• 한국식품영양과학회지
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• 제33권8호
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• pp.1294-1301
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• 2004

본 연구에서는 전립선암 환자를 대상으로 이소플라본 보충제 섭취가 혈중 PSA 농도, 지질 패턴, 면역체계 및 항산화체계에 미치는 영향에 대하여 검토하고자 하였다. 전립선암환자에 게 하루 150 mg의 이소플라본을 섭취시킨 결과, 이소플라본 섭취 전에 비해 소변 내 이소플라본의 배설량이 유의적으로 증가하였다. PSA(prostate specific antigen)의 경우는 이소플라본 섭취 전보다 섭취 2달 후에 약간 증가함을 보였으나 유의적인 수준은 아니었다. 이소플라본 섭취가 전립선암 환자의 혈청 지질패턴에 미치는 영향에 대한 분석결과, 총 콜레스테롤의 경우 이소플라본 섭취 시작 전에 비해 섭취 2달 후에 유의적으로 감소되었으며, LDL 콜레스테롤의 경우 이소플라본 섭취 2달 후에 감소하는 경향을 보였으나 유의적인 차이를 보이지 않았고, HDL 콜레스테롤 수준에는 변화가 없는 것으로 나타났다. IL-6의 경우, 이소플라본 섭취 전에 비해 이소플라본 섭취 후에 수치가 감소하였고, VEGF와 TNF-$\alpha$는 이소플라본 섭취 전보다 섭취 2개월 후에 증가하였으나 유의적인 차이를 보이지는 않았다. 이소플라본 섭취전ㆍ후의 총항산화력을 TAS를 통해 측정한 결과 이소플라본 투여 전에 비 해 투여 2개월 후 수치가 증가하였으나 통계적으로 유의적인 차이는 보이지 않았다. 또한 혈액에서 분리된 임파구의 DNA 손상 정도를 측정하기 위해 comet assay를 시도한 결과 tail moment (TM)의 경우 이소플라본 섭취 2달 후에 감소하였으나 유의적인 차이는 없었으며, tail length(TL)의 경우는 유의적으로 감소하였다. 본 연구의 제한점으로는 연구 대상자의 수가 적었으며, 실험 결과를 비교할 대조군이 없었고, 연구기간이 짧다는 것을 들 수 있다. 따라서 이번 연구에서 이소플라본이 전립선암에 기대되는 효과를 보여주기엔 미비한 점이 있었다. 그러나 본 연구결과 이소플라본은 전립선암 환자의 혈중 지질 패턴과 항산화체계를 개선시키는 효과를 보였다. 따라서 이소플라본이 지질대사에 미치는 영향과 항산화작용기전에 대한 보다 심층적인 연구가 이루어져야 할 것이며, 보다 많은 전립선암 환자를 대상으로 이소플라본 섭취에 따른 장기적인 임상실험연구가 이루어져 이소플라본이 전립선암 환자의 삶의 질을 향상시킬 수 있는지에 대한 다각적인 검토가 필요하다고 본다.

• 대한영양사협회학술지
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• 제18권1호
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• pp.81-89
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• 2012

This study was conducted to examine the association of dietary behaviors, serum lipid profiles according to the progression of angiographically evaluated atherosclerosis. The subjects were 32 male patients aged 59-80 yrs living in the Daegu area who underwent initial angiography for their lower extremities. We classified the subjects into two groups according to the seriousness of iliac lesions based on angiographic results : Group I (lower lesion group) and Group II (higher lesion group). Dietary habits were evaluated by 10-item questionnaires. Daily food intake of each subject was assessed by the 24-hour recall method. There were no significant differences in serum cholesterol and triglyceride levels between the two groups. The food habit score of Group II was significantly lower than that of Group I (P<0.001). Group II showed significantly lower dietary habit scores in the consumption of fish and bean product (P<0.001), seaweed product (P<0.01), and salt use (P<0.001) than those of Group I. Dietary intake of vitamin C was significantly lower in Group II (P<0.01). Our results indicate that the more serious of atherosclerotic lesions the patients had, the poorer dietary habits they exhibited. Therefore, medical nutrition therapy for atherosclerotic patients should emphasize maintaining a balanced diet by consuming more fishes, beans, and seaweed as well as by reducing salt intake.

• 한국임상수의학회지
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• 제33권5호
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• pp.255-260
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• 2016

$Pyunkang-tang^{(R)}$ is a kind of herbal medicine and has been used for the treatment of atopy and allergic disease in humans over forty years. The purpose of this study was to evaluate the hematological, biochemical, and protein and lipid electrophoresis profiles after the oral administration of $Pyunkang-tang^{(R)}$ in healthy dogs. Fifteen clinically healthy beagle dogs were selected and orally administered either 33 ml of $Pyunkang-tang^{(R)}$ (group I, n = 5), 16.5 ml of $Pyunkang-tang^{(R)}$ (group II, n = 5), or 33 ml of distilled water (group III, n = 5) 3 times a day for 4 weeks. The results of the hematological, serum biochemical, and urine analysis did not differ significantly among the 3 groups. The oral administration of $Pyunkang-tang^{(R)}$ for 4 weeks was associated with significant changes in the serum globulin levels and an elevation in the high-density lipoprotein (HDL) concentrations in groups I and II (p < 0.05), compared to group III. The ${\alpha}1-globulin$ and ${\gamma}-globulin$ levels were significantly increased in group I, and the ${\alpha}1-globulin$ and ${\beta}-globulin$ levels were significantly increased in group II. The ${\alpha}2-globulin$ levels were significantly decreased in both groups. During the short-term evaluation of $Pyunkang-tang^{(R)}$ administration, we did not detect any specific adverse effects in the dogs. However, further evaluation of the safety and efficacy of $Pyunkang-tang^{(R)}$ for the treatment of atopic disease in dogs is needed.

• 한방비만학회지
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• 제21권2호
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• pp.49-58
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• 2021

Objectives: The purpose of this study was to investigate the effect of white pan bread added with Kamut (Triticum turgidum spp.) on high fat diet (HFD)-induced obese C57BL/6 mice. Methods: The white pan bread or white pan bread with Kamut (BK) were administered for 8 weeks in HFD-induced obese C57BL/6 mice. To evaluate the effect and its mechanisms of BK on obese mice, we measured body weight change, serum lipid profiles, histopathological analysis, and protein expression of CCAAT/enhancer binding protein-α (C/EBPα) in the liver. Results: Administration of BK significantly decreased body weight in HFD-induced obese mice. In addition, BK-administered group significantly reduced serum total cholesterol, glucose, and high-density lipoprotein cholesterol levels compared with the HFD-induced control group. The HFD-induced mice had damaged liver tissue and increased the size of adipose tissue, but BK-administered group attenuated liver damage and decreased the size of adipocyte. Furthermore, administration of BK significantly down-regulated C/EBPα in the liver compared with HFD-fed mice. In particular, BK-administered group has higher inhibited body weight, serum lipid profiles, and C/EBPα expressions than white pan bread-administered group. Conclusions: This study demonstrated that administration of BK attenuated HFD-induced obesity by regulation of C/EBPα than consumption of white pan bread. Therefore, BK could be developed as a bread for prevention of obesity.

• Journal of Nutrition and Health
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• 제31권3호
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• pp.263-270
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• 1998

The purpose of this study was to investigate the effect of Lycii fructus on the serum lipid in rats fed high fat diet. We compared the effects of L. fructus and L.fructus water extract both adminstered with high fat diets on rats that had previously been on high fat or standard diets. Two separate experiments were conducted for 6 weeks. respectively. In experiment I, 4 groups of rats were fed experimental diets consisting of either \circled1 6 weeks of a standard diet(control), \circled2 6 weeks of a high-fat diet(HHC), \circled3 3 weeks of a high-fat diet followed by 3 weeks of a high-fat diet containing L. fructus(HHL) or \circled4 6 weeks of a high-fat diet with L. fructus extract in place of water for the last 3 weeks (HHT). In the second set of experiments, a high-fat diet (SHC), high-fat diet containing L.fructus(SHL) or high-fat diet with L. fructus extract in place of water (SHT) were fed for 3 weeks after 3 weeks of standard diet feeding. Rats fed L. fructus diet consumed more diets than high-fat diets. THe results of experiment I showed significant decreases(p<0.05) in serum triglyceride(TB) and low density lipoprotein-cholesterol (LDL-C) levels with L. fructus feedings, but did not show andy changes in total cholesterol (TC) level. High density lipoprotein-cholesterol (HDL-C) level was increased significantly(p<0.05) with L. fructus feedings. Therefore, the ration of LDL-C to HDL-C(LDL-C/HDL-C) which is used as an atherosclerosis index was significantly (p<0.05) low, while the HDL-c/TC ration was significantly(p<0.05) high with L.fructus intake. However, no significant were found in serum cholesterols and TG levels in experimentII. The results of these experiments indicate that , regardless of the feeding from, L. fructus can be beneficial in lowering serum TG and LDL-C levels for habitual high-fat diet intakers. L.fructus also seems to be effective in elevating serum HDL-C level, theregy having beneficial effects on atherosclerosis by influencing the serum lipoprotein profile.

• 동의생리병리학회지
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• 제17권3호
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• pp.798-803
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• 2003

The effects of acupuncture and moxibustion at ST 36 (足三理) acupoint on the changes of body weight, related serum lipids and leptin density of the stomach were investigated. 3 groups of male, 7 animals each, were ad libitum standard diet for 5 days. Body weight was effective decreased for 5 days after moxibustion at ST 36 acupoint and the density of leptin which was related food intake and body weight deficiency was decreased remarkerbly in the mucosa of stomach. Moxibustion on ST 36 affected the levels of total cholesterol, glucose, HDL-cholesterol, but acupuncture on ST 36 affected only the levels of total lipid, triglyceride, HDL cholesterol. It is considered that the treatments of acupuncture and moxibustion at ST 36 (足三理) have different effect actively on body weight, serum lipids and leptin density and moxibustion of ST 36(足三理) can be applied as effective therapy for obesity.

• 한국식품영양과학회지
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• 제39권9호
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• pp.1279-1285
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• 2010

본 연구는 국내의 건강한 성인 남녀를 대상으로 녹차와 커피를 섭취하는 군에서의 식이 섭취 상태를 분석하고, 녹차와 커피가 혈중 지질 농도에 어떠한 영향을 미치는지 알아보기 위해 수행 되었다. 전체 대상자의 남여 비율은 56.1%, 43.9%로 비슷한 수준을 나타냈고, 전체 대상자의 연령 분포는 40대와 50대가 전체의 80% 수준을 차지했다. 남자 대상자의 대조군, 녹차섭취군, 커피섭취군은 신장, 체중, 체지방률, 허리둘레, 체질량지수에서 유의적인 차이를 보이지 않았다. 여자 대상자의 세 군 비교 결과 신장, 체지방률, 허리둘레, 체질량지수는 유의적인 차이를 보이지 않았고, 체중에서 커피섭취군이 대조군과 녹차섭취군에 비해 유의적으로 높게 나타났다(p<0.05). 남녀 모두 총 에너지 섭취량에는 유의적인 차이가 없었으며, 남자 대상자의 경우 지방섭취량에서 녹차섭취군과 커피섭취군이 대조군에 비해 유의적으로 높게 나타났다(p<0.05). 혈중 총 콜레스테롤 및 저밀도 지단백 콜레스테롤 농도, Atherogenic Index, Cardiac Index에서 녹차섭취군이 대조군에 비하여 낮은 값을 나타냈으나 유의적인 차이를 보이지 않았다. 그러나 녹차섭취군이 커피섭취군에 비하여 유의적으로 낮은 값을 나타내었다(p<0.05). 이상과 같이 본 연구의 녹차와 커피 섭취에 따른 혈중 지질 농도의 비교 결과, 녹차의 섭취가 혈중 총 콜레스테롤 농도에 미치는 영향은 나타나지 않았으나 커피의 섭취는 혈중 지질성상 중 총 콜레스테롤과 저밀도 지단백 콜레스테롤에 영향을 미치는 것으로 나타났다.

• Preventive Nutrition and Food Science
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• 제11권1호
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• pp.48-53
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• 2006

Although garlic has been reported to have impressive effects in lowering serum lipids, there have been controversial evaluations on these effects. To find the potential fator causing the inconsistency in the previous studies, we examined the effects of two types of garlic according to the producing-area (hangihyung garlic, nangihyung garlic) on serum lipid profiles and leptin level. Thirthy six of 4 wk old Sprague Dawley male rats fed high fat diet (40% of calories as fat) for 6 wks to induce obesity, and subsequently fed 5% garlic powder supplemented (HF+H: hangihyung garlic powder, HF+N: nangihyung garlic powder) high fat diets (w/w) for further 5 wk. For the comparison, normal control group fed AIN-76A diet (11.7% of calories as fat). Supplementation with hangihyung and nangihyung garlic resulted in a significant reduction of high fat induced body weight gain, white fat (i.e., epididymal, visceral and peritoneal fat) development, adipocyte hypertrophy and the development of hyperinsulinemia and hyperliptinemia. Serum triglyceride and total cholesterol level was greatly reduced by hangihyung garlic supplementation (p<0.05). The HDL-cholesterol level was increased by dietary hangihyung and nangihyung garlic. There were slight non-significant decreases in triglyceride and total cholesterol of HF+N group as compared to those of HF group. Leptin level of HF+H group was found to be significantly lower than HF group (p<0.05). There was no significant difference among N group and HF+N group. These results suggest that hangihyung garlic may lead to the higher activity in improving lipid profiles than nangihyung garlic. Whether the hypolipidemic effect of garlic increases in a species-dependent has yet to be determined and awaits further research.

• 한국식품영양과학회지
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• 제37권4호
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• pp.445-451
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• 2008

양파김치를 이용한 가공식품의 개발을 위해 streptozotocin(STZ)으로 유도한 당뇨병 흰쥐를 이용하여 양파김치 추출물 투여에 대한 혈당강하 및 지질성분의 함량 변화를 조사하였다. 체중변화는 정상군은 4주 사육기간 동안 지속적으로 증가하였으나, STZ 유도 당뇨대조군은 유의하게 감소되었다. 양파김치 추출물과 quercetin 투여군에서도 유의한 체중감소가 있었으나 투여군 간에 유의한 차이는 없었다. 혈당 농도는 정상군에 비해 STZ로 유도한 당뇨흰쥐에서 유의하게 증가되었으며, 투여 2주에서부터 대조군에 비해 양파김치 추출물 투여군과 quercetin 투여군에서 유의하게 감소되었다. 그러나 식이농도 증가 및 투여군 간에 유의한 차이는 없었다. 소변량은 정상군에 비해 STZ로 유도한 당뇨흰쥐에서 유의하게 증가되었으나 양파김치 추출물 및 quercetin 투여군의 식이농도 증가에 유의한 차이는 없었다. 신장무게는 정상쥐에 비해 당뇨쥐에서 증대되었으며, 양파김치 추출물 및 quercetin 투여군에서 유의하게 낮은 수준을 나타내어 정상군과 차이가 없었다. 혈청 총콜레스테롤 및 중성지질은 정상쥐에 비해 STZ 유도 당뇨대조군에서 증가되었으나 양파김치 추출물 및 quercetin 투여군에서 낮은 수준을 나타내었다. 이러한 결과는 양파김치 추출물 섭취가 당뇨쥐에서 증가된 혈당 및 혈청 콜레스테롤 수준을 감소시킬 수 있음을 의미하는 것이다.

• 대한지역사회영양학회지
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• 제12권2호
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• pp.142-149
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• 2007

To evaluate the seasonal differences of nutrient intake and serum biochemical indices (total cholesterol, HDL-, LDL- cholesterol, TG, MDA : malondialdehyde, TAS : total antioxidant status, folate) in Korean college women with a mean age of 20.15y, this study was conducted twice: once in winter and a second time in summer. Anthropometric assessment was also measured in the two seasons. As a result body fat mass (p<0.05), body fat% (p<0.05), and abdominal fat% (p < 0.01) in the summer were significantly lower than those in winter. Intake of fat (p < 0.05), polyunsaturated fatty acid (p < 0.01), zinc (p < 0.05), and vitamin E (p < 0.05) were at significantly higher levels in the summer period compared with the winter period. In addition, nutrients with an intake level less than 75% RI of KDRIs were folate in winter and calcium, and folate in the summer. Total cholesterol (p < 0.05) and HDL-cholesterol in summer, according to lipid profiles, were significantly lower than those in winter. Although MDA, one of the products of lipid peroxidation, remained unchanged, TAS was significantly higher in summer than in winter. The level of folate in summer showed significantly lower than that in winter. The present study suggests that nutrient intake of college women women differs according to the seasons and anthropometric indices and serum biochemical indexes were associated with seasons. Thus nutritional education programs on the basis of season are needed for college women.