시한 셀 선정 방법이 이동 단말기에게 최적의 성능을 제공함을 보인다.

• Journal of Communications and Networks
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• 제17권3호
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• pp.267-274
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• 2015

Due to the difficulty of coordination in the cellular uplink, it is a practical challenge how to achieve the optimal throughput scaling with distributed scheduling. In this paper, we propose a distributed and opportunistic user scheduling (DOUS) that achieves the optimal throughput scaling in a single-input multiple-output interfering multiple-access channel, i.e., a multi-cell uplink network, with M antennas at each base station (BS) and N users in a cell. In a distributed fashion, each BS adopts M random receive beamforming vectors and then selects M users such that both sufficiently large desired signal power and sufficiently small generating interference are guaranteed. As a main result, it is proved that full multiuser diversity gain can be achieved in each cell when a sufficiently large number of users exist. Numerical evaluation confirms that in a practical setting of the multi-cell network, the proposed DOUS outperforms the existing distributed user scheduling algorithms in terms of sum-rate.

• IEIE Transactions on Smart Processing and Computing
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• 제3권5호
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• pp.275-284
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• 2014

This paper considers two-tier networks consisting of macrocells and femtocells operating in the same spectrum. This paper proposes a femtocell spectrum reuse scheme that determines the shared spectrum and transmit power for the femtocells to mitigate the effects of cross-tier interference between the macrocells and femtocells. The proposed scheme provides macrocell throughput that is unaffected by the increasing number of femtocells per cell site and improves the femtocell signal quality at the same time by limiting the cross-tier interference. This study analyzed the per-tier signal-to-interference ratio (SIR) and outage probability of the proposed scheme to investigate the macrocell and femtocell performance. The total throughput of the proposed scheme was analyzed based on the outage probabilities. The analysis and numerical results proved that high femtocell throughput can be achieved using only a small fraction of the spectrum while protecting the macrocell throughput. As a result, an improved total throughput was achieved enforcing higher spatial reuse.

• ETRI Journal
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• 제35권5호
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• pp.775-785
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• 2013

Because of their exclusive features, millimeter wave directive mesh networks can be considered for small cell backhaul support in urban environments. For this purpose, a network of closely spaced stations has been considered with very directive line-of-sight links operating in the 60-GHz band. An attempt is made to evaluate channel response and interference behavior in such a network, taking into account the effect of building blockage. A simple grid of building blocks is considered as the propagation environment, and wave propagation is simulated using 2.5-dimensional (2.5D) ray tracing (2D with ground effect) to calculate the received signal at different nodes in the network. The results are compared with free space predictions and used to evaluate interference at all nodes in the channel and describe certain characteristics of links, such as the delay profile and the correlation length.

• 한국정보통신학회논문지
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• 제17권11호
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• pp.2563-2568
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• 2013

최근 옥외용 이동통신시스템과 동일 주파수를 사용하면서 추가적으로 용량을 확보할 수 있는 옥내용 모바일 통신 시스템을 위한 초소형 기지국에 대한 연구 및 개발이 활발히 진행되고 있다. 본 연구에서는 옥내용 모바일 통신 시스템에서 초소형 기지국의 특성을 고려한 시스템 레벨 시뮬레이터를 개발하였고 초소형 기지국 환경에서 혼잡한(Congested) 기지국의 아웃티지 확률(Outage Probability)을 줄이는 적응적 Load-Balancing 방안을 제안하였다. 본 시뮬레이터에서는 초소형 기지국 특성을 고려한 링크 레벨 시뮬레이션 결과를 반영하였으며, 본 시뮬레이터를 이용하여 옥내용 모바일 통신 시스템에서 Load-Balancing 방안을 적용하였을 때와 적용하지 않았을 때의 아웃티지 확률을 비교해 보았다. 제안한 Load-Balancing 방안의 사용을 통해 혼잡한 기지국의 아웃티지 확률을 줄이고 전체 시스템의 성능을 향상시킬 수 있음을 보였다.

• 한국컴퓨터그래픽스학회논문지
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• 제28권1호
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• pp.1-9
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• 2022

비소세포폐암(NSCLC)은 전체 폐암 중 85%의 높은 비중을 차지하며 사망률(22.7%)이 다른 암에 비해 현저히 높은 암으로 비소세포폐암 환자의 수술 후 예후에 대한 예측은 매우 중요하다. 본 연구에서는 종양을 관심영역으로 갖는 비소세포폐암 환자의 수술 전 흉부 CT 영상 패치의 종류를 종양 관련 정보에 따라 총 다섯 가지로 다양화하고, 이를 입력데이터로 갖는 사전 학습 된 ResNet 과 EfficientNet CNN 네트워크를 사용하여 단일 모델과 간접 투표 방식을 이용한 앙상블 모델, 그리고 3 개의 입력 채널을 활용한 앙상블 모델에서의 실험 결과 및 성능을 오분류의 사례와 Grad-CAM 시각화를 통해 비교 분석한다. 실험 결과, 종양 주변부 패치를 학습한 ResNet152 단일 모델과 EfficientNet-b7 단일 모델은 각각 87.93%와 81.03%의 정확도를 보였다. 또한 ResNet152 에서 총 3 개의 입력 채널에 각각 영상 패치, 종양 주변부 패치, 형상 집중 종양 내부 패치를 넣어 앙상블 모델을 구성한 경우에는 정확도 87.93%를, EfficientNet-b7 에서 간접 투표 방식으로 영상 패치와 종양 주변부 패치 학습 모델을 앙상블 한 경우에는 정확도 84.48%를 도출하며 안정적인 성능을 보였다.

• Bulletin of the Korean Chemical Society
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• 제35권5호
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• pp.1294-1298
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• 2014

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer representing 85% of lung cancer patients. Despite several EGFR-targeted drugs have been developed in the treatment of NSCLC, the clinical efficacy of these EGFR-targeted therapies is being challenged by the occurrence of drug resistance. In this regard, Hsp90 represents great promise as a therapeutic target of cancerous diseases due to its role in modulating and stabilizing numerous oncogenic proteins. Accordingly, inhibition of single Hsp90 protein simultaneously disables multiple signaling networks so as to overcome drug resistance in cancer. In this study, we synthesized a series of 11 butein analogues and evaluated their biological activities against gefitinibresistant NSCLC cells (H1975). Our study indicated that analogue 1h inhibited the proliferation of H1975 cells, down-regulated the expression of Hsp90 client proteins, including EGFR, Met, Her2, Akt and Cdk4, and upregulated the expression of Hsp70. The result suggested that compound 1h disrupted Hsp90 chaperoning function and could serve a potential lead compound to overcome the drug resistance in cancer chemotherapy.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2016년도 춘계학술대회
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• pp.583-585
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• 2016

The recent advances in wireless networks area have led to new techniques, such as small cells or full-duplex (FD) transmission, have also been developed to further increase the network capacity. Particularly, full-duplex communication promises expected throughput gain by doubling the spectrum compared to half-duplex (HD) communication. Because this technique permits one set of frequencies to simultaneously transmit and receive signals. In this paper, we focus on the binary power control for the users and the base stations in full-duplex multiple cellulars wireless networks to obtain optimal sum-rate under the effect interference and noise. We investigate with a scenario in there one carrier is assigned to only one user in each cell and construct a model for this problem. In this work, we apply the binary power control by the its simplification in the implemented algorithm for both uplink and downlink simultaneously to maximize sum data rate of the system. At first, we realize the 2-cells case separately to check the optimal power allocation whether being binary. Then, we carry on with N-cells case in general through properties of binary power control.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권8호
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• pp.2648-2665
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• 2022

Device-to-device (D2D) multicast has become a promising technology to provide specific services within a small geographical region with a high data rate, low delay and low energy consumption. However, D2D multicast communications are allowed to reuse the same channels with cellular uplinks and result in mutual interference in a cell. In this paper, an intelligent channel assignment algorithm is designed in D2D underlaid cellular networks with the target of maximizing network throughput. We first model the channel assignment problem to be a throughput maximizing problem which is NP-hard. To solve the problem in a feasible way, a novel channel assignment algorithm is proposed. The key idea is to find the appropriate cellular communications and D2D multicast groups to share a channel without causing critical interference, i.e., finding a channel for a D2D multicast group which generates the least interference to network based on current channel assignment status. In order to show the efficacy and effectiveness of our proposed algorithm, a novel search algorithm is proposed to find the near-optimal solution as the baseline for comparisons. Simulation results show that the proposed algorithm improves the network throughput.

• BMB Reports
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• 제51권10호
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• pp.493-499
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• 2018

Cellular senescence is a state of permanent cell-cycle arrest triggered by different internal and external stimuli. This phenomenon is considered to be both beneficial and detrimental depending on the cell types and biological contexts. During normal embryonic development and after tissue injury, cellular senescence is critical for tissue remodeling. In addition, this process is useful for arresting growth of tumor cells, particularly during early onset of tumorigenesis. However, accumulation of senescent cells decreases tissue regenerative capabilities and induces inflammation, which is responsible for cancer and organismal aging. Therefore cellular senescence has to be tightly regulated, and dysregulation might lead to the aging and human diseases. Among many regulators of cellular senescence, in this review, I will focus on microRNAs, small non-coding RNAs playing critical roles in diverse biological events including cellular senescence.