• 한국통신학회논문지
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• 제29권10A호
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• pp.1223-1229
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• 2004

본 논문에서 ETRI 0.5$\mu\textrm{m}$ MESFET 라이브러리 공정을 이용하여 동작 주파수 5GHz대 저전압구동 가변이득 저잡음 증폭기 MMIC를 설계 및 제작하였다. 이 저잡음 증폭기는 HIPERLAN/2의 Adaptive Antenna Arrays와 함께 사용할 수 있도록 이득조절이 가능하도록 설계하였다. 가변이득 저잡음 증폭기는 2단 캐스케이드 구조이며, 게이트전압에 따라 채널저항이 제어되는 증가형 MESFET과 저항으로 구성된 부귀환 회로를 제안하였다. 제작된 가변이득 저잡음 증폭기의 측정값은 $V_{DD}$ =1.5V, $V_{GG1}$=0.4V, $V_{GG2}$=0.5V일때 5.5GHz의 중심 주파수, 14.7dB의 소신호 이득, 10.6dB의 입력 반사손실, 10.7dB의 출력 반사손실, 14.4dB의 가변이득, 그리고 잡음지수 2.98dB이다. 또한, 가변이득 저잡음 증폭기는 -19.7dBm의 입력 PldB, -10dBm의 IIP3, 52.6dB의 SFBR, 그리고 9.5mW의 전력을 소비한다.다.다.

• Journal of Microbiology
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• 제43권4호
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• pp.345-353
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• 2005

The complex ecosystem of intestinal micro flora is estimated to harbor approximately 400 different microbial species, mostly bacteria. However, studies on bacterial colonization have mostly been based on culturing methods, which only detect a small fraction of the whole microbiotic ecosystem of the gut. To clarify the initial acquisition and subsequent colonization of bacteria in an infant within the few days after birth, phylogenetic analysis was performed using 16S rDNA sequences from the DNA iso-lated from feces on the 1st, 3rd, and 6th day. 16S rDNA libraries were constructed with the amplicons of PCR conditions at 30 cycles and $50^{\circ}C$ annealing temperature. Nine independent libraries were produced by the application of three sets of primers (set A, set B, and set C) combined with three fecal samples for day 1, day 3, and day 6 of life. Approximately 220 clones ($76.7\%$) of all 325 isolated clones were characterized as known species, while other 105 clones ($32.3\%$) were characterized as unknown species. The library clone with set A universal primers amplifying 350 bp displayed increased diversity by days. Thus, set A primers were better suited for this type of molecular ecological analysis. On the first day of the life of the infant, Enterobacter, Lactococcus lactis, Leuconostoc citreum, and Streptococcus mitis were present. The largest taxonomic group was L. lactis. On the third day of the life of the infant, Enterobacter, Enterococcus faecalis, Escherichia coli, S. mitis, and Streptococcus salivarius were present. On the sixth day of the life of the infant, Citrobacter, Clostridium difficile, Enterobacter sp., Enterobacter cloacae, and E. coli were present. The largest taxonomic group was E. coli. These results showed that microbiotic diversity changes very rapidly in the few days after birth, and the acquisition of unculturable bacteria expanded rapidly after the third day.

• 생명과학회지
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• 제15권6호
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• pp.851-856
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• 2005

Although valuable microbes have been isolated from the soil for the various productions of useful components, the microbes which can be cultivated in the laboratory are only $0.1-1\%$ of all microbes. To solve this problem, the study has recently been tried for making the valuable components from the environment by directly separating unculturable micrbial DNA in the soil. But it is known that humic acid originated from the soil interrupts various restriction enzymes and molecular biological process. Thus, in order to prevent these problems, this study modified the method separated soil DNA with phenol, CTAB and PEG. In order to compare the degree of purity for each DNA and the molecular biological application process, $A_{260}/A_{280}$ ratio, restriction enzymes, and PCR were performed. In case of DNA by the modified method, total yield of DNA was lower but $A_{260}/A_{280}$ ratio was higher than the previously reported methods. It was confirmed that the degree of purity is improved by the modified method. But it was not cut off by all kinds of tested restriction enzymes because of the operation of a very small amount of interrupting substances. When PCR was operated with each diluted DNA in different concentrations and GAPDH primer, the DNA by the modified method could be processed for PCR in the concentration of 100 times higher than by the previously reported separation method. Therefore, this experiment can find out the possibility of utilization for the unknown substances by effectively removing the harmful materials including humic acid and help establishing metagenomic DNA library from the soil DNA having the high degree of purity.

• 대한의용생체공학회:의공학회지
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• 제27권5호
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• pp.203-209
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• 2006

The aim of this study is to investigate the feasibility of ex vivo MR diffusion tensor imaging technique in order to observe the diffusion-contrast characteristics of human gastric tissues. On normal and pathologic gastric tissues, which have been fixed in a polycarbonate plastic tube filled with 10% formalin solution, laboratory made 3D diffusion tensor Turbo FLASH pulse sequence was used to obtain high resolution MR images with voxel size of $0.5{\times}0.5{\times}0.5mm^3\;using\;64{\times}32{\times}32mm^3$ field of view in conjunction with an acquisition matrix of $128{\times}64{\times}64$. Diffusion weighted- gradient pulses were employed with b values of 0 and $600s/mm^2$ in 6 orientations. The sequence was implemented on a clinical 3.0-T MRI scanner(Siemens, Erlangen, Germany) with a home-made quadrature-typed birdcage Tx/Rx rf coil for small specimen. Diffusion tensor values in each pixel were calculated using linear algebra and singular value decomposition(SVD) algorithm. Apparent diffusion coefficient(ADC) and fractional anisotropy(FA) map were also obtained from diffusion tensor data to compare pixel intensities between normal and abnormal gastric tissues. The processing software was developed by authors using Visual C++(Microsoft, WA, U.S.A.) and mathematical/statistical library of GNUwin32(Free Software Foundation). This study shows that 3D diffusion tensor Turbo FLASH sequence is useful to resolve fine micro-structures of gastric tissue and both ADC and FA values in normal gastric tissue are higher than those in abnormal tissue. Authors expect that this study also represents another possibility of gastric carcinoma detection by visualizing diffusion characteristics of proton spins in the gastric tissues.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제16권9호
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• pp.918-926
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• 2010

위젯은 자주 이용하는 서비스를 독립적으로 구동시키는 작은 응용프로그램으로서, 콘텐츠를 제공하는 웹 사이트 등을 직접 방문하지 않고도 사용자가 원하는 콘텐츠를 손쉽게 얻을 수 있어서 많은 관심을 끌고 있다. 이러한 위젯은 오픈 API를 이용하면 손쉽게 개발될 수 있다. 하지만 위젯의 다양한 응용 가능성에도 불구하고, 현재 오픈 API를 제공하는 웹 사이트가 많지 않다. 그 이유는 웹 사이트 운영자가 오픈 API를 제공하기 위해서는 기존의 웹 서버 구조를 변경하거나 웹 서버 리소스를 수정해야 하는 어려움이 있기 때문이다. 본 논문에서는 기존의 웹 서버 구조 또는 웹 서버 리소스를 변경하지 않고, 개발자가 위젯 개발을 가능하도록 하는 것은 물론, 사용자가 위젯을 사용할 수 있도록 웹 서버를 대신하여 오픈 API를 제공하는 오픈 API 프록시 서버 시스템을 제안한다. 오픈 API 프록시 서버 시스템의 구성은 크게 오픈 API 소스 코드 생성기와 오픈 API 프록시 서버로 이루어져 있다. 오픈 API 소스 코드 생성기는 사용자가 원하는 오픈 API를 생성하도록 사용자에게 GUI를 제공하여 오픈 API 프록시 서버로 오픈 API 소스 코드 생성 요청을 보내는 프로그램이다. 오픈 API 프록시 서버는 본 논문에서 제안하는 HTML 테이블 처리 라이브러리를 이용하여 웹 사이트로부터 HTML 웹 페이지를 받아서 대상 HTML 테이블로부터 유용한 정보를 추출한다. 그리고 이를 XML 문서로 가공하여 오픈 API를 통해 제공한다. 실제 웹 사이트의 HTML 테이블을 대상으로 실험하여 오픈 API 프록시 서버 시스템의 동작을 검증하였다.

• 융합신호처리학회논문지
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• 제16권4호
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• pp.175-181
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• 2015

본 논문은 전파천문 관측데이터 분석을 위해 소프트웨어를 이용한 디지털필터 설계방법에 대해 제안한다. 전파천문 관측시스템은 컴퓨팅 시스템의 발전과 함께 하드웨어에서 소프트웨어를 이용한 분석방법으로 넘어가는 단계이다. 기존 하드웨어로는 특정규격에 맞도록 설계 제작되었기 때문에 규격을 변경하는 것이 어렵고 제작에 많은 비용이 소요되지만, 소프트웨어는 규격 변경이 유연하고 공개 소프트웨어를 이용할 경우 저렴하게 설계할 수 있는 장점이 있다. 그러나 소프트웨어로 전파천문과 같이 많은 자료를 분석하기 위해서는 컴퓨터 시스템의 성능이 우수해야 하는 점도 있다. 본 연구에서는 한국우주전파관측망에서 운영하고 있는 관측시스템 중에서 하드웨어로 구성된 디지털필터와 같은 성능을 갖는 소프트웨어 디지털 필터 설계에 대해 제안한다. 제안 방법은 표준 C언어를 이용하여 디지털 필터를 설계하였으며, 설계한 디지털필터에 대해 GNU Octave로 시뮬레이션을 수행하여 유효성을 검토하였다. 또한 설계한 디지털필터의 고속연산을 위해 병렬연산이 가능한 SSE 라이브러리를 도입하였다. KVN 관측모드 중에 광대역 관측데이터를 대상으로 제안한 방법의 디지털 필터를 통하여 협대역 관측모드로 데이터 필터링을 수행하였다. 그 결과, 대역 내의 필터링이 설계대로 수행되었고 리플이 발생하지 않아, 제안방법이 유효함을 확인하였다.

• Journal of Dental Anesthesia and Pain Medicine
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• 제21권5호
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• pp.413-429
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• 2021

Background: Migraine headaches are the second leading cause of disability worldwide and are responsible for significant morbidity, reduction in the quality of life, and loss of productivity on a global scale. The purpose of this systematic review and meta-analysis was to evaluate the efficacy of ketamine on migraines and other primary headache disorders compared to placebo and other active interventions, such as midazolam, metoclopramide/diphenhydramine, and prochlorperazine/diphenhydramine. Methods: An electronic search of databases published up to February 2021, including Medline via PubMed, EMBASE, Web of Science, and Cochrane Library, a hand search of the bibliographies of the included studies, as well as literature and systematic reviews found through the search was conducted to identify randomized controlled trials (RCTs) investigating ketamine in the treatment of migraine/headache disorders compared to the placebo. The authors assessed the risk of bias according to the Cochrane Handbook guidelines. Results: The initial search strategy yielded 398 unduplicated references, which were independently assessed by three review authors. After evaluation, this number was reduced to five RCTs (two unclear risk of bias and three high risk of bias). The total number of patients in all the studies was 193. Due to the high risk of bias, small sample size, heterogeneity of the outcomes reported, and heterogeneity of the comparison groups, the quality of the evidence was very low. One RCT reported that intranasal ketamine was superior to intranasal midazolam in improving the aura attack severity, but not duration, while another reported that intranasal ketamine was not superior to metoclopramide and diphenhydramine in reducing the headache severity. In one trial, subcutaneous ketamine was superior to saline in migraine severity reduction; however, intravenous (I.V.) ketamine was inferior to I.V. prochlorperazine and diphenhydramine in another study. Conclusion: Further double-blind controlled studies are needed to assess the efficacy of ketamine in treating acute and chronic refractory migraines and other primary headaches using intranasal and subcutaneous routes. These studies should include a long-term follow-up and different ketamine dosages in diagnosed patients following international standards for diagnosing headache/migraine.

• 정보관리학회지
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• 제38권3호
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• pp.311-334
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• 2021

이 연구의 목적은 합리적인 장서관리정책 수립을 위한 이론적 근거와 계량화된 객관적 기준점 제시이다. 본 연구의 연구결과를 요약하면 다음과 같다. 스테디셀러는 정기간행물 형태의 학습서가 대부분이었다. 또한, 현대소설로서 스테디셀러는 특정 작가에 의존하는 현상을 확인할 수 있었다. 베스트셀러는 출판사와 저자의 영향을 받는 것으로 조사되었다. 특히 만화와 아동용 교재를 출판하는 출판사의 도서는 베스트셀러 선정에 상당부분 상관성을 갖고 있었다. 추천된 도서 한 권당 추천 도서의 대출 수 평균은 14,871권이었으며, 베스트셀러로 선정된 도서 한 권당 평균 대출 수는 53,531권이었다. 한편 대출데이터를 기준으로 약 80~82%의 도서가 전체 상위권 대출의 90%를 감당하고 있고, 약 27~29%의 도서가 전체 상위권 대출의 50%를 감당하고 있었다. 이는 일련의 파레토법칙이 공공도서관 대출패턴에서도 굳건히 적용될 수 있음을 보여주고 있다. 문학의 대출은 전체 대출에서 50.6%를 차지하였으며, 문학 중에서 한국문학작품이 전체 51.3%를 차지하였다. 자연과학은 다른 주제분야에 비해 상대적으로 작은 수의 문헌으로 더 많은 대출을 발생시키고 있었다.

• 기록학연구
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• 제7호
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• pp.37-74
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• 2003

An Old document(Diploma) is a historical and unique record, so it must be collected, arranged, and preserved for research as soon as possible. Especially, for the effective use of the Old Document(Diploma), it is needed to arrange and describe the material systematically on the ground of modern archival theory. The Kyujanggak Archives in the Seoul National University has published 23 volumes of Old document(Diploma) material Old Document(Diploma). But they seem to cause the readers inconvenience, because the materials are classified and gathered only by genre, the titles or the orders of the materials are not standardized, and there is no description about the content of each Old document(Diploma). Jangseo-gak Library in The Academy of Korean Studies has also published the series of Old document(Diploma) material Old Document(Diploma) Collection. However the case is not different, since they are all mixed up with materials classified and gathered by genre, family, academy, or local school. And a great part of the materials have no titles and no description about the content of each Old document(Diploma), either. About the arrangement and description of the records, European and American archival science has established the theory of l)the principle of provenance, 2)the principle of original order, 3)levels of control, 4)collective description. These theories are valuable for the effective use of Old document(Diploma). On the viewpoint of the principle of provenance, Old document(Diploma) materials should not be classified by subject and genre, but by family and person. Then, the Old document(Diploma) materials, after collected by the unit of family or person on the viewpoint of the principle of provenance, should be arranged in their original order for more detailed arrangement and furthermore, for the work to find their relationship. This is so called the principle of original order. The hierarchical management of the Old document(Diploma) materials, for example, classifying by record group, sub-group, series, item and so on, is the concept of the levels of control, and comprehensive description of the each hierarchical structure is the concept of the collective description. Let's apply these archival theories to 34 pieces of the Chung, Man-Seok's material in the series of Old document(Diploma) material Old Document(Diploma). First, collect the Old document(Diploma) materials into Chung, Man-Seok's collection(the principle of provenance), which were scattered in the series classified by genre. Secondly, rearrange them chronologically(the principle of original order), and then we can find the comprehensive information about Chung, Man-Seok. For the hierarchical management of the Old document(Diploma) materials, we should establish a few concepts from the general, large group to specific, small item. The concepts can be organized as following; l)record group(Chung, Man-Seok record group) - 2)sub-group(personnel document, property document, family document, social activity document, political activity document, etc) - 3)series(gyoji-series, gyoseo-series, yuji-series etc. in the personnel document) - 4)folder(document with additions) - 5)item(one document). According to the the theory of the collective description, in the level of record group, there should be a collective description of Chung, Man-Seok's biography or a summary of record group. Similarly, there should be a collective description of a summary of sub-group in the level of sub-group and a summary of series in the level of series.

• Journal of Dental Anesthesia and Pain Medicine
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• 제21권3호
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• pp.183-205
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• 2021

This systematic review and meta-analysis aimed to analyze the effectiveness of maxillary stabilization splint (SS) therapy to reduce headache (HA) intensity and HA frequency in patients with temporomandibular disorders (TMD)-HA comorbidity. Randomized controlled trials (RCTs) using full-arch coverage, hard resin, and maxillary SS therapy were included. Electronic databases, including Cochrane Library, MEDLINE through PubMed, Web of Science, and EMBASE, were searched. The risk of bias was analyzed based on Cochrane's handbook. The search yielded 247 references up to January 28, 2020. Nine RCTs were included at a high risk of bias. The comparison groups included other splints, counseling, jaw exercises, medications, neurologic treatment, and occlusal equilibration. Four studies reported a statistically significant reduction in HA intensity, and five studies reported significant improvement in HA frequency from baseline at 2-12 months in patients with TMD-HA comorbidity treated with a full-arch hard maxillary SS. HA frequency in tension-type HA (TTH) comorbid with TMD diagnoses of myofascial pain (MFP) or capsulitis/synovitis improved significantly with SS than that with full-arch maxillary non-occluding splint (NOS) in two studies. Comparison groups receiving hard partial-arch maxillary splint nociceptive trigeminal inhibition (NTI) showed statistically significant improvements in HA intensity in patients with mixed TMD phenotypes of MFP and disc displacement comorbid with "general HA." Comparison groups receiving partial-arch maxillary resilient/soft splint (Relax) showed significant improvements in both HA intensity and frequency in patients with HA concomitant with MFP. The meta-analysis showed no statistically significant difference in the improvement of pain intensity at 2-3 months with comparison of the splints (partial-arch soft [Relax], hard [NTI], and full-arch NOS) or splint use compliance at 6-12 months with comparison of the splints (partial-arch Relax and full-arch NOS) versus the SS groups in patients with various TMD-HA comorbidities. In conclusion, although SS therapy showed a statistically significant decrease in HA intensity and HA frequency when reported, the evidence quality was low due to the high bias risk and small sample size. Therefore, further studies are required.