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Genome-wide association study identifies 22 new loci for body dimension and body weight traits in a White Duroc×Erhualian F2 intercross population

  • Ji, Jiuxiu;Zhou, Lisheng;Guo, Yuanmei;Huang, Lusheng;Ma, Junwu
    • Asian-Australasian Journal of Animal Sciences
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    • v.30 no.8
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    • pp.1066-1073
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    • 2017
  • Objective: Growth-related traits are important economic traits in the swine industry. However, the genetic mechanism of growth-related traits is little known. The aim of this study was to screen the candidate genes and molecular markers associated with body dimension and body weight traits in pigs. Methods: A genome-wide association study (GWAS) on body dimension and body weight traits was performed in a White $Duroc{\times}Erhualian$ $F_2$ intercross by the illumina PorcineSNP60K Beadchip. A mixed linear model was used to assess the association between single nucleotide polymorphisms (SNPs) and the phenotypes. Results: In total, 611 and 79 SNPs were identified significantly associated with body dimension traits and body weight respectively. All SNPs but 62 were located into 23 genomic regions (quantitative trait loci, QTLs) on 14 autosomal and X chromosomes in Sus scrofa Build 10.2 assembly. Out of the 23 QTLs with the suggestive significance level ($5{\times}10^{-4}$), three QTLs exceeded the genome-wide significance threshold ($1.15{\times}10^{-6}$). Except the one on Sus scrofa chromosome (SSC) 7 which was reported previously all the QTLs are novel. In addition, we identified 5 promising candidate genes, including cell division cycle 7 for abdominal circumference, pleiomorphic adenoma gene 1 and neuropeptides B/W receptor 1 for both body weight and cannon bone circumference on SSC4, phosphoenolpyruvate carboxykinase 1, and bone morphogenetic protein 7 for hip circumference on SSC17. Conclusion: The results have not only demonstrated a number of potential genes/loci associated with the growth-related traits in pigs, but also laid a foundation for studying the genes' role and further identifying causative variants underlying these loci.

Performance Evaluation of Propane(R290)/Isobutane(R600a) Mixture as a Substitute for CFC12 in Domestic Refrigerators (프로판/이소부탄 혼합냉매를 적용한 가정용 냉장고의 성능에 관한 연구)

  • Lim, B.H.;Park, Y.B.;Yoo, H.K.;Jung, D.S.;Kim, C.B.
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.7 no.2
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    • pp.249-265
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    • 1995
  • The performance of a refrigerant mixture of propane(R290)/isobutane(R600a) as a substitute for CFC12 was investigated in a domestic refrigerator with single evaporator. A thermodynamic cycle simulation indicated an increase in COP of a 1.7 to 2.4% with R-290/600a in the composition range of 0.2 to 0.6 mass fraction of R290 compared to CFC12. For the tests, two units($299{\ell}$, $465{\ell}$) were used. All refrigeration components remained the same throughout the tests, except that the length of capillary tube and amount of charge were changed for the mixture. The refrigerators were fully instrumented with more than 20 thermocouples, 2 pressure transducers, and watt/watt-hour meter for each refrigerator. 'Energy consumption test' and 'no load pulldown test' were performed under the same condition. The experimental results obtained with the same compressor indicated that R-290/600a mixture at 0.6 mass fraction of R290 showed a 3 to 5% increase in energy efficiency and a faster cooling speed compared to CFC12. The R-290/600a mixture showed a shorter compressor on-time and a lower compressor dome temperature than CFC12. In conclusion, the proposed hydrocarbon mixture seems to be an appropriate candidate to replace CFC12 without causing more environmental problems.

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Biomechanical Analysis of the Elderly Gait with a Walking Assistive Device (노인의 보행보조기구 사용 보행시 보행패턴의 변화연구)

  • Yoon, Suk-Hoon
    • Korean Journal of Applied Biomechanics
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    • v.17 no.2
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    • pp.1-9
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    • 2007
  • Walking is not only an essential component of the human mobility, but also is a good exercise. Inability to walk freely can reduce an individual's quality of life and independence substantially. Being a relatively low impact activity, walking is particularly good for the elderly and research has shown that regular walking in the elderly reduces the chance of fall-related injuries and mental diseases as well. In spite of the documented benefits of regular walking, it is still difficult to walk without the aid of assistive devices for the frail elderly who have lower extremity problems. Assistive walking devices(AWD), such as crutches, canes, hiking-poles, T-Poles and walkers, are often prescribed to the elderly to make their walking be safe and efficient. Many researchers have demonstrated the effects of AWDs such as reducing lower extremity loading, improved dynamic/gait stability, yet, no study has been done for gait pattern when the elderly gait with AWDs. Therefore, the purpose of this study was to examine whether T-Poles, one of the AWDs, change the elderly gait pattern. Eight community-dwelling female elderly participated in this study. Laboratory kinematics during walking with T-Poles(PW) and with out T-Poles(NPW) was assessed. PW showed significant increase in step width, stride length, gait velocity and decrease in swing time. No significances were found in lower body joint angles but meaningful trend and pattern were found. Maybe the reason was due to the participants. Our participants were healthy enough so that the effect of T-Poles was minimum. PW also showed typical gait phases which are no single support phase during a gait cycle. It indicates that walking with T-Poles may guarantee safe and confident walking to the frail elderly.

A Study on the Implementation and Service of the RSS Based Science and Technology Information Syndication System(STI-RSS) (RSS 기반 과학기술정보 배급표준 시스템(STI-RSS)의 개발과 활용방안에 대한 연구)

  • Kwon, Lee-Nam;Kim, Jae-Soo;Shin, Dong-Gu;Jhun, Sung-Jin;Jeong, Teak-Young
    • Journal of Information Management
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    • v.36 no.4
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    • pp.175-198
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    • 2005
  • Information services adopting RSS(Really Simple Syndication) is on an increase. It is replacing the existing email services. Information in the area of science and technology is of vast amount and various area and their life-cycle and service is complex. Institutions providing information of a single area are not faced with many obstacles in designing information services using RSS in acquiring a channel for the service. However, RSS service in the area of science and technology has to be more specific in designing and implementing the services. In this study, RSS is compared with other information service protocols, domestic and international trends in the area of RSS is analyzed to implement the RSS based Science and Technology information service system(STI-RSS) and its service.

Design of a scalable general-purpose parallel associative processor using content-addressable memory (Content-Addressable Memory를 이용한 확장 가능한 범용 병렬 Associative Processor 설계)

  • Park, Tae-Geun
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.43 no.2 s.344
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    • pp.51-59
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    • 2006
  • Von Neumann architecture suffers from the interface between the central processing unit and the memory, which is called 'Von Neumann bottleneck' In this paper, we propose a scalable general-purpose associative processor (AP) based on content-addressable memory (CAM) which solves this problem and is suitable for the search-oriented applications. We propose an efficient instruction set and a structural scalability to extend for larger applications. We define twelve instructions and provide some reduced instructions to speed up which execute two instructions in a single instruction cycle. The proposed AP performs in a bit-serial, word-parallel fashion and can be considered as a 32-bit general-purpose parallel processor with a massively parallel SIMD structure. We design and simulate a maximum/minumum search greater-than/less-than search, and parallel addition to verify the proposed architecture. The algorithms are executed in a constant time O(k) regardless of the number of input data.

Gene Expression Analysis of Rat Liver Epithelial Cells in Response to Thioacetamide

  • Park, Joon-Suk;Yeom, Hye-Jung;Jung, Jin-Wook;Hwang, Seung-Yong;Lee, Yong-Soon;Kang, Kyung-Sun
    • Molecular & Cellular Toxicology
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    • v.1 no.3
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    • pp.203-208
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    • 2005
  • Thioacetamide (TA) is potent haptotoxincant that requires metabolic activation by mixed-function oxidases. Micrcarray technology, which is massive parallel gene expression profiling in a single hybridization experiment, has provided as a powerful molecular genetic tool for biological system related toxicant. In this study we focus on the use of toxicogenomics for the determination of gene expression analysis associated with hepatotoxicity in rat liver epithelial cell line WB-F344 (WB). The WB cells was used to assess the toxic effects of TA. WB cells were exposed to two concentrations of TA-doses which caused 20% and 50% cell death were chosen and the cells exposed for periods of 2 and 24 h. Our data revealed that following the 2-h exposure at the both of doses and 24-h exposure at the low doses, few changes in gene expression were detected. However, after 24-h exposure of the cells to the high concentration, multiple changes in gene expression were observed. TA treatment gave rise predominantly to up-regulation of genes involved in cell cycle and cell death, but down-regulation of genes involves in cell adhesion and calcium ion binding. Exposure of WB cells to higher doses of the TA gave rise to more changes in gene expression at lower exposure times. These results show that TA regulates expression of numerous genes via direct molecular signaling mechanisms in liver cells.

Electrochemical Characteristics of Metal Coated Graphite for Anodic Active Material of Lithium Secondary Battery (금속 코팅된 흑연 입자로 제조된 전극의 전기화학적 특성)

  • Choi, Won-Chang;Lee, Joong-Kee;Byun, Dong-Jin;Cho, Byung-Won
    • Journal of the Korean Electrochemical Society
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    • v.6 no.2
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    • pp.103-112
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    • 2003
  • Various kinds of metals were coated on synthetic graphite in order to investigate the relationship between film characteristics and their electrochemical performance. Gas suspension spray coating method was employed for the coating of synthetic graphite. In our experimental range, all of the metal coated synthetic graphite showed the higher capacity than that of raw material at high C-rate mainly due to decrease in impedance of passivation film. In cyclic voltammetry experiments, silver-coated and tin-coated graphite anodes found the lithium-alloy reaction. Considering smaller amount of metal coating, the most increase in discharge capacity was caused by improvement of conductivity of the electrode. When single-component metal was coated, silver-coated graphite anode exhibited the highest discharge capacity and better cycleability. Double components of silver-nickel coated active material showed the highest discharge capacity, rate capability and the best cycle performance in the range of our experiments.

The Analysis of Registration of Design Rights in Korean Apparel Industry - Design Rights Registered in Apparel (Classification B1) - (한국 의류산업의 의장(디자인) 등록 추세와 의장제도에 관한 연구 - 의복류(의장분류 B1)의 의장 등록을 중심으로 -)

  • 김용주
    • Journal of the Korean Society of Costume
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    • v.54 no.1
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    • pp.125-139
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    • 2004
  • The present study was to analyze the trend of registration of design rights in apparel products and tc point out problems of current protection law to design. The research data was total 1,850 design rights in apparel that have been registered to the Korean Patent and Trademark Office from the first design registered in March 1, 1963 through those registered in April 24, 2003. All design rights were analyzed by the year, by the type of product, and by the type of applicant. And also design rights registered under the revised design registration system(without examination) were analyzed by the trait. The results of the study were as follows: (1) Sweater & polo shirts, underpants, and the Korean traditional dress were three major single categories registered in apparel : (2) 54.3% of total design rights in apparel was registered since the legal system of design rights has been revised in March 1, 1998 : (3) Registration by individual applicant were 71.7% of total; (4) About 60% of total design rights were for aesthetic, but in some categories such as vest. brassiere, undershirts, designs for function were more frequently registered than others. And total 68 design rights for the symbol of the organization or uniform, were registered in upper outerwear and pants : (5) As problems of the current legal protection system for designs, the term of “design”(expressed in Korean), double registration of similar designs, malicious intention to register other's trademark as his/her own design. The current legal system for design rights were more used for the product that has relatively long life cycle. And the revised law has been effective in encouraging the registration of design rights. However. the current design law still has some problems to be revised to prevent design rights or trademark infringement.

Automatic Detection of the Updating Object by Areal Feature Matching Based on Shape Similarity (형상유사도 기반의 면 객체 매칭을 통한 갱신 객체 탐지)

  • Kim, Ji-Young;Yu, Ki-Yun
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.30 no.1
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    • pp.59-65
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    • 2012
  • In this paper, we proposed a method for automatic detection of a updating object from spatial data sets of different scale and updating cycle by using areal feature matching based on shape similarity. For this, we defined a updating object by analysing matching relationships between two different spatial data sets. Next, we firstly eliminated systematic errors in different scale by using affine transformation. Secondly, if any object is overlaid with several areal features of other data sets, we changed several areal features into a single areal feature. Finally, we detected the updating objects by applying areal feature matching based on shape similarity into the changed spatial data sets. After applying the proposed method into digital topographic map and a base map of Korean Address Information System in South Korea, we confirmed that F-measure is highly 0.958 in a statistical evaluation and that significant updating objects are detected from a visual evaluation.

Displacement Measurement of a Floating Structure Model Using a Video Data (동영상을 이용한 부유구조물 모형의 변위 관측)

  • Han, Dong Yeob;Kim, Hyun Woo;Kim, Jae Min
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.31 no.2
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    • pp.159-164
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    • 2013
  • It is well known that a single moving camera video is capable of extracting the 3-dimensional position of an object. With this in mind, current research performed image-based monitoring to establish a floating structure model using a camcorder system. Following this, the present study extracted frame images from digital camcorder video clips and matched the interest points to obtain relative 3D coordinates for both regular and irregular wave conditions. Then, the researchers evaluated the transformation accuracy of the modified SURF-based matching and image-based displacement estimation of the floating structure model in regular wave condition. For the regular wave condition, the wave generator's setting value was 3.0 sec and the cycle of the image-based displacement result was 2.993 sec. Taking into account mechanical error, these values can be considered as very similar. In terms of visual inspection, the researchers observed the shape of a regular wave in the 3-dimensional and 1-dimensional figures through the projection on X Y Z axis. In conclusion, it was possible to calculate the displacement of a floating structure module in near real-time using an average digital camcorder with 30fps video.