• BMB Reports
• /
• 제57권6호
• /
• pp.305-310
• /
• 2024

T-plastin (PLST), a member of the actin-bundling protein family, plays crucial roles in cytoskeletal structure, regulation, and motility. Studies have shown that the plastin family is associated with the malignant characteristics of cancer, such as circulating tumor cells and metastasis, by inducing epithelial-mesenchymal transition (EMT) in various cancer cells. However, the role of PLST in the EMT of human lung cancer cells remains unclear. In this study, we observed that PLST overexpression enhanced cell migratory and invasive abilities, whereas its downregulation resulted in their suppression. Moreover, PLST expression levels were associated with the expression patterns of EMT markers, including E-cadherin, vimentin, and Slug. Furthermore, the phosphorylation levels of focal adhesion kinase (FAK) and AKT serine/threonine kinase (AKT) were dependent on PLST expression levels. These findings indicate that PLST induces the migration and invasion of human lung cancer cells by promoting Slug-mediated EMT via the FAK/AKT signaling pathway.

• 한국지하수토양환경학회지:지하수토양환경
• /
• 제12권3호
• /
• pp.10-16
• /
• 2007

불포화대 및 포화대에 걸쳐 존재하는 폐석더미의 수리적 특성을 조사하기 위해 물을 주입한 후 수두강하를 측정하는 순간충격시험을 실시하였다. 본 연구지역과 같이 관정이 수리적 특성이 크게 다른 두 지층에 걸쳐 설치된 경우, Bower and Rice해석 방법을 이용하여 두 대수층 각 각의 수리전도도를 산출할 수 있었으며, 하강하는 지하수위의 변곡점을 이용하여 폐석더미의 두께를 추정할 수 있었다. 갈수기 시 관정 내 낮은 지하수위 때문에 인위적인 지하수위를 형성시킨 후 순간충격시험을 실시한 결과, 그 결과는 풍수기 시험 결과와 차이가 크지 않았다. 이와 같은 순간 충격시험은 폐석적치장과 같은 곳의 수리적 특성을 파악할 수 있는 유효한 방법으로 판단된다.

• 대한기계학회논문집B
• /
• 제26권11호
• /
• pp.1559-1569
• /
• 2002

In order to investigate the characteristics of electromagnetic flowmeter in two -phase flow, an AC electromagnetic flowmeter was designed and manufactured. In various flow conditions, the signals and noises from the flowmeter were obtained and analyzed by comparison with the observed flow patterns with a high speed CCD camera. The experiment with the void simulators in which rod shaped non-conducting material was used was carried out to investigate the effect of the bubble position and the void fraction on the flowmeter. Based on the results from the void simulator, two -phase flow experiments encompassed from bubbly to slug flow regime were conducted. The simple relation $\Delta$ $U_{TP}$ = $\Delta$ $U_{SP}$ (l-$\alpha$) was verified with measurements of the potential difference and the void fraction. Due to the lack of homogeneity in a rent two -phase flow, the discrepancy between the relation and the present measurement was slightly increased with void fraction and also liquid volumetric flux jf. Whereas there is no difference in the shape of the raw signal between single-phase flow and bubbly flow, the signal amplitude for bubbly flow is higher than that for single -phase flow at the same water flow rate, since the passage area of the water flow is reduced. In the case of slug flow, the phase and the amplitude of the flowmeter output show dramatically the flow characteristics around each slug bubble and the position of a slug bubble itself. Therefore, the electromagnetic flowmeter shows a good possibility of being useful for identifying the flow regimes.ul for identifying the flow regimes.

• 대한기계학회논문집B
• /
• 제39권7호
• /
• pp.557-566
• /
• 2015

본 논문에서는 $600{\times}600{\mu}m$ 사각 마이크로 채널에서의 기-액체 테일러(슬러그) 흐름의 특성을 실험을 통해 살펴보았다. 실험 유체로는 질소와 물을 사용하였으며, 액체 및 기체 겉보기 속도는 각각 0.01 ~ 3 m/s, 0.1 ~ 3 m/s 의 범위에서 테일러 흐름이 나타나는 구간에서만 데이터를 얻었다. 기포 길이, 액체 슬러그 길이, 기포 속도 그리고 기포 생성 주파수를 고속 카메라를 사용하여 이미지 분석을 통해 측정하였다. 제시된 측정값(기포 길이, 액체 슬러그 길이, 기포 속도)과 이전 문헌에서 제안된 경험적 모델의 비교결과 대부분 오차가 50% 이상으로 나타났다. 따라서 기포와 액체 슬러그 길이 그리고 기포 속도에 대한 개선된 모델을 제시하였고, ${\pm}20%$ 이내의 비교적 우수한 결과를 볼 수 있었다. 또한 기포 생성 주파수는 기포 길이, 액체슬러그 길이 그리고 기포 속도의 관계를 이용하여 ${\pm}20%$ 이내에서 예측가능함을 알 수 있었다.

• 조명전기설비학회논문지
• /
• 제28권7호
• /
• pp.1-12
• /
• 2014

This paper is proposed to design the new heat-sink apparatus for improving the heat transfer characteristics in the power LED chip, and results of the operation characteristics were discussed. The core design is that the soldering through-hole on the FR-4 PCB board is formed to the effective heat transfer. That is directly filled with Ag-nano materials, which shows the high thermal conductivity. The heat transfer medium consisting of Ag-nano materials is classified into two structures. Mediums are called as the heat slug and the multi-pin in this work. The heat of the high temperature generated from the LED chip was directly transferred to the heat slug of the one large size. And the accumulated heat from the heat slug was quickly dissipated by the medium of the multi-pin, which is the same body with the heat slug. This multi-pin was designed for the multi-dissipation of heat by increasing the surface areas with a little pins. Subsequently, the speed of the heat transfer with this new heat-sink apparatus is three times faster than the conventional heat-sink. Therefore, the efficiency of the illuminating light will be improved by adapting this new heat-sink apparatus in the large area's LED.

• 한국해양공학회지
• /
• 제35권1호
• /
• pp.38-49
• /
• 2021

Slug flow is the most common multi-phase flow encountered in oil and gas industry. In this study, the hydrodynamic features of flow in pipes investigated numerically using computational fluid dynamic (CFD) simulations for the effect of slug flow on the vertical and bent pipeline. The compressible Reynold averaged Navier-Stokes (RANS) equation was used as the governing equation, with the volume of fluid (VOF) method to capture the outline of the bubble in a pipeline. The simulations were tested for the grid and time step convergence, and validated with the experimental and theoretical results for the main hydrodynamic characteristics of the Taylor bubble, i.e., bubble shape, terminal velocity of bubble, and the liquid film velocity. The slug flow was simulated with various air and water injection velocities in the pipeline. The simulations revealed the effect of slug flow as the pressure occurring in the wall of the pipeline. The peak pressure and pressure oscillations were observed, and those magnitudes and trends were compared with the change in air and water injection velocities. The mechanism of the peak pressures was studied in relation with the change in bubble length, and the maximum peak pressures were investigated for the different positions and velocities of the air and water in the pipeline. The pressure oscillations were investigated in comparison with the bubble length in the pipe and the oscillation was provided with the application of damping. The pressures were compared with the case of a bent pipe, and a 1.5 times higher pressures was observed due to the compression of the bubbles at the corner of the bent. These findings can be used as a basic data for further studies and designs on pipeline systems with multi-phase flow.

• Nuclear Engineering and Technology
• /
• 제55권11호
• /
• pp.3973-3982
• /
• 2023

As for two-phase flow in rectangular channels, the flow regimes especially like churn-turbulent and annular flow are significant for the physical problem like Countercurrent Flow Limitation (CCFL). In this study, the rectangular channels with cross-sections of 4 × 66 mm, 6 × 66 mm, 8 × 66 mm are adopted to investigate the flow regimes of air-water vertical upward two phase flow under adiabatic condition. The gas and liquid superficial velocities are 0 ≤ j_g ≤ 20m/s and 0.25 ≤ j_f ≤ 3m/s respectively which covering bubbly to annular flow. The flow regimes are identified by random forest algorithm and the flow regime maps are obtained. As the results, the transitional void fraction from slug to churn turbulent flow fluctuate from 0.47 to 0.58 which is significantly affected by the dimensional size of channel and flow rate. Besides, the void fraction at transitional points from churn-turbulent (slug) to annular flow are 0.66-0.67, which are independent with the gap size. Furthermore, a new criteria of slug to churn-turbulent flow is established in this study. In addition, by introducing the interfacial force model, the criteria of churn-turbulent (slug) flow to annular flow is verified.

• 설비공학논문집
• /
• 제24권5호
• /
• pp.401-408
• /
• 2012

Volumetric mass transfer coefficient was measured with carbon dioxide and deionized water for the gas-liquid cocurrent slug flow in 2, 5 and 8 mm tubes. Measurement was repeated with and without a vertical section in an experimental setup and entrance effect was found greater for smaller tubes. Volumetric mass transfer coefficient in the vertical section was found generally a strong function of gas- and liquid-phase superficial velocities. 5 mm- and 8 mm-tube data are highly consistent each other but not with 2 mm tube.

• 융복합기술연구소 논문집
• /
• 제1권2호
• /
• pp.25-28
• /
• 2011

Void fraction has been measured for the gas-liquid cocurrent slug flow in 8mm vertical acrylic tube using an optical method. Bubble speed, length and period could be measured with the two sets of laser-infrared sensor modules mounted 25mm apart alongside the tube, which were designed to detect variation of light intensities with a time delay when two parallel laser beams were refracted successively by a passing bubble. It was found that the results were in good agreement with the previous studies in the literature suggesting that the method used in this study were sound and accurate.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2004년도 추계학술대회
• /
• pp.1569-1573
• /
• 2004

Two ring-type conductance meters were manufactured to measure void fraction and its propagation speed in slug flow. The signal of conductance meter with two rings depends on liquid temperature. Therefore a conductance meter with separated probe designed by Coney (1973), which is independent of liquid temperature, was used and experimentally proved. The manufactured conductance meters showed a good repeatability and agreement with the analytical solution by Coney (1973). From time lag between two conductance meter, we could calculate the propagation speed of void fraction.