• Nutrition Research and Practice
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• 제15권6호
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• pp.715-731
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• 2021

BACKGROUND/OBJECTIVES: Premenstrual syndrome (PMS) is a disorder characterized by repeated emotional, behavioral, and physical symptoms before menstruation, and the exact cause and mechanism are uncertain. Hyperprolactinemia interferes with the normal production of estrogen and progesterone, leading to PMS symptoms. Thus, we judged that the inhibition of prolactin hypersecretion could mitigate PMS symptoms. MATERIALS/METHODS: Hordeum vulgare L. extract (HVE), Chrysanthemum zawadskii var. latilobum extract (CZE), and Lomens-P0 the mixture of these extracts were tested in subsequent experiments. The effect of extracts on prolactin secretion at the in vitro level was measured in GH3 cells. Nitric oxide and pro-inflammatory mediator expression were measured in RAW 264.7 cells to confirm the anti-inflammatory effect. Also, the hyperprolactinemic Institute for Cancer Research (ICR) mice model was used to measure extract effects on prolactin and hormone secretion and uterine inflammation. RESULTS: Anti-inflammatory effects of and prolactin secretion suppress by HVE and CZE were confirmed through in vitro experiments (P < 0.05). Treatment with Lomens-P0 inhibited prolactin secretion (P < 0.05) and restored normal sex hormone secretion in the hyperprolactinemia mice model. In addition, extracts significantly inhibited the expression of pro-inflammatory biomarkers, including interleukin-1𝛽, and -6, tumor necrosis factor-𝛼, inducible nitric oxide synthase, and cyclooxygenase-2 (P < 0.01). We used high-performance liquid chromatography analyses to identify tricin and chlorogenic acid as the respective components of HVE and CZE that inhibit prolactin secretion. The Lomens-P0, which includes tricin and chlorogenic acid, is expected to be effective in improving PMS symptoms in the human body. CONCLUSIONS: The Lomens-P0 suppressed the prolactin secretion in hyperprolactinemia mice, normalized the sex hormone imbalance, and significantly suppressed the expression of inflammatory markers in uterine tissue. This study suggests that Lomens-P0 may have the potential to prevent or remedy materials to PMS symptoms.

• Journal of Preventive Medicine and Public Health
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• 제45권5호
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• pp.283-290
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• 2012

Objectives: People who have chronic diseases, as well as gait imbalance or psychiatric drug use, may be susceptible to injuries from falls and slips. The purpose of this study was to evaluate the effect of musculoskeletal diseases on incidental fall-related injuries among adults in Korea. Methods: We analyzed data from the 4th Korea National Health and Nutrition Examination Survey (2007-2009), which are national data obtained by a rolling survey sampling method. The 1-year incidence of fall-related injuries was defined by health service utilization within the last year due to injury occurring after a slip and fall, and musculoskeletal diseases included osteoarthritis, rheumatoid arthritis, osteoporosis, and back pain. To evaluate the effects of preexisting musculoskeletal diseases, adults diagnosed before the last year were considered the exposed group, and adults who had never been diagnosed were the unexposed group. Results: The weighted lifetime prevalence of musculoskeletal disease was 32 540 per 100 000 persons. Musculoskeletal diseases were associated with a higher risk of fall-related injury after adjustment for sex, age, residence, household income, education, occupation, visual disturbance, paralysis due to stroke, and medication for depression (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.03 to 1.93). As the number of comorbid musculoskeletal diseases increased, the risk of fall-induced injuries increased (p-value for trend <0.001). In particular, patients who had any musculoskeletal condition were at much higher risk of recurrent fall-related injuries (OR, 6.20; 95% CI, 1.06 to 36.08). Conclusions: One must take into account the risk of fall-related injuries and provide prevention strategies among adults who have musculoskeletal diseases.

• 한국임상보건과학회지
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• 제3권2호
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• pp.311-319
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• 2015

Purpose. This study of purpose was to compare and analyze the relationship among the isokinetic trunk muscular functions, flexibility and low back pain of elite weight lifter with regard of sex. Methods. we measured the level of low back pain, isokinetic muscular functions according to gender, then analyzed the relationship between isokinetic functions and the level of low back pain, between flexibility and the level of pain, between Athletic Career and the level. Results. In this study, the gender, the VAS point was $2.6{\pm}2.3$ and the VRS point was $2.3{\pm}1.3$ in males. The other side, in females the VAS points was $3.6{\pm}1.7$ and the VRS was $3.2{\pm}1.1$. There was significant negative correlation(r=-0.826) between the VAS point and the maximal flexion muscular strength per kilogram of $30^{\circ}/sec$ isokinetic exercise in female. also there was negative correlation between the muscular flexion strength per kilogram and the VRS point in female, but there was no significant relationship in male. Conclusions. In current study, these results suggested that the higher muscular flexion strength per kilogram is, the lower the level of low back pain is in female athletes. this is caused by the imbalance between Abdominal Muscles and Back Extensor in weight lifter. Therefore, there is the need to apply the program to improve the balance of trunk.

• 보건교육건강증진학회지
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• 제12권1호
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• pp.151-164
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• 1995

한국보건사회연구원의 조사결과에 의하면 이상적인 성비는 1960년의 160에서 1991년에는 130으로 크게 낮아졌다. 아직도 한국 부인들의 이상자녀수는 여아보다 남아가 더 많게 나타나고 있다. 남아의 가치에 대해서는 1960년대에는 노후봉양이 가장 으뜸가는 변수였으나, 최근에는 가계계승보다도 그 중요도가 떨어지고 있는 경향을 보이고 있다. 또한 정서적 유대, 즉 아들이 있어야 든든하다는 식의 주장이 보다 강한 이유로 지적되고 있다. 이러한 남아선호사상은 사회적으로 상당한 영향을 미치는 요인이 되고 있다. 즉 성비의 불균형과 장래의 결혼시장의 혼란이 초래된다는 문제가 그것이다. 예를 들면 현재 셋째 및 넷째 아이의 성비가 크게 상승하고 있는 문제이다. 즉, 1992년의 경우 첫째 아이의 출생성비는 여아 100명당 남아 196.5이고, 넷째 아이의 경우는 229.0으로 더욱 높게 나타났다. 그리고 2000년에는 결혼적령의 남녀 성비의 차이는 신부보다 신랑이 19.1%나 많아질 것이며, 이러한 차이는 2010년에 가면 더욱 심화되어 신부감보다 신랑감이 무려 28.6%가 초과될 전망이다. 가뜩이나 농촌 총각들이 장가 들기가 어려운 터에 장가 못갈 총각이 크게 늘어날 수 밖에 없는 사정이 된다면 사회적으로 큰 혼란이 야기될 것임에 틀림없다. 이러한 성비의 불균형이 초래되는 배경은 남아선호사상의 잔존으로 저출산 내에서 태아의 성을 감별함으로써 선택적인 인공유산을 하는데서 비롯되는 것으로 볼 수 있다. 따라서 현재에도 불식되지 않고 있는 남아선호사상에 대한 주의를 다시 한번 환기시켜야 할 것이다. 특히 이 분야의 보다 깊은 연구를 지속적으로 실시하여 대응전략의 제시에 노력해야 할 것이며, 우선 무엇보다도 여성들의 사회적 지위향상 등 여권신장에 관한 정책적 노력과 더불어 교육 홍보를 통한 노력이 강화되어야 할 것이다. 아울러 태아의 성감별 등 바람직하지 못한 의술남용 행위 등을 근절토록 보다 강력한 법적 적용에도 행정력을 집중시켜 나가야 할 것이다.

• Journal of Korean Neurosurgical Society
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• 제60권2호
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• pp.174-180
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• 2017

Objective : Proximal junctional kyphosis (PJK) is radiologic finding, and is defined as kyphosis of >$10^{\circ}$ at the proximal end of a construct. The aim of this study is to identify factors associated with PJK after segmental spinal instrumented fusion in adults with spinal deformity with a minimum follow-up of 2 years. Methods : A total of 49 cases of adult spinal deformity treated by segmental spinal instrumented fusion at two university hospitals from 2004 to 2011 were enrolled in this study. All enrolled cases included at least 4 or more levels from L5 or the sacral level. The patients were divided into two groups based on the presence of PJK during follow-up, and these two groups were compared to identify factors related to PJK. Results : PJK was observed in 16 of the 49 cases. Age, sex and mean follow-up duration were not statistically different between two groups. However, mean bone marrow density (BMD) and mean back muscle volume at the T10 to L2 level was significantly lower in the PJK group. Preoperatively, the distance between the C7 plumb line and uppermost instrumented vertebra (UIV) were no different in the two groups, but at final follow-up a significant intergroup difference was observed. Interestingly, spinal instrumentation factors, such as, receipt of a revision operation, the use of a cross-link, and screw fracture were no different in the two groups at final follow-up. Conclusion : Preoperative BMD, sagittal imbalance at UIV, and thoracolumbar muscle volume were found to be strongly associated with the presence of PJK.

• 대한한의학회지
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• 제19권2호
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• pp.211-227
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• 1998

Benign Prostatic Hyperplasia(BPH) is the most common benign tumor seen in the western male, and it is found in 50% of men over 50 years of age. It is characterized by the formation of large discrete lesions in the periurethral region. As they enlarge, these nodules tend to compress the urethra and cause partial or almost complete obstruction of .urine flow. The etiology of BPH is uncertain, but the increasing incidence with advancing age suggests the possibility of an imbalance between male and female sex hormones. In the past, most patients have had multiple indications to support the decision to initiate therapy. But both the urologic surgeon and the patient must be clearly aware of the results that can be expected and the risks involved in achieving them. The aims of this study are to investigate and summarize the current trends of treatment for BPH so as to suggest the effective and available way to treat the disease. In Oriental medicine, the BPH is recognized as uroschesis and ischuria, and the etiology is mainly in stagnated blood and insufficiency of the kidneys. The point of treatment of BPH is recovery of urination, and the treatment can be approached in two ways through herb drugs and acupuncture. Some of the herb drugs have substances which reduce BPB. Acupuncture therapy stimulates the pelvic plexus and is reported to be effective for voiding. Suppository, massotherapy, rectal injection, locus injection and attachment of herb drugs to the navel or the acupoint are announced as the effective treatments. So, this study of the approach and application of these treatments on BPH would be necessary.

• 치위생과학회지
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• 제21권4호
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• pp.213-218
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• 2021

Background: The purpose of this study is to identify the gender sensitivity and gender role stereotypes of students in dental hygiene and to provide basic data to expand social awareness of equal gender sensitivity and gender role in dental hygiene and students by identifying the degree of correlation. Methods: The purpose of this study was to study dental hygiene students at colleges in Gyeonggi and Chungcheong areas. The survey was conducted from April 1 to April 30, 2021. The final sample was analyzed on 157 subjects. T-test and ANOVA analysis were performed to compare gender sensitivity and gender role stereotypes according to general characteristics. Equal variances were tested using the Levene statistic, and significant differences between groups were identified through Scheffe's post hoc analysis. Pearson's correlation analysis was performed to confirm the correlation between gender sensitivity and gender role stereotypes. Results: Gender sensitivity was 2.69 and gender role stereotypes were 1.83. Among the sub-areas of gender sensitivity, gender role openness was the highest at 2.86, and non-violence was the lowest at 2.50. As for gender role stereotypes, social stereotypes were the highest among sub-areas at 1.71. Among the general characteristics, there was a statistically significant difference in gender sensitivity according to the presence or absence of opposite sex friends (p=0.011). The gender identity openness of gender sensitivity and the physical sub-areas of gender role stereotypes showed the highest positive correlation(r=0.955). Among the sub-areas of gender sensitivity, gender role openness and domestic stereotypes showed the lowest negative correlation (r=-0.404) among the sub-areas of gender role stereotypes. Conclusion: Dental hygiene students should be able to critically analyze and solve problems of not only sexual violence but also gender discrimination and imbalance in social life. For this, environmental factors such as school education and professor guidance must be strengthened.

• 대한정형도수물리치료학회지
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• 제24권2호
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• pp.51-58
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• 2018

Backdround: Using RUSI (Rehabilitation Ultra Sound Imiging) method, which showed high reliability in soft tissue measurements, we compared the muscle relax and contraction, sex, and physical characteristics of the activity of the multifidus muscle in patients with chronic low back pain and normal subjects. Methods: In this study, 16 patients (male: 8, female: 8) with chronic low back pain and 16 healthy adult (male: 8, female: 8) were participated. Subjects lied prone posture on the table with elbow flexed $90^{\circ}$ and shoulder abducted $120^{\circ}$ (starting position). Test was applied two types that muscle relax position and muscle contraction position. Muscle relax position is equal to starting position and muscle contraction position is that upper extremity lift up about 5cm from the table. We measured the thickness of the multifidus muscle in each position by ultrasound. Results: There was a statistically significant difference between the two groups in deviation of Both Side Difference of Activated resting-Arm Lifting Ratio according to posture change between the chronic low back pain patient group and the normal group. Conclusion: The result of this study support previous study showing that there is an imbalance in the activity of multifidus in patients with chronic low back pain.

• 한국인구학
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• 제21권2호
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• pp.182-227
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• 1998

정부는 1960년대 초기의 높은 인구증가율이 경제개발의 저해 요인임을 인식하여 1962년부터 시작되는 5개년 단우의 경제개발 장기계획의 일환으로 가족계획사업을 출산조절정책 수단으로 수용하였다. 초창기부터 가족계획사업은 정부의 보건조직망을 통하여 가족계획요원에 의한 피임보급 활동과 지정시술의사에 의한 자궁내장치 및 불임시술 서비스 등이 무료로 제공되었고 특히 피임방법별 목표량 제도와 규제 및 보상 등 사회제도적 지원시책으로 1980년대까지 지속적으로 사업이 강화되었다. 민간단체의 지원활동으로는 대한가족계획협회에 의한 계몽교육사업과 한국 보건사회연구원(초창기에는 가족계획연구원)에 의한 사업평가 및 조사연구사업이 활발히 이루어 졌다. 결과적으로 1960년에 6명 수준이던 합계출산율이 1980년대 중반에 대치수준(2.1)으로 저하되어 30년도 못되는 단기간에 인구전환을 이룩하는 획기적인 성과를 갖게 되었다. 그후 합계출산율은 1.6에서 1.7 범위의 저출산을 유지하고 있으며 이러한 수준이 지속된다면 현 1% 미만인 인구성장률은 2028년에 총인구가 5,060만 수준에서 그 성장을 멈추고 그 후로는 인구의 감소가 초래될 것으로 예상된다. 이에 정부는 1996년 6월에 기존의 인구억제정책을 전면적으로 폐지하고 인구자질향상에 역점을 두는 방향으로 공식적인 정책전환을 이룩하였다. 한편 남아선호사상 등 영향으로 태아의 성감별에 의한 성선별적 인공임신중절로 인하여 출생성비의 불균형이 심화되고 유배우 부인의 인공임신중절도 아직 상당수준으로 높게 지속되고 있어 삶의질 차원에서의 새로운 인구자질향상 정책이 특히 모자보건과 노인보건을 포함하는 전반적인 국민건강증진 프로그램과 함께 더욱 효과적으로 추진되어 복지사회 구현에 기여할 수 있는 사업으로 발전되는 것이 바람직할 것이다.

• 대한물리치료과학회지
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• 제7권2호
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• pp.711-725
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• 2000

The purpose of this study was to determine the effects of knee flexor isokinetic training on the mean peak torque of knee muscles and hamstrings-to-quadriceps ratio(H/Q ratio) in hemiplegia able to walk independently for more than 10 meters, to analyze the effect of torque increasing on functional aspects; fatigability and ambulation times, also. Forty-one adult subjects with hemiplegia secondary to a stroke partipated in this study. All participants were in/out patients at the College of Medicine, Pocheon CHA University, Pundang CHA General Hospital. The patients were allocated to two groups: one group exclusively for isokinetic maximal voluntary knee flexor training at $150^{\circ}$/sec(n=20) and the other exclusively for isokinetic maximal voluntary knee flexor training from $30^{\circ}$/sec to $150^{\circ}$/sec (n=21) gradually. The allocation was performed according to patient age, sex, affected side to minimize imbalance between the two training groups. Training was carried out from February 14th, 2000 to April 15th, 2000. Analysis of the data was done by means of t-test, x2-test, paired t-test, ANOVA, and multiple regression analysis. The results of this study were as follows: 1. There were no significant differences between the two groups in mean peak torque of knee muscles and relative decreases in knee extensor mean peak torque with increased knee flexor velocities before training (P<.05). 2.There was no significant differences between the two groups in the H/Q ratio, and no relative increases with increased knee flexor velocities before training. 3. there were significant changes in mean peak torque in group A after training(P<.05), but no significant differences as the velocity increased 4.there were significant changes in mean peak torque in group B after training(P<.05), but no significant differences as the velocity increased 5.there were no significant differences between the two groups, and no significant differences in mean peak torque increase rate between the groups with increased knee flexor velocities after training 6.H/Q ratio increased with increased knee flexor velocities between the two groups, but not statistically And there was no significant differences between the groups with increased knee flexor velocities 7.After training, Ambulation time and its decreasing rate decreased significantly in group B (P<.05) 8Before and after training, there was no significant differences between the groups in the fatiguability 9. In the multiple regression analysis, mean peak torque increase rate of the knee extensor and flexor were higher in group B than A(P<.05), and significantly higher with increased knee flexor velocities (P<.05) Also, training method influenced on Ambulation times decreases significantly(P<.05). Results indicated that knee flexor isokinetic training was effective to knee extensor and flexor mean peak torque increase in the hemiplegia able to walk independently for more than 10 meters. Therefore, we were able to conclude that gradual training from low to high velocity was more effective in the increase of mean peak torque of knee joint and decrease of Ambulation times than training only at high velocity.