• Journal of the Korean Data and Information Science Society
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• v.23 no.1
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• pp.39-51
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• 2012

Cluster analysis has proven to be a useful tool for investigating the association structure among genes and samples in a microarray data set. We applied several cluster validation measures to evaluate the performance of clustering algorithms for analyzing microarray gene expression data, including hierarchical clustering, K-means, PAM, SOM and model-based clustering. The available validation measures fall into the three general categories of internal, stability and biological. The performance of clustering algorithms is evaluated using simulated and SRBCT microarray data. Our results from simulated data show that nearly every methods have good results with same result as the number of classes in the original data. For the SRBCT data the best choice for the number of clusters is less clear than the simulated data. It appeared that PAM, SOM, model-based method showed similar results to simulated data under Silhouette with of internal measure as well as PAM and model-based method under biological measure, while model-based clustering has the best value of stability measure.

• Journal of Microbiology and Biotechnology
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• v.11 no.1
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• pp.97-105
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• 2001

The viability of Bifidobacterium longum KCTC 3128, entrapped in calcium alginate beds in simulated gastroenteric juices (gastric and bile salt solution), was tested to evaluate the influences of several parameters (gel concentration, bead size, and initial cell number). The death rate of B. longum in beads after being sequentially exposed to simulated gastric juices and bile salt solution decreased propertionally with increasing both the alginate gel concentration and bead size. The number of initial cell loading in beads affected the numbers of survivors after being exposed to these solutions, while the death rate of the viable cells were not affected. From the results obtained, the influence of entrapment parameters on the survival of bifidobacteria was quantitatively and systematically evaluated by using a mathematical method.

• Journal of Biomedical Engineering Research
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• v.13 no.2
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• pp.97-106
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• 1992

The cardiac activation process uslng three dimensional ventricular model is simulated. To study this theme, we constructed a cardiac ventricular model and simulated the cardiac activation process using the action potential duration and the activation time. The cardiac ventricular model is generated by the loglcal combination of the elliptic equations. The action potential duration could be obtained from the fact that It Is linearly distributed between model cells. The cardiac activation process was simulated by the law of "all-or-none". Based on the activation time and the action potential duration the cardiac potential at the arbitrary time after the activation of the model cell was computed. To test the validity of model, the comparison of the results of model simulation with the physiological data was performed. In conclusion, this model shows the simular results which is comparable to the 1 Pal conduction of the cardlac excitation.xcitation.

• Proceedings of the KOSOMBE Conference
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• v.1992 no.11
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• pp.146-149
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• 1992

The cardiac depolarization model using three dimensional ventricular model is simulated. To study this theme, we constructed a cardiac ventricular model and simulated the cardiac activation process using the action potential duration and the activation time. The cardiac potential model is generated by the logical combination of the elliptic equations. The action potential duration could be obtained from the fact that it is linearly distributed between model cells. The cardiac activation process was simulated by the law of "all-or-none". Based on the activation time and the action potential duration the cardiac potential at the arbitrary time after the activation of the model cell was computed. To test the validity of model, the comparison the results of model simulation with the physiological data was performed.

• Journal of Biomedical Engineering Research
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• v.6 no.1
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• pp.55-64
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• 1985

The cardiac activation process using three dimensional ventricular model is simulated.To study this theme, we constructed a cardiac ventricular model and simulated the cardiac activation process using the action potential duration and the activation time. The cardiac ventricular model is generated by the logical combination of the elliptic equations. The action potential duration could be obtained from the fact that it is linearly distributed between model cells. The cardiac activation process was simulated by the law of "all-or-none" Based on the activation time and the action potential do-ration the cardiac potential at the arbitrary time after the activation of the model cell was computed. To test the validity of model, the comparison of the results of model simulation with the physiological data was performed. In conclusion, this model shows the simular results which is comparable to the real conduction of the cardiac excitation.xcitation.

• Magazine of the Korean Society of Agricultural Engineers
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• v.44 no.3
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• pp.146-156
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• 2002

The objective of this study was to develop a modified CREAMS model for paddy field conditions. The model simulates daily balance of water and nutrient from irrigated paddies using meteorological, irrigation, and agricultural management data. The model simulates daily evapotranspiration of paddy using Penman equation and determines daily flooding depth changes. Total nitrogen and phosphorus concentrations within flooding water, surface runoff, and leaching water from a paddy field also can be simulated. Parameters of the model were calibrated using observed data of the Agricultural Experiment Station of the Seoul National University in Suwon Korea. The model was applied for the irrigation period of paddy field in Gicheon area when 1,234 mm annual rainfall was occurred. The simulated losses of the total nitrogen and total phosphorous were 11.27 kg/ha and 0.98 kg/ha, respectively. There was a good agreement between observed and simulated data. It was found that CREAMS-PADDY model was capable of predicting runoff and nutrient losses from irrigated paddy fields.

• Water Engineering Research
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• v.4 no.3
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• pp.141-154
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• 2003

Nonpoint source pollutants from agriculture are identified as one of the main causes of water quality degradation in the United States. The Hydrological Simulation Program-Fortran (HSPF) was used to simulate runoff, nitrogen, and sediment loads from an urbanizing watershed; the Polecat Creek watershed located in Virginia. Model parameters related to hydrology and water quality were calibrated and validated using observed hydrologic and water quality data collected at the watershed outlet and at several sub-watershed outlets. A comparison of measured and simulated monthly runoff at the outlet of the watershed resulted in a correlation coefficient of 0.94 for the calibration period and 0.74 for the validation period. The annual observed and simulated sediment loads for the calibration period were 220.9 kg/ha and 201.5 kg/ha, respectively. The differences for annual nitrate nitrogen ($NO_3$) loads between the observed and simulated values at the outlet of the watershed were 5.1% and 42.1% for the calibration and validation periods, respectively. The corresponding values for total Kjeldahl nitrogen (TKN) were 60.9% and 40.7%, respectively. Based on the simulation results, the calibrated HSPF input parameters were considered to adequately represent the Polecat Creek watershed.

• Journal of Microbiology and Biotechnology
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• v.12 no.6
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• pp.962-971
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• 2002

The current study proposes a simple monodimensional model to estimate the linear growth rate of photosynthetic microorganisms in flat-plate photobioreactors (FPPBRs) during batch cultivation. As a model microorganism, Chlorella kessleri was cultivated photoautotrophically in FPPBRs using light-emitting diodes (LEDs) as the light sources to provide unidirectional irradiation in the photobioreactors. Various conditions were simulated by adjusting both the intensity of the light and the height of the culture. The validity of the proposed model was examined by comparing the linear growth rates measured with the predicted ones obtained from the proposed model. Accordingly, the value of $\frac{K\cdot\mu m}{\alpha\cdot L}log(I_0\cdot{I_s}^{\varepsilon 1)\cdot {I_c}^{-\varepsilon})$ was proposed as an approximate index for strategies to obtain the maximal lightn yield under light-limiting conditions for high-density algal cultures and as a control parameter to improve the photosynthetic productivity and efficiency.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.218-221
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• 1997

In this paper, we designed a myocaldial ischemia model based on L-R dynamic model including hyperkalemia and anoxia. Using the model, we simulated the effects of ionic concentration $[K^+]_o$ and intracellular $[ATP]_i$ on action potential in single cardiac cell. Also we evaluated this model by comparing the simulated results with that of other researches. In luther research, we are going to consider the effect of acidosis quantitatively.

• Proceedings of the KOSOMBE Conference
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• v.1994 no.12
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• pp.61-64
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• 1994

This paper describes the construction of an anisotropic three dimensional ventricular model based on the bidomain model. The cardiac artivation process in the normal cardiac cell and the myocardiac ischemic cell are simulated by the Huygen's principle. The depolarization process in the myocardial ischemia displays the delayed activation compared to the normal state. The repolarization process is simulated by the myocardial potential at the arbitrary ellapsed time after activation process.