• 한국위성정보통신학회논문지
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• 제10권2호
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• pp.30-33
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• 2015

본 논문에서는 Hybrid RF기반 CMOS 카메라를 이용한 피부질환 모니터링 시스템 개발에 대한 연구를 수행하였다. Hybrid RF통신기반 CMOS 카메라를 이용한 영상 전송 기법에 대하여 제시하였으며, 이와 더불어 CMOS 카메라를 이용한 피부질환 모니터링을 위한 원격 모니터링이 가능한 스마트폰 App을 개발하였다. Hybrid RF통신방식을 이용한 영상전송방식은 WiFi통신방식을 적용하여 CMOS 카메라로부터 취득된 영상 정보를 스마트폰 App을 통하여 모니터링할 수 있도록 구성하였다. 피부질환 모니터링 스마트폰 APP은 WiFi통신방식을 이용하여 언제 어디서나 원격 모니터링이 가능하다. 본 논문에서 제안한 Hybrid RF통신기반 CMOS 카메라를 이용한 피부질환 모니터링 시스템은 내시경 응용 활용 사례로서 널리 활용될 수 있을 것으로 예상된다.

• 혜화의학회지
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• 제28권2호
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• pp.41-47
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• 2019

Objectives : Atopic dermatitis is an irritable skin disease accompanying rash and itching leading to impaired skin barrier. ATO-ALL is an ethanol extract of natural products comprising 12 herbs and effective on atopic dermatitis. In this study, we aimed to propose that the effect of ATO-ALL on skin regeneration in human keratinocyte cell line, HaCaT cells. Methods : To evaluate the skin regenerating effects of ATO-ALL, scratch wound healing assay, bromodeoxyuridine (BrdU) assay, and propidum iodide (PI) assay were performed using cultured HaCaT cell line. Result : Scratch wound healing assay showed that ATO-ALL was able to enhance the gap filling activity more than 2-fold at 7 ppm concentration compared with control group. BrdU assay demonstrated that ATO-ALL treatment increased the de novo cell proliferation in a dose-dependent manner. Finally, PI assay indicated that the cell cycle of HaCaT cells was modulated by ATO-ALL treatment. Conclusions : These results suggested that ATO-ALL may have skin regenerating effects by increasing cell proliferation via cell cycle regulation. Taken together, ATO-ALL is supposed to have a potential on regeneration of damaged skin or functional disease including atopic dermatitis.

• 한국콘텐츠학회논문지
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• 제5권6호
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• pp.230-237
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• 2005

본 연구에서 우슈 도장에서의 수련자 신체활동량을 과학적, 정량적으로 분석하여 스포츠의학의 중요한 관심사인 질병의 예방과 만성퇴행성 질환의 조절과 관리 그리고 건강을 증진할 수 있는 방안을 제안한다. 신체활동량을 측정하기 위해 신호획득 장비는 body media사에서 개발한 SenseWear PRO2 Armband를 사용하였다. Armband내에는 체온계(skin temperature sensor), 온도계(near-body temperature sensor), 가속도센서(accelerometer), 몸에서 발산되는 열량을 측정하는 센서(heat flux sensor), 피부의 전기전도도를 측정하는 센서(galvanic skin response sensor)가 있다. 각각의 센서로부터 획득한 데이터는 Armband내의 저장장치에 기록하였다. Armband에 저장된 데이터를 InnerView Wearer Software를 이용하여 우슈 도장에서 수련자의 신체활동에 따른 피부온도변화, 칼로리 소모, 활동량 추이변화를 분석하였다. 연구결과 지속적으로 오랜 기간 동안 운동을 한 사람은 단시간에 많은 에너지 소모를 하는 것으로 나타났으며 Physical activity가 활발하면 에너지 소모가 증가하고 동시에 피부 온도가 상승하는 것을 알 수 있었다. 에너지 소모가 증가하면서 피부온도가 증가하고 난 후 열 발산이 일어나는 것을 실험결과 알 수 있었다. 그리고 피부전도는 Physical activity, 에너지 소모, 피부온도 증가 등의 인자에 아무런 영향을 받지 않는 것으로 나타났다.

• 한방안이비인후피부과학회지
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• 제30권1호
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• pp.29-42
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• 2017

Objectives : Atopic dermatitis accompanies with severe pruritus and collapse of skin barrier, inflammation. Maifanite could be used as an ointment for skin disease. However, there have been few studies about maifanite uses for atopic dermatitis. We report the anti-inflammatory and promoting skin recovery effects of ionized maifanite on damaged skin barrier with experimentally elicited atopic dermatitis. Methods : Nc/Nga mice were divided into 3 groups: control group(CON), atopic dermatitis elicited group(AE group), ionized maifanite treated group after atopic dermatitis elicitation(MT group). After 5% SDS was applied D. pteronyssinus crude extract also applied for 3 weeks to elicit atopic dermatitis-like skin disease. MT group was treated for 3 weeks with ionized maifanite. Ionized maifanite was applied once a day and voluntarily administrated. AE group and control group were treated with normal saline in the same way. Results : In MT group, skin lesions like eczema were more improved than AE group. p-ERK1/2 positive reaction was reduced in MT group. MMP-9 and substance P positive reaction at dermal papillae was also reduced in MT group. With skin angiogram, capillary vessel decreased in MT group. Also, IL-4 positive reaction cell and STAT-6 positive reaction cell reduced more in MT group than in AE group. $NF-{\kappa}B$ p65 positive reaction cell and iNOS positive reaction cell also declined more in MT group than in AE group. Conclusions : It is supposed that ionized maifanite has anti-inflammatory effects on NC/Nga mice's atopic dermatitis with suppressing IL-4 production and Th2 cell differentiation, and controlling $NF-{\kappa}B$ activation.

• 대한치과기공학회지
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• 제29권1호
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• pp.9-21
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• 2007

This study was conducted to determine the cause and prevalence of occupational skin disease in dental technicians working in Seoul, Korea. and to investigate the relation between these work condition and skin disease of the hand, wrist and forearm. This study was based on the Nordic occupational skin questionnaire(NOSQ), a self-administrated questionnaire which was modified to investigate the dental technician's occupational factors in domestic circumstances. The number was distributed to 500 dental technicians who participated in annual continuing education for dental technicians of the Seoul metropolitan area in April 2006. Of the subjects, 62(30.4%) had eczema and 70(32.9%) had urticaria, as diagnosed. Of the subjects with the symptoms of urticaria, 30 complained of atopic dermatitis, 65 complained of allergic rhinitis, 56 complained of allergic conjunctivitis, and 18 complained of asthma. The group with atopic history had a higher frequency of eczema or urticaria than the group without atopic history. From multiple regression analysis, the group who had a history of atopic dermatitis also had high symptom rates of eczema. The group who had a history of allergic rhinitis and allergic conjunctivitis had high symptom rates of urticaria. The urticaria symptom rates were higher in those wearing gloves than those who did not for the type of work.

• 한국응용과학기술학회지
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• 제37권1호
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• pp.66-75
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• 2020

Atopic dermatitis (AD) usually develops in patients with an individual or family history of allergic diseases, and is characterized by chronic relapsing inflammation seen specially in childhood, association with IgE hyperproduction and precipitation by environmental factors. and wished to examine closely effect that Polygonum multiflorum isolated PM-E and PM-70M orally adminstration used to atopy dermatitis disease patient get in atopy eruption control experimentally. Atopic dermatitis is a chronically relapsing inflammatory skin disease. Animal models induced by relevant allergens play a very important role in the elucidation of the disease. This study was investigated the anti-allergic effect of PM-E and PM-70M on BMAC induced atopic dermatitis in NC/Nga mice. We summerized as the follow. PM-E and PM-70M significantly reduced the skin number of total cell number, CD4⁺ and CD11b⁺/Gr-1 cell compared with positive control and decreased the invasion of CD4⁺ cell in dorsal skin tissue compared with positive control group by using immunohistochemical staining and chemokine such as eotaxin and CCR3 compared with positive control group. PM-E and PM-70M markedly suppressed invasion and edema of leukocytes and mast cell in dorsal skin. Taken together, these findings suggested that PM-E and PM-70M has an anti-allergic activity and this might be useful for the clinical application to treat allergic diseases such as atopic dermatitis.

• 대한수의학회지
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• 제47권1호
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• pp.91-94
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• 2007

tisue disease of dog and cat, resembling Ehlers-Danlos syndrome (EDS) in man. EDS is characterizedby loose, hyperextensible and, fragile skin, it is attributed to mutations in connective tisue gene. Thesemutations cause defects in type I or II collagen synthesis and as a result lack of strength or elasticityto skin, joint, ligament and vessels. EDS-affected animals often experience subcutaneous hematomas thathave long bleeding times. The 4-years old male Yorkshire terrier was evaluated because of subcutaneoushematoma after stifle surgery. Clinical examination revealed a thin and hyperextensible skin and jointlaxity. The degree of skin extensibility index was 23.4%, marked skin stretchy. Clinical diagnosis wasconfirmed by histophathological examination of a skin biopsy revealing reduced packing density ofcollagen fiber of skin.

• 대한한의학방제학회지
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• 제15권1호
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• pp.145-161
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• 2007

Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers. The clinical phenotype that characterizes AD is the product of interactions between susceptible genes, the environmental factors, defective skin barrier function, and immunologic responses. This review summarizes recent progress in our understanding of the immunopathophysiology of AD and the implications for mouse models of AD in drug discovery from medicinal plants.

• Annals of Clinical Neurophysiology
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• 제14권1호
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• pp.36-40
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• 2012

Nephrogenic systemic fibrosis (NSF) is a systemic disease that affects the skin and other tissues in patients with renal insufficiency and exposure to gadolinium-containing contrast. A 55-year-old woman with end-stage renal disease on hemodialysis was consulted for progressive general weakness. After she had undergone multiple MRIs with gadolinium-containing contrast media, muscle weakness and skin lesions were developed. Her skin and muscle biopsy specimens showed CD34+ fibroblast entrapping collagen bundles. There are few reports of NSF with myopathy.

• 대한두개안면성형외과학회지
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• 제21권5호
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• pp.323-325
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• 2020

Sclerotic fibroma is a rare fibrous tumor of the skin associated with Cowden's disease. In 1989, Rapini described sclerotic fibroma without Cowden's disease as solitary sclerotic fibroma of the skin. It is a solid, well-circumscribed, slow-growing nodular tumor and it looks similar to a keloid scar. Consequently, it is extremely difficult to make a differential diagnosis of solitary sclerotic fibroma with keloid scar based on clinical findings only. The authors report a case of solitary sclerotic fibroma arising at the left lateral thigh of a 25-year-old man.