• 대한한의학회지
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• 제40권1호
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• pp.99-113
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• 2019

Objectives: This study is designed to identify the responses of autonomic nervous system and gastrointestinal function which are induced by acupuncture at abdominal anterior cutaneous nerve. Methods: This study is one group before and after pilot study. Subjects were treated once, after having been fasting six hours. They had before tests, labeling points for acupuncture, acupuncture, and after tests in order. The points of acupuncture were motor points of rectus abdominis where the abdominal anterior cutaneous nerve came to the skin from abdominal wall. Before and after tests were consisted of three things: Digital Infrared Thermographic Imaging(D.I.T.I.), Heart Rate Variability(HRV), and Recording of bowel sounds. Results: There were significant differences on the skin temperature of upper body and the frequency of bowel sounds(p<0.001, p<0.001). The HRV parameters and volume of bowel sounds had no significant differences(p>0.05, p>0.05). Conclusion: Even though no significant differences in HRV parameters, the significant differences of skin temperature of upper body and frequency of bowel sounds could mean acupuncture at abdominal anterior cutaneous nerve could affect the autonomic nervous system and gastrointestinal function. However, this study had no group to compare with. Future randomized project should address this issue.

• 대한화장품학회지
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• 제49권4호
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• pp.349-354
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• 2023

자외선 차단제는 자외선을 차단 및 산란시켜 자외선으로부터 보호하는 제품으로 이제 화장품을 넘어서 생활필수품으로 자리 잡고 있다. 자외선 차단제 바르기는 일반적이면서도 손쉬운 자외선에 의한 피부 손상 예방법이다. 이러한 중요성에 따라 자외선 차단제 평가시험은 1978 년 Fod and Drug Administration (FDA)에서 규정을 마련한 이후, 현재는 International Organization For Standardization (ISO)에서 표준화된 방법까지 발전되었다. 더불어 물이나 땀 등 신체활동에 의한 자외선 차단제 손실을 평가하기 위해 국내 식약처와 ISO에서 내수성 자외선 차단지수 평가시험을 제정하고 있다. 그러나 지금까지의 내수성 자외선 차단지수 평가시험은 주로 일반 물을 사용한 시험 방법에 국한되어 있으며, 해변에서의 레저, 스포츠 및 여가활동에 의한 해수의 영향을 고려한 시험 방법은 아직 정립되지 않았다. 본 연구는 기존의 내수성 자외선 차단지수 평가시험 방법 가이드라인을 기반으로 일반 물, 인공 해수(소금물) 및 자연 해수(바닷물)에서의 내수성 자외선 차단지수를 비교하여 해양 레저, 스포츠 및 여가활동 등과 같은 실제 상황에서의 자외선 차단지수를 평가할 수 있는 방법에 대하여 조사하였다. 이러한 결과를 통해 일반 물과 인공 해수 및 자연 해수에서의 내수성 자외선 차단지수 평가시험의 차이를 비교하여 자연 해수를 이용한 내수성 자외선 차단지수 평가시험 방법을 제시할 수 있었다.

• Food Science and Biotechnology
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• 제18권5호
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• pp.1218-1223
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• 2009

Total phenolics and antioxidant activities of water and 80% methanol extract of chestnut inner skin were investigated. The antioxidant properties of both extracts of chestnut inner skin were evaluated using different antioxidant tests, including 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging activities, reducing power, ferric reducing ability of plasma (FRAP), and inhibitory effects on ${\beta}$-carotene bleaching. The 80% methanol extract of inner skin exhibited the higher DPPH, ABTS radical scavenging activities, reducing power, and FRAP than water extract of inner skin and did also in a concentration-dependent manner. However, inhibitory effects on ${\beta}$-carotene bleaching of 80% methanol extract was similar to those of water extract, 35.09 and 39.07% at 1 mg/mL, respectively. The total phenolic contents of water and 80% methanol extract from chestnut inner skin were 5,801.42 and 9,735.56 mg/100 g, respectively. High performance liquid chromatography (HPLC) analysis showed that gallic acid was the predominant phenolic compound in water and 80% methanol extract from inner skin. These water and 80% methanol extracts of chestnut inner skin can be utilized as an effective and safe source of antioxidants.

• 한국항공우주학회지
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• 제42권7호
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• pp.567-575
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• 2014

본 논문에서는 스마트 스킨 시제품을 항공기에 장착하고 비행데모시험을 수행하는 절차와 시험결과를 제시하였다. 통신항법용 4개의 안테나를 한 개의 안테나 내장 스킨구조(CLAS)에 삽입하였다. 대수주기 패치형 안테나를 4개의 안테나 주파수 대역을 포함하도록 다중대역 안테나로 설계하였다. 항공기에 장착하기 전에 안테나 내장 스킨구조의 요구조건은 지상시험으로 입증하였다. CLAS 스피드브레이크를 KT-1 항공기에 장착하고 2개 이상의 안테나를 작동시키는 다중 안테나 시험을 지상에서 수행하였다. 항공기에 장착된 기존 장비들과 CLAS와의 호환성을 확인하기 위해 전자파 적합성시험을 수행하였다. 비행데모시험은 4개의 안테나에 대하여 각 1회의 비행을 수행하였다. 비행 중 안테나 통신항법 신호의 작동상태와 지속성, 항공기 원형 비행 시 사각지대 유무 확인을 하였다. 안테나 내장 스킨구조의 안테나는 4회 비행데모시험 동안 기대 이상의 성능을 보여주었다.

• 대한한의학회지
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• 제16권1호통권29호
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• pp.227-249
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• 1995

Pursuant to the Medical Product Safety Administration Guidelines for safety assessment of Korean bee vonom for herb-acupuncture, rabbits were used for skin, eye balls, subcutaneous and muscle irritation test. The results were as follows; 1. The skin irritation test of bee venom for herb-acupuncture did not produce any irritation reactions, when the skin was covered with bee venom. 2. The eye irritation test produced moderate to severe stimulating reactions, once the eye mucous membrane was contacted with bee venom. 3. The subcutaneous and muscle irritation test of bee venom showed such local inflammatory reactions as death of cells, infiltration of inflamed cells, dropsical swelling, and congestion, once injected under the skin and in the muscle. As the results of the study on bee venom for herb-acupuncture indicate that severe reactions in such tests as eye balls, subcutancous and muscle irritation exist in the laboratory, more professional caution should be taken in clinical application of the therapy. In addition, further study on subacute, chronic toxicity and allergy reactions should be pursued.

• Journal of Pharmaceutical Investigation
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• 제29권2호
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• pp.137-143
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• 1999

Ketoprofen together with various permeation enhancers was incorporated into a novel soft hydrogel which is semi-solid in a container and to form a thin film within a few minutes after applying on the skin. The effect of various enhancers on the skin permeation of ketoprofen from a soft hydrogel was investigated using in vitro and in vivo method. In vitro rat skin permeation of ketoprofen from soft hydrogel was conducted using modified Keshary-Chien diffusion cells. In vivo ketoprofen absorption was also investigated in rats, and the results were compared with that of commercial products. Anti-inflammatory activities were determined using carrageenan-induced paw edema method and adjuvant-induced arthritis method in rats. The anti-inflammatory activity of ketoprofen soft hydrogel formulation with that of commercial products were compared. In vitro as well as in vivo studies showed that $HPE-101^{\circledR}$ was the most effective skin permeation enhancer among those used in this study. Addition of an adhesive (polyisobutylene) in the soft hydrogel decreased skin permeation of ketoprofen. Paw edema and anti-arthritis tests showed that soft hydrogel containing $HPE-101^{\circledR}$ was more effective than the commercial products, which was consistent with the in vivo absorption experiment results.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1990년도 춘계학술대회
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• pp.43-46
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• 1990

Modern society is prevailed a lot of allergies. So, the allergy test is very important. There are many kinds of allergy test. A doctor usually uses skin allergy test among many allergy tests. However, little standadization and objectivity of grading-standard has been established in the skin allergy test. A measurement of the reaction area has been a major objective to perform skin allergy test. Recently, a doctor's method is to measure the reaction area after drawing a line that represents the reaction area on the skin. But this method differs slightly from the real reaction area and individual doctor's measurement is different, because the edge of the reaction area is obscure. In this paper, we propose a algorithm which is able to detect vague edges using the fuzzy set. The algorithm that detects the line and curve is proposed first. Here, the maximum value is calculated by comparing the membership function of the line and curve seperately. We also encode the direction of the line and curve by using 8-direction code. Then, we calculate the reaction area by measuring the pixels which are inside the reaction area. And finally the Allergy grade is decided by grading-standard, and we accomplish faster, the 80re accurate and objective allergy grade decision.

• 한국지반환경공학회 논문집
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• 제3권2호
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• pp.15-21
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• 2002

건설공사에서 발생하는 환경문제에 대한 관심이 고조되는 가운데 기성 말뚝을 항타하는 과정에서 유발되는 소음, 진동문제를 해결하기 위해 저소음, 저진동 공법인 매입말뚝공법이 많이 적용되고 있다. 국내에서는 매입말뚝공법으로 SIP공법이 주로 사용되고 있다. 그러나 아직까지 SIP공법에 관한 합리적인 지지력 산정식이 제시되어있지 못한 실정이다. 이에 대해 본 연구에서는 SIP 말뚝의 주면저항력 특성을 고찰하여 이러한 문제점들을 개선, 보완하기 위하여 다양한 조건에서 SIP 말뚝 주면과 지반흙 사이의 경계면에 대하여 직접전단시험을 실시하였다. 그 결과를 토대로 통일분류상 SM, SC 지반에서의 SIP 말뚝 주면저항력 특성을 고찰하고 해당 지반에서 최대주면저항력 산정식을 제시하였다.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2006년도 춘계 학술발표회 논문집
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• pp.1269-1278
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• 2006

These days the construction of extra-long piles increases. It is not unusual to install piles whose length exceed 45m. In such cases, the estimated value of negative skin friction becomes larger, often larger than the design load. In order to be sure of the safety of the super structure, the magnitude of the positive skin friction and the base bearing capacity should be known. In practice dynamic pile loading tests using PDA is the only possible measure to meet this requirement. However the analysis of dynamic pile loading test for such extra-long piles requires a thorough understanding of the pile-soil behaviour. In this paper, a new method to evaluate the positive skin friction and end bearing capacity from the normally performed PDA test is proposed. The proposed method was verified by performing specially designed pilot testings.

• 한국수의병리학회지
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• 제3권1호
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• pp.45-50
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• 1999

Canine dermatosis associated with zinc deficiency naturally occurred in three districts of Kyungpook. A diagnosis was made by clinical findings, clinico-pathological examinations, skin biopsy, and therapeutic tests. The result was diagnosed as a zinc-deficient dermatosis. The disease occurred in rapidly growing Tosa-dog hybrids 5 to 7 months old. Skin lesions included erytherma, alopecia, crusting, scaling around the mouth, eyes, legs and tail. Clinico-pathological findings were decreased serum zinc levels, slightly increased white blood cells, and secondary Staphylococcus intermedius infection of the crusts. The skin biopsies for histopathological examination revealed marked parakeratotic hyperkeratosis. The patients with skin lesions were successfully treated by zinc methonine(Zinpro) medication In conclusion, serum zinc level and skin biopsy are very helpful in diagnosis of canine zinc-deficient dermatosis.