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Matrix Metallopeptidase 2 Gene Polymorphism is Associated with Obesity in Korean Population

  • Han, Dong-Hee;Kim, Su-Kang;Kang, Sung-Wook;Choe, Bong-Keun;Kim, Keon-Sik;Chung, Joo-Ho
    • The Korean Journal of Physiology and Pharmacology
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    • v.12 no.3
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    • pp.125-129
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    • 2008
  • The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) of matrix metallopeptidase 2 (MMP2) are associated with obesity. MMP2 is an enzyme with proteolytic activity against matrix and nonmatrix proteins, particularly basement membrane constituents. To identify the relationship between polymorphisms of MMP2 and overweight/obese, we genotyped 5 SNPs (rs17242319, rs1053605, rs243849, rs2287074, and rs10775332) of the coding region of MMP2 using the Golden Gate assay on an Illumina BeadStation 500 GX. One hundred and forty two overweight/obese ($BMI\;{\ge}\;23$) and 145 normal (BMI 18 to < 23) subjects were analyzed. SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs were used for the analysis of genetic data. A linkage disequilibrium (LD) block was discovered among the 5 SNPs selected, including rs17242319, rs1053605, rs243849, and rs2287074. Of the 5 polymorphisms, 2 synonymous SNPs [rs17242319 (Gly226Gly) and rs10775332 (Phe602Phe)] were found significant associations with overweight/obese. Recently, rs1132896 replaced rs17242319 as a new number (SNP database, BUILD 129). In haplotype analysis using Haploview, a haplotype (haplotype: CCCA) containing a meaningful polymorphism (rs17242319) was found to be significantly different. The results suggest that MMP2 may be associated with overweight/obese in Korean population.

Evaluation of Genetic Diversity among Soybean Genotypes Using SSR and SNP

  • Lee, Suk-Ha;P. Tanya;O, Srinives;T. Toojinda;A. Vanavichit;Ha, Bo-Keun;Bae, Jeong-Suk;Moon, Jung-Kyung
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.46 no.4
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    • pp.334-340
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    • 2001
  • Two different types of molecular markers, simple sequence repeat (SSR) and single nucleotide polymorphism (SNP), were used to measure genetic diversity among five Korean, eight Thai, and three wild soybeans. For SSR analysis, a total of 20 markers were surveyed to detect polymorphisms. For SNP analysis, four primers were designed from consensus sequence regions on disease resistance protein homolog genes, and used to amplify the genomic region. The PCR products were sequenced. A number of polymorphic SSR and SNP bands were scored on all genotypes and their genetic similarity was measured. Clustering analysis was performed independently on both types of markers. Clustering based on SSR markers separated the genotypes into three main groups originated from Korea, Thailand, and wild soybeans. On the other hand, two main groups were classified using SNP analysis. It seemed that SSR was more informative than SNP in this study. This may be due to the fact that SNP was surveyed on the smaller genomic region than SSR. Grouping based on the combined data of both markers revealed similar results to that of SNP rather than that of SSR. This might be due to the fact that more loci from SNP were considered to measure genetic relatedness than those from the SSR.

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Change in the Spatial Structure of Commercial Areas in Daegu (대구시 상업지역의 구조 변화)

  • Kim, Ta-Yeul;Jin, Won-Hyung
    • Journal of the Korean association of regional geographers
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    • v.14 no.4
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    • pp.367-381
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    • 2008
  • The purpose of this paper is to analyze the change in the distribution and hierarchical structure of commercial land use. Tools for analyzing the spatial structure are index of concentration, coefficient of localization and location quotient. This research is applied to Daegu, focusing on the period 1985-2003. During the 1985-2003 period, the growth rate of commercial land use volume amounted to 330%, compared with a population growth rate of 118%. The biggest component of commercial land use is the retail sector. As the lodging, medical, transportation-warehouse and entertainment sectors have the propensity for concentration and comprise the specialized commercial areas in the suburbs, the other sectors arc evenly distributed. Jung-gu has functioned as a downtown core in the hierarchical structure of commercial areas. So, in the structure of commercial land use, Daegu has continued to be a single nuclear structure. But, Dongdaegu Station influence area has evolved into the second order center since 2000. This is the sign of change in spatial structure from single-nuclear pattern to multi nuclear pattern.

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A Study on the Application of TRS Communication System for the Small Fishing ship (소형어선과의 통신을 위한 TRS통신방식의 도입에 관한 연구)

  • 김정년;최조천;조학현
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2002.11a
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    • pp.196-201
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    • 2002
  • The SSB(Single Side Band) communication in the 27MHz band has mainly been using between fishiery station and small fishing ship less than 10tons, but the most of small fishing ship are depend on cellular system. When accident for small ship at sea happens, It's very important to communicate continuously for preventing the collision and taking action. At present it is hard to control small fishing ship and provide information properly by using 27MHz SSB channel. Therefore in this paper We present TRS communication system applied for small fishing ship to protect the safy and life at sea and to prepare for emmergency, and also validate it's application.

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Performance of IEEE 802.16j using Cooperative Relaying in Correlated Shadow Fading (음영감쇄 환경에서의 IEEE 802.16j 상호 협조 중계 방식 성능 평가)

  • Ha, Dong-Ju;Kim, Suk-Chan;Park, Dong-Chan;Kim, Young-Il
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.44 no.5
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    • pp.47-53
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    • 2007
  • The purpose of IEEE 802.16j is to extend coverage and to enhance throughput by using relay station additionally to conventional IEEE 802.16e . The cellular system experiences performance degradation at the cell edge due to pathloss, shadow and multipath fading. We can get advantage of spatial diversity gain by using relays more than two cooperatively in the IEEE 802.16j system. Cooperative relaying using space-time code provides better performance under multipath fading and has more robustness against the shadow fading than single relaying. In this paper, we investigate the performance of IEEE 802.16j using cooperative relaying by link level simulation. We also show that the cooperative relaying system achieves better performance than the conventional single relaying system. We apply realistic shadow model considering correlations between shadow fadings of different relaying paths. It is shown that the performance of the system depends highly on the spatial location of relay stations.

A Pilot Symbol Insertion Method for SC-FDMA Mobile Communication Systems (SC-FDMA 이동통신 시스템을 위한 파일럿 심벌 삽입 방법)

  • Rim, Min-Joong;Ryu, Chul
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.44 no.6 s.360
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    • pp.48-56
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    • 2007
  • OFDMA (Orthogonal Frequency Division Multiple Access) is widely used as multiple access techniques for next generation mobile communication systems. However, OFDMA has a disadvantage of high peak-to-average power ratio and SC-FDMA (Single-Carrier Frequency Division Multiple Access) was proposed for uplink systems to overcome the drawback. SC-FDMA also has several demerits including degraded performance with high-order modulations or with multiple antenna techniques, and less flexibility in resource allocation and pilot patterns. In order to achieve the best performance over a wide range of environments, each mobile station should select either of OFDMA and SC-FDMA according to the given condition and a pilot structure for SC-FDMA systems should be similar to that of OFDMA to maintain the same frame structure. While conventional SC-FDMA schemes require an entire SC-FDMA symbol or a separate short symbol for pilots, this paper proposes a method which supports the pilots included in SC-FDMA data parts and enables a SC-FDMA frame to hold the same structure as an OFDMA frame.

A Software Framework to provide multiple VPMN MSISDNs with a Single IMSI (단일 IMSI로 다중 VPMN MSISDN을 제공하기 위한 소프트웨어 프레임워크)

  • Lee, Dong-Cheul;Rhee, Byung-Ho
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.11 no.4
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    • pp.75-81
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    • 2011
  • The UMTS is the most widely used specifications to deploy a mobile system and it supports an automatic roaming function. Users in the UMTS can use their phone numbers even in foreign countries without having to change their mobile phones. Also some users want to use other phone numbers which are allocated in foreign countries. To meet such requirements, many methods have been proposed. However, those require much cost to adopt or are not easy to use. In this paper, we propose a software framework that provides multiple MSISDNs with a single IMSI. The roaming SCP is adopted to modify the procedure of the location update and the mobile-terminated call. In the performance evaluation, we compared the proposed scheme with the standard scheme and the schemes in the related works. The results showed that the proposed scheme has 7.6% lower signaling cost than the mobile-station-based scheme and 9.7% lower cost than the telecommunication-network-based scheme.

A Residual Ionospheric Error Model for Single Frequency GNSS Users in the Korean Region (한국지역에서의 단일주파수 GNSS 사용자를 위한 전리층 잔류 오차 모델 개발)

  • Yoon, Moonseok;Ahn, Jongsun;Joo, Jung -Min
    • Journal of Advanced Navigation Technology
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    • v.25 no.3
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    • pp.194-202
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    • 2021
  • Ionosphere, one of the largest error sources, can pose potentially harmful threat to single-frequency GNSS (global navigation satellite system) user even after applying ionospheric corrections to their GNSS measurements. To quantitatively assess ionospheric impacts on the satellite navigation-based applications using simulation, the standard deviation of residual ionospheric errors is needed. Thus, in this paper, we determine conservative statistical quantity that covers typical residual ionospheric errors for nominal days. Extensive data-processing computes TEC (total electron content) estimates from GNSS measurements collected from the Korean reference station networks. We use Klobuchar model as a correction to calculate residual ionospheric errors from TEC (total electron content) estimate. Finally, an exponential delay model for residual ionospheric errors is presented as a function of local time and satellite elevation angle.

Delay and Doppler Profiler based Channel Transfer Function Estimation for 2×2 MIMO Receivers in 5G System Targeting a 500km/h Linear Motor Car

  • Suguru Kuniyoshi;Rie Saotome;Shiho Oshiro;Tomohisa Wada
    • International Journal of Computer Science & Network Security
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    • v.23 no.9
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    • pp.8-16
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    • 2023
  • In Japan, high-speed ground transportation service using linear motors at speeds of 500 km/h is scheduled to begin in 2027. To accommodate 5G services in trains, a subcarrier spacing frequency of 30 kHz will be used instead of the typical 15 kHz subcarrier spacing to mitigate Doppler effects in such high-speed transport. Furthermore, to increase the cell size of the 5G mobile system, multiple base station antennas will transmit identical downlink (DL) signals to form an expanded cell size along the train rails. In this situation, the forward and backward antenna signals are Doppler-shifted in opposite directions, respectively, so the receiver in the train may suffer from estimating the exact Channel Transfer Function (CTF) for demodulation. In a previously published paper, we proposed a channel estimator based on Delay and Doppler Profiler (DDP) in a 5G SISO (Single Input Single Output) environment and successfully implemented it in a signal processing simulation system. In this paper, we extend it to 2×2 MIMO (Multiple Input Multiple Output) with spatial multiplexing environment and confirm that the delay and DDP based channel estimator is also effective in 2×2 MIMO environment. Its simulation performance is compared with that of a conventional time-domain linear interpolation estimator. The simulation results show that in a 2×2 MIMO environment, the conventional channel estimator can barely achieve QPSK modulation at speeds below 100 km/h and has poor CNR performance versus SISO. The performance degradation of CNR against DDP SISO is only 6dB to 7dB. And even under severe channel conditions such as 500km/h and 8-path inverse Doppler shift environment, the error rate can be reduced by combining the error with LDPC to reduce the error rate and improve the performance in 2×2 MIMO. QPSK modulation scheme in 2×2 MIMO can be used under severe channel conditions such as 500 km/h and 8-path inverse Doppler shift environment.

Evaluation of Accuracy Improvement of SWAT Model for the Yongdam-Dam Watershed based on Multi-Point Hydrological Observations (용담댐유역의 다지점 유량관측 자료 이용에 따른 SWAT 모형의 정확도 향상성 평가)

  • SHIN, Hyung-Jin;PARK, Min-Ji;LEE, Ji-Won;HWANG, Eui-Ho;KANG, Seok-Man;CHAE, Hyo-Sok
    • Journal of the Korean Association of Geographic Information Studies
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    • v.21 no.3
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    • pp.104-118
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    • 2018
  • This study is to evaluate the accuracy improvement of the model using SWAT(Soil and Water Assessment Tool) model and multi - point hydrological observation data. The watershed is located in the Yongdam Dam($930.4km^2$), the Donghyang($165.5km^2$), the Chuncheon($290.9km^2$), the Juchun($57.8km^2$) and the Seokjeong($80.5km^2$). The watershed covers 70.0 % forest. In order to improve the accuracy of the model, precipitation data were used from two weather stations(Jangsu, Geumsan) and 16 AWS stations daily precipitation data(2003~2011) managed by KMA, MLIT, and K-water. Based on the reliable data of the Yongam test basin in 2003~2011, the runoff of single point (Yongdam dam) and multi-point (Donghyang, Chuncheon, Jucheon, Seokjeong). Simulation results show that the $R^2$ of the single subwatershed (Donghyang, Chuncheon, Jucheon, Seokjeong) is single point(0.84) and multipoint(0.88). For model efficiency coefficient of Nash-Sutcliffe at single point(0.45) and multipoint(0.70).