• Nutritional Sciences
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• v.4 no.1
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• pp.55-62
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• 2001

Consumers'frequent use of micronutrient supplements has caused concerns o possible overdoses and prompted the view that the appropriate provision of nutrition information on such supplements is needed. In this study the nutrition information on vitamin-mineral supplements in Korea was evaluated based on the labels on the supplements. Consumers'use, reliance on and demand for nutrition information were examined by self-administered questionnaire. Subjects were 1,203 middle-aged housewives. Under examination were 141 multinutrient products (86.6%) and single nutrient products (13.4%). Various names and units were used for the same nutrient and the labels were not informative to consumers. The mode of nutrients contents in the supplements were several fold of RDA though not in the range of toxicity. %RDA value was seldom shown on the label. Currently these supplements are classified as general drugs in Korea so they are not subject to regulations on nutrition labeling. Half of the subjects read the nutrient content list but two-thirds of them did not understand the information. Numerous health claims related to diseases were listed on the label and more than half of the subjects read them and one-third believed those health claims. These results indicate the need for an appropriate format for nutrition information on vitamin-mineral supplements.

• Current Optics and Photonics
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• v.4 no.4
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• pp.368-372
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• 2020

We report the terahertz time-domain spectroscopy (THz-TDS) of transdermal drug delivery in human skin. The time evolution of transdermal nicotine delivery in nicotine patches was assessed by detecting the transmission coefficient of sub-picosecond THz pulses and using a semi-analytic model based on the single-layer effective medium approximation. Using commercial nicotine patches (Nicoderm CQ^®, 7 mg/24 h), THz transmission coefficients were measured to quantitatively analyze the cumulative amounts of nicotine released from the patches in the absence of their detailed specifications, including multilayer structures and optical properties at THz frequencies. The results agreed well with measurements by conventional in vitro and in vivo methods, using a diffusion cell with high-performance liquid chromatography and blood sampling respectively. Our study revealed the ability of the THz-TDS method to be an effective alternative to existing methods for noninvasive and label-free assessments of transdermal drug delivery, showing its high promise for biomedical, pharmaceutical, and cosmetic applications.

• Smart Media Journal
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• v.11 no.4
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• pp.38-45
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• 2022

Object detection models have become the current tool of choice for plant disease detection in precision agriculture. Most existing research improves the performance by ameliorating networks and optimizing the loss function. However, the data-centric part of a whole project also needs more investigation. In this paper, we proposed a systematic strategy with three different annotation methods for plant disease detection: local, semi-global, and global label. Experimental results on our paprika disease dataset show that a single class annotation with semi-global boxes may improve accuracy. In addition, we also studied the noise factor during the labeling process. An ablation study shows that annotation noise within 10% is acceptable for keeping good performance. Overall, this data-centric numerical analysis helps us to understand the significance of annotation methods, which provides practitioners a way to obtain higher performance and reduce annotation costs on plant disease detection tasks. Our work encourages researchers to pay more attention to label quality and the essential issues of labeling methods.

• Journal of the Korean Institute of Intelligent Systems
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• v.19 no.4
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• pp.568-573
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• 2009

Marine accidents have always caused huge economic losses, as well as environmental pollution. Prevention of marine accidents has become a focus of argumentation. The analysis of past accident cases, reviewing the experience and lessons, is important and necessary for preventing marine accidents. With the same subject above, the Korean Maritime Safety Tribunal provides for past marine accidents' written judgments and analysis of judgment and associated retrieval system on its homepage. In these systems, the name of the ship, accident occurrence time, accident pattern or related keywords are used as search conditions. However, most of the marine events' happening were not due to a single reason, but multiple ones. In addition, one marine event could often come under several categories. In this case, now the retrieval systems' DB is used on the Korean Maritime Safety Tribunal homepage was built based on single category and failed to be able to retrieve according to multiple reasons or multiple categories. In order to solve this problem, a more practical retrieval approach might be needed. Therefore, in this paper, a new retrieval system will be proposed, which using the linguistic label to describe the cluster after analyzing the relational properties between marine accidents and clustering by FCM algorithm, and then adding an interface to allow users to get the results they want through choosing multiple reasons or multiple categories.

• Bulletin of the Korean Chemical Society
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• v.27 no.3
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• pp.407-412
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• 2006

Bioluminescence single-site immunometric assay for methamphetamine (MA) using the native aequorin, a photoprotein, as a signal generator was developed for the first time. MA is a potent sympathomimetic amine with stimulant effects on the central nervous system. MA abuse induces hallucinations and, thus, may cause a serious social problem. The single-site immunometric MA assay was optimized and its dose-response behavior was examined. The dose-response curve shows that the detection limit is 1.1 ${\times}$ $10^{-10}$ M and a dynamic range is four orders of magnitude with 15 $\mu$g/mL BSA-MA conjugate and 1.0 ${\times}$ $10^{-8}$ M anti-MA antibody-biotin conjugate. In order to evaluate this assay, the structurally similar compounds, amphetamine, ephedrine, norephedrine, benzphetamine and N-4-(aminobutyl)methamphetamine were examined for their crossreactivity. None of these five compounds showed any cross-reactivity. Additionally, an artificial urine solution spiked with MA was analyzed by the MA assay, and the result of the analysis demonstrated the usefulness of the present assay for the determination of MA in urine.

• The Korean Journal of Nuclear Medicine
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• v.34 no.3
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• pp.159-168
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• 2000

In the 1980s, techniques to image the human subjects in a three-dimensional direction were developed. Two major techniques are SPECT (Single Photon Emission Computed Tomography) and PET (Positron Emission Tomography) which allow the detector to detect a single photon or annihilation photons emitted from the subjects injected with radiopharmaceuticals. Since the latter two techniques can measure the density of receptors, enzymes and transporters in living human, it may be very important project to develop selective methods of labeling with radionuclides and to develop new radiopharmaceuticals. There has been a considerable interest in developing new compounds which specifically bind to dopamine and serotonin receptor and transporters, and it will be thus very useful to label those compounds with radionuclides in order to gain a better understanding in biochemical and pharmacological interactions in living human. This review mentions the characteristics of radioligands for the imaging of dopamine and serotonin receptors and transporters. Although significant progress has been achieved in the development of new PET and SPECT ligands for in vivo imaging of those receptors and transporters, there are continuous needs of new diagnostic radioligands.

• The Journal of Korea Robotics Society
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• v.13 no.4
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• pp.230-236
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• 2018

3D depth perception has played an important role in robotics, and many sensory methods have also proposed for it. As a photodetector for 3D sensing, single photon avalanche diode (SPAD) is suggested due to sensitivity and accuracy. We have researched for applying a SPAD chip in our fusion system of time-of-fight (ToF) sensor and stereo camera. Our goal is to upsample of SPAD resolution using RGB stereo camera. Currently, we have 64 x 32 resolution SPAD ToF Sensor, even though there are higher resolution depth sensors such as Kinect V2 and Cube-Eye. This may be a weak point of our system, however we exploit this gap using a transition of idea. A convolution neural network (CNN) is designed to upsample our low resolution depth map using the data of the higher resolution depth as label data. Then, the upsampled depth data using CNN and stereo camera depth data are fused using semi-global matching (SGM) algorithm. We proposed simplified fusion method created for the embedded system.

• Journal of the Ergonomics Society of Korea
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• v.36 no.5
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• pp.437-446
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• 2017

Objective: This study aims to draw an efficient UI design by comparing the usability of App drawer and single-layered home screens, which are smartphone home screens. Background: Because smartphone home screen is frequently used including the installation, deletion, and editing of APPs, it should be designed with easily controllable information structure. There is a need to seek a user-friendly UI by comparing the usability of App drawer and single-layered home screens, of which methods to search Apps are different. There is also a need to examine an efficient UI and the factors to improve from the user perspective. Method: This study targeted 30 Android OS and iOS users to evaluate the App drawer and single-layered home screens, of which UI structures are different. Each participant was instructed to carry out an App searching task and App deleting task, and the execution time and the number of errors were measured. After the tasks were completed, they evaluated satisfaction through a questionnaire survey. Results: In the App searching task with low task level, there was no difference in execution level between the App drawer and single-layered home screens. However, the single-layered home screen showed higher efficiency and accuracy in the App deleting task with high task level. As for the group difference according to use experience, there was no difference in satisfaction among Android OS users, but iOS user satisfaction with single-layered home screen with which they were familiar was higher. Conclusion: As for home screen usability, the single-layered home screen UI structure can be advantageous, as task level is higher. Repulsion was higher, when users, who had used easier UI, used complex UI in comparison with user satisfaction, when users familiar with complex UI used easier UI. A UI indicating the current status with clear label marking through a task flow chart-based analysis, and a UI in which a user can immediately recognize by exposing hidden functions to the first depth were revealed as things to improve. Application: The results of this study are expected to be used as reference data in designing smartphone home screens. Especially, when iOS users use Android OS, the results are presumed to contribute to the reduction of predicted barriers.

• The KIPS Transactions:PartB
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• v.8B no.5
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• pp.533-538
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• 2001

In this paper, we extend FARGs single mode attribute to multiple attributes for real image application and present a new CBIR using FMARG(Fuzzy Multiple Attribute Relational Graph), which can handle queries involving multiple attributes, not only object label, but also color, texture and spatial relation. In the experiment using the synthetic image database of 1,024 images and the natural image database of 1.026 images built from NETRA database and Corel Draw, the proposed approach shows 6~30% recall increase in the synthetic image database and a good performance, at the displacements and the retrieved number of similar images in the natural image database, compared with the single attribute approach.

• Journal of Ginseng Research
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• v.37 no.4
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• pp.451-456
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• 2013

Compound K is a major metabolite of ginsenoside Rb1, which has various pharmacological activities in vivo and in vitro. However, previous studies have focused on the pharmacokinetics of a single metabolite or the parent compound and have not described the pharmacokinetics of both compounds in humans. To investigate the pharmacokinetics of ginsenoside Rb1 and compound K, we performed an open-label, single-oral dose pharmacokinetic study using Korean Red Ginseng extract. We enrolled 10 healthy Korean male volunteers in this study. Serial blood samples were collected during 36 h after Korean Red Ginseng extract administration to determine plasma concentrations of ginsenoside Rb1 and compound K. The mean maximum plasma concentration of compound K was $8.35{\pm}3.19$ ng/mL, which was significantly higher than that of ginsenoside Rb1 ($3.94{\pm}1.97$ ng/mL). The half-life of compound K was 7 times shorter than that of ginsenoside Rb1. These results suggest that the pharmacokinetics, especially absorption, of compound K are not influenced by the pharmacokinetics of its parent compound, except the time to reach the maximum plasma concentration The delayed absorption of compound K support the evidence that the intestinal microflora play an important role in the transformation of ginsenoside Rb1 to compound K.