• Korean Journal of Acupuncture
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• v.30 no.4
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• pp.272-280
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• 2013

Objectives : The aim of this study was to observe effects of manual acupuncture(MA), electro-acupuncture(EA) and moxibustion (MO) on the rat with loperamide-induced constipation. Methods : This study measured small intestinal motility and number of fecal pellets in rats with loperamide induced constipation. MA and EA(intensity, 5 times muscle twitch threshold) was applied for 30 minutes and MO was treated on 5 times moxa cautery to the groups divided with age and sex. Results : The small intestinal motility was decreased by ST36 EA and ST37 EA in 5 weeks male group and ST37 EA in 7 weeks male and female groups, and ST36 MO in 7 weeks female group, but it was increased by ST39 EA in 7 weeks male group and ST37 MO and ST39 MO in 7 weeks male group. The number of fecal pellets was decreased by MA, EA, MO of ST36 in all group except 5, 7 weeks male groups only, and MA, EA of ST37 in 5, 7 weeks male group and ST37 MO in 7 weeks female group, and ST39 EA in 5 weeks male group and 7 weeks female group and ST39 MO in 7 weeks female group, but increased by ST37 EA in 5 weeks female group and ST39 EA in 7 weeks male group. Conclusions : Although these differences do not have a established tendency, it suggests that acupuncture and moxibustion are experimentally dependent upon the sex and age on intestinal motility in rats.

• Korean Journal of Oriental Medicine
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• v.2 no.1
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• pp.289-306
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• 1996

This study are performed to reveal the origin of the Sasang constitutional theory made by Lee-jae-ma(李濟馬), confucianist as well as famous oriental doctor, who succeeded to Han- suck-jie(韓錫地)'s Anti-Neo-Confucianism. Han wrote a book na mod Myung-Suen-Lock(明善錄) which criticized Neo-Confucianism formed at times of Song dynasty in China and proposed a new doctrine i.e Anti-Neo-Confucianism. He asserted that The Sacred and Ordinary Men are all the same in nature, and that The Acatul Mind of Universe and The Actual Mind of Human also are all the same ultimately These two assertions cleary contrasted with pre-existing Neo-confucianism led Lee-jae-ma to successively organize Sasang constitutional theoy. This study is aimed to illuminate this point : How under the effects of Han's new doctrine Lee-jae-ma could find four general constitutions due to the functional variation of the four organs. At first, Lee indicated four organs as the very general basement providing human nature for all men including The Sacred. In consequence, he justified one of the Han's assertions that The Sacred and Ordinary Men are all the same in nature. Secondly, Lee indicated the Mind as the actual center which bring forth the individual spontaneity. As far as this individual spontaneity is rightly aimed, which means harmonize his own's with the actual process of the Universe, all men could be The Sacred. So he come to justify the other of Han's assertions that The Actual Mind of Universe and The Actual Mind of Human also are all the same ultimately. Therefore, it is clearly verified that the Lee-jae-ma's Sasang doctrine is the successive achievement origined from Han-suck-jie(韓錫地)'s Anti-Neo-Confucianism abundantly represented in his own book, Myung-Suen-Lock.

• Food Science of Animal Resources
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• v.26 no.2
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• pp.218-222
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• 2006

This study was conducted to determine the effect of L. casei KCTC 3109 on physico-chemical characteristics and TBARS values of fermented pork meat. Each pork meat were allotted to two treatments ; Control (0%), $T_1$ (supplemented with L. casei KCTC 3109 10%). The pH tenderness and water holding capacity (WHC) of $T_1$ were higher than those of control (p<0.05), cooking loss of control was higher than $T_1$. Water content, crude Int and ash were not significantly different crude protein was higher in $T_1$ compared with control (p<0.05). $L^*,\;a^*$ and $b^*$ values of control were higher than those of $T_1$ (p<0.05). TBARS values was higher in $T_1$(0.02 MA mg/1,000 g) than control (0.19 MA mg/1,000g) (P<0.05).

• Atmosphere
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• v.30 no.2
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• pp.155-167
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• 2020

In order to produce more detailed and accurate information of river discharge and freshwater discharge, global high-resolution hydrodynamic model (CaMa-Flood) is applied to an operational land surface model of global seasonal forecast system. In addition, bias correction to grid runoff for the hydrodynamic model is attempted. CaMa-Flood is a river routing model that distributes runoff forcing from a land surface model to oceans or inland seas along continentalscale rivers, which can represent flood stage and river discharge explicitly. The runoff data generated by the land surface model are bias-corrected by using composite runoff data from UNH-GRDC. The impact of bias-correction on the runoff, which is spatially resolved on 0.5° grid, has been evaluated for 1991~2010. It is shown that bias-correction increases runoff by 30% on average over all continents, which is closer to UNH-GRDC. Two experiments with coupled CaMa-Flood are carried out to produce river discharge: one using this bias correction and the other not using. It is found that the experiment adapting bias correction exhibits significant increase of both river discharge over major rivers around the world and continental freshwater discharge into oceans (40% globally), which is closer to GRDC. These preliminary results indicate that the application of CaMa-Flood as well as bias-corrected runoff to the operational global seasonal forecast system is feasible to attain information of surface water cycle from a coupled suite of atmospheric, land surface, and hydrodynamic model.

• Journal of Ginseng Research
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• v.47 no.3
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• pp.440-447
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• 2023

Background: The human hair follicle undergoes cyclic phases-anagen, catagen, and telogen-throughout its lifetime. This cyclic transition has been studied as a target for treating hair loss. Recently, correlation between the inhibition of autophagy and acceleration of the catagen phase in human hair follicles was investigated. However, the role of autophagy in human dermal papilla cells (hDPCs), which is involved in the development and growth of hair follicles, is not known. We hypothesized that acceleration of hair catagen phase upon inhibition of autophagy is due to the downregulation of Wnt/β-catenin signaling in hDPCs, and that components of Panax ginseng extract can increase the autophagic flux in hDPCs. Methods: We generated an autophagy-inhibited condition using 3-methyladenine (3-MA), a specific autophagy inhibitor, and investigated the regulation of Wnt/β-catenin signaling using the luciferase reporter assay, qRT-PCR, and western blot analysis. In addition, cells were cotreated with ginsenoside Re and 3-MA and their roles in inhibiting autophagosome formation were investigated. Results: We found that the unstimulated anagen phase dermal papilla region expressed the autophagy marker, LC3. Transcription of Wnt-related genes and nuclear translocation of β-catenin were reduced after treatment of hDPCs with 3-MA. In addition, treatment with the combination of ginsenoside Re and 3-MA changed the Wnt activity and hair cycle by restoring autophagy. Conclusions: Our results suggest that autophagy inhibition in hDPCs accelerates the catagen phase by downregulating Wnt/β-catenin signaling. Furthermore, ginsenoside Re, which increased autophagy in hDPCs, could be useful for reducing hair loss caused by abnormal inhibition of autophagy.

• The Journal of the Petrological Society of Korea
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• v.28 no.4
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• pp.251-277
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• 2019

The Gogunsan Archipelago is composed of two island groups; the first group includes Mal-do, Myeong-do, Gwangdae-do, and Bangchuk-do islands consisting of Neoproterozoic rocks, and the second group includes Yami-do, Sinsi-do, Muneo-do, Jangja-do, and Seonyu-do islands consisting of Cretaceous rocks. The first group mainly consists of the Bangchuk formation which can be divided into two layers; the lower layer was more deformed than the upper layer. The former was intruded by mafic and felsic volcanic rocks formed in the volcanic arc tectonic setting 930-890 Ma and the latter was deposited ca. 825-800 Ma. In these islands, large scale folds with east-west fold axes were beautifully formed; the Maldo island fold was designated as natural monument and large scale beautiful chevron fold was developed on the Gwangdae-do island. In addition, there are unique zebra-shaped outcrop formed by a mixing of basic and acidic magma and Independent Gate shaped outcrop formed by coastal erosion. On the other hand, the Yami-do, Sinsi-do, Muneo-do, Jangja-do and Seonyu-do islands consist of 92-91Ma Cretaceous volcanic rocks and, in Sinsi-do island, the Nanshan formation deposited ca. 92 Ma. These Cretaceous volcanic rocks formed by melting of the continental crust by the heat supplied from the uplifting mantle due to the extension caused by a retreat of subducting ocean slab. Yami-do and Sinsi-do islands are composed of rhyolite. In Yami-do island, bands with vertical joint formed by cooling of the bottom part of the lava, are shown. In Sinsi-do island, large-scale vertical joints formed by cooling of lava flow, were developed. The Jangja-bong of Jangja-do island and Mangju-bong of Seonyu-do island are composed of brecciated rhyolite and formed a ring shaped archipelago contributing to the development of marine culture by providing natural harbor condition. They also provide beautiful views including 'Seonyu 8 views' along with other islands. As mentioned above, the Gogunsan archipelago is rich in geoheritages and associated cultural and historical resources, making it worth as a National Geopark.

• Korean Journal of Mineralogy and Petrology
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• v.36 no.2
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• pp.125-134
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• 2023

The Naedeokri and Nonggeori granites are early Proterozoic granites of the Taebaek-Sangdong area in the northeastern part of the Yeongnam Massif. In this paper, rare earth elements (REEs) concentrations of the minerals in Naedeokri and Nonggeori granites and Rb-Sr mineral isochron age are reported. Except zircon, the constituent minerals such as mica, feldspar, quartz, and tourmaline show LREE-enriched and HREE-depleted REE patterns with relatively large Eu negative anomaly. However, zircon has geochemical characteristic of LREE- and HREE-enriched REE pattern with large Eu positive anomaly. This pattern suggests that zircon should be hydrothermal zircon due to deuteric hydrothermal alteration. In addition, the Rb-Sr mineral age of Naedeokri granite indicates an age value of 1.814±142(2σ) Ma. The Rb-Sr whole rock age including pervious data of Naedeokri and Nogggeori granite indicates an age value of 1,707±74(2σ) Ma. This value is younger than the Sm-Nd isochron of 1.87 Ga, indicating that the Rb-Sr isotope system may be re-homogenized by hydrothermal alteration during the transition from a magmatic to a hydrothermal system.

• 한국약용작물학회:학술대회논문집
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• 2008.11a
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• pp.471-472
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• 2008

• 대한예방의학회:학술대회논문집
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• 2002.10a
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• pp.332-333
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• 2002

• Proceedings of the Korean Society of Crop Science Conference
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• 2005.10b
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• pp.264-265
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• 2005