• Nuclear Engineering and Technology
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• v.50 no.8
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• pp.1210-1216
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• 2018

Site or multi-unit (MU) risk assessment has been a major issue in the field of nuclear safety study since the Fukushima accident in 2011. There have been few methods or experiences for MU risk assessment because the Fukushima accident was the first real MU accident and before the accident, there was little expectation of the possibility that an MU accident will occur. In addition to the lack of experience of MU risk assessment, since an MU nuclear power plant site is usually very complex to analyze as a whole, it was considered that a systematic method such as probabilistic safety assessment (PSA) is difficult to apply to MU risk assessment. This paper proposes a new MU risk assessment methodology by using the conventional PSA methodology which is widely used in nuclear power plant risk assessment. The logical failure structure of a site with multiple units is suggested from the definition of site risk, and a decomposition method is applied to identify specific MU failure scenarios.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.4B
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• pp.363-374
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• 2008

Intensity-Duration-Frequency (IDF) curve that is essential to calculate rainfall quantiles for designing hydraulic structures in Korea is generally formulated by regression analysis. In this study, IDF curve derived by the cumulative distribution function ("IDF by CDF") of the proper probability distribution function (PDF) of each site is suggested, and the corresponding parameters of IDF curve are computed using genetic algorithm (GA). For this purpose, IDF by CDF and the conventional IDF derived by regression analysis ("IDF by REG") were computed for 22 Korea Meteorological Administration (KMA) rainfall recording sites. Comparisons of RMSE (root mean squared error) and RRMSE (Relative RMSE) of rainfall intensities computed from IDF by CDF and IDF by REG show that IDF by CDF is more accurate than IDF by REG. In order to accommodate the effect of the recent intensive rainfall of Korea, the rainfall intensities computed by the two IDF curves are compared with that by at-site frequency analysis using the rainfall data recorded by 2006, and the result from IDF by CDF show the better performance than that from IDF by REG. As a result, it can be said that the suggested IDF by CDF curve would be the more efficient IDF curve than that computed by regression analysis and could be applied for Korean rainfall data.

• Proceedings of the Korea Contents Association Conference
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• 2007.11a
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• pp.231-233
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• 2007

The e-Science for High Energy Physics is to study high energy physics anytime and anywhere even if we are not on-site of accelerator latboratories. The concepts are 1) data production, 2) data processing and 3) data publication. The data production is to do remote control and take shifts remotely. The data processing is to run jobs anytime, anywhere with grid farms. The data publication is to work together to publish papers using collaborative environment such as EVO (Enabling Virtual Organization) system. We apply this concept to high energy physics, espessically, CDF experiment and show the results.

• Nuclear Engineering and Technology
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• v.53 no.2
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• pp.498-508
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• 2021

Micro reactors are increasingly being considered for utilization as distributed power sources. Hence, the probabilistic safety assessment (PSA) of a direct supercritical-CO₂-cooled fast reactor, called micro modular reactor (MMR), was performed in this study; this reactor was developed using innovative design concepts. It adopted a modular design and passive safety systems to minimize site constraints. As the MMR is in its conceptual design phase, design weaknesses and valuable safety insights could be identified during PSA. Level 1 internal event PSA was carried out involving literature survey, system characterization, identification of initiating events, transient analyses, development of event trees and fault trees, and quantification. The initiating events and scenarios significantly contributing to core damage frequency (CDF) were determined to identify design weaknesses in MMR. The most significant initiating event category contributing to CDF was the transients with the power conversion system initially available category, owing to its relatively high occurrence frequency. Further, an importance analysis revealed that the safety of MMR can be significantly improved by improving the reliability of reactor trip and passive decay heat removal system operation. The findings presented in this paper are expected to contribute toward future applications of PSA for assessing unconventional nuclear reactors in their conceptual design phases.

• Nuclear Engineering and Technology
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• v.44 no.7
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• pp.745-754
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• 2012

The correlations between Large Early Release Frequency (LERF) and Early Fatality need to be investigated for risk-informed application and regulation. In Regulatory Guide (RG) -1.174, while there are decision-making criteria using the measures of Core Damage Frequency (CDF) and LERF, there are no specific criteria on LERF. Since there are both huge uncertainties and large costs needed in off-site consequence calculation, a LERF assessment methodology needs to be developed, and its correlation factor needs to be identified, for risk-informed decision-making. A new method for estimating off-site consequence has been presented and performed for assessing health effects caused by radioisotopes released from severe accidents of nuclear power plants in this study. The MACCS2 code is used for validating the source term quantitatively regarding health effects, depending on the release characteristics of radioisotopes during severe accidents. This study developed a method for identifying correlations between LERF and Early Fatality and validates the results of the model using the MACCS2 code. The results of this study may contribute to defining LERF and finding a measure for risk-informed regulations and risk-informed decision-making.

• The Journal of the Korean bone and joint tumor society
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• v.1 no.2
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• pp.226-232
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• 1995

Survival rate of osteosarcoma has been improved recently due to the neoadjuvant and adjuvant chemotherapy. Limb-salvaging operation(LSO) has replaced the amputation technique without' lowering the survival rate. And there occurred a lot of patients who are suffering from the high cost of artificial implants and forced to choose amputation due to economic problem. In LSO, usually relatively high cost artifical implant is needed. When a patient and not afford such an expensive implant he had to choose an inexpensive way, amputation. Authors tried bone lengthening by adopting Ilizarov technique after wide resection of tumor in two patients. Bone transportation was successful in one patient and less successful in the other. One case in CDF(continuosly disease free since the surgical procedure) state at follow-up 3 year 4 months after knee joint fusion. And the other was given lobectomy for lung metastasis at postop. 1 year and 9 months, and given osteosynthesis for infected nonunion at the docking site. Bone transportation was thought to be a good method for the bony coverage of dead space caused by wide resection. Bone transportation technique was economical as well as biological We present two osteosarcoma patient who treated with Ilizarov bone transportation.

• Korean Journal of Soil Science and Fertilizer
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• v.45 no.1
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• pp.107-111
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• 2012

Eight marine sediments from Busan port in Korea were annually analyzed to examine the concentration distribution of dioxins from 2006 to 2010. Yearly mean concentration of dioxins ranged from 186.3 to $383.3pg\;g^{-1}$ in real values and 5.087 to 8.541 pg-TEQ (Toxicity equivalency) based on dry weight of samples. The dioxin concentration at the site near fishing market was the highest concentration among all sampling sites. Also the dioxin concentration at the sites with various pollutant sources such as large ships, sewage influx and thermal power station as well as fishing market was higher than that of the sites without specific pollutant sources. Another main factor that affects the dioxin concentration is topography characteristics of the bay. The bay has relatively high dioxin concentration because of the lack of the pollutant diffusion. This study demonstrated that the dioxin concentration in the site with pollutant sources and the lack of the pollutant diffusion was relatively high as compared with the other sites. As a result of contribution ratio of dioxin congeners, OCDD (Octachlorodibenzodioxin) in all sites was major contributor in real value, in contrast, dioxin congeners in TEQ values were dominated by 2,3,4,7,8-PeCDF.

• Korean Journal of Environmental Biology
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• v.26 no.4
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• pp.330-342
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• 2008

A comprehensive quality survey for PCDDs/PCDFs and coplanar PCBs as well as heavy metals (Cu, Zn, Cd and Pb) in sediments has been investigated in August 2006, Korea. Monitoring was undertaken at five streams representing different surrounding environments throughout Juwang and Gapyeong streams (reference sites), Jungrang stream (dense population site), Ansan stream (mixed small population and industrial site), and Siheung stream (heavy industrial site). The levels of heavy metal in samples were found to be significantly higher in sediment from Siheung stream compared to those of other stream sites. The heavy metal concentrations (dry weight basis) in sediment from Siheung stream were as follows; Cd (3.7 ${\mu}g$/g), Pb (1,295 ${\mu}g$/g), Cu (713.4 ${\mu}g$/g) and Zn (358.1 ${\mu}g$/g). Among 12 coplanar PCBs and 17 PCDDs/PCDFs selected as target compounds in this study, PCB (IUPAC no. 118) and OCDD were the most abundant congeners found in all sediment samples, followed by 1,2,3,4,6,7,8-HpCDD, OCDF and 1,2,3,4,6,7,8HpCDF as well as PCB (IUPAC no. 105). These results were shown to be in the same trend as the sediment samples of other countries. The levels of PCDDs/PCDFs/coplanar PCBs in sediment samples were expressed as concentrations and WHO- TEQ values. The PCDDs/PCDFs/coplanar PCBs concentrations and their WHO-TEQ values in sediment from Siheung stream were remarkably high. The levels detected were 788.16 pg/g and 36.080 pg WHO-TEQ/g dry weight for PCDDs/ PCDFs and 314 pg/g and 0.4189 pg WHO-TEQ/g dry weight for coplanar PCBs, respectively, beyond the safety level of sediment value 20 pg WHO-TEQ/g. Sediment samples of the five streams were also monitored by sensitive biomarkers using insect immune responses: hemocyte-spreading behavior and immune-associated enzyme activities of phospholipase A$_2$ (PLA$_2$) and phenoloxidase. Organic extracts of Siheung and Jungrang sediments significantly interfered with the hemocytespreading behavior, whereas those of Ansan, Gapyeong, and Juwang did not. These organic extracts did not inhibit the PLA$_2$ and phenoloxidase activities. However, phenoloxidase was highly susceptible to exposure to aqueous extracts in all site sediments. In comparison, PLA$_2$ activities of the hemocytes were significantly inhibited only by aqueous extracts of Siheung, Jungrang, and Gapyeong sediments, but not by those of Ansan and Juwang. Despite some disparity between bioand chemical monitoring results, the biomarkers can be recommended as a device warning the contamination of biohazard environmental chemicals because of a fast and inexpensive detection method.

• International Journal of Highway Engineering
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• v.8 no.3 s.29
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• pp.29-37
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• 2006

The primary objective of this study is to characterize traffic axle loadings that consider Korea specific traffic conditions for developing mechanistic-based pavement design method as a part of Korea Pavement Research Program(KPRP). Although the concept of equivalent single axle load(ESAL) has been generally used since the 1960s for the pavement design, the mechanistic-based pavement design procedure requires more accurate axle loading data on the specific pavement. In this study, axle loading data were collected according to vehicle type and highway functional classification. Axle-load spectrum was then standardized by cumulative density function(cdf), because the axle load spectrum could vary from the observed site, truck traffic volume, and truck type, Finally, this study presented the procedure and S-shaped exponential models for characterizing axle load spectra according to vehicle type and highway functional classification.

• The Journal of Korean Society of Virology
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• v.28 no.1
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• pp.71-78
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• 1998

Vaccinia virus is the prototype orthopoxvirus that has been used as a vaccine strain for small pox. This virus has been used to express a variety of cellular and viral genes in mammalian cells at high levels. Interleukin-4 (IL-4) has been found to stimulate the proliferation of T cells and enhance the cytolytic activity of cytotoxic T lymphocytes. To test the immunotherapeutic potential of IL-4 delivered in vivo by poxvirus, a recombinant vaccinia virus expressing the murine IL-4 gene (RVVmIL-4) was constructed. A high level of IL-4 production was confirmed by infecting HeLa cells and measuring IL-4 in cell culture supernatant by ELISA. As a tumor model, two cell lines were used; the murine T leukemic line P388 and the murine breast cancer line TS/A. CDF1 mice were intraperitoneally inoculated with $1\;{\times}\;10^5$ cells of P388. Mice were injected at the same site with $5\;{\times}\;10^5\;PFU$ of recombinant vaccinia virus; first, 3 days after the injection of tumor cells and thereafter once every week for 3 weeks. Intraperitoneal injections of RVVmIL-4 significantly prolonged the survival time of mice inoculated with tumor cells. All mice injected with RVVmIL-4 remained alive for 30 days after the postinoculation of tumor cells, while 100% and 70% of the animals injected with saline or wild type vaccinia virus died, respectively. In another tumor model using TS/A, tumor was established by subcutaneously inoculating $2{\times}10^5$ tumor cells to BALB/c mice. After tumor formation was confirmed on day 4 in all mice, $5\;{\times}\;10^6\;PFU$ of RVVmIL-4 was inoculated subcutaneously three times, once every week for 3 weeks. The TS/A tumor was eradicated in two of the nine mice. Seven of the nine mice treated with RVVmIL-4 developed a tumor, but tumor growth was significantly delayed compared to those treated with saline or wild type vaccinia virus. These results indicate that recombinant vaccinia viruses may be used as a convenient tool for delivering immunomodulator genes to a variety of tumors.