• BMB Reports
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• 제50권8호
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• pp.391-392
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• 2017

Overexpression of mammalian 2-Cys peroxiredoxin (Prx) enzymes is observed in most cancer tissues. Nevertheless, their specific roles in colorectal cancer (CRC) progression has yet to be fully elucidated. Here, a novel molecular mechanism by which PrxII/Tankyrase (TNKS) interaction mediates survival of adenomatous polyposis coli (APC)-mutant CRC cells was explored. In mice with an inactivating APC mutation, a model of spontaneous intestinal tumorigenesis, deletion of PrxII reduced intestinal adenomatous polyposis and thereby increased survival. In APC-mutant human CRC cells, PrxII depletion hindered PARP-dependent Axin1 degradation through TNKS inactivation. $H_2O_2-sensitive$ Cys residues in the zinc-binding domain of TNKS1 was found to be crucial for PARsylation activity. Mechanistically, direct binding of PrxII to ARC4/5 domains of TNKS conferred vital redox protection against oxidative inactivation. As a proof-of-concept experiment, a chemical compound targeting PrxII inhibited the growth of tumors xenografted with APC-mutation-positive CRC cells. Collectively, the results provide evidence revealing a novel redox mechanism for regulating TNKS activity such that physical interaction between PrxII and TNKS promoted survival of APC-mutant colorectal cancer cells by PrxII-dependent antioxidant shielding.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 심포지엄 논문집 정보 및 제어부문
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• pp.29-31
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• 2007

In this paper we propose an directional analytic approach in image data space for X-ray image which is detected from the X-ray projection system. Such a radiographic nondestructive testing has long been used for steel-tube inspection and weld monitoring. The welded area and thickness of steel-tube are detected from gradient radiating mechanism based on the evaluation of biased X-ray source position. The welded area is an ellipse type on low contrast X-ray image including noise. Noise originates from most of elements of the system. such as shielding CCD camera, imaging screen, X-ray source, inspected object, electronic circuits and etc.. Projection incorrectness and noise influence on imaging quality is to be represented by vertical pixels' distribution. Space analysis due to vertical direction also shows the segmental possibility between regions by visual edge evaluation.

• Journal of electromagnetic engineering and science
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• 제11권3호
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• pp.174-182
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• 2011

The On-line Electric Vehicle (OLEV) is an electric transport system in which the vehicle's power is transferred wirelessly from power lines underneath the surface of the road. Advantages of the OLEV include reducing battery size and cost to about 20 percent of that of conventional battery-powered electric vehicles, thereby minimizing the vehicle's weight and price, as well as the cost of charging the system. In this paper, we introduce a wireless power transfer mechanism to maximize the electrical performance of the power transfer system. Power transfer capacity, power transfer efficiency, and magnitude of leakage in the electromagnetic field (EMF) are analyzed, and the optimization methodology of the design parameters is discussed.

• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part 1
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• pp.525-526
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• 2006

Calcium-hexaluminate phase $(CA_6)$ is known to be effective for the crack shielding due to the spinel block crystal structure. In this study, we focused to the control of $CA_6$ morphology for good damage tolerance behavior in alumina and zirconia/calcium-hexaluminate $(CA_6)$ composites. Calcium-hexaluminate $(CA_6)$ composites were prepared from zirconia, alumina and calcium carbornate powders. Calcium-hexaluminate $(CA_6)$ phase was obtained by the solid reaction through the formation of intermediate phase $(CA_2)$. $CA_6$ phase showed the column type abnormal grain grown behavior composed of small blocks. Due to the typical microstructure of $CA_6$, alumina and zirconia/calcium-hexaluminate composites provide a well controlled crack propagation behavior.

• 한국산학기술학회논문지
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• 제14권2호
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• pp.554-560
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• 2013

본 연구에서는 양쪽 대칭으로 지지할 수 있는 쉴드캔 클립을 제안하며, 그 특징은 장착과 탈착의 하중을 일정하게 하고 납땜 부위의 평판도를 유지 할 수 있도록 개발하였다. 또한 인쇄회로기판에 부착 고정되는 베이스부 및 쉴드캔의 측벽을 집게 형태로 집을 수 있도록 하는 클립부로 구성되며, 클립부 중앙을 절단하여 2군데를 지지 할 수 있게 이루어진다. 또한 넓어진 베이스부와 인쇄회로기판 사이에 납땜이 잘될 수 있도록 오목한 홈을 만들었다. 연구절차는 우선 메커니즘을 설정하고 구조해석 및 진동모드 해석을 수행하여 설계변수를 확정한 후, 제품을 설계하였다. 제조를 위한 전용기를 개발한 후 시제품을 제작하여 성능 평가 후 해석값과 비교 분석하였다.

• Journal of Radiation Protection and Research
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• 제40권2호
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• pp.118-123
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• 2015

최근 의료기관에서의 진단방사선검사 빈도는 2011년 2억 2천만건, 연간 일인당 피폭선량은 1.4 mSv로 2007년 대비 각 51%, 35% 증가하였다. 여기서 흉부촬영건수는 일반촬영 중 가장 높은 빈도인 27.59%로 나타났다. 따라서 본 연구에서는 흉부 방사선 촬영 시 영상판독에 불필요한 신체부위를 차폐하여 피폭선량을 최소화 시키는 차폐기구를 개발하고, 그 유용성 평가를 위해 국제 표준 소아(10세) 팬텀과 유리선량계를 사용하여 기구 사용 전, 후의 입사표면선량(entrance surface dose; ESD)과 장기의 흡수선량 차를 측정하였다. 또한 몬테카를로 시뮬레이션 기반 프로그램(PCXMC 2.0.1)을 이용하여 유효선량을 산출하였고 암발생의 생애귀속위험도(lifetime attributable risk of cancer incidence; LAR)를 비교하여 그 감소율을 간접적으로 평가하였다. 방어기구를 사용할 때, 입사표면선량(감소율)은 비강 $0.55{\mu}Sv$ (74.06%), 갑상선 $1.43{\mu}Sv$ (95.15%), 식도 $6.35{\mu}Sv$ (78.42%)로 평균 86.36% 감소되었고, 심부선량(감소율)은 경추 $1.23{\mu}Sv$ (89.73%), 침샘 $0.5{\mu}Sv$ (92.31%), 식도 $3.85{\mu}Sv$ (59.39%), 갑상선 $2.02{\mu}Sv$ (73.53%) 흉추 $5.68{\mu}Sv$ (54.01%) 로 평균 72.30%로 감소되어 차폐기구의 유용성을 확인할 수 있었다. 또한, 유효선량은 착용 전 $8.33{\mu}Sv$에서 착용 후 $7.35{\mu}Sv$로 11.76% 감소하였고, LAR 평가에서는 갑상선 암은 10세 소아 백만 명당 남아 0.14명(95.12%), 여아 0.77명(95.16%), 모든 암은 남아 0.14명(11.70%), 여아 0.25명(11.70%)의 감소(감소율)를 확인할 수 있었다. 진단방사선검사는 질병과 치료 등 건강을 위해 꼭 필요한 검사이지만, 가능한 진단에 불필요한 부위에 이러한 차폐기구를 적극적으로 사용하여 ALARA 개념에 입각한 의료방사선 최적화를 도모해야 할 것이다.

• Geomechanics and Engineering
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• 제22권4호
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• pp.349-359
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• 2020

Quantification of the influence of the fracture of thick magmatic rock (TMR) on the behavior of its overlying strata is a prerequisite to the understanding of the deformation behavior of the earth's surface in deep mining. A three-dimensional numerical model of a special geological mining condition of overlying TMR was developed to investigate the overburden movement and fracture law, and compare the influence of the occurrence horizon of TMR. The research results show that the movement of overlying rock was greatly affected by the TMR. Before the fracture of TMR, the TMR had shielding and controlling effects on the overlying strata, the maximum vertical and horizontal displacement values of overlying strata were 0.68 m and 0.062 m. After the fracture, the vertical and horizontal displacements suddenly increased to 3.06 m and 0.105 m, with an increase of 350% and 69.4%, respectively, and the higher the occurrence of TMR, the smaller the settlement of the overlying strata, but the wider the settlement span, the smaller the corresponding deformation value of the basin edge (the more difficult the surface to crack). These results are of tremendous importance for the control of rock strata and the revealing of surface deformation mechanism under TMR mining conditions in mines.

• 한국식품영양과학회지
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• 제24권3호
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• pp.446-453
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• 1995

The improtant components of extracellular matrix(ECM) are collagen and chondroitin sulfate. The hydrophobic surface of collagen is one of the determining factors of diameter of collagen fiber and also is closely related to the aging phenomena. The controlling mechanism of the diameter of collagen fiber influenced by the interaction with chondroitin sulfate was evaluated using bis-ANS as a hydrophobic probe. Hydrophobic surface area of collagen molecule shielded by chondroitin sulfate was evaluated. Relative fluorescence intensity of collagen in thepresence of chondroitin sulfate was measured using bis-ANS as a hydrophobic probe. The fluorescence intensity decreased with the increase in chondroitin sulfate up to 3.8 chondroitin sulfate/collagen(mole/mole). Further increase in the ratio of chondroitin sulfate to collagen did not change the fluorescence intensity. Similar changes in the relative fluorescence intensity were observed for both rat tail and lathyrific rat skin collagen. The fluorescence intensity indicated by the binding between bis-ANS and hydrophobic sites of collagen was pH dependent, and the shielding effect of collagen-chondroitin sulfate interaction could not be detected at pH above 6.0. This is probably due to the charge repulsions caused by negative charged collagen molecules at higher pH.

• Nuclear Engineering and Technology
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• 제45권7호
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• pp.921-928
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• 2013

A future nuclear energy system is being developed at Korea Atomic Energy Research Institute (KAERI), the system involves a Sodium Fast Reactor (SFR) linked with the pyro-process. The pyro-process produces a source material to fabricate a SFR fuel rod. Therefore, an isotopic fissile content assay is very important for fuel rod safety and SFR economics. A new technology for an analysis of isotopic fissile content has been proposed using a lead slowing down spectrometer (LSDS). The new technology has several features for a fissile analysis from spent fuel: direct isotopic fissile assay, no background interference, and no requirement from burnup history information. Several calculations were done on the designed spectrometer geometry: detection sensitivity, neutron energy spectrum analysis, neutron fission characteristics, self shielding analysis, and neutron production mechanism. The spectrum was well organized even at low neutron energy and the threshold fission chamber was a proper choice to get prompt fast fission neutrons. The characteristic fission signature was obtained in slowing down neutron energy from each fissile isotope. Another application of LSDS is for an optimum design of the spent fuel storage, maximization of the burnup credit and provision of the burnup code correction factor. Additionally, an isotopic fissile content assay will contribute to an increase in transparency and credibility for the utilization of spent fuel nuclear material, as internationally demanded.

• Journal of Welding and Joining
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• 제30권4호
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• pp.38-43
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• 2012

Using a fiber laser heat source, an oil pressure sensor was fabricated to measure the pressure in commercial vehicles. A stepping motor was used for the rotational and translational motion in the diaphragms and hardware joining. Laser welding process algorism including shielding gas control and vision system was integrated by using LabVIEW software for the high quality welding and in-line monitoring purpose. For the maximum flexibility in pressure transmission to the pressure sensor, thin sheet metal diaphragm, $25{\sim}50{\mu}m$(SUS-316L), was used and the diaphragms were optimally designed with FEM analysis. The welded samples were cross-sectioned the observation showed that the maximum depth ratio was more than seven times of diaphragms. The maximum welding speed was measured to be as high as 50in/mm by the developed automation mechanism. The fabricated prototypes were tested for the proof pressure, spring constant and sealing. The FEM results of spring constant measurement was as accurate as up to 80% of the design value and the sensor was safely operated up to the nominal pressure of 10bars.