• 한국의사학회지
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• 제32권1호
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• pp.11-20
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• 2019

Queen Myeongseong was the wife of King Hyeonjong, the 18th king of the Joseon Dynasty, and the mother of King Sukjong. The clinical records of Queen Myeongseong are summarized on the basis of the Seungjeongwon Ilgi (The Daily Records of Royal Secretariat of Joseon Dynasty 承政院日記) and reviewed through Donguibogam. Queen Myeongseong gave birth to one male and three female children in the time of the queen. She took Geumgaedangguihwan (金櫃當歸丸), Dalsaengsan (達生散), Antaeum (安胎飮) during her pregnancy and Gungguitang (芎歸湯) during postnatal care. Since 1669, chest tightness, sleeplessness, arm pain and numbness of arms had been appeared. Ondamtang (溫膽湯) and Dodamtang (導痰湯) were used but they were not effective. However, when her symptoms were regarded as a benign tumor due to cold and wetness, there was a difference in the use of Ohjuksan (五積散). In 1683, when king Sukjong was caught in a smallpox, she took care of him. She exorcised in the middle of winter to pray for her son's recovery, and died of the flu.

• 대한한의학방제학회지
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• 제16권1호
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• pp.185-205
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• 2008

The purpose of this study is to determine whether the clinical activity of patients with atopic dermatitis(AD) correlate with their serum cytokine levels. 86 patients with AD were treated with KHS, YMH and GHT. On each visit to the clinic, their skin status was evaluated using the SCORAD index and serum IL-4, $IFN-{\gamma}$, IL-12, IL-13, IL-2 and IL-10 were measured by ELISA. After oral administration of herbal medicine, patients' skin status and subjective parameters such as pruritus and sleeplessness were significantly improved according to regression analysis. In particular, patients aged 0-9 showed stronger responses to treatment, which implies that the younger patients aged, the easier the treatment by herbal formula became. In analysis of the type of chosen herbal medicines, YMH treated group showed a stronger response in reduction of affected lesion, intensity of a lesion and subjective symptoms, while KHS treated group showed the least reduction. The levels of serum IL-4, $IFN-{\gamma}$ and IL-2 correlated with disease activity. Moreover, in patients under 0-9, the IL-4 level had a corrleation with disease activity; patients under 10-19 showed a correlation between the levels of IL-4 and IL-2 and disease activity; patients under 20-29 showed a correlation between the levels of IL-2, IL-12 and $IFN-{\gamma}$ and disease activity. In comparison with chosen herbal medicines, the groups treated with YMH or GHT treated group showed a correlation between the levels of IL-4, IL-12 and IL-2 and disease activity while KHS treated group did not. Our data suggest that serum levels of IL-4 and IL-13 are good indicators of clinical improvement in treating AD.

• 농촌의학ㆍ지역보건
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• 제22권1호
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• pp.49-59
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• 1997

Backgrounds : There has been many studies investigating the causes of farmers' syndrome. In some studies, psychologic stress is related to farmer's syndrome. And the diagnostic criteria of farmer's syndrome is similar to those of generalized anxiety disorder. So we carried out this study to investigate the psychiatric causes of farmers' syndrome. Methods : This study was done in some rural and urban areas of Kyoungsangnam Province, July, August, October and November of 1996. Those who came to free medical service and completed interview, medical examination and laboratory examination and 20-59 years old were 150 persons. And those who came to health center for health examination and completed only interview and 20-59 years old were 94 persons. The questionnaire was composed of sociodemographic factors, health risk factors, farmer's syndrome, work load, BEPSI(inventory to measure stress), Spielberger's state-trait anxiety inventory, self-rating depression scale. To examine statistical significance, we used X2-test, Mantel-Haenszel test for linear association, t-test, ANCOVA, correlation, multiple regression, logistic regression. Results : The prevalence of farmer's syndrome, adjusted for age and sex with population of Kyungsangnam Province of 1993 was 208 per 1,000(90 per 1,000 in men and 329 per 1,000 in women). In bivariate analysis, farmer's syndrome was significantly related to age, sex, job, income, smoking, alcohol drinking, work load, BEPSI, state anxiety, trait anxiety, depression, body mass index, Hwa-Byung, hypertension, anemia. However, when age and sex were adjusted, job was not significantly related to farmer's syndrome. The score of farmer's syndrome was significantly related to age, sex, work load, BEPSI, trait anxiety by multiple regression. Farmer's syndrome was significantly related to increasing age(odd ratio 1.079, 95% C.I. 1.060 - 1.099), sex(odds ratio of male 0.434, 95% C.I. 0.349 - 0.540), and BEPSI(odds ratio 1.231, 95% C.I. 1.148 - 1.320) by logistic regression. Results of logistic regression analysis of the component symptoms of farmer's syndrome were as follows. Shoulder stiffness was significantly related to increasing age, female sex and BEPSI. Lumbago was significantly related to increasing age, female sex and trait anxiety. Numb limbs and nocturia was significantly related to increasing age and female sex. Breathlessness was significantly related to work load, sleeplessness was significantly related to depression, dizziness was significantly related to job and state anxiety, and abdominal fullness was significantly related to female sex. Conclusion : Farmers' syndrome was related to work load, but was more related to psychiatric factors such as BEPSI and trait anxiety. And the occupation was not risk factor of farmers' syndrome in this study, so further study is needed to investigate the cause of farmers' syndrome.

• 대한한방소아과학회지
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• 제24권3호
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• pp.106-120
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• 2010

Objectives: Sanjointang has been clinically used much for treating sleeplessness. However, the effects of Sanjointang in artificial sleep deprivation situations are not known. The purpose of this study is to evaluate the heart rate, left ventricular systolic pressure, left ventricular diastolic pressure, +dp/dt maximum, -dp/dt maximum, and -dp/dt / +dp/dt ratio which are related to the hemodynamic functions of the heart by using sleep-deprived Sparague-Dawley rats, in order to clarify the impact of Sanjointang on hemodynamic functions of the heart of sleep deprived rats. Methods: Eighteen hearts were removed from the male Sparague-Dawley rats weighting about 180g were perfused by the Langendorff technique with modified 37 Krebs-Henseleit's buffer solution at a constant perfusion pressure (60mmHg). They were randomly assigned to one of the following three groups, 1) Normal group (those which did not have sleep deprivation and received normal saline administration), 2) Control group (sleep deprived and normal saline administered), 3) Sample group (sleep deprived and Sanjointang was administered). Control and sample groups rats were deprived 96 hours of sleep by using the modified multiple platform technique. Heart rate, left ventricular systolic pressure, left ventricular diastolic pressure, +dp/dt maximum, -dp/dt maximum, -dp/dt / +dp/dt ratio were evaluated at baseline after the administration of either normal saline or Sanjointang. Results: The heart rate and -dp/dt / +dp/dt ratio was significantly decreased in rats with 96 hours of sleep deprived significantly decreased. The change in the heart rate after administering Sanjointang did not show any significant difference. The left ventricular systolic pressure of the removed heart significantly decreased due to Sanjointang administration, while the left ventricular diastolic pressure significantly increased (p<0.05). The +dp/dt maximum and -dp/dt maximum both significantly decreased in the removed heart after administering Sanjointang. (p<0.05). There was no significant difference observed in the -dp/dt / +dp/dt ratio after administering Sanjointang. Conclusions: According to the results above, sleep deprivation significantly decreases heart rate and -dp/dt / +dp/dt ratio. This is considered as a result of exhaustion due to accumulation of fatigue. Meanwhile, Sanjointang reduced left ventricular systolic pressure and raised left ventricular diastolic pressure, and relieved the contractility and relaxation of the myocardium. Consequently, this reduces the burden of the heart and creates a relatively stabilized heart condition similar to a sleeping condition.

• 항공우주정책ㆍ법학회지
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• 제25권1호
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• pp.55-95
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• 2010

'lesion corporelle'의 직역에 대한 의견에 있어서 약간의 차이가 있지만, 그것의 의미와 정신 또는 정신적 상해의 다양한 문맥상 적용함에 있어서는 분명하지 못하다. 미국 법원은 Floyed 사건이 바르샤바 협약 제17조에 따라 정신적 상해를 포함하는 범위에 대한 배상을 허용한 이후로 신체적 상해의 관련 또는 동반 여부에 따라 다르게 결정하고 있다. 대부분의 법원은 동 협약에 따라 순수한 감정적 손해에 대해서는 배상이 불가능하다는 의견에는 일치한다. 또한 신체적으로만 나타나는 증상 예를 들어 체중이 감소하거나 불면증과 같은 경우에는 감정적인 손해에 대한 배상을 인정하지 않는데 동의한다. 동시에 감정적 손해가 신체적 상해로부터 야기된 경우에는 그에 대한 배상에 동의한다. 이와 관련하여 현재는 바르샤바 협정의 용어가 그대로 유지되고 있어 많은 국가들의 판례가 상이하게 나타나고 있어 조약의 본래의 목적에 기여하지 못하고 있는 실정이다. 또한 정신적 상해와 관련된 PSTD 등의 사안은 현 바르샤바에 따르든지, ICAO에서 제안한 새로운 협약에 따르든지 그 여하를 불문하고 '신체적 상해'라는 용어 내에서 법원이 정신적 고통과 관련된 과학적 증거와 그 적용문제에 있어서 감당할 준비가 되어 있는지의 여부에 따라 달라질 것이다. 이러한 점들을 종합해 볼 때 현재의 바르샤바 협정 제17조의 '신체적 상해'라는 개념은 '정신적 상해'까지 확대되어야 할 것이다. 따라서 향후 조약에서 '신체적 상해'라는 용어는 '상해' 혹은 '건강훼손'이라는 용어로 개정 내지 교체해야 할 것이다.

• Journal of Nutrition and Health
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• 제50권5호
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• pp.460-471
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• 2017

본 연구는 인천지역 인문계 여자고등학생 340명의 에너지음료 섭취 실태, 카페인 중독 수준과 에너지음료 섭취에 관한 교육 요구도를 알아보기 위하여 설문조사를 실시하였고, 학년, BMI와 카페인 중독 자가진단 결과에 따라 분류하여 분석하였다. 에너지음료를 알고 있는 대상자는 328명 (97.9%)이었고, 에너지음료 섭취 경험자는 249명 (74.3%)이었다. 에너지음료 섭취 경험자 249명을 대상으로 분석한 결과, 에너지음료 첫 섭취 경험 시기는 학년과 유의한 관련이 있는 것으로 나타났고 (p < 0.05), 1학년은 중학생과 초등학생 순으로, 2학년과 3학년은 중학생과 고등학생 순으로 에너지음료 첫 섭취 시기가 조사되었다. 에너지음료의 구입처는 집 근처 75.1%와 학교 근처 10.8%의 자판기와 편의점으로 나타났고, 에너지음료를 마신 후 느꼈던 효과는 대상자의 44.6%가 졸리지 않았던 반면 41.7%는 효과를 느끼지 못하였다고 답하였다. 그리고 에너지음료 섭취 후 부작용은 대상자의 24.5%가 가슴 두근거림, 현기증, 떨림, 설사 등의 부작용을 경험한 반면 75.5%는 부작용이 없었다. 에너지음료 섭취 경험자를 대상으로 카페인 중독 자가진단 결과, 카페인 중독 평균 점수는 0.9점 (8점 만점)으로 낮은 점수를 보이었으나 5점 이상의 카페인 중독군에 해당하는 대상자는 6명 (2.4%), 2~4점의 카페인 중독 위험군은 44명 (17.7%), 0~1점의 일반군은 199명 (79.9%)으로 조사되었다. 카페인 중독 점수는 BMI에 따라 유의한 차이가 나타났으며 저체중군 1.3점이 과체중군 0.6점에 비하여 카페인 중독 평균 점수가 높았다 (p < 0.05). 그러나 카페인 중독 점수에 따라 분류 된 세 그룹은 학년, BMI, 생활습관과는 유의적인 관련이 나타나지 않았다. 카페인 중독 점수에 따라 에너지음료 섭취 효과와 부작용은 유의적인 관련이 있는 것으로 나타났다 (p < 0.001). 에너지음료 섭취 효과에 대하여 카페인 중독군과 일반군은 각각 83.3%와 36.7%가 졸리지 않았다고 한 반면 16.7%와 47.2%는 효과가 없었다고 하였고, 부작용이 나타난 경우는 카페인 중독군의 경우 83.3%이었으나 일반군은 16.6%가 부작용이 나타난 것으로 조사되었다. 학년에 따라 부모님 또는 선생님으로부터 에너지음료의 부작용에 대하여 들어본 적이 있는지 여부는 유의적으로 관련이 있는 것으로 나타났다 (p < 0.01). 그리고 카페인 중독 점수에 따라 에너지음료에 대하여 섭취를 줄이거나 중단 할 의향의 정도 (p < 0.001)와 에너지음료에 대한 영양교육의 필요성 (p < 0.05)은 카페인 중독군이 일반군 보다 낮은 점수를 보였다. 전체 335명을 대상으로 올바른 에너지음료 섭취를 위해 요구하는 영양교육 내용은 에너지음료에 대한 부작용 59.7%, 카페인의 부작용 14.9% 순으로 나타났다. 본 연구는 인천지역 일부 여고생들을 대상으로 이루어진 제한점이 있으나, 인문계 여자고등학생의 학년, BMI와 카페인 중독 점수에 따른 에너지음료 섭취관련 요인과 에너지음료 관련 교육요구도에 관한 연구가 이루어진 것에 의의가 있다. 청소년기의 건강한 식습관이 성인이 되어서도 건강에 중요한 영향을 미치기 때문에 여자고등학생의 에너지음료에 대한 올바른 섭취 방법과 카페인 함유 식품에 대한 위해성에 관한 영양교육 자료 개발이 필요하며, 이를 활용한 지속적인 교육이 필요하다.