• Genomics & Informatics
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• v.10 no.2
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• pp.117-122
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• 2012

A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases. Genome-wide association studies require much larger sample sizes to achieve an adequate statistical power. We estimated the statistical power with increasing numbers of markers analyzed and compared the sample sizes that were required in case-control studies and case-parent studies. We computed the effective sample size and statistical power using Genetic Power Calculator. An analysis using a larger number of markers requires a larger sample size. Testing a single-nucleotide polymorphism (SNP) marker requires 248 cases, while testing 500,000 SNPs and 1 million markers requires 1,206 cases and 1,255 cases, respectively, under the assumption of an odds ratio of 2, 5% disease prevalence, 5% minor allele frequency, complete linkage disequilibrium (LD), 1:1 case/control ratio, and a 5% error rate in an allelic test. Under a dominant model, a smaller sample size is required to achieve 80% power than other genetic models. We found that a much lower sample size was required with a strong effect size, common SNP, and increased LD. In addition, studying a common disease in a case-control study of a 1:4 case-control ratio is one way to achieve higher statistical power. We also found that case-parent studies require more samples than case-control studies. Although we have not covered all plausible cases in study design, the estimates of sample size and statistical power computed under various assumptions in this study may be useful to determine the sample size in designing a population-based genetic association study.

• Journal of Environmental Health Sciences
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• v.8 no.1
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• pp.55-60
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• 1982

This study was carried out in order to clarify the combined effect of cadmium and lead on rat bones when exposed to single metal (1 mg cd/kg body weight) and cambined metals (1 mg cd + 4 mg pb/kg body weight). Seventy five mature rats of Sprague-Dawley species were divided into a control group and a treatment group that were administered by daily peritoneum injection for 7 to 9 weeds, and their body weights were measured every week. The results were summarized as follows 1. Body weight gains of the combined injection group and the single injection groups were lower than that of the control group. 2. In case of the combined injection group, the amount of cadmium accumulated in femur was more than that of the cadmium group. These amounts of cadmium accumulated showed an increasing trend. 3. The lead amount in bone tissue of the combined injection group presented also an increasing trend. In this case, the additive action of cadmium to the lead accumulation in bone tissue was conspicuous. 4. The amounts of calcium and phosphorus in femur showed clear a decreasing trend in the cadmium group and combined administration group. The ratio of calcium and phosphorus (ca/p) in the cadmium group was not different from that of the control group, but in the combined injection group the ratio was a little lower.

• Journal of radiological science and technology
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• v.13 no.2
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• pp.51-51
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• 1990

This study was undertaken to observe the effects of $^{60}Co\;{\gamma}-irradiation$ on the cell of spermatogenic epithelium in the testis of the chicken. 16-week-old chicken were provided as an experimental group and compared with control group. The experimental group was divided into a single irradiation (800, 1000, 1200 rads) and into three partial irradiation group (800/3, 1000/3, 1200/3 rads). The morphological changes of epithelial cell of the testis were observed by means of hematoxyline and eosin stain. Microstructure of spermatocyte and sperm was observed by means of semithin section of electron microscopic specimen. The results obstained are summerized as follows. 1. Spermatogonia and sertoli cells were found to be isolated from the basal membrane of seminiferous tubules as dose of $^{60}Co\;{\gamma}-irradiation$ was increased. 2. Spermatocytes of pachytene stage were seperated from the cytotplasmic process of sertoil cell in case of 1000 rads of $^{60}Co\;{\gamma}-irradiation$. 3. Normal arrangement of the cell of spermatogenic epithelium was found in control group and only the partial irradiation group of 800 rads. Vaculation in the seminiferous was pronounced in case of a single irradiation group of 800 rads, but the irradiation group of 1000 rads and 1200 rads were found to be damaged severely in both a single and a partial dose.

• Transactions on Control, Automation and Systems Engineering
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• v.3 no.1
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• pp.21-26
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• 2001

In this study, we propose a two degree of freedom robust output tracking control method for a class of nonlinear system. We consider hyperbolically nonminimum phase single-input single-output uncertain nonlinear systems. We also consider the case that the nominal input-state equation is differentially flat. Nominal stable state trajectory is obtained in the flat output space via the flat output. Nominal feedforward control input is also computed from the nominal state trajectory. Due to the nature of the method, the generated flat output trajectory and control input are noncausal. Robust feedback control is designed to stabilize the systems around the nominal trajectory. A numerical example is given is given to demonstrate that robust tracking is achieved.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.8 s.227
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• pp.1152-1158
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• 2004

In this study a MRAC(model reference adaptive control) for fluid power elevator model system was designed. The MRAC was compared with PI control in case of applying to the elevator model system with constant external load and changing external load. In this case external load was produced by a single fluid power cylinder combined with pressure control valve. In conclusion the MRAC control performance was better than PI control performance because overshoot and steady state error of the elevator model system controlled by the MRAC were not appeared for constant and changing external load.

• Smart Structures and Systems
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• v.23 no.6
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• pp.615-626
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• 2019

Inerter-based damping devices (IBBDs), which consist of inerter, spring and viscous damper, have been extensively investigated in vehicle suspension systems and demonstrated to be more effective than the traditional control devices with spring and viscous damper only. In the present study, the control performance on cable vibration reduction was studied for four different inerter-based damping devices, namely the parallel-connected viscous mass damper (PVMD), series-connected viscous mass damper (SVMD), tuned inerter dampers (TID) and tuned viscous mass damper (TVMD). Firstly the mechanism of the ball screw inerter is introduced. Then the state-space formulation of the cable-TID system is derived as an example for the cable-IBBDs system. Based on the complex modal analysis, single-mode cable vibration control analysis is conducted for PVMD, SVMD, TID and TVMD, and their optimal parameters and the maximum attainable damping ratios of the cable/damper system are obtained for several specified damper locations and modes in combination by the Nelder-Mead simplex algorithm. Lastly, optimal design of PVMD is developed for multi-mode vibration control of cable, and the results of damping ratio analysis are validated through the forced vibration analysis in a case study by numerical simulation. The results show that all the four inerter-based damping devices significantly outperform the viscous damper for single-mode vibration control. In the case of multi-mode vibration control, PVMD can provide more damping to the first four modes of cable than the viscous damper does, and their maximum control forces under resonant frequency of harmonic forced vibration are nearly the same. The results of this study clearly demonstrate the effectiveness and advantages of PVMD in cable vibration control.

• Journal of Korean Association for Spatial Structures
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• v.19 no.3
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• pp.93-100
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• 2019

In this study, the retractable-roof spatial structure was chosen as the analytical model and a tuned mass damper (TMD) was installed in the analytical model in order to control the seismic response. The analysis model is mainly consisted of runway trusses (RT) and transverse trusses (TT), and the displacement response was analyzed by installing TMD on those trusses. The mass of the single TMD which is installed in the analytical model was set to 1% of the total structure mass and the total TMD mass ratio was set to be 8% or 6%. In addition, the mass of a single TMD was varied depending on the number of installations. As a result of analyzing the optimal number of installations of TMD, the displacement response was reduced in all cases compared to the case without TMD. Above all, the case with 8 TMDs was the most effective in reducing he displacement response. However, in this case, as the load on the upper structure of the retractable-roof spatial structure increases, the total mass ratio of TMD was maintained and the number of TMDs was increased to reduce the mass ratio of one TMD.

• Journal of Oriental Neuropsychiatry
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• v.20 no.4
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• pp.137-148
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• 2009

Objectives : The purpose of this study is to review the recent trends in the clinical trial studies that have been published since 2004. Methods : We reviewed the Medline & Pubmedcentral databases by using searching word of "acupuncture". Then 20 articles were selected within total 803 articles. In oriental medicine journals in Korea, we investigated 6 journals represented Korean Oriental medicine and chose 13 articles. Results & Conclusions : 1. We found 33 articles in journals. 2. The patterns of study were as follows: Randomized Controlled Trials(18), Single case series clinical study(9), Case-Control clinical study(4), Randomized crossover Trial(1) and Prospective Clinical analysis(1). 3. The fields of study were as follows: Combined anxiety, depression & other psychiatic symptoms(18), Stress & heart rate variablity(5), The single study of anxiety(5), The single study of depression(3), Stress & pupil variablity(1), Stress and heart rate & pupil variablity(1). 4. The methods of acupuncture were as follows: Acupuncture on points of 14 meridians(24), Auricular acupuncture(3), Electro acupuncture(2) and Both Auricular & Electro acupuncture(1). 5. Stomach meridian(足陽明胃經) and ST36(足三里) were used mostly.

• Transactions of the Korean Society of Automotive Engineers
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• v.3 no.6
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• pp.23-29
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• 1995

In this study, Active noise controlis implemented with single channel and multi-channel adaptive algorithm in 3 dimensional reverberant enclosure sound. field, which occurrs in complicated acoustic mode. First, for the one case excited with the resonant frequency of an enclosure, a target of control and the other cases excited with band-pass filtered random noise(100~400Hz), it is implemented to control reducing interior noise of enclosure with single channel and realtime multi-channel adaptive algorithm for global noise reduction in enclosure.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.183-188
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• 2013

Background: Breast cancer (BC), the most common female cancer in Pakistan, is associated with a very high mortality. However, the roles of individual risk factors for BC among Pakistani women are still controversial. To assess potential risk factors for BC, a matched case-control study was conducted in two tertiary care hospitals of Karachi, Pakistan. Materials and Methods: The study population included 297 pathologically confirmed incident cases of BC patients diagnosed between January 2009 and December 2010. 586 controls without any history of BC were matched on hospital and ${\pm}5$ years of ages. Results: Positive family history of BC (MOR=1.72; 95%CI: 1.10, 2.80 for first degree vs. none), single marital status (MOR=1.55; 95%CI: 1.10, 2.39 for single/divorced/widowed women vs. married women), older age at menopause (MOR=3.92; 95%CI: 2.52, 6.18 for menopausal women aged below 45 years, MOR=6.42; 95%CI: 3.47, 11.98 for menopausal women above 45 years of age compared with premenopausal women) conferred an increased risk of BC for women. Increasing parity decreased the risk of BC (MOR=0.90; 95%CI: 0.85, 0.97 for each live birth). Intake of Vitamin D supplements (MOR=0.30; 95%CI: 0.12, 0.81 for ${\leq}3$ years and MOR=0.27; 95%CI: 0.13, 0.56 for >3 years) was protective compared to non-users of Vitamin D. Conclusions: This study confirmed only few of the recognized risk factors in Pakistani women. The protective effect of Vitamin D is important from public health perspective and needs to be further explored through a randomized controlled trial.