• 제목/요약/키워드: Simulated biological model

검색결과 121건 처리시간 0.021초

3차원 심실모델에서의 탈분극과 재분극 (Depolarization and Repolarization in the Three Dimensional Cardiac Ventricular Model)

  • 이경중
    • 대한의용생체공학회:의공학회지
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    • 제15권4호
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    • pp.407-412
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    • 1994
  • This paper describes the construction of an anisotropic three dimensional ventricular model based on the bidomain model. The cardiac activation process in the normal cardiac cell and the myocardial ischemic cell are simulated by the Huygen's principle. The depolarization process in the myocardial ischemia displays the delayed activation compared to the normal state. The repolarization process is simulated by the myocardial potential at the arbitrary ellapsed time after activation process. Using the potential data, the equivalent cardiac source at the arbitrary time can be computed. In conclusion, this simulation suggests the possibilities of the depolarization and the repolarization process in the normal and abnormal myocardiac cells.

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심근세포의 동기현상과 그 모델화 (The Syncronization Phenomena and Its Model of Myocardial Cells)

  • 박민용;제승정남
    • 대한의용생체공학회:의공학회지
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    • 제3권2호
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    • pp.101-104
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    • 1982
  • Even one embryonic myocardial cell exhibits a spontaneous, periodic beating phenomena. When these cells come in contact with each other, they beat synchronously with a certain period. In this paper, the mechanism of this phenomena is investigated, and the synchronization model is presented. The physiological experimental results are compared with the simulated results of the model.

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준 경험 생물막 모델(Semi-Empirical Biofilm Model)을 이용한 BAF 운전평가 및 적정 운전방안 도출 (A Study on Performance Estimation and Operation Strategy of Biological Aerated Filter Using Semi-Empirical Biofilm Model)

  • 유광태;김종락;윤주환;황호재;이한샘;김성표
    • 한국물환경학회지
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    • 제30권3호
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    • pp.269-282
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    • 2014
  • The objective of this study is to find out whether the developed semi-empirical biofilm model can be applicable to real BAF pilot-scale wastewater treatment. In addition, the optimum operating conditions of BAF as a function of process variables such as organic loading change can be drawn based on the simulation results of model. The results will provide the economic and efficient BAF process design and operating control. As a result, developed semi-empirical biofilm model which is relatively simple compared to mathematical model can simulate three BAF processes consisted of 25 layers within 1 seconds. When this model was used for simulating real pilot scale BAF process and the simulated water quality values were compared to experimental ones, simulated TCOD, SCOD, TN, $NH_4{^+}$-N, $NO_x{^-}$-N, alkalinity values were different to experimental ones within 21%, 20%, 8.1%, 48%, 10%, and 23%, respectively. Therefore, if the BAF system was equipped with automatic control, the BAF process can be better efficiently adapted under the condition of significant change of influent loading.

1차원 동적수질모형을 활용한 용담댐 하류하천의 수온변동 모의 (Modeling of Water Temperature in the Downstream of Yongdam Reservoir using 1-D Dynamic Water Quality Simulation Model)

  • 노준우;김상호;신재기
    • 한국물환경학회지
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    • 제26권2호
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    • pp.356-364
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    • 2010
  • The chemical and biological reaction of the aquatic organism is closely related with temperature variation and water temperature is one of the most important factors that should be considered in establishing sustainable reservoir operation scheme to minimize adverse environmental impacts related with dam construction. This paper investigates temperature variation in the downstream of Yongdam Reservoir using sampled data collected from total 8 temperature monitoring stations placed along the main river and the major tributaries. Using KoRiv1, 1-dimensional dynamic water quality simulation model, temperature variation in the downstream of Yongdam Reservoir has been simulated. The simulated results were compared with sampled data collected from May 15 to August 1 2008 by applying two different temperature modeling schemes, equilibrium temperature and full heat budget method. From the result of statistical analysis, seasonal temperature variation has been simulated by applying the equilibrium temperature scheme for comparison of the difference between the reservoir operation and the natural conditions.

VFSMOD-w 모형과 유전자 알고리즘을 이용한 식생여과대의 최적화 (Optimization of Vegetative Filter Strip using VFSMOD-w model and Genetic-Algorithm)

  • 박윤식;현근우
    • 한국물환경학회지
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    • 제30권2호
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    • pp.159-165
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    • 2014
  • Vegetative Filter Strip (VFS) is one of effective Best Management Practices (BMPs) to prevent sediment-laden water problem, is installed at the edge of source area such agricultural area so that sediment occurred in source area is trapped by VFS before it flow into stream or river. Appropriate scale of it needs to be simulated before it is installed, considering various field conditions. In this study, a model using VFSMOD-w model and Genetic Algorithm to determine effective VFS length was developed, it is available to calibrate input parameter related to source area sediment yield through thousands of VFSMOD-w simulations. Useful DBs, moreover, are stored in the model so that very specific input parameters can be used with reasonable values. Compared simulated values to observed data values for calibration, R2 and Nash-Stucliffe model efficiency coefficient were 0.74 and 0.65 in flow comparison, and 0.89 and 0.79 in sediment comparison. The model determined 1.0 m of Filter Length, 0.18 of Filter Slope, and 0.2 cm of Filter Media Spacing to reduce 80% of sediment by VFS. The model has not only Auto-Calibration module also DBs for specific input parameters, thus, the model is expected to be used for effective VFS scale.

가속도에 의한 뇌의 미만성 부상에 관한 연구 (Analysis of Diffuse Brain Injury due to Accelerations)

  • 남대훈;김영은
    • 대한의용생체공학회:학술대회논문집
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    • 대한의용생체공학회 1997년도 추계학술대회
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    • pp.213-217
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    • 1997
  • In this study, three-dimensional inite element model was developed and analyzed or DAI using ABAQUS. To verify the developed FE model, simulated results were compared to experimental results of human cadaver by Nahum et. al. (1977). The effect of acceleration pattern and accelerating duration time or DAI was analyzed by means of maximum shear stress and pressure distribution. DAI was favored or angular acceleration rather than linear acceleration, and occured in brain stem, pons and midbrain easily as accelerating duration time was increased.

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인공심장내의 혈류유동의 컴퓨터 시뮬레이션 (Numerical Simulation of Flow in a Total Artificial Heart)

  • 김상현
    • 대한의용생체공학회:학술대회논문집
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    • 대한의용생체공학회 1992년도 춘계학술대회
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    • pp.123-126
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    • 1992
  • In this paper, a numerical simulation of steady laminar and turbulent flow in a two dimensional model for the total artificial heart is presented. A trileaflet polyurethane valve was simulated at the outflow orifice while the inflow orifice had a trileaflet or a flap valve. The numerical solutions of the simulated model show that regions of relative stasis and trapped vortices were smaller wi thin the ventricular chamber wi th the flap valve at the inflow orifice than that with the trileaflet valve. The predicted Reynolds stresses distal to the inflow valve within the ventricular chamber were also found to be smaller with the flap valve than with the trileaflet valve. Analysis of the numerical solutions suggests that geometries similar to the flap valve(or a tilting disc valve) results in a better flow dynamics within the total artificial heart chamber compared to a trileaflet valve.

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복잡계를 응용한 인체 골절치료 모델링과 해석에 관한 연구 (Simulation of Bone Fracture Healing by the Complex System Rule)

  • 문병영;박정홍
    • 한국정밀공학회지
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    • 제20권12호
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    • pp.198-204
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    • 2003
  • The bone fracture healing is simulated by using one of the complex system rules, named cellular automata method. It is assumed that each cell has property of Bone, Cartilage or Fibrous connective tissue. Nine local rules are adopted to change the property of each cell against the mechanical stimulus, which consists of the strain energy density, and the existence of bone in the surroundings. Two dimensional sheep metatarsal model is considered and the bone fracture healing is simulated. The simulation results agree well with those obtained by using fuzzy logic model and experimental data. The cellular automata method found to be one of the simulation methods to express the bone fracture healing. The cellular automata method is expected to be effective in representing biological phenomenon.

Individual-Based Models Applied to Species Abundance Patterns in Benthic Macroinvertebrate Communities in Streams in Response to Pollution

  • Cho, Woon-Seok;Nguyen, Tuyen Van;Chon, Tae-Soo
    • 생태와환경
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    • 제45권4호
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    • pp.420-443
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    • 2012
  • An Individual-Based Model (IBM) was developed by employing natural and toxic survival rates of individuals to elucidate the community responses of benthic macroin-vertebrates to anthropogenic disturbance in the streams. Experimental models (dose-response and relative sensitivity) and mathematical models (power law and negative exponential distribution) were applied to determinate the individual survival rates due to acute toxicity in stressful conditions. A power law was additionally used to present the natural survival rate. Life events, covering movement, exposure to contaminants, death and reproduction, were simulated in the IBM at the individual level in small (1 m) and short (1 week) scales to produce species abundance distributions (SADs) at the community level in large (5 km) and long (1~2 years) scales. Consequently, the SADs, such as geometric series, log-series, and log-normal distribution, were accordingly observed at severely (Biological Monitoring Working Party (BMWP<10), intermediately (BMWP<40) and weakly (BMWP${\geq}50$) polluted sites. The results from a power law and negative exponential distribution were suitably fitted to the field data across the different levels of pollution, according to the Kolmogorov-Smirnov test. The IBMs incorporating natural and toxic survival rates in individuals were useful for presenting community responses to disturbances and could be utilized as an integrative tool to elucidate community establishment processes in benthic macroin-vertebrates in the streams.

Modelling the capture of spray droplets by barley

  • Cox, S.J.;Salt, D.W.;Lee, B.E.;Ford, M.G.
    • Wind and Structures
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    • 제5권2_3_4호
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    • pp.127-140
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    • 2002
  • This paper presents some of the results of a project whose aim has been to produce a full simulation model which would determine the efficacy of pesticides for use by both farmers and the bio-chemical industry. The work presented here describes how crop architecture can be mathematically modelled and how the mechanics of pesticide droplet capture can be simulated so that if a wind assisted droplet-trajectory model is assumed then droplet deposition patterns on crop surfaces can be predicted. This achievement, when combined with biological response models, will then enable the efficacy of pesticide use to be predicted.