• 대한한방소아과학회지
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• 제22권1호
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• pp.103-111
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• 2008

Objectives Seunggal-tang is one of the prescriptions of oriental herbal medicine, which has been applied to several allergic diseases such as atopic dermatitis. This study was planned to compare differences of anti-allergic effects based on different form of Seunggal-tang by manufacturing differently. Methods Two types herb medicine products were used; aqueous extract (SG-T, Seunggal-Tang) and powder (SG-S, Seunggal-San) which were made from the same mixed formula of Seunggal-tang. To investigate in vitro anti-allergic activities, rat basophilic leukemia (RBL-2H3) cells were treated with SG-T and SG-S for 1 hour, and then stimulated with the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187. We examined the release of beta-hexosaminidase, as a marker of degranulation, and the releases of tumor necrosis factor (TNF)-alpha and interleukin (IL)-4, as proinflammatory cytokines. Results SG-T and SG-S didn't have effects on cell viabilities in concentrations under 2㎎/㎖. In additionto that, SG-T more inhibited releasing ${\beta}$-hexosaminidase, TNF-${\alpha}$ and IL-4 than SG-S. Conclusions These results indicate that SG-T is more effective against mast cell-mediated allergic reactions than SG-S.

• 동의생리병리학회지
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• 제17권6호
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• pp.1564-1568
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• 2003

Urticaria is a common disease and a well known reaction pattern of the skin characterized by erythema or wheal and edema, that is result of a local leakage of plasma from minute vessel into the connective tissue of the dermis. The urticaria that lasts for more than six of eight weeks, is categorized as chronic urticaria. In Oriental medicine, urticaria is classified as Yeun-jin(慇疹) and similar to Poong-yeun-jin(風慇疹), Poong-so-yeun-jin(風瘙慇疹), Poong-yum-leu, Poong-dan(風丹) and Poong-jin-geu(風疹塊). We report four improved cases of chronic urticaria that had lasted for more than eight weeks. We regarded their chronic urticaria as wind-heat(風熱) and prescribed Bangpungtongsungsan-gami(防風通聖散加味) and Seunggaltang-gami(升葛湯加味) to these patients. These patients showed improvement of chronic urticaria.