• Journal of Life Science
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• v.18 no.3
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• pp.369-373
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• 2008

Staphylococcus intermedius (S. intermedius) has been rarely isolated from horse. In this study, we investigated the antimicrobial susceptibility patterns of S. intermedius isolated from skin lesions of Thoroughbred horse in Daegu Equestrian Association. The skin lesions were showed with dehairing and slight purulent inflammation. Bacteria were isolated from skin lesions and identified as S. intermedius by biochemical tests and MicroLog (BIOLOG, California, USA). Antimicrobial susceptibility test of S. intemedius isolates was performed with 33 antimicrobial agents (BBL, Maryland, USA) by using the agar disk diffusion method. It showed a high sensibility in the amikacin, amoxycillin/clavuramic acid, ampicillin, cefoxitin, cephalothin, chloramphenicol, ciprofloxacin, enrofloxacin, florfenicol, kanamycin, neomycin, nitrofurantoin, norfloxacin, ofloxacin, oxacillin, penicillin G, tetracycline and vancomycin. The horse was treated with penicillin, and cured completely after two weeks. The present results showed valuable information for treatment and prevention of skin disease in horse.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.21 no.1
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• pp.1-18
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• 1995

We had tested the effect of amino propane sulfonic acid(APSA) on the human skin with non-invasive technique. It was tested with four parameters that were hydration, elasticity, color and skin wrinkles. In vitro culture systems, APSA stimulated the proliferation of fibroblasts bolt it didn't stimulate that of keratinocyte. Also we obtained the similar effects in the raft culture method. So we concluded that APSA affected the dermal region than the epidermal region. In clinical tests, APSA changed the skin color, pbiomechanical properties(especially elasticity) and reduced skin wrinkles of the volunteers. And we could get the better results of skin wrinkle improvement by use of Skin Visiometer than Silflo Image analysis systems.

• Proceedings of the SCSK Conference
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• 1999.10a
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• pp.145-154
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• 1999

A novel retinol derivative, polyethoxylated retinamide (Medimin A) was synthesized, as an anti-aging agent. Collagen synthesis, skin permeation, stability, and toxicity of Medimin A were evaluated and compared with those of retinol and retinyl palmitate. In vitro collagen synthesis was evaluated by quantitative assay of [$^3H$]-proline incorporation into collagenase sensitive protein in fibroblast cultures. For in vitro skin permeation experiments, Franz diffusion cells (effective diffusion area: $1, 766{\;}\textrm{cm}^2$) and the excised skin of female hairless mouse aged 8 weeks were used The stabilities of retlnoids were evaluated at two different temperature ($25{\;}^{\circ}C$ and $40{\;}^{\circ}C$) and under UV in solubilized state and in OW emulsion. To estimate the safety, acute oral toxicity, acute dermal toxicity, primary skin irritation, acute eye irritation and human patch test were performed The effect of Medimin A on collagen synthesis was similar to that of retinol. The skin permeability of Medimin A was higher than those of retinol and retinyl palmitate. The Medimin A was more stable than retinol and retinyl palmitate. Medimin A was nontoxic in various toxicological tests. These results suggest that Medimin A would be a good anti-aging agent for enhancing bioavailability and stability.

• International Journal of Advanced Culture Technology
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• v.11 no.1
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• pp.363-369
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• 2023

In this study, to check the function of managing the severity of ultraviolet rays with a smart watch, a popular health care IT device, It was tested whether measuring heart rate using a PPG(Photoplethysmography) sensor representatively used in a smart watch could tell skin changes caused by ultraviolet rays. Through this experiment, we examined the possibility that the skin color tanned by ultraviolet rays can be determined only by the heart rate measurement function of the PPG sensor. In addition, the possibility of expanding the heart rate measurement function of the PPG sensor to the use of skin condition management was considered. we used an Arduino-based reflective PPG sensor to measure changes in heart rate by selecting body sites with high and low UV rays exposure. A significant value was derived through tests considering factors such as gender, UV exposure, and age. As a result, the study identified the possibility of adding ultraviolet rays and skincare items to future smart watch healthcare items and the possibility of expanding skin measurement methods. It is also possible to suggest the direction of future research.

• Proceedings of the Korean Geotechical Society Conference
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• 1999.03a
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• pp.249-258
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• 1999

Dynamic load and static load tests are performed on steel pipe piles and concrete piles at five construction sites in highway to compare the difference of load bearing mechanisms. At each site, one steel pile is instrumented with electric strain gages and dynamic tests are performed on the pile during installation. Damages of strain gages due to the installation are checked and static test is performed upon the same pile after two or seven days as well. It shows that load transfer from side friction to base resistance behaves somewhat differently according to the results of load-settlement analysis obtained from PDA and static load test. Initial elastic stage of load settlement curves of two load tests is almost similar. But after the yielding point, dynamic resistance of pile behaves more stiffer than static resistance, thus, dynamic load test result might overestimate the real pile capacity compared with static result. Analysis of gage readings shows that unit skin friction increases exponentially with depth. The skin friction is mobilized at the 1∼2m above the pile tip and contributes to the considerable side resistance. Comparison of side and base resistances between the measured value and the calculated value by Meyerhof's bearing capacity equation using SPT N value shows that the calculated base resistance is higher than the measured. Therefore, contribution of side resistance to total capacity shouldn't be ignored or underestimated. Finally, based upon the overall test results, a construction control procedure is suggested.

• Geotechnical Engineering
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• v.8 no.3
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• pp.13-22
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• 1992

Model pile tests using calibration chamber are performed in !his paper in order to clarify the effect of the fundamental differences between the newly developed SPLT(Simple Pile Loading Test)and the conventional pile loading test on the pile bearing capacity. They are : (1) the direction of the applied load to mobilize the skin friction ; and (2) the use of reduced sifted sliding core. The conclusions obtained from the model pile tests are as follows : (1) The skin friction in tension loading is found to be somewhat smaller than that in compression loading. The average ration is 0.73 with the coefficient of variation (COV) of 0.18. (2) The ratio of the tip resistance rosin연 the reduced sized sliding core to that using the whole shoe shows wide scattering ; its average is 0.99 and the COV is 0.28. The aver - age of 0.99 means that there is no considerable difference in the tip resistance whether the reduced sized sliding core or the whole shoe is used, on condition that penetration depth ratio is larger than 4 : if the boundary effect of the chamber test is considered, the resistance of the whole shoe might be even larger.

• Korean Journal of Human Ecology
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• v.20 no.2
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• pp.449-465
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• 2011

This study was performed to investigate the effects of food habits and life style on the skin health of young Korean females in their late teens and twenties. The study focused on facial skin and used a self-administered questionnaire survey, an examination of skin type, and pH tests. More than half of the females had combination skin type or pH level higher than 5.8 which is regarded as normal. The variables that turned out to significantly (p<0.05) effect their facial skin types were body mass index (BMI), the type of residence, the amount of water intake, whether or not they intake drinks, the frequency and amount of alcohol drinking, favorite foods as side dishes at meals, intake frequency of fruit, the dairy, seaweed, and fast food, the frequency of washing their faces per day, the method of how they used water during face washing, whether or not they had professional skin care, and whether or not they wore color make up. The variables of the females' age, BMI, the amount of alcohol drinking, the frequency and duration of exercise, the controlling methods of stress, their favorite foods as side dishes at meals, and the intake frequency of soy products or animal foods significantly affected their facial pH levels (p<0.05). The results of this study indicate that some food habits and life styles are significantly related with facial skin health. More importantly BMI and favorite foods as side dishes during daily food intake could have remarkable effects on facial skin health.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.22 no.2
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• pp.141-152
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• 1996

Many eastern females concern themselves about the condition and the color of their skin. The purpose of the present study is to classify the skin trouble and the change of the facial color due to hormonal cycle in female. We examined the actual cricumstances by questionnaires, and made patch tests of methyl nicotinate, representing rubefacient, to estimate the epidermal penetratin rate, and measured the facial color change during the menstrual cycle period to invest the correlation factors between skin trouble due to cosmetics and facial color change. Fifty-two percent of subjects had skin trouble relating to cosmetics. One second of subjects with skin trouble due to cosmetic complained the change of sysptom by menstrual cycle. The changes of systptom were related on premenstrual period. The skin trouble developed mainly on the first trimester of the pregnancy. In patch test of methyl nicotinate, most cases showed decreased threshold of the reaction on minstruation, and other cases showed increased reactivity of the skin of menstruation. In facial color measurements, it proves in the appearance of red spot, darkness, increasing the value and turning the hue to yellowish, Also it demonstrates that premenstruation hue turn red and value level decrease. During the period, facial color turns pale and hue progress to yellow. This fact coincides with the questionnaire. We have quqntified through questionnaire, which demonstrates it has good correlation with done to the subjects among the internal environment factors hormonal cycle influences the facial color change and the skin trouble due to cosmetics. Through this paper the development of an more fragmented make-up and skin care products is required to increase the interest to females, to make true the creation of beauty.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.36 no.1
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• pp.65-69
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• 2010

Collagen is the most abundant animal protein in mammals, accounting for about 30 % of all proteins. It is present in connective tissue and contributes to the structural framework of most organs. The tripeptide (glycineproline-hydroxyproline) with the INCI name Tripeptide-29 is main component of collagen type I. The palmitoyl tripeptide (palmitoyl-glycine-proline-hydroxyproline) with the INCI name Paimitoyi Tripeptide-29 is a synthetic material that was designed as a topical agent to stimulate collagen production. We synthesized the palmitoyl tripeptide as a potential anti-wrinkle compound. This compound has been characterized using HPLC. This compound proved, through in vitro tests, to stimulate collagen production and fibroblast proliferation. These results were very promising, so human studies were subsequently performed. We investigated the skin improvement effect of the palrnitoyl tripeptide on human skin by using non-invasive instruments. We measured physiological effects such as skin wrinkles and elasticity after volunteers applied the cosmetic products for 8 weeks. We observed significant improvement in skin wrinkles and elasticity after use of the cosmetic products for 8 weeks. We concluded that the palmitoyl tripeptide had an anti-aging effect on human facial skin.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.700-718
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• 2003

Fructan, a polysaccharide existing in plants or produced by microorganisms, is a sugar polymer of fructose with $\beta$-2,6 linkages. In this study, we investigated some cosmeceutical properties of Fructan such as moisturizing effect, cell proliferation effect, anti-inflammation effect and cell cytotoxicity. Zymomonas mobilis, a microorganism producing Fructan, was cultured in a medium containing 10％ sucrose and 2％ yeast extract as main components for 24 hours at 37$^{\circ}C$ and pH 7. Fructan was obtained by precipitation from the cultured medium by adding alcohol (alcohol ratio of 1:3) after removing the enzyme by centrifuging. Fructan exhibited almost same moisturizing effect as hyaluronic acid and cell proliferation effect on human fibroblast and keratinocyte as well. Moreover, on cell proliferation test on bio-artificial skin constructed by 3-dimensional(3-D) culture after inducing primary skin inflammation with 0.5％ sodium lauryl sulfate (SLS), the 3-D artificial skin treated with 0.01 mg/ml, 0.05mg/ml of Fructan exhibited higher cell proliferation than the 3-D artificial skin treated with SLS only. On anti-inflammation test on 3-D artificial skin evaluated by measuring secreted quantity of interleukin-1$\alpha$ (IL-1$\alpha$) which is a pre-inflammatory mediator induced by SLS, the quantity of IL-1$\alpha$on the 3-D artificial skin treated with 0.01 mg/ml, 0.05mg/ml of Fructan was less than the one on the 3-D artificial skin treated with SLS only. As a result of these studies, Fructan has anti-inflammation effect against inflammatory reaction by a skin irritant as well as cell proliferation effect in bio-artificial skin. Fructan was also evaluated as a safe material without any toxicity in safety tests using fibroblasts and animals.