• 정신신체의학
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• 제29권1호
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• pp.11-16
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• 2021

연구목적 항정신병약물로 인한 QTc간격연장은 심각한 심실성 부정맥을 초래할 가능성 때문에 주의가 필요한 부작용이다. 하지만 현재까지 국내에서 항정신병약물에 의한 QTc간격연장에 대한 연구는 많지 않았다. 본 연구는 조현병 환자에서 QTc간격연장에 영향을 주는 인구학적 및 임상적 변수를 알아보고자 한다. 방 법 일 병원에 입원치료를 받았던 441명 조현병 환자들의 의무기록을 후향적으로 검토하여 QTc간격과 인구학적 및 임상적 변수들을 파악하였다. QTc간격에 영향을 주는 변수를 알아보기 위해 QTc간격을 종속변수로 하여 위계적 중다회귀분석을 수행하였다. 결 과 평균 QTc간격은 417.2±28.4 ms였다. 위계적 중다회귀분석 결과 항정신병약물 단기작용주사제의 사용이 QTc간격연장의 가장 강한 예측인자였다. 결 론 본 연구는 조현병 환자에서 항정신병약물 단기작용주사제 사용이 QTc간격연장에 영향을 줄 수 있으며 조현병 환자의 치료 시 항정신병약물 단기작용주사제 사용에 보다 주의를 기울여야 함을 시사한다.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권6호
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• pp.437-442
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• 2022

Background: Propofol is a short-acting intravenous sedative widely used for procedural sedation and general anesthesia. However, pain during propofol injection is a distressing adverse effect. This study was designed to investigate whether transcutaneous electrical nerve stimulation (TENS) could reduce pain during propofol injection compared to sham TENS. Methods: In a randomized controlled trial, 80 patients were allocated to two groups: the active TENS group received electrical stimulation via two electrodes on the venous cannulation site, whereas the sham TENS group received no stimulus. After 20 min following TENS, propofol 0.5 mg/kg pain was injected intravenously and pain was evaluated using a four-point score (0 = none, 1 = mild, 2 = moderate, 3 = severe). Adverse effects associated with TENS were also recorded. Results: The overall incidence of pain during propofol injection was 47.5% in the TENS group and 87.5% in the sham group (P < 0.001). The incidence of moderate pain was significantly lower in the TENS group (7.5%) than in the sham TENS group (42.5%) (P < 0.001). There were no complications associated with TENS. Conclusion: Pre-treatment with TENS significantly reduced the incidence and intensity of pain during propofol injection.

• 한국지반환경공학회 논문집
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• 제11권10호
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• pp.25-31
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• 2010

사면보강 및 기초공법으로 앵커공법, 소일네일공법 및 소구경 말뚝공법 등이 널리 사용되고 있다. 이들 공법은 공통적으로 보강재를 설치한 후 그라우팅을 실시한다. 국내의 경우 중력식과 가압식 그라우팅 방식을 주로 사용하고 있다. 반면, 재주입 그라우팅 방식은 시공장비와 적용 실적의 부족 및 보강효과 검증이 어려워 널리 적용되지 못하고 있는 실정이다. 재주입 그라우팅은 포스트 그라우팅 방식의 일종으로 그라우트체 주면의 응력을 증대시키고 정착장에 불규칙한 표면을 조성함으로써 그라우트와 지반의 저항을 크게 할 수 있다. 이에 본 연구에서는 그라우팅 주입 방식에 따른 보강효과를 비교하고, 재주입 그라우팅 방식으로 시공된 보강재의 인발특성을 평가하기 위하여 현장실험을 실시하였다. 실험결과 재주입 그라우팅에 따른 인발력 증대를 확인할 수 있었다.

• 대한치과의사협회지
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• 제11권1호
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• pp.45-52
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• 1973

Ketamine HC1(Phencyclidine derivative) is a white, crystalline substance with melting point 259℃. It is soluble in water to a 20% clear, colorless solution. a 10% aqueous solution has a pH 3.5. The chemical structure is 2-(O-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is a rapid acting, nonhypnotic, nonbarbiturate drug with a wide safety margin. The author used the anesthetic ketamine hydrochloride for oral surgery procedure in 16 patients(2 to 33 years). Anesthesia was achieved with a single intramuscular injection by introduction of manufacture. Result obtained as follows : 1. It was easily administered. 2. Onset time was rapid and duration was short. 3. The mild cardiac stimulation resulted in moderate increase in the blood pressure and pulse. 4. There was no significant respiratory depression. 5. The airway can be maintained without artificial support or endotracheal intubation. 6. All protective reflex maintained, which was important in oral surgery. 7. The best results were achieved in pediatric patients than adults.

• 한방안이비인후피부과학회지
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• 제14권1호
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• pp.182-189
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• 2001

This study was performed to compare the effect of Ojeoksan which have extracted by varied extractor(press extractor : PE, pressless extractor : PLE, short acting extractor : SE) on model of blood stasis in rats, Except for the normal group, hydrocortisone acetate(HA;25mg/kg in ethanol. IM) to induce experimental blood stasis model for 1 weeks and each extract of Ojeaksan was administrated after 1hr following HA injection for 1week. We measured the hematocrit, the platelet count, the prothrombin time, levels of fibrinogen in rats' blood, The sample Ⅰ(Ojeoksan extracted by PE) group showed significant decrease of hematocrit. prothrombin time and significant increase of the platelet count, levels of fibrinogen in comparison with those of the control group, The sample Ⅱ(Ojeaksan) extracted by PLE) group showed significant decrease of hematocrit and significant increase of levels of fibrinogen in comparison with those of the control group. Administration of the sample Ⅲ(Ojeaksan extracted by SE) group showed significant decrease of hematocrit and significant increase of the platelet count, levels of fibrinogen in comparison with those of the control group.

• Animal cells and systems
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• 제1권1호
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• pp.115-121
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• 1997

To precisely analyze the role of ovarian steroids in the regulation of laminin chain gene expression in mouse uterine tissues, the ovariectomized mouse model was used. Ovariectomized mice received a single injection of steroid hormones and total RNA was isolated from whole uterine tissues. Messenger RNA levels of each laminin chain (A, 81, and 82) were determined by competitive RT-peR procedures. Estradiol decreased mRNA levels of laminin 81 chain about two-fold, and 82 chain rather moderately. Estradiol-induced inhibition of laminin 81 and 82 chain mRNA levels were completely blocked by pretreatment with estrogen receptor antagonist tamoxifen. Estriol, a short acting estrogen which cannot induce hyperplastic responses of rodent uterine tissues, also showed an inhibitory effect on 81 and 82 chain mRNA levels, while estrone, an inactive estrogen, failed to influence either 8 chain mRNA levels. Effects of steroids on A chain mRNA level were quite different from those on 8 chains. Laminin A chain mRNA level was slightly increased by estradiol treatment, but negatively affected by progesterone. Progesterone treatment greatly increased both 8 chain mRNA levels, but slightly decreased A chain mRNA level compared to the control. The effect of progesterone on laminin chain-specific mRNA levels was further increased by co-injection of estradiol in a time-dependent manner. Progesterone-induced 81 and 82 chain mRNA transcription was inhibited by RU486, a synthetic anti-progesterone /anti-glucocorticoid. The present study demonstrates for the first time that steroids are able to regulate laminin gene expression in mouse uterine tissues, indicating that steroid-regulated laminin gene expression is involved in uterine growth and probably differentiation.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8797-8800
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• 2014

Objective: To analyze cost-effectiveness of morphine, MS contin and oxycodone in the treatment of cancer pain, providing guidance for rational drug use in the clinic. Methods: Confirmed by histology, a total of 171 patients with various cancers who required analgesic treatment were selected and divided into 3 groups, 57 cases for each group, given morphine, MS contin and oxycodone, respectively. If there appeared a poor short-term effect or aggravated sudden pain during the treatment, a short-acting morphine injection was given and adverse reactions were processed by symptomatic treatment. The pain relief rate and adverse reactions of groups were observed and pharmacoeconomics evaluation was undertaken. Results: The pain relief rates with morphine, MS contin and oxycodone were 89.5%(51/57), 91.2%(52/57) and 93.0%(53/57), respectively, with no difference samong groups (${\chi}^2=4.4489$, P=0.6162). The occurrence rates of adverse reactions were 59.7%(34/57), 54.4%(31/57) and 43.9%(25/57), again with no significant variation (P>0.05). The ratios of cost-effectiveness (C/E) for the 3 groups were $14.6{\pm}7.21$, $15.0{\pm}7.44$ and $16.1{\pm}8.10$. When the price of 3 kinds of analgesics was reduced by 10%, the ratios of cost-effectiveness were $12.2{\pm}6.53$, ($13.4{\pm}6.08$ and $14.5{\pm}6.74$ but there was no differences when compared with before the price adjustment (t=1.86, P=0.0651; t=1.30, P=0.1948; t=1.17, P=0.2453). Conclusion: Morphine, MS contin and oxycodone give similar pain relief and adverse reaction rates but of all, morphine is the preferred drug for the treatment of cancer pain from the perspective of pharmacoeconomics.

• Journal of Nutrition and Health
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• 제22권4호
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• pp.237-246
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• 1989

본연구는 인슐린 투여가 생체내에 어떤 영향을 주는지 알아보기 위한 기본단계로 생후 약 10주령되는 정상쥐에 인슐린을 복강 주사한 뒤 혈청내 변화와 조직학적 변화를 조사하였다. 결과를 요약하면 다음과 같다. 가. Acute phase에서의 인슐린 투여 효과 \circled1 인슐린 주사후 1.5시간만에 혈당치는 최저를 나타냈으나 그후 점차 증가하여 4시간후에는 처음 수준으로 복귀하였으나 Hb,Ht,혈청 단백직과 알부민 등은 인슐린 투여에 의해 큰 변화를 보이지 않았다. \circled2 혈청 총지질, 중성지방은 인슐린을 주사한지 2시간까지는 약간 증가하다 차츰 감소하였고, 혈청 콜레스테롤은 감소하다가 4시간 이후에 다시 증가추세로 바뀌었다. 그러나 인지질은 별다른 변화를 보이지 않았다. 나. Chronic phase에서의 인슐린 투여 효과 \circled1 인슐린 투여에 따라 공복혈당치는 큰 영향을 받지 않았으며,Hb, Ht, 혈청 알부민과 단백질등은 실험기간중 별다른 변화가 없었다. \circled2 혈청 총지질은 인슐린 투여 20일까지는 큰 변화가 없었으나 그후 30일째는 처음 수준의 절반으로 감소함을 보였다. 그러나 중성지방, 인지질, 혈청콜레스테롤 등은 뚜렷한 증가나 감소가 없는 경향을 보였다. \circled3 인슐린 투여가 간과 aorta의 지발 침착에 미치는 영향은 뚜렷한 변화가 없었다.

• 한국지반환경공학회 논문집
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• 제13권9호
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• pp.83-89
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• 2012

지반 및 사면보강을 위해 국내에서 널리 사용되고 있는 공법으로 앵커, 쏘일네일 및 마이크로파일공법 등을 들 수 있다. 상기 공법들은 공통적으로 보강재를 설치한 후 그라우팅을 실시하는 공정을 포함한다. 압력재주입 그라우팅은 그라우트체의 직경확대와 그라우트체 주면의 응력 증가 및 불규칙한 표면을 조성함으로써 지지력을 증대시킬 수 있다. 그러나 국내에서는 시공장비와 적용실적의 부족 및 보강효과의 검증이 어려워 널리 적용되지 못하고 있는 실정이다. 이에 본 연구에서는 점성토 지반을 대상으로 그라우팅 방법에 따른 보강효과를 평가하기 위하여 실내 모형실험을 실시하였다. 실험결과, 인발력은 압력재주입 그라우팅 방식이 중력식 그라우팅에 비해 최소 1.22배에서 최대 2.61배까지 크게 발휘되는 것으로 나타났다.

• Journal of Pharmaceutical Investigation
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• 제40권3호
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• pp.175-180
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• 2010

Albumin-modification has been viewed as one of the most effective ways of extending the short in vivo lifetimes of peptide drugs by delaying glomerular filtration. In this study, we describe a new type 2 anti-diabetic exendin-4 (Ex4) peptide derivative with significant binding ability to human serum albumin (HSA). This exendin-4 derivative consists of a 4-branched polyethylene glycol $(PEG)_{5k}$ (Mw: 20 kDa) modified with three stearylamines ($C_{18}-NH_2$) and one exendin-4 on its branches. PEG and stearylamine were selected to provide functionality to increase molecular size and bind to albumin, respectively. This derivative ($3C_{18}-4PEG_{5k}$-Ex4) was shown to have larger molecular size (Ca. 152 kDa) than actual (25.0 kDa) when subjected to size-exclusion chromatography, and the fluorescein-tagged $3C_{18}-4PEG_{5k}$-Ex4 displayed significant binding to the HSA-immobilized Sepharose CL-4B resin using confocal laser scanning microscopy. Furthermore, $3C_{18}-4PEG_{5k}$-Ex4 was found to have acceptable anti-hyperglycemic efficacy via three consecutive oral glucose tolerance testings (OGTT) in fasted type 2 diabetic db/db mice. The $HD_{total}$ value ($57.6{\pm}12.3%$) of $3C_{18}-4PEG_{5k}$-Ex4 at a 50 nmol/kg dose was 2-fold greater than that ($31.0{\pm}8.7%$) of native exendin-4 in non-fasted db/db mice. Especially, the blood glucose levels in the mice group treated with $3C_{18}-4PEG_{5k}$-Ex4 did not rebound to ~150 mg/dL until 24 h after the injection, which obviously shows the extended hypoglycemia. We believe that this derivative has great pharmaceutical potential as a novel long-acting type 2 anti-diabetic injection treatment.