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Effects of Vinblastine and Vincristine on the Primary and Secondary Cell-mediated Immunity (Vinblastine과 Vincristine이 1차(次) 및 2차(次) 세포성(細胞性) 면역반응(免疫反應)에 미치는 영향(影響))

  • Pyo, Myoung-Yun
    • Korean Journal of Pharmacognosy
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    • v.17 no.3
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    • pp.248-254
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    • 1986
  • Effects of vinblastine(VLB) and vincristine(VCR) on cell-mediated immunity(CMI) were studied with the microcytotoxicity test(MCT) after normal or pre-sensitized Balb/c mice had been treated in vivo with a combination of two different doses of VLB or VCR(single dose of 20% and 60% $LD_{50}$, i.p.) at different times (from day -6 to day +4) plus allo-transplantation antigen(allo-TA, cells from C3H mice at day 0). The results were that $LD_{50}$ of VLB for female Balb/c mouse was 7.3mg/kg body weight (i.p.) and $LD_{50}$ of VCR was 4.3mg/kg body weight and that VLB and VCR acted as immunosuppressive agents on the primary CMI when administered after allo-TA(antigen-drug-phase), but showed no effect when administered prior to allo-TA(drug-antigen-phase). Change of doses of VLB and VCR(20% $LD_{50}$, 60% $LD_{50}$) caused quantitative or qualitative variations in the immunomodulating effects of these two drugs. Neither VLB nor VCR had any immunomodulating effect on the secondary CMI. Lastly, the results support that the four parameters (type of drug, sensitization status, time of drug treatment in relation to antigen injection, and drug dosis) are significant for the effects of the VLB and VCR on the CMI, and that VLB and VCR may inhibit the proliferation of antigen-stimulated T effector lymphocytes but not memory-cytotoxic T lymphocytes.

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Microstructure and Ferroelectric Properties of Sol-gel Derived $PbTiO_3$ Interlayered PZT Thin Films (졸-겔법으로 제조한 $PbTiO_3$ Interlayered PZT 박막의 미세구조와 강유전 특성)

  • 임동길;최세영;정형진;오영제
    • Journal of the Korean Ceramic Society
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    • v.32 no.12
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    • pp.1408-1416
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    • 1995
  • Microstructure and ferroelectric properties of sol-gel derived PZT(52/48) and PT interlayered PZT(52/48) thin films on Pt/Ti/SiO2/Si substrates were investigated. Films were fabricated using Acetylacetone chelated PT and PZT(52/48) sols. PZT(52/48) thin films annealed at $700^{\circ}C$ for 20 min showed the rosette structure with the size of 1.2~1.6${\mu}{\textrm}{m}$ and the pyrochlore phse was contained. PT interlayered PZT thin films, which is inserted by PbTiO3 thin layer with the thickness of 130 $\AA$ between PZT thin film and electrode, consisted of a single perovskite phase after annealing above 55$0^{\circ}C$. They exhibited the uniform and columnar grains of 0.1~0.16${\mu}{\textrm}{m}$, which are applicable for microelectronic device including non-volatile memory. Typical P-E hysteresis loops could be obtained from PT interlayered PZT thin film at as low as the annealing temperature of 50$0^{\circ}C$. Ferroelectric properties of PT interlayered PZT thin films were improved as increasing annealing temperature up to $700^{\circ}C$, and then deteriorated at 75$0^{\circ}C$. PZT(52/48) and PT interlayered PZT(52/48) thin film annealed at $700^{\circ}C$ for 20 min displayed Ps=38.8$\mu$C/$\textrm{cm}^2$, Pr=10.0$\mu$C/$\textrm{cm}^2$, Ec=65.3 kV/cm and Ps=28.5$\mu$C/$\textrm{cm}^2$, Pr=9.8$\mu$C/$\textrm{cm}^2$, Ec=76.1 kV/cm, respectively.

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A GPU-enabled Face Detection System in the Hadoop Platform Considering Big Data for Images (이미지 빅데이터를 고려한 하둡 플랫폼 환경에서 GPU 기반의 얼굴 검출 시스템)

  • Bae, Yuseok;Park, Jongyoul
    • KIISE Transactions on Computing Practices
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    • v.22 no.1
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    • pp.20-25
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    • 2016
  • With the advent of the era of digital big data, the Hadoop platform has become widely used in various fields. However, the Hadoop MapReduce framework suffers from problems related to the increase of the name node's main memory and map tasks for the processing of large number of small files. In addition, a method for running C++-based tasks in the MapReduce framework is required in order to conjugate GPUs supporting hardware-based data parallelism in the MapReduce framework. Therefore, in this paper, we present a face detection system that generates a sequence file for images to process big data for images in the Hadoop platform. The system also deals with tasks for GPU-based face detection in the MapReduce framework using Hadoop Pipes. We demonstrate a performance increase of around 6.8-fold as compared to a single CPU process.

Magnetic Semiconductors Thin Films-Unidirectional Anisotropy

  • Lubecka, M.;Maksymowicz, L.J.;Szymczak, R.;Powroznik, W.
    • Journal of Magnetics
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    • v.4 no.1
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    • pp.33-37
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    • 1999
  • Unidirectional magnetic anisotropy field ($H_an$) was investigated for thin films of $CdCr{2-2x}In_{2X}Se_4 (0$\leq$x$\leq$0.2). This anisotropy originates from the microscopic anisotropic Dzyaloshinskii-Moriya (DM) interaction which arise from the spin-orbit scattering of the conduction electrons by the nonmagnetic impurities. This interaction maintains the remanent magnetization in the direction of the initial applied field. Then the single easy direction of the magnetization is parallel to the direction of the magnetic field. The anisotropy produced by field cooling is unidirectional I.e. the spins system deeps some memory of the cooling field direction. The chalcogenide spinel of$ CdCr_{2-2x}In){2X}Se_4$belongs to the class of the magnetic semiconductors. The magnetic disordered state is obtained when ferromagnetic structure is diluted by In. Then we have the mixed phase characterised by coexistence the magnetic long range ordering (IFN-infinite ferromagnetic network) and the spin glass order (Fc-finite clusters). The total magnetic anisotropy energy depends on the state of magnetic ordering. In our study we concentrated on the magnetic state with reentrant transition and spin glass state. The polycrystalline $ CdCr_{2-2x}In){2X}Se_4$ thin films were obtained by rf sputtering technique. We applied the ferromagnetic resonance (FMR) and M-H loop techniques for determining the temperature composition dependencies of Han. From the experimental data, we have found that Han decreases almost linearly when temperature is increased and in the low temperature is about three times bigger at SG state with comparison to the state with REE.

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High Density MRAM Device Technology Based on Magnetic Tunnel Junctions (자기터널접합을 활용한 고집적 MRAM 소자 기술)

  • Chun, Byong-Sun;Kim, Young-Keun
    • Journal of the Korean Magnetics Society
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    • v.16 no.3
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    • pp.186-191
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    • 2006
  • Ferromagnetic amorphous $Ni_{16}Fe_{62}Si_8B_{14}$ and $Co_{70.5}Fe_{4.5}Si_{15}B_{10}$ layers have been devised and incorporated as free layers of magnetic tunnel junctions (MTJs) to improve MRAM reading and writing performance. The NiFeSiB and CoFeSiB single-layer film exhibited a lower saturation magnetization ($Ms=800emu/cm^3,\;and\;560emu/cm^3$, respectively) compared to that of a $Co_{90}Fe_{10}(Ms=1400emu/cm^3)$. Because amorphous ferromagnetic materials have lower Ms than crystalline ones, the MTJs incorporating amorphous ferromagnetic materials offer lower switching field ($H_{sw}$) values than that of the traditional CoFe-based MTJ. The double-barrier MTJ with an amorphous NiFeSiB free layer offered smooth surface resulting in low bias voltage dependence, and high $V_h\;and\;V_{bd}$ compared with the values of the traditional CoFe-based MTJ.

Template Fusion for Fingerprint Recognition (지문 등록을 위한 템플릿 융합 알고리즘)

  • 류춘우;문지현;김학일
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.41 no.2
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    • pp.51-64
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    • 2004
  • This paper proposes an algerian of generating a tuner-template from multiple fingerprint impressions using a data fusion technique for fingerprint enrollment. The super-template is considered as a single fingerprint template which contains most likely true minutiae based on multiple fingerprint images. The proposed algorithm creates the super template by utilizing a recursive Bayesian estimation method (RBEM), which assumes a sequential fingerprint input model and estimates the credibility of the minutiae in previous input templates froma current input template. Consequently. the RBEM assigns a higher credibility to commonly detectable minutiae from several input templates and a lower credibility to rarely found minutiae from other input templates. Likewise, the RBEM is able to estimate a credibility of the minutia type (ridge ending or bifurcation). Preliminary experiments demonstrate that, as the number of fingerfrint images increases, the performance of recognition can be improved while maintaining the processing time and the size of memory storage for tile super-template almost constant.

Transaction Scheduling Technique Using Doible Locking in a Soft Real-Time Databaes System (소프트 실시간 데이타베이스 시스템에서 이중 록킹을 이용한 트랜잭션 스케쥴링 기법)

  • Choi, Eui-In;Go, Byeong-O
    • The Transactions of the Korea Information Processing Society
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    • v.4 no.3
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    • pp.639-648
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    • 1997
  • As the areas of computer application are expanded, the real-time applicition enviroments that must process as many transactions as possible within their deadlines have been increased recently. Conventional disk based databaes system is not appropriate in real-time transaction processing due to delying time for disk I/O processing. When the system is overloaede, the performance of transaction scheduling technique using earliest deadline first deteriorates rapidly because it can assign the highest priority ot a transaction that has already missed or is about to miss tis deadline. Therfore, the performance of suggested transaction secheduling technique is made to improved by propos-ing the doule locking mechanism based on priority. Finally, in order to evaluate the performance of the proposed priority-based double locking techniques under single proessor and main memory database system environments, the simulation model was developed using the SLAM II language.

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k-Bitmap Clustering Method for XML Data based on Relational DBMS (관계형 DBMS 기반의 XML 데이터를 위한 k-비트맵 클러스터링 기법)

  • Lee, Bum-Suk;Hwang, Byung-Yeon
    • The KIPS Transactions:PartD
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    • v.16D no.6
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    • pp.845-850
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    • 2009
  • Use of XML data has been increased with growth of Web 2.0 environment. XML is recognized its advantages by using based technology of RSS or ATOM for transferring information from blogs and news feed. Bitmap clustering is a method to keep index in main memory based on Relational DBMS, and which performed better than the other XML indexing methods during the evaluation. Existing method generates too many clusters, and it causes deterioration of result of searching quality. This paper proposes k-Bitmap clustering method that can generate user defined k clusters to solve above-mentioned problem. The proposed method also keeps additional inverted index for searching excluded terms from representative bits of k-Bitmap. We performed evaluation and the result shows that the users can control the number of clusters. Also our method has high recall value in single term search, and it guarantees the searching result includes all related documents for its query with keeping two indices.

Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation

  • Ghaeminia, Mehdy;Rajkumar, Ramamoorthy;Koh, Hwee-Ling;Dawe, Gavin S.;Tan, Chay Hoon
    • Journal of Ginseng Research
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    • v.42 no.3
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    • pp.298-303
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    • 2018
  • Background: Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic, and cognition improving effects. Methods: We investigated the effects of Rg1 on the medial prefrontal cortex (mPFC), a key brain region involved in cognition, information processing, working memory, and decision making. In this study, the effects of systemic administration of Rg1 (1 mg/kg, 3 mg/kg, or 10 mg/kg) on (1) spontaneous firing of the medial prefrontal cortical neurons and (2) long-term potentiation (LTP) in the hippocampal-medial prefrontal cortical (HP-mPFC) pathway were investigated in male Sprague-Dawley rats. Results: The spontaneous neuronal activity of approximately 50% the recorded pyramidal cells in the mPFC was suppressed by Rg1. In addition, Rg1 attenuated LTP in the HP-mPFC pathway. These effects were not dose-dependent. Conclusion: This report suggests that acute treatment of Rg1 impairs LTP in the HP-mPFC pathway, perhaps by suppressing the firing of a subset of mPFC neurons that may contribute to the neurocognitive effects of Rg1.

A Low Complex and Low Power Baseband IR-UWB Transceiver for Wireless Sensor Network (무선 센서 네트워크 응용을 위한 초광대역 임펄스 통신용 저복잡도, 저전력 베이스밴드 트랜시버)

  • Lee, Soon-Woo;Park, Young-Jin;Kang, Ji-Myung;Kim, Young-Hwa;Kim, Kwan-Ho
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.45 no.7
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    • pp.38-44
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    • 2008
  • In this paper, we introduce an low complexity and low power IR-UWB (impulse radio ultra wideband) baseband transceiver for wireless sensor network. The proposed baseband, implemented by TSMC 0.18um CMOS technology, has a simple structure in which a simplified packet structure and a digital synchronizer with 1-bit sampler to detect incoming pulses are used. Besides, clock gating method using gated clock cell as well as customized clock domain division can reduce the total power consumption drastically. As a result, the proposed baseband has about 23K digital gates with an internal memory of 2Kbytes and achieves about 1.8mW@1Mbps power consumption.