• Advances in nano research
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• 제13권3호
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• pp.297-312
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• 2022

Coughing and breath shortness are common symptoms of nano (small) cell lung cancer. Smoking is main factor in causing such cancers. The cancer cells form on the soft tissues of lung. Deformation behavior and wave vibration of lung affected when cancer cells exist. Therefore, in the current work, phase velocity behavior of the small cell lung cancer as a main part of the body via an exact size-dependent theory is presented. Regarding this problem, displacement fields of small cell lung cancer are obtained using first-order shear deformation theory with five parameters. Besides, the size-dependent small cell lung cancer is modeled via nonlocal stress/strain gradient theory (NSGT). An analytical method is applied for solving the governing equations of the small cell lung cancer structure. The novelty of the current study is the consideration of the five-parameter of displacement for curved panel, and porosity as well as NSGT are employed and solved using the analytical method. For more verification, the outcomes of this reports are compared with the predictions of deep neural network (DNN) with adaptive optimization method. A thorough parametric investigation is conducted on the effect of NSGT parameters, porosity and geometry on the phase velocity behavior of the small cell lung cancer structure.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제7권1호
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• pp.78-82
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• 2004

보존적인 스테로이드 치료로 호전이 없는 심한 복부증상을 동반한 HSP 환자의 치료에는 아직까지 정설이 없으나, 저자들은 면역글로불린 정맥투여로 증상이 호전된 증례와 소장의 경장괴사를 동반하고 수술적 치료로 호전된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• BMB Reports
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• 제43권9호
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• pp.635-641
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• 2010

Piwi proteins and Piwi-interacting RNAs (piRNAs) have been implicated in transposon control in germline from Drosophila to mammals. To examine the profile of small RNA expression in human cancer cells and explore difference in small RNA transcriptome, small RNA libraries prepared from wildtype, HILI overexpressed and HILI knockdowned Hela cells were sequenced using Solexa technology. piRNAs and other repeat-associated small RNAs were observed in Hela cells. By using in situ hybridization, piR-49322 was localized in the nucleolus and around the periphery of nuclear membrane in Hela cells. Following the overexpression of HILI, the retrotransposon elements LINE1 was significantly repressed, while LINE1-associated small RNAs decreased in abundance. The present study demonstrated that HILI along with piRNAs plays a role in LINE1 suppression in Hela cancer cell line.

• Tuberculosis and Respiratory Diseases
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• 제73권1호
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• pp.56-60
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• 2012

A patient who has multiple lung masses with a history of malignancy in organs other than the lung is more likely to be diagnosed with metastatic rather than primary lung cancer. Rarely, metastatic cancer can coexist with primary. We experienced a case of concurrent diagnosis of primary small cell lung cancer and pulmonary metastasis of uterine malignant mixed M$\ddot{u}$llerian tumor (MMMT). The patient was a 52-year-old female with femur fracture and multiple lung masses with a history of an operation for uterine MMMT. The small cell lung cancer was diagnosed by bronchoscopic biopsy. The central lung mass decreased after chemotherapy for small cell lung cancer but multiple peripheral masses increased. A percutaneous biopsy for one of peripheral masses revealed metastatic uterine MMMT. We suggest that we have to consider the possible presence of concomitant malignancies of different origins in one organ especially with patients who had a history of malignancy in another organ.

• Korean Journal of Radiology
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• 제21권1호
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• pp.25-32
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• 2020

Objective: To comparatively evaluate the scan coverage and diagnostic performance of the two-view scan technique (2-VST) of the automated breast ultrasound system (ABUS) versus the conventional three-view scan technique (3-VST) in women with small breasts. Materials and Methods: Between March 2016 and May 2017, 136 asymptomatic women with small breasts (bra cup size A) suitable for 2-VST were enrolled. Subsequently, 272 breasts were subjected to bilateral whole-breast ultrasound examinations using ABUS and the hand-held ultrasound system (HHUS). During ABUS image acquisition, one breast was scanned with 2-VST, while the other breast was scanned with 3-VST. In each breast, the breast coverage and visibility of the HHUS detected lesions on ABUS were assessed. The sensitivity and specificity of ABUS were compared between 2-VST and 3-VST. Results: Among 136 breasts, eight cases of breast cancer were detected by 2-VST, and 10 cases of breast cancer were detected by 3-VST. The breast coverage was satisfactory in 94.1% and 91.9% of cases under 2-VST and 3-VST, respectively (p = 0.318). All HHUS-detected lesions were visible on the ABUS images regardless of the scan technique. The sensitivities and specificities were similar between 2-VST and 3-VST (100% [8/8] vs. 100% [10/10], and 97.7% [125/128] vs. 95.2% [120/126], respectively), with no significant difference (p > 0.05). Conclusion: 2-VST of ABUS achieved comparable scan coverage and diagnostic performance to that of conventional 3-VST in women with small breasts.

• 대한세포병리학회지
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• 제17권2호
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• pp.120-125
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• 2006

Distinguishing small cell carcinoma from other lung malignancies is of great clinico-therapeutic significance. Small cell carcinoma is an aggressive tumor with a tendency to metastasize early. Survival time if untreated is low but this tumor is highly responsive to chemotherapy. We have occasionally experienced difficulties in differentiation between adenocarcinoma and small cell carcinoma of the lung in fine needle aspiration cytology (FNAC). The aim of this study was to investigate the possibility of distinguishing small cell carcinoma from adenocarcinoma of the lung in FNAC. We evaluated cytomorphological features of FNAC specimens from 62 small cell carcinomas and 57 adenocarcinomas from the lung that were confirmed by biopsy and/or immunohistochemistry on cell block. Cytomorphological details of the two tumors were compared. Nuclear smearing and nearly absent cytoplasm were the most distinct findings in small cell carcinoma compared to adenocarcinoma (p<0.05). Necrotic background, architecture and chromatin pattern, nuclear molding and nucleoli were significantly different (p<0.05). Nuclear size, nuclear membrane nature and nuclear size variation however were not helpful in distinguishing the two tumors. Combining several features described above, small cell carcinoma can be properly differentiated from adenocarcinoma on FNAC. FNAC is proposed as a diagnostic tool of small cell carcinoma of the lung in the case of inaccessibility to biopsy, and so may allow the proper therapeutic strategies to be determined in such cases

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2591-2596
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• 2014

Purpose: To evaluate the prognostic value of the expression of excision repair cross-complementation group l (ERCC1), MutS protein homolog 2 (MSH2) and poly ADP-ribose polymerase 1 (PARP1) in non-small-cell lung cancer patients receiving platinum-based postoperative adjuvant chemotherapy. Methods: Immunohistochemistry was applied to detect the expression of ERCC1, MSH2 and PARP1 in 111 cases of non-small cell lung cancer paraffin embedded surgical specimens. Through og-rank survival analysis, we evaluated the prognostic value of the ERCC1, MSH2, PARP1 and the related clinicopathological factors. COX regression analysis was used to determine whether ERCC1, MSH2 and PARP1 were independent prognostic factors. Results: In the enrolled 111 non-small cell lung cancer patients, the positive expression rate of ERCC1, MSH2 and RARP1 was 33.3%, 36.9% and 55.9%, respectively. ERCC1 (P<0.001) and PARP1 (P=0.033) were found to be correlated with the survival time while there was no correlation for MSH2 (P=0.298). Patients with both ERCC1 and PARP1 negative cancer had significantly longer survival time than those with ERCC1 (P=0.042) or PARP1 (P=0.027) positive alone. Similalry, the survival time of patients with both ERCC1 and PARP1 positive cancer was shorter than those with ERCC1 (P=0.048) or PARP1 (P=0.01) positive alone. Conclusion: Patients with ERCC1 or PARP1 negative non-small cell lung cancer appear to benefit from platinum-based postoperative adjuvant chemotherapy.

• Tuberculosis and Respiratory Diseases
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• 제65권3호
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• pp.230-234
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• 2008

본 증례에서 환자는 폐렴 치료 중 갑자기 발생한 복통을 주소로 급성 충수염을 진단받고 수술을 시행 받았다. 그 후 조직 검사 결과 소세포암으로 진단되었고 폐병변에 대해 추가적인 검사 결과 소세포폐암이 진단된 경우이다. 저자들은 소세포폐암의 충수 전이를 국내에서 처음으로 경험하여 문헌고찰과 함께 보고하는 바이다.

• 간호행정학회지
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• 제18권1호
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• pp.56-66
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• 2012

Purpose: This study was conducted to compare internal marketing, job satisfaction and customer orientation between nurses in small-medium hospitals and nurses in general hospitals. Method: The participants were 470 nurses were working in 8 small-medium hospitals and 5 general hospitals. Data were collected with structured questionnaires in July, 2010, and analyzed using descriptive statistics, ${\chi}^2$-test, MANCOVA, t-test, One-way ANOVA, and Scheffe test with PASW (SPSS) 18.0 program. Results: There was no significant difference between small-medium hospital nurses and general hospital nurses in internal marketing and customer orientation. But nurses in small-medium hospitals had higher levels of job satisfaction than general hospital nurses. Conclusions: These findings demonstrate the necessity of developing programs that will help to improve job satisfaction in nurses.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제8권1호
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• pp.60-63
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• 2005

자석을 삼킨 소아가 방문한 경우, 위안에 있으면 내시경을 통해 제거하는 것이 필요하며, 위유문부를 이미 통과한 후에 자석이 계속 같은 위치에 있거나 장천공 또는 폐쇄와 같은 합병증이 발생하면 수술적으로 이물을 제거하여야 한다. 저자들은 삼킨 자석 5개로 인하여 소장 내 누공이 형성되어 수술을 시행하였던 드문 례를 문헌 고찰과 더불어 보고하는 바이다.