• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2015년도 추계학술대회
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• pp.958-960
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• 2015

말기 암환자를 위해 시행되는 화학적 항암치료는 다양한 합성 운반체를 이용한 표적치료를 통해 그 효과와 안정성을 증가시킨다. 항암치료의 약물 운반체로 쓰이기 위해 다음과 같은 독특한 두 가지 특성을 만족시켜야 하는데, 이것은 약물유출의 사용자 중심 제어기능과 표적 고형암으로의 높은 전달성이다. 하지만 현재 임상에서 사용되는 합성 운반체는 다양한 부작용을 유발하여 항암치료의 효과를 억제하고 환자들의 신체적 정신적 고통을 증가시키고 있다. 따라서 본 논문에서는 생착성과 생분해능력을 가지고 있는 겸형적혈구에 활성화된 광감응제를 부착하고 형광물질을 주입하여, 지연적 용혈을 이용한 유출제어기능과 겸형적혈구의 표적기능을 일반 형광물질 주입결과와 비교하여 실험을 진행하였다. 이를 위하여 유전적으로 변이된 전임상 모델에서 생성된 겸형적혈구를 암세포가 자라는 설치류에 주입한 후, 일정 시간 간격으로 유출정도를 초분광이미징 시스템을 이용하여 모니터링 하였고, 그 결과 약물전달 운반체로서의 겸형적혈구의 역할 및 합성 운반체의 대체 가능성을 보이고자 한다.

• Korean Journal of Radiology
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• 제25권2호
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• pp.210-211
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• 2024

• IMMUNE NETWORK
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• 제11권6호
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• pp.309-323
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• 2011

MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs of about 22 nucleotides that have recently emerged as important regulators of gene expression at the posttranscriptional level. Recent studies provided clear evidence that microRNAs are abundant in the lung, liver and kidney and modulate a diverse spectrum of their functions. Moreover, a large number of studies have reported links between alterations of miRNA homeostasis and pathological conditions such as infectious diseases, sickle cell disease and endometrium diseases as well as lung, liver and kidney diseases. As a consequence of extensive participation of miRNAs in normal functions, alteration and/or abnormalities in miRNAs should have importance in human diseases. Beside their important roles in patterning and development, miRNAs also orchestrated responses to pathogen infections. Particularly, emerging evidence indicates that viruses use their own miRNAs to manipulate both cellular and viral gene expression. Furthermore, viral infection can exert a profound impact on the host cellular miRNA expression profile, and several RNA viruses have been reported to interact directly with cellular miRNAs and/or to use these miRNAs to augment their replication potential. Here I briefly summarize the newly discovered roles of miRNAs in various human diseases including infectious diseases, sickle cell disease and enodmetrium diseases as well as lung, liver and kidney diseases.

• 보존과학회지
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• 제31권4호
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• pp.489-497
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• 2015

철겸은 다양한 형태를 가지고 다양한 용도로 사용된 도구이다. 농기구는 물론 무기로 사용된 경우도 있다. 지금까지의 연구는 주로 농기구의 특징에 초점을 맞추어 형태적 변화에 대해 이루어졌다. 과학적 분석 사례는 많지 않으므로 이 논문에서는 철겸의 금속학적 분석에 대해 다루고자 하였다. 연기 장재리의 철겸 2점을 분석하고 인근 유적인 연기 송원리에서 출토된 철겸의 금속학적 연구 결과와 비교하였다. 3점 모두 단조 성형, 열처리 공정으로 제작되었다. 연기 장재리의 No.1 철겸은 담금질의 마르텐사이트 조직이 확인되었다. 연기 장재리의 No.2 철겸은 다른 2점에 비해 고온의 제작환경을 겪었던 것으로 나타났다. 이로 보아 연기 송원리의 철겸보다는 기술적 난이도가 높았던 것을 알 수 있었다.

• 한국정보통신학회논문지
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• 제20권12호
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• pp.2395-2400
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• 2016

암 환자들을 대상으로 하는 항암치료법은 나노입자, 폴리머 중합체, 지질, 리포솜 등을 치료 전달체로 이용하여 항암치료를 진행하는 방법들이 주로 활발하게 사용되고 있다. 이러한 전달체는 항암 치료제를 직접 암세포로 정확하게 표적 운반하는 정확성, 정확하게 운반한 후 선택적으로 항암치료제를 방출해야하는 유출제어, 다른 일반 세포들을 약물로부터 보호하는 기능 등을 동시에 가지고 있어야 하지만, 대부분 항암약물의 독성에 기인한 부작용이 발생하고 있다. 겸형적혈구는 암세포주변 혈관세포와 멤브레인 표면에 존재하는 리셉터 사이에의 점착성이 존재하며 추가적 생화학처리 없이 암세포 주변에 표적화가 가능함을 보인다. 또한, 암세포 주변의 혈관의 구조적 변화특성은 겸형적혈구의 중합화 반응을 증가시킨다. 따라서 본 논문에서는 겸형적혈구를 이용한 새로운 항암치료법의 효과를 정량적 혈관분석 방법을 통해 제시하고자 한다.

• Mycobiology
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• 제29권2호
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• pp.104-106
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• 2001

Alternaria cassiae Jurair & Khan was recorded on seeds of sickle senna(Cassia tora L.). Seed infection ranged from $25{\sim}45%$ in two samples. Developing roots and shoots turn brown and died in case of severe infection. Detailed descriptions were given on the habit characters of the fungus and on the morphology of conidiophores and condia. This is the first report of A. cassiae on seeds of Cassia.

• BLOOD RESEARCH
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• 제53권4호
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• pp.325-329
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• 2018

• Journal of Genetic Medicine
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• 제13권1호
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• pp.26-30
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• 2016

Purpose: Genetic disorders can be prevented by basic public health measures and activities that focus primarily on education and approaches in Primary Health Care. Premarital screening is one such approach that can identify asymptomatic carriers of hemoglobinopathies and provide genetic counseling to couples for a healthy reproductive life. This study aimed to estimate the prevalence of beta thalassemia and sickle cell disorders in the adult population screened as a part of the United Arab Emirates Premarital Screening Program and to measure the effectiveness of the program in decreasing high-risk marriages in Ras Al Khaimah (RAK). Materials and Methods: A retrospective, population-based study was conducted at the RAK Primary Health Care Center, where the National Premarital Screening Program is implemented. The study included data collected from the premarital screening records of all couples who had applied for a marriage license during 2008-2015. Results: Of the 17,826 individuals screened during the studied period, 4.02% (717) were diagnosed as positive for hemoglobinopathies. The prevalence of beta thalassemia and sickle cell disorders among the total study population was 2.98% and 1.05%, respectively. The hemoglobinopathy trait was more prevalent than the disease. Among these 8,913 couples who were issued certificates for compatibility based on screening tests, 28 (0.31%) couples were declared high-risk (unmatched). Seventy percent of these unmatched couples reported consanguineous marriages. Conclusion: The program was successful in achieving its objective of identifying high-risk marriages. In spite of the counseling, however, all of the high-risk couples still married each other.

• Archives of Plastic Surgery
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• 제50권3호
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• pp.315-324
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• 2023

Hemoglobinopathies such as sickle cell disease (SCD) are traditionally considered a relative contraindication to free tissue transfer, due to concerns that erythrocyte sickling will increase the risk of microvascular thrombosis and flap failure. This article describes a case report with the successful use of free tissue transfer in a patient with SCD and provides a systematic literature review on free tissue transfer in SCD. A retrospective chart review was performed of a patient with SCD who underwent free tissue transfer at the authors' institution. A systematic literature review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was performed using the keywords "free tissue transfer," "free flap," or "microsurgery" and "sickle cell" on PubMed, Ovid/Medline, and Scopus. A 29-year-old male with delayed presentation of an electrical burn to the face and scalp underwent wound closure with a free anterolateral thigh flap. Key management principles included red blood cell transfusion to keep hemoglobin S under 30% and hemoglobin greater than 10 g/dL, maintenance of hydration, normothermia, adequate analgesia, and postoperative anticoagulation. Systematic literature review identified 7 articles describing 13 cases of free tissue transfer in 10 patients with SCD, with combined complete free flap success in 10 of the 13 flaps. Free tissue transfer can be successfully performed in patients with SCD. However, evidence on the optimal management of this unique patient population in the perioperative period after free tissue transfer is limited to case reports in the literature.

• 식품보건융합연구
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• 제5권4호
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• pp.25-28
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• 2019

Now a days problem in health has become common. So, instead of curing them, prevention through dietary supplements has proven to be useful. In the case of patients who have already developed the disease atleast relieving pain and suffer is a challenging thing. In this context L- arginine is doing better compared to other essential aminoacids up to some extent. Arginine was found to reduce the pain associated with pulmonary hypertension foun to be associated with sickle cell anaemia. It also reduces the reperfusion injury after ischemia, trauma and shock. Some of the drugs with L-arginine as component are under clinical trials and hope to be available in the market soon. Severe preeclampsia is characterised by headaches, blurred vision, and inability to have high photovision, nausea and vomiting. L-Arginine along with Vit C and E are given as medical food to the patients and decrease in condition symptoms is the project now under phase II clinical trial. However the role of arginine in ameolirating preeclampsia symptoms is uncertain except with that of hypertension. Arginine is used to treat pain in sickle cell anaemia, lung damage, reperfusion injury, Trauma and shock but should be excluded during sepsis.