• Herbal Formula Science
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• v.30 no.3
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• pp.175-182
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• 2022

Objective : This study aims to investigate the active ingredients and potential mechanisms of the beneficial herb on human cancers such as the liver by employing network pharmacology. Methods : Ingredients and their target information was obtained from various databases such as TM-MC, TTD, and Drugbank. Related protein for liver cancer was retrieved from the Comparative Toxicogenomics Database and literature. A hypergeometric test and gene set enrichment analysis were conducted to evaluate associations between protein targets of red ginseng (Panax ginseng C. A. Meyer) and liver cancer-related proteins and identify related signaling pathways, respectively. Network proximity was employed to identify active ingredients of red ginseng on liver cancer. Results : A compound-target network of red ginseng was constructed, which consisted of 363 edges between 53 ingredients and 121 protein targets. MAPK signaling pathway, PI3K-Akt signaling pathway, p53 signaling pathway, TGF-beta signaling pathway, and cell cycle pathway was significantly associated with protein targets of red ginseng. Network proximity results indicated that Ginsenoside Rg1, Acetic Acid, Ginsenoside Rh2, 20(R)-Ginsenoside Rg3, Notoginsenoside R1, Ginsenoside Rk1, 2-Methylfuran, Hexanal, Ginsenoside Rd, Ginsenoside Rh1 could be active ingredients of red ginseng against liver cancer. Conclusion : This study suggests that network-based approaches could be useful to explore potential mechanisms and active ingredients of red ginseng for liver cancer.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.35S no.1
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• pp.39-51
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• 1998

In this paper, we propose signaling procedures amon network elements for a connection rerouting method which can reduce inter-switch handoff processing delay reduces the delay in the connection re-routing by reserving VPI/VCIs for possible inter-switch handoff calls in advance. Additionally, we mathematically analyze the signaling procedures and then suggest solutions to the relations with cluser size, network topoloty, handoff-request rete and handoff delay. With simulation, the solutions are validated. From numerical examples, we concluded taht handoff delay, one of the handoff QoSs, can be satisfied by adjusting the cluster size and network topology according to the handoff -request rate of service area. With our proposed signaling and analytic methods, we concluded that the connection rerouting method using cluster-sectoring effectively reduces the delay of inter-switch handoff processing than dynamic connection rerouting method. Our solutions are useful in guaranteeing the requested handoff delay (especially, inter-switch handoff delay) when the connection rerouting method is applied to ATM-based wireless/wired integrated network.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.34S no.3
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• pp.1-11
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• 1997

Since the radio spectrum is limited, future wireless system will have micro cellular architecture in order to provide multimedia traffic services on personal communicatons network. The small coverage area of micro cellular systems results in frequent hadnoffs and location updates. We focuse on network load and terminal power due to frequent location updates and propose a location tracking scheme using embedded-pager PCS terminals. The proposed scheme is expected to minimize theconsumption of PCS terminal powr and improve the receiving rate of callee because of the power saving mechanism and the embedded-pager PCS terminal. This paper proposes signaling flows among the network elements for the proposed location tracking scheme. The signaling flows are accomodated to not only the existed network architectures but alsothe ATM backbone network arcitecture. To verify the signaling flows, we used petri-Net model. The resutls show that the signaling flows are suitable to our proposed location tracking scheme.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.6
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• pp.339-344
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• 2011

Ulmus davidiana var. japonica Rehder (Urticales: Ulmaceae) (UD) is a tree widespread in northeast Asia. It is traditionally used for anticancer and anti-inflammatory therapy. The present study investigated the effect of an ethanol extract of UD on vascular tension and its underlying mechanism in rats. The dried root bark of UD was ground and extracted with 80% ethanol. The prepared UD extract was used in further analysis. The effect of UD on the cell viability, vasoreactivity and hemodynamics were investigated using propidium iodide staining in cultured cells, isometric tension recording and blood pressure analysis, respectively. Low dose of UD ($10{\sim}100{\mu}g/ml)$ did not affect endothelial cell viability, but high dose of UD reduced cell viability. UD induced vasorelaxation in the range of $0.1{\sim}10{\mu}g/ml$ with an $ED_{50}$ value of $2{\mu}g/ml$. UD-induced vasorelaxation was completely abolished by removal of the endothelium or by pre-treatment with L-NAME, an inhibitor of nitric oxide synthase. UD inhibited calcium influx induced by phenylephrine and high $K^+$ and also completely abolished the effect of L-NAME. Intravenous injection of UD extracts (10~100 mg/kg) decreased arterial and ventricular pressure in a dose-dependent manner. Moreover, UD extracts reduced the ventricular contractility (+dP/dt) in anesthetized rats. However, UD-induced hypotensive actions were minimized in L-NAME-treated rats. Taken together, out results showed that UD induced vasorelaxation and has antihypertensive properties, which may be due the activation of nitric oxide synthase in endothelium.

• Molecules and Cells
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• v.26 no.4
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• pp.368-372
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• 2008

Recent molecular and genetic studies in rice, a short-day plant, have elucidated both conservation and divergence of photoperiod pathway genes and their regulators. However, the biological roles of rice genes that act within the autonomous pathway are still largely unknown. In order to better understand the function of the autonomous pathway genes in rice, we conducted molecular genetic analyses of OsFVE, a rice gene homologous to Arabidopsis FVE. OsFVE was found to be ubiquitously expressed in vegetative and reproductive organs. Overexpression of OsFVE could rescue the flowering time phenotype of the Arabidopsis fve mutants by up-regulating expression of the SUPPRESSOR OF OVEREXPRESSION OF CO1 (SOC1) and down-regulating FLOWERING LOCUS C (FLC) expression. These results suggest that there may be a conserved function between OsFVE and FVE in the control of flowering time. However, OsFVE overexpression in the fve mutants did not rescue the flowering time phenotype in in relation to the response to intermittent cold treatment.

• The Korean Ginseng Research and Industry
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• v.4 no.2
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• pp.14-23
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• 2010

• Proceedings of the KIEE Conference
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• 2008.10c
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• pp.205-207
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• 2008

Much signaling equipments are installed along railway tracks, and these are working in cooperation with each other, referring to other signaling equipment status. Existing railway signaling system uses signal cables to transmit this information. This system requires high cost for construction and have the problems like many faults from mistakes in cable connection, etc To solve these problems, JREast Inc. has developed a new signaling system based on network technology, utilizing Ethernet-Passive Optical Network(E-PON). In this paper, we review the system proposed by JREast Inc. and field test results performed on railway.

• Proceedings of the KSR Conference
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• 2004.06a
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• pp.1495-1500
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• 2004

The interface link for railway signaling systems is generally point-to-point communication scheme, but there have been several efforts to apply the network technology to these interface link in overseas country. However general Ethernet scheme has several drawbacks, so this scheme cannot meet the very high reliability, safety and real-time properties. To overcome these drawbacks, there have been studies reduction and modeling of data collision probability for this ethernet at the industrial and academic world. Therefore, in this paper we analyzed describe a interface trend using network technology between railway signaling equipments and will describe a major technology and framework of a network for railway signaling system.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.55 no.9
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• pp.485-490
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• 2006

According to the computerization of railway signaling systems, the interface link between the signaling systems has been replaced by the digital communication channel. At the same time, the importance of the communication link is more pronounced than before. In this paper, new Network-based protocol between railway signaling and SCADA (Supervisory Control and Data Acquisition system) has designed and the overview of designed protocol is briefly represented. And also this paper addresses analysis of newly designed train control systems. Fame error rates of the data transmissions are calculated and compared for the two cases that the CTC (Centralized Traffic Control)/SCADA has an extra data transmission error control (CRC16) besides the inherent error control of the Ethernet and that the CTC/SCADA has no extra data transmission error control. With simulation results it has been verified that the additional error control code contributes to lowering the frame error rate. It will be expected to increase the safety, reliability and efficiency of maintenance of the signaling systems by using the designed protocol for railway signaling system.

• Journal of the Korea Society of Computer and Information
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• v.18 no.10
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• pp.47-54
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• 2013

In this paper, the structural design of optical Internet is analyzed and by using UNI (User Network Interface) signaling protocol an optical transmission experiment was performed. The hierarchical structure of the basic optical Internet consists of the backbone network, the service network and the access network. The necessary functions for each layer were described as follows: Control structure of the optical transport layer, network operation and management structure, internetworking technology of sub networks, routing and signaling technology. By using UNI signaling protocol from OIF (Optical Internetworking Forum), the optical transmission in the proposed structure of the optical Internet network was experimented. By the traffic generation of LSP (Label Switched Path) data packets along the route-configuration was delivered to UNI. Finally, by showing the value of TCP (Transmission Control Protocol) packets the optical transmission was completely and successfully demonstrated.