• Radiation Oncology Journal
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• 제25권2호
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• pp.118-124
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• 2007

목 적: 투과성 필터를 이용하여 방사선치료를 받은 부비동 및 비암 환자에서 생존율 및 치료실패 양상을 분석하여 향후 치료계획을 할 때 도움을 주고자 한다. 대상 및 방법: 1992년 2월부터 2002년 3월까지 계명대학교 동산의료원 방사선종양학과에서 부비동 및 비암으로 진단받고 투과성 필터를 이용하여 방사선치료를 받은 환자 17명을 대상으로 후향적 분석을 시행하였다. 대상환자의 성별분포는 남자가 9명, 여자가 8명이었으며 연령분포는 $40{\sim}75$세(중앙값 59세)였다. 비강암이 7명, 부비동암이 10명이었고 조직학적으로 편평상피세포암이 11명, 선양낭성암종이 4명, 후신경모세포종이 2명이었다. AJCC 병기에 따라 II기가 3명, III기가 7명, IV기가 7명이었다. 방사선치료단독은 5명, 수술 후 방사선치료를 받은 환자는 12명이었다. 방사선치료는 일회 $1.8{\sim}2.0\;Gy$로 총 $44{\sim}76\;Gy$ (중앙값 60 Gy)를 조사하였다. 추적관찰기간은 $3{\sim}173$개월(중앙값 78개월)이었다. 결 과: 2년 생존율과 무병생존율은 76.4%이었고 5년, 10년 생존율은 각각 76.4%, 45.6%, 5년, 10년 무병생존율은 70.6%이었다. 수술유무에 따른 5년 무병생존율은 수술을 시행한 군은 91.6% 수술을 시행하지 않은 환자군은 20%로 통계적으로 유의하게 차이가 있었다(p=0.006). 병리 형태나 병기에 따른 생존율의 차이는 없었다. 5명(29%)의 국소재발률을 보였으며 원격전이는 없었고 수술을 요하는 심각한 부작용은 없었다. 결 론: 부비동 및 비암에서 투과성 필터를 이용한 방사선치료는 안전하고 효과적이며 국소제어율을 높이기 위해 수술과 방사선치료의 병합요법이 바람직하며 방사선 단독으로 치료할 때는 국소제어와 생존율을 향상시키기 위해 정교한 치료계획을 통해 방사선량을 증가시키고 다학제 치료를 고려해야 할 것이다.

• 한국산업안전학회:학술대회논문집
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• 한국안전학회 1998년도 추계 학술논문발표회 논문집
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• pp.89-92
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• 1998

Tannins are complex polyphenolic substances present in plants. They may be classified as either hydrolysable or condensed tannins, and extracts of the latter type have displayed carcinogenic properties in animal studies (Hausen, 1981). The International Agency for Research on Cancer has determined that exposure to airborne wood dust, especially hardwood dust during furniture manufacture, is a cause of sino-nasal cancer, notably nasal adenocarcinoma. (omitted)

• 한국산업보건학회지
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• 제10권2호
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• pp.68-77
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• 2000

This study was performed to evaluate tannin exposure by wooddusts for workers in furniture factories and to investigate the relationship between tannin exposure and sino-nasal cancer risk. In order to explore possible cytological changes leading to nasal cancer, we have examined 50 male furniture workers and 50 matched controls using brush cytology. The results we have obtained in this study were as follows: 1. The tannin contents of woods used in woodworking factories have been measured and varied from 0.43 to 8.72 mg tannic acid equivalent per gram wood, for reconstituted softwood and turpentine (Syncarpia glomuliferia) respectively. 2. Airborne tannins in wooddusts were also determined by area and personal exposure. The values of mean exposures for both methods are ranged from 3.1 to $5.0{\mu}g/m^3$ and from 4.6 to $14.5{\mu}g/m^3$ in furniture manufactures. 3. Over nasal cytology scores 2, the scores of study group were slightly more than control group and this kind of metaplasias seemed to be occurred over $2mg/m^3$ wooddust and $6{\mu}g/m^3$ tannin exposure. Keratinising squamous metaplasia was investigated at nasal cytology score 3 and $10{\mu}g/m^3$ tannin exposure. The nasal cytology score 4 was seemed to be atypical squamous metaplasia. 4. To find out contributing factors to nasal cytology change, odds ratio that is one of fundmental biostatistics was applied. Actually the relationship between wooddust, tannin concentration and metaplasia were not meaningful, but the relationship between working experence more than 15 years and metaplasia was calculated as 1.83. This reveals that significant clinical abnormalities could be influenced from the years of woodworking experiences. However further research is required to evaluate the significance of the data, for the purposes of sino-nasal risk assessment, standard setting to prevent nasal cancer occurrences and possibility of changing workplace.

• 대한두경부종양학회지
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• 제34권2호
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• pp.23-28
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• 2018

Background/Objectives: Adenoid cystic carcinoma is the second most common salivary carcinoma. It occurs commonly in the submandibular gland, sublingual gland and minor salivary gland. Local recurrence and distant metastasis are the leading cause of death. The aim of this study was to evaluate long-term oncologic outcomes of patients with head and neck adenoid cystic carcinoma focusing on distant metastasis. Materials & Methods: We retrospectively studied 39 patients who were diagnosed with and treated for adenoid cystic carcinoma of the head and neck from December 1996 to May 2018. The clinicopathologic characteristics of patients such as age, sex, primary site and TNM stage, and treatment methods, recurrence and distant metastasis after treatment, survival rate, and treatment method for recurrence were analyzed. Results: Of 39 patients, 18 were males and 21 were females, and the mean age was $5.9{\pm}14.4$ (28-89) years. The most common primary site was oral cavity (12 cases), and followed by sino-nasal cavity (11 cases), parotid gland (5 cases), and etc. For treatment, 17 patients underwent surgery alone, 16 received surgery with postoperative radiation therapy, and 3 patients received radiation therapy only. Three patients refused any further treatments. Recurrence occurred in 15 patients. The most common site of recurrence was the lung. The mean time to recurrence was 31.7 months. The 5 and 10 years' overall survival rate was 79.3% and 74%, respectively. The 2 and 5 years' overall survival rate was 69.6% and 62.6% in patients with distant metastasis. Conclusion: Distant metastasis is an important prognostic factor in adenoid cystic carcinoma, and eventually one third of patients have distant metastasis, especially in the lung. An appropriate treatment for lung metastasis is necessary because some patients with pulmonary metastasis survive for a quite long time.