• Title/Summary/Keyword: Shuttle

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Mutation spectra induced by 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide in the supF gene of human XP-A fibroblasts

  • Kim, Byung-Wook;Kim, Byung-Chun;Cha, Jin-Soon;Pfeifer, Gerd P.;Lee, Chong-Soon
    • BMB Reports
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    • v.41 no.8
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    • pp.604-608
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    • 2008
  • 1-Nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide are oxidative metabolites that are responsible for the mutagenicity of 1-nitropyrene. In this study, the mutation spectra induced by oxidative metabolites in human cells were determined using a shuttle vector assay. The mutation frequencies induced by 1-nitropyrene 9,10-oxide were 2-3 times higher than those induced by 1-nitropyrene 4,5-oxide. The base substitutions induced by 1-nitropyrene 4,5-oxide were $G{\rightarrow}A$ transitions, $G{\rightarrow}C$ transversions, and $G{\rightarrow}T$ transversions. In the case of 1-nitropyrene 9,10-oxide, $G{\rightarrow}A$ transitions, $G{\rightarrow}T$ transversions, $A{\rightarrow}G$ transitions and $G{\rightarrow}C$ transversions were observed. Most base substitution mutations induced by oxidative metabolites occurred at the guanine sites in the supF gene. These sequence-specific hot spots were commonly identified as 5'-GA sequences for both metabolites. On the other hand, the sequence-specific hot spots at the adenine sites were identified as 5'-CAC sequences for 1-nitropyrene 9,10-oxide. These results suggest that the oxidative metabolites of 1-nitropyrene induce sequence-specific DNA mutations at the guanine and adenine sites at high frequency.

Proposal of Pipe Pressure Mode Analysis Method in Propulsion System for Predicting the Pogo of Space Launch Vehicle (우주 발사체의 포고현상 예측을 위한 공급/추진계의 파이프 압력모드 해석 기법 제안)

  • Lee, SangGu;Lee, SiHun;Shin, SangJoon
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 2017.05a
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    • pp.714-717
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    • 2017
  • Among the factors considered in the design stage of a space launch vehicle using liquid propellant, research has been focused out on the pogo phenomenon, longitudinal dynamic instability. The pogo phenomenon refers to the instability that the longitudinal vibration of the launch vehicle structure causes a change in the pressure and flow rate of the fluids in propulsion system, and this change re-excites the fuselage structure. This mechanism constitutes a closed system to gradually increase the vibration of the launch vehicle. This paper specifically focuses on the dynamic analysis of pressure and flow changes in the propulsion system. Based on the example study of the space shuttle, the acoustic modal analysis of the propulsion system is performed to predict the modes of the supply line causing instability of the fuselage.

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Experimental Study on Interaction of Side-by-Side Moored Vessels (병렬계류 선박의 동유체력 상호간섭에 관한 실험연구)

  • Kim, Jin-Ha;Hong, Sa-Young;Cho, Seok-Gyo;Choi, Yoon-Rak;Song, Myong-Jae;Kim, Duk-Su
    • Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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    • 2003.05a
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    • pp.208-213
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    • 2003
  • Recently, Side-by-side mooring system of LNG FPSO and shuttle tanker is one of hot issues in offshore floating body dynamics, which requires accurate analysis of hydrodynamic interactions between side by side moored LNG FPSO and shuttle tanker than tandem moored vessels. This paper aims to investigate basic interaction characteristics of side-by-side moored multiple vessels both numerically and experimentally. A higher-order boundary element method combined with generalized nwde approach will be applied to analysis of motion and drift force of side by side moored multiple-body. Model tests were carried out for the same multiple floating bodies in regular and irregular waves. Motion responses and drift forces of vessels for two mooring situation(coupled & uncoupled) were compared with those of calculations. Discussions will be highlighted on applicability of numerical method to prediction of sophisticated multi-body interaction problem of which motion behavior is very important to analysis of mooring dynamics of deep sea floating bodies.

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A Study of the changes of the Dan (緞) Fabrics for Hanbok Since 1945 (해방이후 한복용 단직물의 변천에 관한 연구)

  • 신혜성;홍나영
    • Journal of the Korean Society of Clothing and Textiles
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    • v.27 no.6
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    • pp.715-724
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    • 2003
  • The Korean clothing culture has shown rapid changes along with influences of western cultures, with social changes due to the liberation from Japan, the Korean War, and the economic growth concentrated on export since the westernization of Korea had begun. Also clothing materials, as a phase of such culture, have been changed. Among silk fabrics, "Dan (단: damask of satin texture with Korean traditional patterns are inwoven)", which has been concerned one of the most beautiful and precious fabrics due to its complexity and difficulty of processing. Since the beginning of the Era of Enlightenment(Kae-hwa-gi), Dan fabric materials and weaving methods have changed. It seems that the figured texture using the Jacquard loom began in 1936. when the Jacquard machine began to be imported from Japan into Korea. From that time on, new fabric materials, such as yangdan (양단), and popdan (법단), hobakdan (호박단), silk and rayon mixed Dan(교직양단) began to be produced. Before 1950's there were some restrictions about the Number of wefts, so the production of the one colored dan(단색단) was more common than that of the multi colored dan(다색단). But with the spread of 4$\times$4 shuttle box loom (양사정직기), various kinds of the multi colored dan have been produced after 1960's. Around the end of 1980's, automatic shuttle change loom have been generalized and 7 color dan(칠색단), 9 color gumsadan (구색금사단) have been current in multi colored dan. In terms of materials, synthetic and chemical textiles had been used widely and alter 1980's most fabrics, of which the ground weave is not being woven with satin-weave but being woven with plain or twill-weave, are named Dan in general.

From Airborne Via Drones to Space-Borne Polarimetric- Interferometric SAR Environmental Stress- Change Monitoring ? Comparative Assessment of Applications

  • Boerner, Wolfgang-Martin;Sato, Motoyuki;Yamaguchi, Yoshio;Yamada, Hiroyoshi;Moon, Woo-Il;Ferro-Famil, Laurent;Pottier, Eric;Reigber, Andreas;Cloude, Shane R.;Moreira, Alberto;Lukowski, Tom;Touzi, Ridha
    • Proceedings of the KSRS Conference
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    • 2003.11a
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    • pp.1433-1435
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    • 2003
  • Very decisive progress was made in advancing fundamental POL-IN-SAR theory and algorithm development during the past decade. This was accomplished with the aid of airborne & shuttle platforms supporting single -to-multi-band multi-modal POL-SAR and also some POL-IN-SAR sensor systems, which will be compared and assessed with the aim of establishing the hitherto not completed but required missions such as tomographic and holographic imaging. Because the operation of airborne test-beds is extremely expensive, aircraft platforms are not suited for routine monitoring missions which is better accomplished with the use drones or UAVs. Such unmanned aerial vehicles were developed for defense applications, however lacking the sophistic ation of implementing advanced forefront POL-IN-SAR technology. This shortcoming will be thoroughly scrutinized resulting in the finding that we do now need to develop most rapidly POL-IN-SAR drone-platform technology especially for environmental stress-change monitoring with a great variance of applications beginning with flood, bush/forest-fire to tectonic-stress (earth-quake to volcanic eruptions) for real-short-time hazard mitigation. However, for routine global monitoring purposes of the terrestrial covers neither airborne sensor implementation - aircraft and/or drones - are sufficient; and there -fore multi-modal and multi-band space-borne POL-IN-SAR space-shuttle and satellite sensor technology needs to be further advanced at a much more rapid phase. The existing ENVISAT with the forthcoming ALOSPALSAR, RADARSAT-2, and the TERRASAT will be compared, demonstrating that at this phase of development the fully polarimetric and polarimetric-interferometric modes of operation must be viewed and treated as preliminary algorithm verification support modes and at this phase of development are still not to be viewed as routine modes.

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Correction of Mt. Baekdu DEM Generated from SPOT-5 Stereo Images (SPOT-5 스테레오 영상을 이용한 백두산 DEM 제작과 보정)

  • Lee, Hyo-Seong;Ahn, Ki-Weon;Park, Byung-Uk;Oh, Jae-Hong;Han, Dong-Yeob
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.28 no.5
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    • pp.555-560
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    • 2010
  • The geoscientists are very interested in a volcanic reactivity of Mt. Baekdu. Periodical observation and monitoring are thus needed to detect the topographic and environmental changes of Mt. Baekdu. It is, however, very restrictive to survey with difficulty of observer's accessibility in the field due to political problems. This study therefore is to produce digital elevation model (DEM) of Mt. Baekdu using SPOT-5 stereo images. The produced DEM is very not accurate because of using without ground control points (GCP). To correct the previously generated DEM, scale-invariant feature transform(SIFT) matching method is adopted with shuttle radar topography mission(SRTM) DEM of NASA Jet Propulsion Laboratory(JPL). The results of the produced DEM to SRTM DEM matching indicate that the corrected DEM from SPOT-5 stereo images has more detail topographic structures. In addition, difference of spatial distances between the corrected DEM and SRTM DEM are much smaller than non-corrected DEM.

Analysis of Forest Stand Structure Using Spaceborne Synthetic Aperture Radar(SAR) Data (인공위성 레이다 영상자료를 이용한 임분구조의 물리적 특성파악)

  • 이규성
    • Korean Journal of Remote Sensing
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    • v.8 no.2
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    • pp.79-91
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    • 1992
  • With recent development in spaceborne imaging radar system, there are growing interests using satellite synthetic aperture radar(SAR) data in various applications. This study attempted to identify the relationships between several forest stand characteristics and radar backscatter, measured from space altitude altitude at three incidence angles. Shuttle Imaging Radar-B(SIR-B) data were collected over a forested area in northern Florida in October, 1984. By using various sources of reference data (forest type maps, inventory records, aerial photographs, and Landsat Thematic Mapper data), about 400 forest stands of known characteristics were carefully located in the radar data. Relative radar backscatter for the three incidence angles of SIR-B data were compared with known forest stand parameters such as mean tree height, diameter at breast height(DBH), stand density, biomass, and relative amount of understory vegetation. The results show that these stand parameters have statistically significant correlations with the radar backscatter. In addition, the SIR-B radar backscatter from a certain stand parameter turned out differently at the three different incidence angles. Finally, the types and characteristics of currently available satellite SAR data are discussed.

Reentry Guidance for Korean Space Plane Based on Reference Drag Following (한국형 우주비행기의 기준 항력 추종 기반 재진입 유도 기법)

  • Yoon, Da-In;Kim, Young-Won;Lee, Chang-Hun;Choi, Han-Lim;Ryu, Hyeok
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.49 no.8
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    • pp.637-648
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    • 2021
  • This paper aims to propose new reentry guidance for Korean Space plane (KSP). Similar to the Space Shuttle guidance concept, a reference drag profile is first determined to satisfy several flight path constraints and boundary conditions, and the proposed guidance commands are realized in a way to track the predetermined reference drag profile. To this end, the drag dynamics is examined. The investigation uncovers that the dynamics characteristics of the drag and the flight path angle are considerably different. Based on this fact, the proposed guidance commands are determined using the time-scale separation technique and the feedback linearization methodology. The key feature of the proposed guidance lies in its simple structure and a clear working mechanism. Therefore, the proposed method is simple to implement compared to existing methods. Numerical simulations are performed to investigate the performance of the proposed method.

The Effects of Transcranial Direct Current Stimulation Combined High Intensity Interval Training on Aerobic Exercise Capacity of the Soccer Player (tDCS를 결합한 고강도 인터벌 훈련이 축구선수의 유산소 운동능력에 미치는 영향)

  • Yang, Dae-Jung;Uhm, Yo-Han
    • Journal of The Korean Society of Integrative Medicine
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    • v.9 no.4
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    • pp.105-117
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    • 2021
  • Purpose : This study examined the effect of transcranial direct current stimulation (tDCS) combined high intensity interval training (HIIT) on the aerobic exercise capacity of college soccer players. Methods : The subjects of this study were 30 college soccer players. They were divided into a high intensity interval training group combining transcranial direct current stimulation (Group I) and a high intensity interval training group (Group II). Each group had 15 subjects randomly assigned. After receiving general soccer training, each group additionally received high intensity interval training combined with transcranial direct current stimulation and high intensity interval training for 30 minutes 5 times a week for 8 weeks. Their VO2max and 20 meter shuttle run test, Yo-Yo intermittent recovery test were analyzed before the intervention. After 8 weeks of intervention, the above items were re-measured and an intergroup analysis was performed. Results : As a result of comparative analysis of VO2max intake between groups, 20 meter shuttle run test and Yo-Yo intermittent recovery test, a statistically significant difference was found. The high intensity interval training group (Group I) combined with transcranial direct current stimulation showed a significant difference in aerobic exercise capacity compared to the high intensity interval training group (Group II). Conclusion : These results showed that high intensity interval training group combined with transcranial direct current stimulation was more effective for aerobic exercise. Based on this study, this study proposes an effective program for patients as well as elite athletes. In the future, it is necessary to develop an effective transcranial direct current stimulation program and to study how to apply it for various patients.

Characterization of Two Cryptic Plasmids from Levilactobacillus zymae GU240

  • Le, Huong Giang;Kim, Min Jae;Jeon, Hye Sung;Yoo, Ji Yeon;Kang, Yun Ji;Kim, Tae Jin;Kim, Jeong Hwan
    • Microbiology and Biotechnology Letters
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    • v.50 no.1
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    • pp.63-70
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    • 2022
  • Two small cryptic plasmids, pHG1 and pHG2, were isolated from Levilactobacillus zymae (formerly Lactobacillus zymae) GU240 and characterized. pHG1 is 1,814 bp in size with a GC content of 37.4% and contains two open reading frames. orf1 can potentially encode a protein of 101 amino acids (aa) with 99% identity with the copy number control protein of Lacticaseibacillus paracasei. orf2 can potentially encode a protein of 230 aa with 99% identity with a replication protein from multiple species. Six inverted repeats (IR I-VI) and six direct repeats (DR I-VI) were found in pHG1. pHG2 is 2,864 bp in size, with a GC content of 39.6%. pHG2 has two orfs. orf1 might encode a protein with 99% identity with the TrsL transmembrane protein. orf2 might encode a protein with 99% identity with plasmid recombination proteins from lactic acid bacteria. Both pHG1 and pHG2 may be useful as frames for constructing lactic acid bacteria-Escherichia coli shuttle vectors.