• 대한골관절종양학회지
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• 제6권4호
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• pp.173-177
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• 2000

횡문근양 종양은 주로 소아기의 신장에서 발생하는 신생물로, 침습적인 양상을 보이는 비교적 드문 종양이다. 최근에 신장 외의 다양한 부위에서 발생한 예들이 보고되고 있으며, 연부 조직에 발생한 경우에는 미분화된 횡문근 육종으로 오진되기 쉽다. 횡문근양 종양은 횡문근 육종보다 침습적이고 나쁜 예후를 보이는 종양으로, 횡문근 육종과의 조직학적인 정확한 감별이 필요하며, 면역조직화학 검사가 그 감별에 도움을 줄 수 있다. 저자들은 치골 부위와 하복벽 부위에서 발생한 횡문근양 종양을 경험하여 문헌의 고찰과 함께 보고하고자 한다.

• Journal of the Korean Physical Society
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• 제73권10호
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• pp.1577-1583
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• 2018

Tumor-treating fields therapy involves placing pads onto the patient's skin to create a low- intensity (1 - 3 V/cm), intermediate frequency (100 - 300 kHz), alternating electric field to treat cancerous tumors. This new treatment modality has been approved by the Food and Drug Administration in the USA to treat patients with both newly diagnosed and recurrent glioblastoma. To deliver the prescribed electric field intensity to the tumor while minimizing exposure of organs at risk, we developed an optimization method for the electric field distribution in the body and compared the electric field distribution in the body before and after application of this optimization algorithm. To determine the electric field distribution in the body before optimization, we applied the same electric potential to all pairs of electric pads located on opposite sides of models. We subsequently adjusted the intensity of the electric field to each pair of pads to optimize the electric field distribution in the body, resulting in the prescribed electric field intensity to the tumor while minimizing electric fields at organs at risk. A comparison of the electric field distribution within the body before and after optimization showed that application of the optimization algorithm delivered a therapeutically effective electric field to the tumor while minimizing the average and the maximum field strength applied to organs at risk. Use of this optimization algorithm when planning tumor-treating fields therapy should maintain or increase the intensity of the electric field applied to the tumor while minimizing the intensity of the electric field applied to organs at risk. This would enhance the effectiveness of tumor-treating fields therapy while reducing dangerous side effects.

• Radiation Oncology Journal
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• 제26권2호
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• pp.113-117
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• 2008

목적: 노령의 피부암에서 방사선치료 후 국소 제어률, 생존율, 실패양상, 부작용을 알아보기 위해 이 연구를 시행하였다. 대상 및 방법: 1990년 1월부터 2002년 10월까지 계명대학교 동산의료원 방사선종양학과에서 방사선치료를 받은 노령 환자 15명을 대상으로 하였다. 연령 분포는 72세에서 95세로 평균 78.8세였다. 병리학적으로 10명은 편평상피암이었고 3명은 기저세포암이었고 1명은 사마귀상암, 1명은 피부부속기원암이었다. 종괴의 위치로는 두부가 13명으로 대부분을 차지하였다. 종괴의 장경은 평균 4.9cm($2{\sim}9cm$)이었다. 방사선치료는 $6{\sim}15$ MeV의 전자선을 종괴의 크기와 깊이에 맞추어 사용하였으며 80% 등선량곡선에 하루에 2 Gy 씩 주 5회 사용하였으며 총방사선량은 $50{\sim}80$ Gy(평균 66 Gy)를 조사하였다. 림프절전이가 있었던 1명은 6 MV X-선으로 치료한 후 전자선으로 추가 조사하였다. 추적기간은 10개월에서 120개월로 중앙값 48개월이었다. 결과: 모든 환자에서 완전관해를 얻었으며 5년 무병생존율은 80%이었다. 전체 15명 중 12명은 재발이 없었다. 3명은 재발없이 평균 90개월($68{\sim}120$개월)동안 생존하고 있으며 방사선치료 후 20%(3/15)에서 재발하였고 9명은 재발이나 전이없이 평균 55.8개월 살다가 다른 병으로 사망하였다. 방사선치료 중 방사선 피부염 외에는 특별한 부작용은 없었으며 방사선피부염은 치료 종료 후 보존적 치료로 회복 되었다. 결론: 노령의 피부암의 방사선치료는 매우 효과적이며 안전하며 좋은 생존율을 보인다고 사료된다.

• Fisheries and Aquatic Sciences
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• 제9권3호
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• pp.107-114
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• 2006

A dermal sarcoma was found in a freshwater, soft-shelled turtle Pelodiscus sinensis. The neoplasm consisted of proliferating fibrous tissue and extended from the dermis. The overlying epidermis was hyperplastic and partially folded. The deeper dermis and hypodermis contained three large, discrete necrotic foci of -10 mm diameter. Numerous eosinophilic granule cells and macro phages surrounded the necrotic areas. A mixed population of cells with nuclear pleomorphism was observed between the papillary layers of vessels. This area also had regions of different histological structures: (l) regularly arranged, spindle-shaped cells with compact nuclei in a fine-fibrillar matrix; (2) haphazardly arranged cells ($\leq$ 23 11m diameter) with ovoid, highly hypertrophic, faintly stained nuclei; and (3) cells (3.6-5.8 11m diameter) with irregularly shaped nuclei and marginal condensed chromatin in a myxomatous matrix. Some mitotic figures, binucleate cells, and multinucleate giant cells of up to 50 11m in length were also found. Flow cytometry of propidium iodide-stained cells yielded different histograms for the normal skin and the skin (primarily epidermis) and fibrous dermis of the tumor, indicating DNA heterogeneity in the dermal portion of the tumor. The ploidy indices for the dermal cells were 1.91 and 0.78, as compared to normal cells.

• 대한두개안면성형외과학회지
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• 제17권1호
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• pp.35-38
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• 2016

Chondroid synringoma (CS), pleomorphic adenoma of skin, is a benign tumor found in the head and neck region. CS was first reported in 1859 by Billorth for the salivary gland tumor. The usual presentation is an slowly growing, asymptomatic mass. A 53-year-old female with a history of chondroid synringoma had presented with multiple firm, nodular masses found in the left nostril area. The lesion had been excised 8 years prior and was diagnosed histopathologically, but had gradually recurred. Excision of the mass located in subcutaneous layer revealed four whitish, firm tumors surrounded with capsular tissue. Neither recurrence nor complications occurred during the 18 months follow-up period. In the head and neck region, chondroid syringoma should always be considered in differential diagnosis of soft tissue masses despite its rare incidence. For that reason, excisional biopsy with clear margin is the optimal diagnostic as well as therapeutic choice. We report a case of recurred chondroid syringoma on the nose in female patient.

• Applied Microscopy
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• 제20권2호
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• pp.102-116
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• 1990

To investigate the ultrastructural features of rat back skin tumor induced by 7, 12-Dimethylbenz[a]anthracene(DMBA), morphological changes during carcinogenesis were undertaken by the light and the electron microscopes. On the light microscopic levels, dysplasia was observed at the 6th week of treatment with 0.5% DMBA, hyperplasia at the 8th week, and carcinoma in sitv or invasive carcinoma at the 12th week. In addition to those characteristics, papillomatosis was observed at the 18th week. Under the electron microscopy, intercellular spaces were enlarged in the early phase. Nucleolar enlargement, the increase of free ribosomes, the condensation of tonofibrils, and the irregular arrangement of desmosomes appeared at the 6th week of application. Thereafter, the degradation of desmosomes and the discontinuity of basal lamina were characterized. And then, epidermal cell processes were protruded toward the connective tissue at the site of discontinuity of basal lamina at the 12th week. At the 14th to 18th week, DMBA-induced fibrosarcomas or papillomas were observed.

• Journal of Chest Surgery
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• 제21권6호
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• pp.1111-1116
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• 1988

Neurofibromatosis is very rare syndrome characterized by abnormal cutaneous pigmentation and numerous skin tumors was described by Smith in 1849, which is inherited as an autosomal dominant trait. Von Recklinghausen reported 2 cases of multiple skin and subcutaneous tumors in 1982. Malignant peripheral nerve tumors, although generally rare, are one of the most characteristic malignant tumors associated with Neurofibromatosis. We have experienced 3 cases of malignant Schwannoma in neurofibroma patients from 1982 to 1988 for 6 years at Thoracic and Cardiovascular surgery department, College of Medicine, Yonsei University, Seoul, Korea. l. One is 62 years old female who was taken total hysterectomy followed by irradiation treatment due to Uterine Carcinoma 21 years ago. She had a large bulging mass on left anterior chest wall and was taken enbloc resection of tumor including rib confirmed malignant Schwannoma. 2. Another is 18 years old female who had large bulging mass on right chest wall and pleural effusion in right thoracic cavity. Thoracentesis revealed a large amount of lymphocytes misdiagnosed of Tbc, pleurisy with Neurofibromatosis. We performed tissue biopsy on bulging mass and the specimen was confirmed malignant Schwannoma 2 months after first diagnosis of Tbc. pleurisy. She was not accessible to radical resection because of far advanced malignant Schwannoma at that time. 3. Third case is 28 years old male who was taken enbloc resection of tumor including rib due to Neurofibroma with Neurofibromatosis at M. hospital 6 months ago. But he had rapid growing mass at operation site again and taken tissue biopsy confirmed of malignant Schwannoma. He was not accessible to enbloc resection due to malignant Schwannoma extending to mediastinal structures.

• Investigative Magnetic Resonance Imaging
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• 제10권2호
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• pp.121-125
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• 2006

두피의 융기성 피부섬유육종이 국소 재발한 48세 남자의 예를 보고하고자 한다. MR영상 소견상 두피의 피부와 피하층에 T1 강조영상에서 저신호강도를 T2 강조영상에서 중등도 고신호강도를 지닌 종괴가 있었고, 조영증강 영상에서 강하게 조영증강되는 종괴는 피부와 피하 및 모상층(galea)으로 파급되는 소견을 보였다. 두피의 융기성 피부섬유 육종은 매우 드문 병변이나 침습적인 종양으로서, MR 영상에서 주변 조직으로의 병변 파급을 진단하고 초기에 광범위 국소절제술을 시행하는 것이 재발을 방지하는 데 중요하다.

• Journal of Korean Neurosurgical Society
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• 제58권2호
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• pp.163-166
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• 2015

The prophylactic use of phenytoin during and after brain surgery and cranial irradiation is a common measure in brain tumor therapy. Phenytoin has been associated with variety of adverse skin reactions including urticaria, erythroderma, erythema multiforme (EM), Stevens-Johnson syndrome, and toxic epidermal necrolysis. EM associated with phenytoin and cranial radiation therapy (EMPACT) is a rare specific entity among patients with brain tumors receiving radiation therapy while on prophylactic anti-convulsive therapy. Herein we report a 41-year-old female patient with left temporal glial tumor who underwent surgery and then received whole brain radiation therapy and chemotherapy. After 24 days of continous prophylactic phenytoin therapy the patient developed minor skin reactions and 2 days later the patient returned with generalized erythamatous and itchy maculopapuler rash involving neck, chest, face, trunk, extremities. There was significant periorbital and perioral edema. Painful mucosal lesions consisting of oral and platal erosions also occurred and prevented oral intake significantly. Phenytoin was discontinued gradually. Systemic admistration of corticosteroids combined with topical usage of steroids for oral lesions resulted in complete resolution of eruptions in 3 weeks. All cutaneous lesions in patients with phenytoin usage with the radiotherapy must be evoluated with suspicion for EM.

• 대한두개안면성형외과학회지
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• 제17권3호
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• pp.176-179
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• 2016

Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm derived from the eccrine glands. PCMC most commonly arises in the head and neck, with the eyelid being the most common site of origin. This case report describes a 51-year-old male with a painless, pigmented superficial nodular lesion over his right lower eyelid. The lesion was considered to be benign, and the initial treatment was simple excision with a 3-mm margin. However, histologic examination revealed the diagnosis of PCMC, and the patient underwent re-excision of the tumor site with an additional 3-mm margin from the initial scar. Histologic study of this second margin was free of any malignant cells. The patient experienced no postoperative complication or recurrence after 2 years. In our case, the skin lesion had benign morphologic findings and was strongly suspected to be a benign mass. Physicians should be aware of this tumor and be able to differentiate it from benign cystic or solid eyelid lesions.