• Journal of Korean Neurosurgical Society
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• v.41 no.1
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• pp.30-38
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• 2007

Objective : To elucidate the role of aquaporin-4[AQP4] in cerebral edema formation, we studied the expression and subcellular localization of AQP4 in astrocytes after focal cerebral ischemia. Methods : Cerebral ischemia were induced by permanent middle cerebral artery[MCA] occlusion in rats and estimated by the discoloration after triphenyltetrazolium chloride[TTC] immersion. Change of AQP4 expression were evaluated using western blot. Localization of AQP4 was assessed by confocal microscopy and its interaction with ${\alpha}-syntrophin$ was analyzed by immunoprecipitation. Results : After right MCA occlusion, the size of infarct and number of apoptotic cells increased with time. The ratio of GluR1/GluR2 expression also increased during ischemia. The polarized localization of AQP4 in the endfeet of astrocytes contacting with ventricles, vessels and pia mater was changed into the diffuse distribution in cytoplasm. The interactions of AQP4 and Kir with ${\alpha}-syntrophin$, an adaptor of dystrophin complex, were disrupted by cerebral ischemia. Conclusion : The deranged spatial buffering function of astrocytes due to mislocalized AQP4/Kir4.1 channel as well as increased assembly of $Ca^{2+}$ permeable AMPA receptors might contribute to the development of edema formation and the excitotoxic neuronal cell death during ischemia.

• International Journal of Naval Architecture and Ocean Engineering
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• v.8 no.6
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• pp.577-588
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• 2016

Due to the uncertainties related to the flaw assessment parameters, such as flaw size, fracture toughness, loading spectrum and so on, the probability concept is preferred over deterministic one in flaw assessment. In this study, efforts have been made to develop the reliability based flaw assessment procedure which combines the flaw assessment procedure of BS7910 and first-and second-order reliability methods (FORM/SORM). Both crack length and depth of semi-elliptical surface crack at weld toe were handled as random variable whose probability distribution was defined as Gaussian with certain means and standard deviations. Then the limit state functions from static rupture and fatigue perspective were estimated using FORM and SORM in joint probability space of crack depth and length. The validity of predicted limit state functions were checked by comparing it with those obtained by Monte Carlo simulation. It was confirmed that the developed methodology worked perfectly in predicting the limit state functions without time-consuming Monte Carlo simulation.

• Journal of the Korean Society of Visualization
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• v.15 no.1
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• pp.41-46
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• 2017

Control of mixing and transport processes are the key areas that can be benefited by understanding the hydrodynamics in gas-liquid two-phase flows. In particular, the enhanced bubble-induced liquid-phase mixing is known to be a function of void fraction distribution, gas phase velocity and so on. To further our insight on the characteristics of the liquid-phase mixing induced by the bubbles, in the present study, we experimentally investigate the mixing performance of a rectangular bubble column while changing the void fraction from 0.006 to 0.075%. A shadowgraphy technique is used to measure the gas-phase properties such as void fraction and size/velocity of bubbles. On the other hand, we use dye visualization with low diffusive buoyant dye to directly measure the level of mixing. Finally, we confirm that the time taken for full mixing scales with the inverse of volume void fraction.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.2
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• pp.223-229
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• 2004

Combustion using oxygen enriched air is known as a technology which can increase thermal efficiency due to increase of the flame temperature. Flame shapes, schlieren photos, OH radical chemiluminescence and local flame temperature were examined as a function of OEC(Oxygen Enriched Concentration) in a coaxial non-premixed jet. With increase of OEC, flame length and width decreased, but its brightness increased significantly, and the size of vortices in the flame also increased. Especially, the reaction around the flame surface became active. The strong OH intensity appeared to be made and moved from middle stream to upper one with increase of OEC, which shows combustion reaction in the upper stream becomes more dominant In addition, the temperature distributions of the flames showed similar tendency with OH radical intensities. A flame with high temperature and strong stability was obtained with increasing OEC of the coflow.

• Journal of Institute of Control, Robotics and Systems
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• v.5 no.6
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• pp.753-763
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• 1999

The existing SCADA(Supervisory Control and Data Acquisition) system software is usually developed to suitable for the specific hardware platforms. However, as per rapid improvement of computer performance and development of network technology, it is required to support scalability and inter-operability in existing different SCADA systems. In order to meet such requirements, in this paper, we propose a new type of SCADA testbed using Java for electric distribution applications. The system consists of three modules; development support tools, client and server modules. The basic architecture of the proposed SCADA system is similar to existing one, however, we improve the function of MTU and MMI interface to facilitate LAN and WAN environment. Also, the proposed system can deals with alarm and history data by using heterogeneous DBMS. Since the system is built in Java environment, the development cost is cheap and it can support sacalability and portability. Our experience can be utilized to develop next generation of small and medium size of SCADA system.

• Proceedings of the IEEK Conference
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• 2001.10a
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• pp.759-764
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• 2001

The separation performance of zigzag air classifier with angle of 90 degrees was studied using narrow size fractions of thin square samples and granular samples. The simulation results of air velocity inside the classifier indicated that the zigzag geometry induces a new pattern consisting of an upward flow and a circulation flow, Experimental results showed that overflow product recovery was described as an integral calculus of normal distribution as a function of dimensionless air velocity ( $V_{A}$ $V_{A50}$), where $V_{A}$ is superficial air velocity and $V_{A50}$ is the $V_{A}$ at the fifty percent recovery. The $V_{A}$ values were predicted using the equations derived from dynamics for a particle dropping in air. A monitoring system that utilizes changes in acoustic signals emitted during the process of air classification was developed to separate PET with desired recovery or grade. The technical feasibility of the on-line monitoring of the PET recovery and grade was demonstrated by measuring relative energy of the signals.signals.als.

• Journal of the Semiconductor & Display Technology
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• v.9 no.1
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• pp.17-21
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• 2010

Currently miniaturized electron-optical columns find their way into electron beam lithography systems. For better lithography process, it is required to make smaller spot size and longer working distance. But, the micro-columns of the multi-beam lithography system suffer from chromatic and spherical aberration, even when the electron beam is exactly on the symmetric axis of the micro-column. The off-axis error of the electron emitting source is expected to become worse with increasing off-axis distance of the focusing spot. Especially the electron beams far from the system optical axis have a non-negligible asymmetric intensity distribution in the micro-column. In this paper, the effect of the off-axis e-beam source is analyzed. To analyze this effect is to introduce a micro-column model of which the e-beam emitting source is aligned with the center of the electron beam by shifting them perpendicular to the system optical axis. The presented solution can be used to analysis the performance of the multi-electron-beam system. The performance parameters, such as the working distances and the focusing position are obtained by the computational simulations as a function of the off-axis distance of the emitting source.

• Journal of Environmental Impact Assessment
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• v.22 no.6
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• pp.713-724
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• 2013

In terms of waste load allocation, inequality of waste load discharge must be considered as well as economic aspects such as minimization of waste load abatement. The inequality of waste load discharge between areas was calculated with Gini coefficient and was included as one of the objective functions of the multi-objective waste load allocation. In the past, multi-objective functions were usually weighted and then transformed into a single objective optimization problem. Recently, however, due to the difficulties of applying weighting factors, multi-objective genetic algorithms (GA) that require only one execution for optimization is being developed. This study analyzes multi-objective waste load allocation using NSGA-II-aJG that applies Pareto-dominance theory and it's adaptation of jumping gene. A sensitivity analysis was conducted for the parameters that have significant influence on the solution of multi-objective GA such as population size, crossover probability, mutation probability, length of chromosome, jumping gene probability. Among the five aforementioned parameters, mutation probability turned out to be the most sensitive parameter towards the objective function of minimization of waste load abatement. Spacing and maximum spread are indexes that show the distribution and range of optimum solution, and these two values were the optimum or near optimal values for the selected parameter values to minimize waste load abatement.

• Journal of computational fluids engineering
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• v.20 no.4
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• pp.109-115
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• 2015

In this study, the Stokes flow in the microchannel is analysed where the semicircular protuberances with constant spacing are attached on the upper and lower walls with staggered arrangement. For the low Reynolds number flow in microchannel, Stokes approximation is used and the periodicity and symmetry of the flow are considered to determine the stream function and pressure distribution in the flow field by using the method of least squared error. As results, the streamline patterns and pressure distributions in the flow field are shown for some specific values of the size and spacing of the protuberances, and shear stress distributions on the surface of semicircular protuberances are plotted. Especially, for an important physical property, the average pressure gradient along the microchannel is obtained and compared with that for the case of in-phase arrangement of the upper and lower protuberances. And, for the small clearance between the protuberances of upper and lower walls or between the protuberances and the opposite wall, the average pressure gradient is derived from the lubrication theory and compared with that of the present study.

• KIEAE Journal
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• v.15 no.5
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• pp.5-12
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• 2015

Purpose: Retention and infiltration of small and frequently-occurring rainfall by LID facilities account for a large proportion of the annual precipitation volume. Based on 4 standard facilities such as Porous Pavement, Infiltration Trench, Cylindrical Infiltration Well, Rectangular Infiltration Well by Seoul Metropolitan Handbook of the Prior Consultation for LID. The total retention volume of each facility was calculated according to the type and size. The Purpose of this study is to find out the quantitative relationship between Percentile Rainfall Event and Design Volume of Infiltration Facilities. Methode: For the estimation of Percentile Rainfall Event, Daily Precipitation of Seoul from 2005 to 2014 was sorted ascending and the distribution of percentile was estimated by PERCENTILE spreadsheet function. The managed Rainfall Depth and Percentile of each facility was calculated at the several sizes. In response to the rainwater charge volume of 5.5mm/hr by the Category "Private large site", the 3 types of facilities were planned for example. The calculated Rainfall Depth and Percentile were 54.4mm and 90% by the use of developed Calculation-Module based on the Spreadsheet program. Result: With this Module the existing Designed Infiltration volume which was introduced from Japan was simply converted to the Percentile-Rainfall-Event used in USA.