• Title/Summary/Keyword: Silica/titania nanocomposite

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Biocompatible Formation of Silica/Titania Nanocomposite Shells on Living Chlorella Cells

  • Go, Eun-Hye;Yun, Yeon-Jeong;Jin, Seung-Uk;Hwang, Ji-Min;Lee, Gyu-Nam;Yang, Seong-Ho;Choe, In-Seong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.02a
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    • pp.553-553
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    • 2012
  • The artificial shells of hard inorganic nanocomposites on individual cells would protect the cells physically and chemically, and control cell division. These emerging properties could be combined with cell-surface functionalizations for applications to cell-based sensors and assays as well as for fundamental studies on single-cell biology. In this work, individual Chlorella cells were encapsulated within a silica/titania nanocomposite shell in a biocompatible fashion that utilized a designed peptide, RKKRKKRKKRKKDDDDDDDD, as a catalytic template for formation of both $SiO_2$ and $TiO_2$ on the cell surface. The cell viability was maintained, and the division of the encapsulated Chlorella cells was controlled. The cell viability was enhanced compared with the $TiO_2$-shell formation. In addition, the incorporation of $TiO_2$ to the shell made it possible to anchor the ligands of interest to the shell via catechol chemistry. All in all, the combination of biological $SiO_2$ and abiolgical $TiO_2$ for the shell formation gave more tunability of the artificial shells compared with the $SiO_2$ or $TiO_2$ shells only.

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