• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.8
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• pp.1075-1081
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• 2010

Recently, the results of many studies have clarified the successful performance of magnetostrictive transducers in which a ferromagnetic patch is used for the transduction of guided shear waves; this is because a thin ferromagnetic patch with strong magnetostriction is very useful for generating and detecting shear wave. This investigation deals with bulk shear wave transduction by means of magnetostriction; on the other hand, the existing studies have been focused on guided shear waves. A modular transducer was developed; this transducer comprised a coil, magnets, and a thin ferromagnetic patch that was made of Fe-Co alloy. Some experiments were conducted to verify the performance of the developed transducer. Radiation directivity pattern of the developed transducer was obtained, and a test to detect the damage on a side drill hole of a steel block specimen was carried out. From the results of these tests, the good performance of the transducer for nondestructive testing was verified on the basis of the signal-to-noise ratio and narrow beam directivity.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.8
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• pp.1587-1595
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• 2016

P wave is cardiac parameters that represent the electrical and physiological characteristics, it is very important to diagnose atrial arrhythmia. However, It is very difficult to detect because of the small size compared to R wave and the various morphology. Several methods for detecting P wave has been proposed, such as frequency analysis and non-linear approach. However, in the case of conduction abnormality such as AV block or atrial arrhythmia, detection accuracy is at the lower level. We propose P wave detection algorithm through adaptive threshold and QRS peak variability. For this purpose, we detected Q, R, S wave from noise-free ECG signal through the preprocessing method. And then we classified three pattern of P wave by peak variability and detected adaptive window and threshold. The performance of P wave detection is evaluated by using 48 record of MIT-BIH arrhythmia database. The achieved scores indicate the average detection rate of 92.60%.

• Smart Media Journal
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• v.2 no.4
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• pp.60-65
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• 2013

In this paper, we propose a high-resolution disparity map generation method using a low-resolution time-of-flight (TOF) depth camera and color camera. The TOF depth camera is efficient since it measures the range information of objects using the infra-red (IR) signal in real-time. It also quantizes the range information and provides the depth image. However, there are some problems of the TOF depth camera, such as noise and lens distortion. Moreover, the output resolution of the TOF depth camera is too small for 3D applications. Therefore, it is essential to not only reduce the noise and distortion but also enlarge the output resolution of the TOF depth image. Our proposed method generates a depth map for a color image using the TOF camera and the color camera simultaneously. We warp the depth value at each pixel to the color image position. The color image is segmented using the mean-shift segmentation method. We define a cost function that consists of color values and segmented color values. We apply a weighted average filter whose weighting factor is defined by the random walk probability using the defined cost function of the block. Experimental results show that the proposed method generates the depth map efficiently and we can reconstruct good virtual view images.

• The Journal of the Korea Contents Association
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• v.8 no.11
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• pp.182-188
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• 2008

The MLC(multi leaf collimator) in charge of important role in radiation therapy field recently have been exchanging from shielding block into it rapidly, owing to being convenient. However, MLC can be occurred the leakage dose of inter_leaves and the error of algorithm in imput and output from digital signal. We compared the difference of imput method to MLC made by Varian Cop. with the error and effective field induced by MLC shaper and film scanner based on XimaVision value as using MLC layer of various shapes. According to comparing standard value with them to basic MLC layer (test1-5), MLC shaper was $0{\sim}0.29cm$, $0.23{\sim}3.59cm^2$ and film scanner was $0{\sim}0.78cm$, $0.24{\sim}3.89cm^2$. At the MLC layer to be applied in clinic, MLC shaper was $0{\sim}0.54cm$, $0.04{\sim}1.68cm^2$ and film scanner was $0{\sim}0.78cm$, $0.24{\sim}3.89cm^2$. The more distance and field from axis of central line increase, the more bigger the error value increases. There is a few mm error from standard point at the process which imput various information to apply MLC in clinic. and effective field did not have variation of monitor unit and dose owing to being a few cm2 error against real field. But there are some problem to shield critical organs because some part of target volume induced by the movement of organs can be not included, therefore we have to pay attention on the process to imput MLC layer

• Molecules and Cells
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• v.25 no.3
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• pp.390-396
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• 2008

Calreticulin (CRT) is one of the major $Ca^{2+}$ binding chaperone proteins of the endoplasmic reticulum (ER) and an unusual luminal ER protein. Postnatally elevated expression of CRT leads to impaired development of the cardiac conductive system and may be responsible for the pathology of complete heart block. In this study, the molecular mechanisms that affect $Ca^{2+}$-dependent signal cascades were investigated using CRT-overexpressing cardiomyocytes. In particular, we asked whether calreticulin plays a critical role in the activation of $Ca^{2+}$-dependent apoptosis. In the cells overexpressing CRT, the intracellular calcium concentration was significantly increased and the activity of PKC and level of SECAR2a mRNA were reduced. Phosphorylation of Akt and ERKs decreased compared to control. In addition the activity of the anti-apoptotic factor, Bcl-2, was decreased and the activities of pro-apoptotic factor, Bax, p53 and caspase 8 were increased, leading to a dramatic augmentation of caspase 3 activity. Our results suggest that enhanced CRT expression in mature cardiomyocytes disrupts intracellular calcium regulation, leading to calcium-dependent apoptosis.

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.109-113
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• 2001

Oxidized low-density lipoprotein (oxLDL) has been shown to modulate transactivations by the peroxisome proliferator activated receptor (PPAR)$\gamma$ and nuclear factor-kappa B (NF$\kappa$B). In this study, the oxLDL signaling pathways involved with the NF$\kappa$B transactivation were investigated by utilizing a reporter construct driven by three upstream NF$\kappa$B binding sites, and various pharmacological inhibitors. OxLDL and its constituent lysophophatidylcholine (lysoPC) induced a rapid and transient increase of intracellular calcium and stimulated the NF-KB transactivation in resting RAW264.7 macrophage cells in an oxidation-dependent manner. The NF$\kappa$B activation by oxLDL or lysoPC was inhibited by protein kinase C inhibitors or an intracellular calcium chelator. Tyrosine kinase or PI3 kinase inhibitors did not block the NF$\kappa$B transactivation. Furthermore, the oxLDL-induced NF$\kappa$B activity was abolished by the PPAR$\gamma$ ligands. When the endocytosis of oxLDL was blocked by cytochalasin B, the NF$\kappa$B transactivation by oxLDL was synergistically increased, while PPAR transactivation was blocked. These results suggest that oxLDL activates NF-$\kappa$B in resting macrophages via protein kinase C- and/or calcium-dependent pathways, which does not involve the endocytic processing of oxLDL. The endocytosis-dependent PPAR$\gamma$ activation by oxLDL may function as an inactivation route of the oxLDL induced NF$\kappa$B signal. Short heterodimer partner (SHP), specifically expressed in liver and a limited number of other tissues, is an unusual orphan nuclear receptor that lacks the conventional DNA-binding domain. In this work, we found that SHP expression is abundant in murine macrophage cell line RAW 264.7 but suppressed by oxLDL and its constituent I3-HODE, a ligand for peroxisome proliferator-activated receptor y. Furthermore, SHP acted as a transcription coactivator of nuclear factor-$\kappa$B (NF$\kappa$B) and was essential for the previously described NF$\kappa$B transactivation by lysoPC, one of the oxLDL constituents. Accordingly, NF$\kappa$B, transcriptionally active in the beginning, became progressively inert in oxLDL-treated RAW 264.7 cells, as oxLDL decreased the SHP expression. Thus, SHP appears to be an important modulatory component to regulate the transcriptional activities of NF$\kappa$B in oxLDL-treated, resting macrophage cells.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.5C
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• pp.532-538
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• 2003

In this paper we have investigated a novel approach applying low-density parity-check coding to a COFDM-CDMA system, which operates in a multi-path fading mobile channel. Developed as a linear-block channel coder, the LDPC code is known for a superior signal reception capability in AWGN and/or flat fading channels with respect to increased encoding rates, however, its performance degrades when the communication channel becomes multi-path fading. For a typical multi-path fading mobile channel with a SNR of 16㏈ or lower. in order to obtain a BER lower than 1 out of 10000, the LDPC code with encoding rates below 1:3 requires not only the inherent parity check information but also the piloting information for refreshing front-end equalizer taps of COFDM-CDMA, periodically. For instance, while the 1:3-rate LDPC coded transmission symbol is consisted of data bits and parity-check bits in 1 to 3 proportion, on the other hand, in the proposed method the same rate LDPC transmission symbol contains data bits, parity check bits, and pilot bits in 1 to 2 to 1 proportion, respectively. The included pilot bits are effective not only for channel estimation and channel equalization but for symbol decoding by assisting the parity-check bits, hence, improving SNR vs BER performance over the conventional 1:3-rate LDPC code. The proposed system performance has been verified using computer simulations in multi-path, Rayleigh fading channels, and the results show us that the proposed method out-performs the general LDPC channel coding methods in terms of SNR vs BER measurements.

• Korean Journal of Biological Psychiatry
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• v.27 no.1
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• pp.1-8
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• 2020

Objectives In electroconvulsive therapy (ECT) research and practice, the precise determination of seizure duration is important in the evaluation of clinical relevance of the ECT-induced seizure. In this study, we have developed computerized algorithms to assess the duration of ECT-induced seizure. Methods Subjects included 5 males and 6 females, with the mean age of 33.1 years. Total 55 ECT sessions were included in the analysis. We analyzed the standard deviation of a finite block of electroencephalography (EEG) data and the change in the local slope of RR intervals in electrocardiography (ECG) signals during ECT-induced seizure. And then, we compared the calculated seizure durations from EEG recording (EEG algorithm) and ECG recording (ECG algorithm) with values determined by consensus of clinicians based on the recorded EEG (EEG consensus), as a gold standard criterion, in order to testify the computational validity of our algorithms. Results The mean seizure durations calculated by each method were not significantly different in sessions with abrupt flattened postictal suppression and in sessions with non-abrupt flattened postictal suppression. The intraclass correlation coefficients (95% confidence interval) of the three methods (EEG algorithm, ECG algorithm, EEG consensus) were significant in the total sessions [0.79 (0.70-0.86)], the abrupt flattened postictal suppression sessions [0.84 (0.74-0.91)], and the non-abrupt flattened postictal suppression sessions [0.67 (0.45-0.84)]. Correlations between three methods were also statistically significant, regardless of abruptness of transition. Conclusions Our proposed algorithms could reliably measure the duration of ECT-induced seizure, even in sessions with non-abrupt transitions to flat postictal suppression, in which it is typically difficult to determine the seizure duration.

• Journal of Biosystems Engineering
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• v.26 no.5
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• pp.461-468
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• 2001

Impact between fruits and other materials is a major cause of product damage in harvesting and handling systems. The oriental pears are more susceptible to bruising than other fruits such as European pears and apples, and are required more careful handling. The interest in the handling of the pears for the processing systems has raised the question of the allowable drop height to which pears can be dropped without causing objectionable damage. Drop tests on pears were conducted using an impact device developed by authors to estimate the allowable drop height without bruising. The impact device was constructed to hold in a selected orientation and to release a fruit by vacuum for dropping on to a force transducer. The drop height was adjustable for zero to 60 cm to achieve the desired distance between the bottom of the fruits and the top of the impact force transducer. The transducer was secured to 150 kg$\sub$f/ concrete block. The transducer signal was sampled every 0.17 ms with a strain gage measurement board in the micro computer where it was digitaly stored for later analysis. The selected sample fruit was Niitaka cultivar of pears which is one of the most promising fruit for export in Korea. The pears were harvested during the 1998 harvest season from an orchard in Daejeon. The sample fruit was selected from two groups which were stored for 3 months and 5 months respectively by the method of current commercial practice. The pears were allowed to stabilize at environmental condition(18$^{\circ}C$, 65% rh) of the experimental room. One hundred fifty six pears were tested from the heights of 5, 7.5. 10 and 12.5 cm while measurement were made of impact peak force, contact time, time to peak force, dwell time, pear diameter and mass. The bioyield strength and modulus of elasticity were measured using UTM immediately after each drop test. The allowable drop height was estimated on the base of bioyield strength of the pears in two ways. One was assumed the peak force during impact test increasing linearly with time, and the other was based on the actual drop test results. The computer program was developed for measuring the impact characteristics of the pears and analyzing the data obtained in the study. The peak force increased while contact times decreased with increasing drop height and contact times of the sample from the hard tissue group. The allowable drop height increased with increasing bioyield strength and contact times, and also varied with Poisson\`s ratio, mass and equilibrium radius of the pears. The allowable drop height calculated by a theoretical method was in the range from 1 to 4 cm, meanwhile, the estimated drop height considering the result of the impact test was in the range from 1 to 6 cm. Since the physical properties of fruits affected significantly the allowable drop height, the physical properties of the fruits should be considered when estimating the allowable drop height.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.4
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• pp.271-279
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• 2019

The lamina II, also called the substantia gelatinosa (SG), of the trigeminal subnucleus caudalis (Vc), is thought to play an essential role in the control of orofacial nociception. Glycine and serotonin (5-hydroxytryptamine, 5-HT) are the important neurotransmitters that have the individual parts on the modulation of nociceptive transmission. However, the electrophysiological effects of 5-HT on the glycine receptors on SG neurons of the Vc have not been well studied yet. For this reason, we applied the whole-cell patch clamp technique to explore the interaction of intracellular signal transduction between 5-HT and the glycine receptors on SG neurons of the Vc in mice. In nine of 13 neurons tested (69.2%), pretreatment with 5-HT potentiated glycine-induced current ($I_{Gly}$). Firstly, we examined with a $5-HT_1$ receptor agonist (8-OH-DPAT, $5-HT_{1/7}$ agonist, co-applied with SB-269970, $5-HT_7$ antagonist) and antagonist (WAY-100635), but $5-HT_1$ receptor agonist did not increase $I_{Gly}$ and in the presence of $5-HT_1$ antagonist, the potentiation of 5-HT on $I_{Gly}$ still happened. However, an agonist (${\alpha}$-methyl-5-HT) and antagonist (ketanserin) of the $5-HT_2$ receptor mimicked and inhibited the enhancing effect of 5-HT on $I_{Gly}$ in the SG neurons, respectively. We also verified the role of the $5-HT_7$ receptor by using a $5-HT_7$ antagonist (SB-269970) but it also did not block the enhancement of 5-HT on $I_{Gly}$. Our study demonstrated that 5-HT facilitated $I_{Gly}$ in the SG neurons of the Vc through the $5-HT_2$ receptor. The interaction between 5-HT and glycine appears to have a significant role in modulating the transmission of the nociceptive pathway.