• Title/Summary/Keyword: Skullcapflavon II

Search Result 1, Processing Time 0.015 seconds

Antineoplastic natural products and the analogues V - Antitumor Activity of Skullcapflavon II

  • Ryu, Sung-Ho;Ahn, Byung-Zun;Pack, Moo-Young
    • Archives of Pharmacal Research
    • /
    • v.8 no.4
    • /
    • pp.253-256
    • /
    • 1985
  • The effect of skullcapflavon II, 5, 2'- dihydroxy-6, 7, 8, 6'-tetramethoxyflavone, on the growth of transplantable L 1210 and sarcoma 180 tumors in mice was studied. Intraperitional treatment of skullcapflavon II cased a significant (T/C = 166%) and a moderate (T/C = 122 %) prolongations of the life spans of ICR and $BDF_{1}$ mice respectively, which had been intraperitioneally inoculated with sarcoma 180 and L 1210 cells. Peritumoral injection of skullacapflavon II on the solid form of sarcoma 180 in mice inhibited the tumor growth strongly (Inhibition rate = 71%).

  • PDF