• 한국물환경학회지
• /
• 제34권3호
• /
• pp.301-307
• /
• 2018

This study investigated the effects of sediment removal on water quality and phytoplankton development by setting up mesocosms at Uiam Lake, South Korea, and analyzing the environmental parameters and phytoplankton communities between June and October 2015. The comparison between testbed without sediment removal (TB-1) and testbed after sediment removal (TB-2) gave similar values for water temperature, pH, dissolved oxygen (DO), and electrical conductivity. Nevertheless, the average electrical conductivities of the two testbeds were $139{\mu}S/cm$ and $135{\mu}S/cm$, which were lower than the value obtained from the external control point (TB-con; $154{\mu}S/cm$). The small difference in total phosphorus (TP) and total nitrogen (TN) concentrations between the two testbeds implied that sediment removal did not greatly reduce nutrients; however, the phytoplankton cell count had decreased by approximately 37 % in TB-2 (average 1,663 cells/mL) compared to TB-1 (average 2,625 cells/mL). Compared to TB-con, the phosphorus and nitrogen concentrations of the two testbeds had decreased by 39 % and 30 %, respectively, whereas the phytoplankton abundance had decreased by up to 73 %, perhaps because of the blocked inflow of nutrients and the stabilized body of water caused by the installation of the mesocosm. The concentration of geosmin was lower in testbeds than in the external point, because installation of the structures had reduced the cyanobacteria biomass.

• 한국지하수토양환경학회지:지하수토양환경
• /
• 제15권6호
• /
• pp.9-16
• /
• 2010

Groundwater sampling was performed at 38 wells where they are located in the areas with high uranium and radon (marked as A and B, respectively) concentrations, which were based on the previous research results. In-situ parameters (temperature, pH, EC, Eh, DO) and natural radionuclides (uranium and radon) were analyzed to figure out the characteristics of groundwater environments. In-situ data did not show any relations to natural radionuclide data, which could be caused by groundwater mixing, depths of wells, and geological settings, etc. But the highest radon well presented relatively low temperature value and the highest uranium well presented relatively low pH values The highest uranium concentration ranging $1.14{\sim}188.19{\mu}g/L$ showed in the area of A region consisted of Jurassic two-mica granite. The areas of Jurassic biotite granite and Cretaceous granite in the A region have the uranium concentrations ranging $0.10{\sim}49.78{\mu}g/L$ and $0.36{\sim}3.01{\mu}g/L$, respectively. The uranium values from between wells of community water systems (CWSs) penetrating fractured bed-rock aquifers and personal boreholes settled in shallow aquifers near the wells of CWSs show big differences. It implies that the groundwaters of the two areas have evolved from different water-rock interaction paths that may caused by various types of wells having different aquifers. High radon activities in the area of B region composed of Precambrian gneiss showed ranging from 6,770 to 64,688 pCi/L. Even though the wells are located in the same geological settings, their rodon concentration presented different according to depth and distance.

• The Korean Journal of Pain
• /
• 제28권1호
• /
• pp.11-21
• /
• 2015

Background: Epidural injections are performed utilizing 3 approaches in the lumbar spine: caudal, interlaminar, and transforaminal. The literature on the efficacy of epidural injections has been sporadic. There are few high-quality randomized trials performed under fluoroscopy in managing disc herniation that have a long-term follow-up and appropriate outcome parameters. There is also a lack of literature comparing the efficacy of these 3 approaches. Methods: This manuscript analyzes data from 3 randomized controlled trials that assessed a total of 360 patients with lumbar disc herniation. There were 120 patients per trial either receiving local anesthetic alone (60 patients) or local anesthetic with steroids (60 patients). Results: Analysis showed similar efficacy for caudal, interlaminar, and transforaminal approaches in managing chronic pain and disability from disc herniation. The analysis of caudal epidural injections showed the potential superiority of steroids compared with local anesthetic alone a 2-year follow-up, based on the average relief per procedure. In the interlaminar group, results were somewhat superior for pain relief in the steroid group at 6 months and functional status at 12 months. Interlaminar epidurals provided improvement in a significantly higher proportion of patients. The proportion of patients nonresponsive to initial injections was also lower in the group for local anesthetic with steroid in the interlaminar trial. Conclusions: The results of this assessment show significant improvement in patients suffering from chronic lumbar disc herniation with 3 lumbar epidural approaches with local anesthetic alone, or using steroids with long-term follow-up of up to 2 years, in a contemporary interventional pain management setting.

• 한국정보통신학회논문지
• /
• 제16권12호
• /
• pp.2800-2807
• /
• 2012

애드-혹 네트워크는 기간망에 의존하지 않고, 노드들끼리 자율적으로 데이터 이동 경로를 형성하는 네트워크이다. 일반적으로 애드-혹 네트워크는 다중-홉 통신을 기반으로 하며 네트워크의 규모가 커질수록 경로 설정을 위한 제어 패킷의 양이 급격히 증가하게 되고 노드의 수명이 단축 된다. 이러한 노드들의 특성으로 인해서 네트워크 크기에 따른 보다 에너지 효율성 적용이 가능한 경로 설정 기법에 대한 연구가 요구되고 있다. 본 논문에서는 특히 계층적인 클러스터 구조 기반의 애드-혹 네트워크 환경에서 노드가 동질적 공간-포아송의 조건에서 노드의 분포 밀도와 속성정보를 고려한 클러스터의 계층 깊이 결정 알고리즘인 CACHE-R(Context-Aware Clustering Hierarchy, Efficient and Resilient)를 제안한다. 제안하고자 하는 CACHE-R기법은 최적화된 계층의 깊이와 속성정보를 적용함으로써 에너지 보존적인 경로를 설정하여, 전체 네트워크의 에너지 소비량을 감소시키고 네트워크 수명을 향상되는 특성을 보여주었다.

• 약학회지
• /
• 제49권3호
• /
• pp.230-236
• /
• 2005

The purpose of this study was to investigate the effect of naringin pretreatment on the bioavailability and phar-macokinetics of diltiazem and one of its metabolites, deacetyldiltiazem, in rabbits. Pharmacokinetic parameters of diltiazem and deacetyldiltiazem were determined after oral administration of diltiazem (15 mg/kg) pretreated with naringin (1.5, 7.5 and 15 mg/kg). Absorption rate constant ($k_a$) of diltiazem after oral administration of diltiazem pretreated with naringin was significantly (p<0.05 or p<0.0l) increased compared to the control group. Area under the plasma concentration-time curve (AUC) and peak concentration ($C_{max}$) of the diltiazem were significantly (p<0.05 or p<0.01) higher than those of the control. Absolute bioavailability ($AB\%$) of diltiazem pretreated with naringin ranged from $13.5\%$ to $18.6\%$, being enhanced compared to that of the control, $7.2\%$. Relative bioavailability ($RB\%$) of diltiazem was $1.9\~2.6$ times higher than that of the control group. There was no significant change in terminal half-life ($t_{1/2}$) and $T_{max}$ of diltiazem in the presence of naringin. AUC of deacetyldiltiazem pretreated with naringin was significantly (p<0.05) higher than (p<0.05) that of the control. But the metabolite ratios (MR) were significantly decreased (p<0.05), implying that pretreatment of naringin could be effective to inhibit the CYP 3A4-mediated metabolism of diltiazem. In this study, pretreatment of naringin significantly enhanced the oral bioavailability of diltiazem. These results suggested that the diltiazem dosage should be adjusted when it is administered with naringin or a naringin-containing dietary supplement in the clinical setting.

• Journal of Pharmaceutical Investigation
• /
• 제34권3호
• /
• pp.185-192
• /
• 2004

The objective of this study was to evaluate the effects of surfactant type and concentration upon dissolution rates of carbamazepine from an immediate-release tablet. The dissolution media used in this study were aqueous solutions containing 0.1-2% sodium lauryl sulfate, cetyltrimethylammonium bromide, or polysorbate 80. The solubility of carbamazepine in the dissolution media was determined at first. A dissolution study was then conducted by using the USP dissolution apparatus II (paddle method) with an agitation rate of 75 rpm. Aliquots of the dissolution media were taken at predetermined time intervals, and the amount of carbamazepine dissolved was measured spectrophotometrically at 285 nm. The dissolution data obtained were fitted into a biphasic exponential equation with four parameters. Excellent correlations were observed between the experimental data and the theoretical ones predicted by the equation. This equation permitted the calculation of $T_{50%}$ (the time required for dissolving 50% of carbamazepine) under various experimental conditions. Differentiation of the equation also led to the attainment of dissolution rates at dissolution time points. The addition of a surfactant to an aqueous solution led to increasing the solubility of carbamazepine by 3- to 12-folds, depending upon its type and concentration. This event also resulted in enhancing the magnitude of a sink condition during the dissolution study. As a result, the dissolution rate of carbamazepine was affected by the aqueous surfactant concentration in a proportional manner. Subsequently, $T_{50%}$ values declined rapidly, as the surfactant concentration increased. Such effects were observed in decreasing order of sodium lauryl sulfate, cetyltirmethylammonium bromide, and polysorbate 80. These results clearly demonstrated that it was possible to tailor a dissolution rate and $T_{50%}$ of carbamazepine by manipulating the type and concentration of a surfactant. Relevant information would be beneficial to setting up dissolution specifications for poorly water-soluble drug products.

• 한국정보통신학회논문지
• /
• 제14권4호
• /
• pp.831-840
• /
• 2010

무선 인터넷 서비스 특히 PDA, 스마트 폰과 같이 이동성이 높은 무선 단말들의서비스가 활성화 되면서 현재 많은 사용자들은 공간에 제약 없이 다양한 인터넷 서비스들을 사용할 수 있게 되었다. 그러나 사용자가 다양한 무선네트워크를 사용함에 따라 서로 다른 네트워크를 이동 할 경우 이기종 간의 네트워크에서 핸드오버를 지원할 수 있는 기술이 미흡하기 때문에 네트워크 설정에 있어 많은 제약이 발생한다. 따라서 본 논문에서는 PMIPv6에서 IEEE8 02.21 MIH를 활용하여 이 기종 네트워크간의 핸드오버를 지원하고 핸드오버 지연시간을 단축할 수 있는 기법을 제안하고, 제안 기법에 대하여 저속과 고속에서의 이동성을 바탕으로 성능 평가하여, 기존의 PMIPv6 에서의 핸드오버 지연시간에 대하여 26%의 지연시간 단축을 통해 향상된 성능을 확인하였으며 손실되는 데이터 역시 최대 90% 이상 줄일 수 있었다.

• 한국정보통신학회논문지
• /
• 제20권10호
• /
• pp.1881-1886
• /
• 2016

본 논문에서는 기지국의 도움없이 인접한 기기 간에 직접 통신을 수행하는 D2D 단말에서 발생한 데이터를 인접한 D2D 단말로 릴레이하는 환경을 가정하였다. 이러한 환경에서 데이터를 수신한 전체 단말의 수를 최대화하기 위하여 모든 데이터 수신 단말들이 자신의 전송 범위 내의 인접 단말들에게 데이터를 릴레이하는 Epidemic 라우팅을 고려하였다. 또한, 다양한 네트워크 환경을 고려하여 특정 지역에 다양한 밀도로 단말이 밀집되어 분포하는 상황에 대한 MATLAB 시뮬레이션을 수행하고, 이를 기반으로 D2D SD의 전송 범위와 이 데이터를 릴레이 하는 다른 D2D 단말들의 전송 범위를 파라미터로 설정하여 Epidemic 라우팅의 데이터 확산 성능에 대한 비교 분석을 수행하였다.

• Archives of Pharmacal Research
• /
• 제28권8호
• /
• pp.970-976
• /
• 2005

The purpose of this study was to investigate the effect of morin, a flavonoid, on the pharmacokinetics of diltiazem and one of its metabolites, desacetyldiltiazem in rats. Pharmacokinetic parameters of diltiazem and desacetyldiltiazem were determined after oral administration of diltiazem (15 mg/kg) in rats pretreated with morin (1.5, 7.5, and 15 mg/kg). Compared with the control group (given diltiazem alone), pretreatment of morin significantly increased the absorption rate constant $(K_a)$ and peak concentration $(C_{max})$ of diltiazem (p<0.05, p<0.01). Area under the plasma concentration-time curve (AUC) of diltiazem in rats pretreated with morin were significantly higher than that in the control group (p<0.05, p<0.01), hence the absolute bioavailability $(AB\%)$ of diltiazem was significantly higher than that of the control group (p<0.05, p<0.01). Relative bioavailability $(RB\%)$ of diltiazem in rats pretreated with morin was increased by 1.36- to 2.03-fold. The terminal half-life $(t_{1/2})$ and time to reach the peak concentration $(T_{max})$ of diltiazem were not altered significantly with morin pretreatment. AUC of desacetyldiltiazem was increased significantly (p<0.05) in rats pretreated with morin at doses of 7.5 and 15 mg/kg, but metabolite-parent ratio (MR) of desacetyldiltiazem was decreased significantly (p<0.05), implying that pretreatment of morin could be effective to inhibit the CYP 3A4-mediated metabolism of diltiazem. There were no apparent changes of $T_{max}$ and $t_{1/2}$ of desacetyldiltiazem with morin pretreatment. Collectively, the pretreatment of morin significantly altered pharmacokinetics of diltiazem, which can be attributed to increased intestinal absorption as well as reduced first-pass metabolism. Based on these results, dose modification should be taken into consideration when diltiazem is used concomitantly with morin or morin-containing dietary supplements in clinical setting.

• 한국음향학회지
• /
• 제39권4호
• /
• pp.237-245
• /
• 2020

수중표적의 저소음화로 표적의 방사소음이 감소함에 따라 수동소나의 한계가 나타나면서 신호를 송신하고 표적 반사 신호를 탐지하는 능동탐지에 대한 연구가 활발해 지고 있다. 일반적으로 선체고정소나(Hull-Mounted Sonar, HMS)를 이용한 능동탐지 시 음파가 도달하지 않는 음영구역을 줄이기 위해 수직지향각을 조정하면서 다수의 Linear Frequency Modulation(LFM) 부펄스를 대역분할하여 순차적으로 송신한다. 하지만 최근에 Sinusoidal Frequency Modulation(SFM)의 일반화된 형태인 Generalized SFM(GSFM) 펄스가 제안되었고, 파라미터 설정에 따라 GSFM 부펄스 간에 직교성이 확인되었다. 따라서, 본 논문에서는 GSFM을 선체고정소나의 다중 수직지향각 능동탐지에 활용함으로써 부펄스의 대역폭 사용을 극대화 하여 신호처리 이득에 따른 능동탐지 성능을 향상 시킬 수 있음을 보였다. 모의실험을 통해 부펄스가 3개일 때, GSFM이 LFM 대비 약 5 dB 정도의 정합필터 이득이 있음을 확인하였다.