• Journal of Oral Medicine and Pain
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• v.38 no.1
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• pp.1-5
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• 2013

Erythema multiforme(EM), a blistering and ulcerative inflammatory disorder, affect skins or mucosa, and is thought to be triggered mainly by preceding infection, such as Herpes simplex virus, or exposure to drugs and medication, particular antibiotics or analgesics. Symptoms include typical cutaneous target lesions on skins and in case of oral manifestation, erosive and ulcerative lesions on lips, buccal mucosa, and tongue are known to occur, which needs differential diagnosis with other intraoral lesions. In this case, EM assumed that it is occurred by giving Trichomonas infection or Metronidazole in oral region is introduced with a review of diagnosis and treatment of EM.

• Journal of the Korean Society of Costume
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• v.5
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• pp.7-11
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• 1981

In the vast extent of time, man and his ancestors have existed on earth about 2,000,000 years. For Near-Man, they knew how to make fire and protected themselves with hairs. Old-Man covered their bodies with the skins of wild animals. New Man improved the quality, the range and ingenuity, so they fabricated clothes with the animal skins. New Man is considered as ancestor of Modern Man. They had spread widely over the earth to take advantage of their surroundings. The next period, New Stone Age was chiefly distinguished by agricultural age. He was now about to make clothes from natural fibers. The two most obvious orgins of clothing are to protect the body against environment and to decorate the body. The forms of clothing were different from the various climates and regions they had settled, for example Yo-po Hyung (Apron), Kwae-po Hung (Sewn garment), Kwan-doo Hyung (Poncho), Chun-kae Hyung (Frontopend garment), Chai-hyung Hyung (Body-conforming shape). Our ancestor had moved from Baikal Lake, Central Asia toward northeast; Shun-tung in China, Manchuria and at last Han Panninsula. Considering our basic costume of ancient times were Yu(jacket), Ko(trousers), Sang(skirt), Po (coat) with the accessories of Kwan (crown), Mo (hat), Dai (belt), Hwa, Eie (footwear), here I conjecture our costume of prehistoric period was Chaihyung Hyung(Body-conforming shape) in the purpose of body covering.

• Journal of Pharmaceutical Investigation
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• v.26 no.4
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• pp.315-321
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• 1996

It has been indicated that problems associated with insulin iontophoresis are low bioavailability, slow absorption rate and the use of high dosage. Pretreatment of skin as a method of solving these problems was used in alloxan-induced diabetic white rabbits. Skins were treated with skin needle, electric razor, knife razor and scotch tape. Transport data shows that insulin delivery was enhanced significantly by the treatment which disrupt the barrier properties of stratum corneum. The data also shows that insulin absorption lasted for several hours after the cessation of iontophoresis. The degree of skin treatment was estimated by measuring the electrical resistance of skin. When the skins were treated with skin needle and electric razor, the standard deviations of resistance were small, which suggests the possibility of uniform delivery of insulin. The dermal responses after the invasive delivery were evaluated in accordance with OECD Guideline. It seems that electrical resistance of the skin correlate well with the dermal irritation.

• Fisheries and Aquatic Sciences
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• v.26 no.4
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• pp.241-255
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• 2023

The robust development of frog farming offered high economic benefits but created a large waste residue of frog bones and skin that received little attention. Over the years, inedible by-products have often been processed into biomolecules of potential value and environmental benefits, such as collagen, gelatin, and bioactive peptides. An overview of bioactive compounds on frog skins from various countries indicated that brevinin was the most abundant biological peptide found in frog skin. Other remaining compounds also possessed their highlighted activities, including antibacterial, stimulating insulin release and gastric hormone release, anti-cancer, and neuroregulatory. Notably, various components have been analyzed in the structure and sequence to give meaningful insight into clustering components related to their biological activity. This review may create a source of raw materials for the developmental research of by-products from frog skin and concomitantly reduce environmental pollution.

• Steel and Composite Structures
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• v.45 no.3
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• pp.467-482
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• 2022

One of the major failure modes in composite sandwich structures is the separation between skins and core. In this study, the effect of employing foam filled composite corrugated core on the skin/core debonding (resistance to separation between skin and core) is investigated both experimentally and numerically. To this aim, triangular corrugated core specimens are manufactured and compared with reference specimens only made of PVC foam core in terms of skin/core debonding under bending loading. The corrugated composite laminates are fabricated using the hand layup method. Also, the Vacuumed Infusion Process (VIP) is employed to join the skins to the core with greater quality. Utilizing an End Notched Shear (ENS) fixture, three point bending tests are performed on the manufactured sandwich composite panels. The results reveal that the resistance to separation capacity and flexural stiffness of sandwich composite has been increased about 170% and 76%, respectively by using a triangular corrugated core. The Cohesive Zone Model (CZM) with appropriate cohesive law in ABAQUS finite element software is used to model the progressive face/core interfaces debonding the difference between experimental and numerical results in predicting the maximum born load before the skin/core separation is about 6 % in simple core specimens and 3% in triangular corrugated core specimens.

• Smart Structures and Systems
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• v.29 no.5
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• pp.705-714
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• 2022

In this paper, the effect of magnetic field on the vibration behavior of a Magnetorheological elastomer (MRE) sandwich MEMS actuated by electrostatic actuation with conductive skins are examined within the multiple scales (MMS) perturbation method. Magnetorheological smart materials have been widely used in vibration control of various systems due to their mechanical properties change under the influence of different magnetic fields. To investigate the vibrational behavior of the movable electrode, the Euler-Bernoulli beam theory, as well as Hamilton's principle is used to derive the equations and the related boundary conditions governing the dynamic behavior of the system are applied. The results of this study show that by placing the Magnetorheological elastomer core in the movable electrode and applying different magnetic fields on it, its natural vibrational frequency can be affected so that by increasing the applied magnetic field, the system's natural frequency increases. Also, the effect of various factors such as the electric potential difference between two electrodes, changes in the thickness of the core and the skins, electrode length, the distance between two electrodes and also change in vibration modes of the system on natural frequencies have been investigated.

• Structural Engineering and Mechanics
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• v.91 no.1
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• pp.63-73
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• 2024

Improving the blast resistance of structural establishments has become an imperative engineering commitment to prevent property damage and fatalities in terrorist incidents. This study investigates the effects of blast mass and stand-off distance on CFRP skin concrete core sandwich bunkers of varying thicknesses using ABAQUS/Explicit software with CONWEP functionality. The considered parameters include TNT masses of 1, 10, and 25 kg and stand-off distances of 0.1, 1, 2, and 2.5 meters on structures with 200, 250, and 500 mm core thicknesses. The study finds that there exists a declining response corresponding to the blasting mass reduction coupled with increases in the stand-off distance and core thickness. The 500 mm thick bunker sustains less damage compared to those with 200 mm and 250 mm core thicknesses. The sandwich configuration remains structurally advantageous vs. those without skins. The sandwich bunker with a 500 mm thick concrete core gives the best performance against the 10 kg TNT blast load with a 1 m standoff distance exhibiting a 22.8% reduction in damage vs. that without skins. Mathematical expressions are then formulated for predicting maximum von Mises stress, principal stress, and displacement of sandwich bunkers as functions of TNT masses, stand-off distances, and core thicknesses.

• Asian-Australasian Journal of Animal Sciences
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• v.21 no.2
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• pp.277-290
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• 2008

The process of wound repair involves an ordered sequence of events such as overlapping biochemical and cellular events that, in the best of circumstances, result in the restoration of both the structural and functional integrity of the damaged tissue. An important event during wound healing is the contraction of newly formed connective tissues by fibroblasts. The polypeptide growth factors, like transforming growth factor-${\beta}$(TGF-${\beta}$, insulin-like growth factor I (IGF- I) and epidermal growth factor (EGF), play very important mediator roles in the process of wound contraction. Deer antlers, as models of mammalian regeneration, are cranial appendages that develop after birth as extensions of a permanent protuberance (pedicle) on the frontal bone. Antlers contain various growth factors which stimulate dermal fibroblast growth. They are involved in digestion and respiration and are necessary for normal wound healing and skin health. In order to investigate and evaluate the effects of red deer antlers on skin wound site, the speed of full-thickness skin wound healing and the expression of IGF-I, TGF-${\beta}$ and EGF in skin wounds, three groups of skin full-thickness rat models with a high concentration of antler ointment, a low concentration of antler ointment and without antler ointment were compared. At post-injury days 0, 2, 4, 8, 16, 20, 32, 40 and 60, the skin wound area was measured, the expressions of IGF-I, TGF- ${\beta}$ and EGF mRNA were detected by reverse transcriptase polymerase chain reaction (RT-PCR) and collagen formation by sirius red dye and the localization of IGF-I, TGF-${\beta}$ and EGF peptides were inspected by histological immunohistochemical techniques. Wound healing was significantly more rapid in antler treated skins. In addition, the wound treated with a high concentration antler ointment, a low concentration antler ointment, and the control closed completely at post-injury day 40, day 44 and day 60, respectively. Via RT-PCR, the expressions of IGF-I (day 8 and day 16), TGF-${\beta}$(day 8, day 16 and day 20) and EGF (day 4, day 8, day 16, and day 32) were obviously up-regulated in high concentration antler-treated skins compared to control skins. Similar results could be seen in the histological detection of collagen dye and immunohistochemical methods using the corresponding polyclone antibodies of IGF-I, TGF-${\beta}$ and EGF. These results illustrate that antlers stimulate and accelerate the repair of cutaneous wounds.

• Asian-Australasian Journal of Animal Sciences
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• v.25 no.5
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• pp.708-716
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• 2012

In order to investigate and evaluate the effects of red deer antlers on hair growth in the full-thickness wound healing model, Sprague-Dawley rats were given incision wounds through the full thickness of their dorsal skin and deer antler was applied for 40 days. At specified intervals thereafter (4, 8, 16, 32 and 40 days), the animals were sacrificed and the wound site skins were excised, processed, and sectioned. At post-injury days 16, 32 and 40, longer and more active new hair appeared around the healing wound of antler-treated skin. Histological studies showed that the antler extract markedly increases the depth, size, and number of hair follicles. Expression of IGF-I (insulin-like growth factor) mRNA was detected by RT-PCR and real time RT-PCR. The result showed that the expression of IGF-I (days 16, 32, and 40) was obviously up-regulated in antler-treated skins compared to control skins. Similar results were seen in the ELISA analysis to quantify the IGF-I expression. These results support the notion that wound healing can cause hair growth by enhancing the expression of IGF-I. Deer antler extract appears to have the potential to promote hair growth and could be used in hair growth products.

• Polymer Science and Technology
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• v.26 no.4
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• pp.274-281
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• 2015