• 대한약침학회지
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• 제16권3호
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• pp.23-29
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• 2013

Objectives: Dyslipidemia in diabetes mellitus is a significant risk factor for the development of cardiovascular complications. The aim of this study was to evaluate the effect of the ethyl-acetate fraction of an ethanolic extract from Streospermum suaveolens on lipid metabolism in streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes was induced by intraperitonial injection of STZ (50 mg/kg). Diabetic rats were treated with an ethyl-acetate fraction orally at doses of 200 and 400 mg/kg daily for 14 days. On the $15^{th}$ day, serum lipid profiles, such as total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were estimated in experimental rats. The atherogenic (AI) and the coronary risk (CRI) indices were also evaluated. Results: The ethyl-acetate fraction at doses of 200 and 400 mg/kg significantly (P < 0.001) and dose-dependently reduced serum cholesterol, triglycerides and LDL, but increased HDL towards near normal levels as compared to diabetic control rats. The fraction also significantly (P < 0.001) lowered the atherogenic index (AI) and coronary risk index (CAI) in a dose-dependent manner. Conclusion: The present study demonstrated that the ethyl-acetate fraction of Stereospermum suaveolens exhibits a potent antihyperlipidemic activity in hyperglycemic rats and suggests that the plant may have therapeutic value in treating the diabetic complication of hyperlipidemia.

• Journal of Nutrition and Health
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• 제31권5호
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• pp.927-938
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• 1998

Epidemiological studies have indicated that a relationship between overweight and cardiovascular disease exists. To assess the relationship of unfavorable changes in serum lipid concentrations, apolipoprotein B, lipoprotein(a), blood sugar and blood pressure to anthropometric variables, nutrient intakes and dietary behavior,64 obese children were chosen as subjects and 24-hour dietary intake, dietary behavior as well as blood pressure, apolipoprotein B, lipoprotein(a), three kinds of cholesterol concentrations were measured in November 1976. More than half(57.8%) of the children had serum cholesterol concentrations over 175mg/d1, and 26.6% of them had over 200mg/d1 and this group could be classified as a high risk group. Abdominal obesity as measured with waist circumference and waist hip ratio was negatively co..elated to high density lipop개tein(HDL) cholesterol. Dietary behavior rather than nutrient intakes appeared to have associations with unfavorable lipid profiles. Total dietary behavior scores and fish and bean product consumption had strong correlations with potentially atherogenic lipoprotein concentrations. This study suggests that fir the early prevention of cardiovascular disease, waist hip ratio together with obese rate should be included in selective programs to identify risk group of children in Korea. furthermore, interventions in cardiovascular disease risk groups in obese children should emphasize maintenance of ideal body weight through reducing body fat and adopting desirable dietary behaviors such as increasing intake of fish or bean products. (Korean J Nutrition 31(5) : 927~938, 1998)

• 대한방사선기술학회지:방사선기술과학
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• 제30권4호
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• pp.365-371
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• 2007

최근 연구들은 골다공증과 동맥경화증의 병인 간의 연관성을 제시한다. 이 연구에서는 건강한 중년 여성에서 high-sensitivity C-reactive protein(hs-CRP), 지질 농도 등을 포함한 심혈관 위험인자들과 요추 골밀도의 상관관계를 분석하였다. 총 300명의 성인여성을 대상으로 하여 신체계측을 시행하였고, 공복혈당, 지질, hs-CRP를 포함한 심혈관질환 위험인자들을 측정하였다. 동맥경화지수는 총콜레스테롤 농도를 고밀도지단백 콜레스테롤 농도로 나누어서 계산하였다. Dual X-ray abosorptiometry를 이용하여 요추 골밀도를 측정하였다. 연구결과 연령, 수축기 및 이완기 혈압, 총 콜레스테롤, 고밀도지단백 콜레스테롤은 요추 골밀도와 음의 상관관계를 보였다. 통계적으로는 연령과 체질량지수, 고밀도지단백 콜레스테롤이 요추 골밀도와 의미 있는 상관관계를 보였다. 요추 골밀도에 영향을 미치는 심혈관 인자들은 연령과 고밀도지단백 콜레스테롤이 요추 골밀도($R^2=0.272$)의 독립적 위험인자로 나타났다.

• Advances in Traditional Medicine
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• 제8권3호
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• pp.279-285
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• 2008

Diospyros peregrina Gurke. (Ebenaceae) is a small middle sized tree grows luxuriantly in the plains of costal West Bengal, India. The objective of the study was to explore the antidiabetic activity of methanol extract of matured fruits of Diospyros peregrina to substantiate the folklore claim of traditional practitioners. It was also aimed to establish correlation with reduction of oxidative state associated with diabetes. Methanol extract of matured fruits of Diospyros peregrina was administered orally at doses of 150 and 300 mg/kg body weight for 12 consecutive days to normal and streptozotocin induced diabetic rats. Fasting blood glucose level was estimated in both normal and diabetic rats while serum lipid profiles, liver glycogen level and pancreatic thiobarbituric acid reactive substances (TBARS) were evaluated for diabetic rats. Initial and final changes in body weight were also recorded. Oral glucose tolerance test was performed during the course of study. Experimental findings showed significant antidiabetic potential of extract in term of reduction of fasting blood glucose level of both normal and diabetic rats. It was found that extract at the dose of 300 mg/kg body weight is more effective and percentage reduction (55.64) of elevated blood glucose level is comparable to that of standard drug glibenclamide (60.60) at a dose of 10 mg/kg body weight. Observed data found statistically significant in reduction of serum lipid and pancreatic TBARS levels whilst improvement was observed in liver glycogen level and body weight profiles in extract treated diabetic rats.

• 대한지역사회영양학회지
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• 제19권1호
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• pp.27-40
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• 2014

Dyslipidemia is a component of the metabolic syndrome and a risk factor for cardiovascular diseases. Nutrition counseling is important to improve dyslipidemia. The purpose of this study was to evaluate the effectiveness of nutrition counseling in adults with risk factors for dyslipidemia diagnosed by the national health screening program. The nutrition counseling for adults with risk factors for dyslipidemia was carried out at a public health center in Gyeonggi-do. Thirty four patients out of forty five participants in the program completed the nutrition counseling program. The nutrition counseling was provided 3 times during a 12-week period. Individualized nutrition counseling to improve dietary habits was conducted after examining participants' dietary intake through questionnaires about dietary habits and whether they practice dietary guidelines. Data about serum lipid profiles, body composition, nutrition knowledge, the practice of dietary guidelines, and dietary behavior were collected before and after nutrition counseling to evaluate the effectiveness of nutrition counseling. All data were statistically analyzed by SPSS program (Korea ver.18.0) and significant difference was evaluated by paired t-test and ${\chi}^2$-test. Body weight, body fat and WHR were significantly decreased after nutrition counseling. Total-cholesterol, TG, and LDL-cholesterol were significantly decreased but HDL-cholesterol did not show significant changes. Both scores of nutrition knowledge and the practice of dietary guidelines improved significantly (p < 0.001). This study shows that nutrition counseling helps to encourage healthy eating practices and to improve serum lipid profiles of adults with risk factors for dyslipidemia. Overall, results indicated that nutrition counseling resulted in positive changes to lower the reliance on medications. Therefore, nutrition counseling should be considered for the initial treatment of dyslipidemia.

• Nutrition Research and Practice
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• 제5권1호
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• pp.28-33
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• 2011

Limited information from human studies indicates that dietary quercetin supplementation influences blood lipid profiles, glycemic response, and inflammatory status, collectively termed cardiometabolic risks. We tested the hypothesis that quercetin-rich supplementation, derived from onion peel extract, improves cardiometabolic risk components in healthy male smokers in a randomized, double blinded, placebo-controlled parallel design. Randomly assigned subjects were instructed to take either the placebo (n=43) or 100 mg quercetin capsules each day (n=49) for 10 weeks. Anthropometric parameters and blood pressure were measured, and blood lipids, glucose, interleukin-6, and soluble vascular cell adhesion molecule-1 (sVCAM-1) were determined at baseline and after 10 weeks of quercetin supplementation. Quercetin-rich supplementation significantly reduced serum concentrations of total cholesterol (P<0.05) and LDL-cholesterol (P<0.01), whereas these effects were not shown in the placebo group. Furthermore, significant increases were observed in serum concentrations of HDL-cholesterol both in the placebo (P<0.005) and quercetin-rich supplementation group (P<0.001); however, changes in HDL-cholesterol were significantly greater in subjects receiving quercetin-rich supplementation than the placebo. Both systolic (P<0.05) and diastolic blood pressure (P<0.01) decreased significantly in the quercetin-rich supplementation group. Glucose concentrations decreased significantly after 10 weeks of quercetin-rich supplementation (P<0.05). In contrast, no effects of quercetin-rich supplementation were observed for the inflammatory markers-IL-6 and sVCAM-1. Daily quercetin-rich supplementation from onion peel extract improved blood lipid profiles, glucose, and blood pressure, suggesting a beneficial role for quercetin as a preventive measure against cardiovascular risk.

• 한국식품영양과학회지
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• 제34권8호
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• pp.1175-1181
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• 2005

녹즙분말과 콜레스테롤 첨가식이로 8주간 사육한 흰쥐의 혈중 지질, 호모시스테인 및 엽산수준에 미치는 효과를 관찰한 결과는 다음과 같다. 흰쥐의 혈중 총 콜레스테롤 농도는 녹즙이나 콜레스테롤 보충에 의해 유의한 영향을 받지 않았으나 중성지질 농도는 녹즙군에서 낮았다(p<0.001). HDL-콜레스테롤과 LDL-콜레스테롤의 경우, 식이 콜레스테롤의 영향을 받아, HDL-콜레스테롤은 콜레스테롤군보다 무콜레스테롤군에서 높았으며 (p<0.001), LDL-콜레스테롤은 콜레스테롤군에서 높았다(p<0.05). HDL-콜레스테롤 수준은 녹즙군에서 높았으며 (p<0.05), LDL-콜레스테롤 농도는 콜레스테롤과 케일의 상호효과가 나타나 무콜레스테롤군에서 만 녹즙에 의한 감소효과를 보였다 HDL/LDL비율은 콜레스테롤 보충군에서 낮았으며 (p<0.05), 녹즙보충군에서 높았으나 통계적으로 유의한 결과를 나타내지 못하였다. 혈청 엽산, 비타민 $B_{12}$ 및 혈장 호모시스테인 농도는 녹즙분말이나 콜레스테롤 보충에 의해 영향을 받지 않았다. 혈중 엽산과 비타민 $B_{12}$ 농도사이에는 유의한 양의 상관성 (r=0.5632, p<0.001)이 관찰되었으나, 혈중 호모시스테인 농도는 혈중 엽산, 비타민 $B_{12}$ 및 콜레스테롤 농도 사이에는 모두 유의한 상관성이 관찰되지 않았다. 본 연구결과를 종합하여 보면, 엽산이 충분히 공급되는 경우, 녹즙보충시 나타나게 되는 심혈관계질환 예방효과는, HDL 농도의 증가 및 중성지방 농도의 감소에 의한 것이며, 녹즙내 엽산보충에 의한 호모시스테인 농도 변화와는 관련이 적은 것으로 사료된다.

• Journal of Nutrition and Health
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• 제41권4호
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• pp.299-306
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• 2008

The purpose of this research was to investigate the effect of the calcium intake on lipid profile and antioxidant capacities in ovariectomized (OVX) rats. Rats were divided into 3 groups and fed diet with different levels of calcium (low 0.1%, adequate 0.5%, high 1.5%) for 4 weeks. The half of rats in each group was ovariectomized and the others were sham-operated. And rats were fed same diets for 8 weeks after operation. Feed intake and weight gain were significantly higher in OVX group than those in sham-operated. Serum HDL-cholesterol was the highest in high-calcium group of OVX. Hepatic triglyceride of low-calcium group in sham-operated was the highest, while that of highcalcium group in OVX was the highest. Hepatic activities of glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px), and catalase were significantly decreased by increasement of calcium intake. Hepatic TBARS level was the lowest in high-calcium group of OVX. And hepatic level of TBARS induced by AAPH was significantly decreased by increasement of calcium intake. These results may indicate that the high calcium intake have the potential role to improve lipid profiles and antioxidant capacities in OVX rats.

• 분석과학
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• 제19권1호
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• pp.73-85
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• 2006

고분해능 가스크로마토그래피/고분해능 질량분석기를 이용하여 자원회수시설 근로자와 자원회수시설 주변 지역 주민(<0.3 km), 자원회수시설과 관련이 없는 지역주민(>10 km)의 혈액으로부터 PCBs의 모든 이성질체를 분석하였다. 전체 87개의 혈액시료 중에서 PCBs의 평균농도와 다이옥신 유사 PCBs의 평균농도는 각각 242.77 ng/g lipid, 8.83 TEQ pg/g lipid 이었다. 5, 6, 7 염소 치환 동족체가 전체 농도의 80%이상을 차지하였으며 가장 많은 농도 분포를 보이는 이성질체는 PCB153, PCB138, PCB180, PCB187, PCB118이었다. PCBs의 농도와 설문을 통해 조사된 나이, 성별, 흡연여부, 직업, BMI (Body Mass Index), 거주기간 등과 같은 변수와의 유의한 상관관계를 알기위해 통계분석을 한 결과 나이만이 혈액 내 PCBs농도와 상관관계가 있었다. 또한, 총 PCBs 농도와 PCB153 농도(r=0.93, p<.0001), dioxin-like PCBs와 PCB118의 농도(r=0.98, p<.0001)는 상관관계가 매우 높았다. 따라서 이 두 개의 이성질체는 인체 혈액에서 각각 PCBs농도와 dioxin-like PCBs의 농도의 지표물질(indicator)이 될 수 있다.

• Journal of Nutrition and Health
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• 제49권1호
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• pp.28-35
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• 2016

한국 성인 여성들을 대상으로 비타민 D 영양상태에 대한 기초자료를 얻고자 혈청 $25(OH)D_3$ 수준, 신체계측 및 체조성 분석, 일조시간 활동량, 혈중 지질 농도 및 아디포카인 농도를 측정하여, 혈중 $25(OH)D_3$ 수준과 비만지표와의 관계를 분석하였다. 156명의 연구 대상자 중 혈중 $25(OH)D_3$ 농도가 12 ng/ml 미만은 77% (121명)로 결핍상태에 해당하였고, 12~19.9 ng/ml는 19.2% (30명)으로 불충분상태에 해당하였으며 충분상태에 해당하는 20 ng/ml 이상은 3.2% (5명)으로 나타났다. 혈중 $25(OH)D_3$ 농도는 체중, 체질량지수, 체지방량, 허리엉덩이 비율과 유의한 양의 상관관계가 있어 비만지표와 양의 상관성을 보였다. 이러한 결과는 우리나라 성인 여성의 비타민 D 영양상태가 취약한 상태이고, 비만과의 관련 가능성이 있음을 나타내며, 이에 비타민 D 결핍예방을 위한 방안 강구가 필요함을 시사한다.