• Asian-Australasian Journal of Animal Sciences
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• 제26권6호
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• pp.812-819
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• 2013

Forty two Malpura lambs (21 d old) were divided into three groups of 14 each consisting of 8 females and 6 males. Lambs were allowed to suckle their respective dams twice daily up to weaning (13 wks) and offered free choice concentrate and roughage in a cafeteria system. The lambs in control group were fed conventional concentrate mixture, in RBO group concentrate mixture fortified with 4% industrial grade rice bran oil and in Ca-soap rice bran oil (as in RBO group) was supplemented in the form of calcium soap. The concentrate intake decreased($p{\leq}0.05$) in RBO group as a result total dry matter, crude protein and metabolizable energy intake decreased compared to control whereas Ca-soap prepared from the same rice bran oil stimulated the concentrate intake leading to higher total dry matter, crude protein and energy intakes. The digestibility of dry matter ($p{\leq}0.05$), organic matter ($p{\leq}0.05$) and crude protein ($p{\leq}0.05$) was higher in RBO group followed by Ca-soap and control whereas no effect was observed for ether extract digestibility. Higher cholesterol ($p{\leq}0.05$) content was recorded in serum of oil supplemented groups (RBO and Ca-soap) while no effect was recorded for other blood parameters. Rice bran oil as such adversely affected and reduced the body weight gain ($p{\leq}0.001$) of lambs in comparison to control whereas the Ca-soap of rice bran oil improved body weight gain and feed conversion efficiency in lambs. Fat supplementation decreased total volatile fatty acids ($p{\leq}0.05$) and individual volatile fatty acid concentration which increased at 4 h post feeding. Fat supplementation also reduced ($p{\leq}0.05$) total protozoa count. Ca-soap of rice bran oil improved pre slaughter weight ($p{\leq}0.05$) and hot carcass weight ($p{\leq}0.05$). It is concluded from the study that rice bran oil in the form of calcium soap at 40 g/kg of concentrate improved growth, feed conversion efficiency and carcass quality as compared to rice bran oil as such and control groups.

• Journal of Yeungnam Medical Science
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• 제24권2호
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• pp.137-147
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• 2007

배경 : 검사결과의 판독과 보고는 진단검사의학과에서 시행해야 할 업무이지만 일일 발생하는 검사건수의 방대함으로 쉽게 접근하기 어려움이 있어 검사결과의 판독과 해석을 할 수 있는 보조 프로그램의 개발이 필요하다. 따라서 저자는 판독 프로그램을 개발하여 검사항목이 적으며, 묶음 검사항목으로 되어 있는 건강검진자를 대상으로 임상 적용시의 문제점과 보완점을 알아보고자 하였다. 재료 및 방법 : 연관성이 있는 검사항목을 기준으로 각 검사결과에 따른 rule-based expert 시스템을 개발하여 2007년 8월 본원 건강증진센터를 방문한 535명을 대상으로 검증하였다. 룰의 구성은 "if-then"로 구성하였으며, 즉 검사결과가 조건에 맞는 경우 미리 입력되어 있는 판독문구가 출력되도록 하였다. 결과 : 50.5%에서 해석적 보고가 필요한 것으로 나타났다. 고지혈증이 34%, 빈혈관련 질환이 8.0%, 뇨검사에서 9.9%, 종양표지자가 4.7%, 갑상선 장애가 7.7%, B형간염표지자에서 4.7%, 혈당 관련 질환에서 4.3%, 등으로 나타났으며, 이는 실제 추적검사를 시행한 환자 수(49명, 9.1%) 보다 상당히 높게 나타났다. 이는 해석적 보고가 단순히 검사항목에 대한 검증으로 대상자의 임상적 소견을 감안하지 않아 더 높은 비율로 나타난 것으로 보인다. 결론 : 임상의에 보고하기 전에 시행하는 검사의 판독은 검사실내의 정도관리적 측면에서도 도움이 되며, 임상의가 최종 진단전 고려해야 할 질환 등을 감별함으로써 보다 질적인 측면에서 향상된 정보를 제공함으로써 입원 및 외래 내원 환자에 적용하면 치료 등에 도움이 될 수 있을 것으로 생각된다.

• Journal of Nutrition and Health
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• 제40권sup권
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• pp.3-8
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• 2007

Sugars are a ubiquitous component of our food supply and are consumed as a naturally occurring component of many foods and as additions to foods during processing, preparation, or at the table. Most fruits and dairy products are high in sugars and thus naturally occurring sugars are consumed as part of a healthy diet. Some countries developed recommended daily intake figures(daily values : DVs or guideline daily amounts: GDA) for nutrients, and some countries, but not most have developed DV/GDA for total sugars. Dietary Reference Intakes for Koreans established by the Korean Nutrition Society in 2005, did not include the reference values for total sugar or added sugar. The committee on Dietary Reference Intakes for sugar was constituted in 2006 and discussed whether to special added sugars or total sugar. Although added sugars are not chemically or physiologically different from naturally occurring sugars, many foods and beverages that are major sources of added sugars have lower micronutrient densities compared with foods and beverages that are major sources of naturally occuring sugars. But it was so hard to calculate a dietary intake of added sugar for Korean people, because there was insufficient information about contents of added sugar during processing or preparation of Korean food. Currently Korean or US food labels contain information on total sugars per serving but do not distinguish between sugars naturally present in food and added sugars. Therefore the committee decided to set the reference value for total sugar for Koreans. According to the recommended diet pattern for Koreans suggested by the Korean Nutrition Society, estimated sugar intake from the sugar containing food based on 2,000 kilocalories is 67 g or 13% of total energy. Based on the data available on risk of obesity, hypertension, hyperlipidemia, insulin resistance, and metabolic syndrome from the analysis of Korean NHANES, it was insufficient evidence to set a UL for total sugar, but tended to increase serum LDL cholesterol and obesity at over 20-25% of energy from total sugar when consumed with high carbohydrates. Therefore the committee on Dietary Reference Intakes for sugar set the Acceptable Macronutrient Distribution Range for total sugar as 10-20% of total energy intake.

• 한국식품영양과학회지
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• 제26권1호
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• pp.103-108
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• 1997

본 실험에서는 사람의 본태성 고혈압과 가장 유사 한 증상을 나타내는 SHR을 이용하여 고혈압의 악성기에 해당하는 6개월간의 장기간 동안 생마늘과 익힌 마늘 첨가식이를 급여함으로써 마늘의 열처리가 혈청 지질과 혈액 응고에 미치는 효과를 비교 관찰하였다. 실험 결과를 요약하면 다음과 같다. 식이 섭취량은 익힌 마늘 3% 첨가군이 다소 낮았으며, 체중 증가량 및 식이 효율은 마늘 첨가군과 대조군간이 차이는 없었다. 총 콜레스테롤 수준은 마늘 첨가군이 대조군에 비해 현저히 저하되었으며, 특히 익힌 마늘군이 생마늘 군 보다 낮게 나타났다. 중성 지질 수준은 마늘 첨가군 들이 대조군에 비해 낮았다. 혈장 prothrombin time은 마늘 첨가군들이 대조군 보다 길었으며, 마늘 열처리에 따른 차이는 없었다. Fibrinogen 농도는 익힌 마늘군이 대조군이나 생마늘군 보다 낮았다. Fibrinogen과 pro- thrombin time은 유의한 부의 상관관계를 나타내었다. 이상을 종합하여 살펴보면, 익힌 마늘 3%와 생마늘 3% 첨가군 모두 체중이나 식이 섭취량 및 식이 효율에서 대조군과 큰 차이가 나타나지 않은 것으로 보아 일상 식이 섭취 수준으로서 섭취할 수 있는 농도로 여겨진 다. 열처리 효과를 비교해 보면, 익힌 마늘의 생리 효과가 생마늘에 비해 낮다고 보고된 타 연구 결과와는 달리 , 본 실험에서는 익힌 마늘과 생마늘의 효과가 유사 한 것으로 나타났다.

• Asian-Australasian Journal of Animal Sciences
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• 제13권9호
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• pp.1263-1271
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• 2000

A total of 80 piglets ($5.85{\pm}0.62kg$ BW; 21 d of age) were used to study the effect of carnitine addition to extruded full-fat soybean (EFS) diets on the growth of weaned pigs. Pigs were allotted into five treatments based on body weight, in a completely randomized block design. Each treatment has 4 replicates of 4 heads each. Treatments were 1) SBM (positive control), 2) EFS without carnitine (negative control), 3) EFS with 50 ppm carnitine, 4) EFS with 100 ppm carnitine and 5) EFS with 150 ppm carnitine. During d 0 to 14, piglets were fed diets containing 3,400 kcal ME, 23% crude protein, 1.65% lysine, 0.9% Ca and 0.8% P and for the period of d 15 to 28, piglets were fed diets supplying 3,300 kcal ME, 20% crude protein, 1.55% lysine, 0.9% Ca and 0.8% P. The urease activity of EFS (0.18) were three times higher than SBM (0.07). During d 0-14, pigs fed SBM had greater ADG and ADFI compared to pigs fed extruded full-fat soybean diets (p<0.05). Feed conversion ratio was not different among treatments. No linear or quadratic effect of carnitine addition was found in growth performance. During d 15-28, piglets fed SBM diet also showed better ADG and FCR with no significant differences among treatments. Feed intake tended to increase as carnitine addition level was increased (p=0.10). For overall period (d o to 28), the best performance was observed in pigs fed SBM diet. CP digestibility was higher in pigs fed SBM diet than piglets fed EFS diet at d 14, and DM and CP digestibility tended to be higher in pigs fed SBM diet at d 28. Blood metabolites (BUN, glucose and cholesterol)were not affected by treatments. In conclusion, based on the results of this study piglets at 21 d of age appeared to be not ready for extruded full-fat soybean (FFSB) in their diets. Piglets fed extruded FFSB showed decreased growth rate compared to piglets fed SBM diet. Nutrient utilization was also poor in piglets fed extruded FFSB diets. L-carnitine addition at the level of 50 to 150 ppm was not effective in improving the growth performance of pigs fed EFS diets.

• Asian-Australasian Journal of Animal Sciences
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• 제13권9호
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• pp.1255-1262
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• 2000

A total of 80 pigs ($5.68{\pm}0.61kg$ BW; 21 d of age) were used to evaluate the effect of fat sources in weaned pigs. Pigs were allotted into five treatments based on body weight, in a completely randomized block design. Treatments consisted of diets representing different ratio between soy oil or corn oil and tallow; 1) S100 (soy oil 100%), 2) S75 (soy oil:tallow=75:25), 3) S50 (soy oil:tallow=50:50), 4) C75 (corn oil:tallow=75:25), 5) C50 (corn oil:tallow=50:50). During d 0 to 14, pigs were fed diets containing 3,400 kcal ME, 23% crude protein, 1.65 % lysine and for the period of d 15 to 28, pigs were fed diets supplying 3,400 kcal ME, 20.5% crude protein, 1.355% lysine. For d 0 to 14, a significant differences in ADG and ADFI were observed among treatments, pigs fed animal-vegetable fat blends gained more than pigs fed the S100. As tallow addition was increased from 25% to 50% replacing soy or corn oil, ADG was improved from 6.32% to 28.38%. In phase II (d 15 to 28) period, ADG, ADFI and FCR were not significantly different among treatments. For overall period (d 0 to 28), pigs fed 50% animal:50% vegetable fat blends diets consumed more feed and grew faster than pigs fed control diet and 75% vegetable oil:25% tallow groups, but the differences was not significant among treatments. Apparent DM, CP and fat digestibility were increased with time postweaning for each treatment. There were no differences in digestibilities of total amino acid during overall period. The combination of soy oil or corn oil with tallow produced slightly higher serum triglycerides (TG) and total cholesterol (TC) combination compared with the soy oil alone. In conclusion, tallow:soy (or corn) oil blends diets improved growth rate and the ratio of 50% tallow plus 50% soy (or corn) oil blends diets were favorable for growth and nutrient digestibilities of weaned pigs.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.1083-1087
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• 2013

Background: Colorectal cancer has several modifiable behavioural risk factors but their relationship to the risk of colon and rectum cancer separately and between countries with high and low incidence is not clear. Methods: Data from participants in the Asia Pacific Cohort Studies Collaboration (APCSC) were used to estimate mortality from colon (International Classification of Diseases, revision 9 (ICD-9) 153, ICD-10 C18) and rectum (ICD-9 154, ICD-10 C19-20) cancers. Data on age, body mass index (BMI), serum cholesterol, height, smoking, physical activity, alcohol and diabetes mellitus were entered into Cox proportional hazards models. Results: 600,427 adults contributed 4,281,239 person-years follow-up. The mean ages (SD) for Asian and Australia/New Zealand cohorts were 44.0 (9.5) and 53.4 (14.5) years, respectively. 455 colon and 158 rectum cancer deaths were observed. Increasing age, BMI and attained adult height were associated with increased hazards of death from colorectal cancer, and physical activity was associated with a reduced hazard. After multiple adjustment, any physical activity was associated with a 28% lower hazard of colon cancer mortality (HR 0.72, 95%CI 0.53-0.96) and lower rectum cancer mortality (HR 0.75, 95%CI 0.45-1.27). A 2cm increase in height increased colon and all colorectal cancer mortality by 7% and 6% respectively. Conclusions: Physical inactivity and greater BMI are modifiable risk factors for colon cancer in both Western and Asian populations. Further efforts are needed to promote physical activity and reduce obesity while biological research is needed to understand the mechanisms by which they act to cause cancer mortality.

• 한국수산과학회지
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• 제36권2호
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• pp.113-119
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• 2003

A feeding trial was carried out to Investigate the effect of lipid level and herb mixture in the diets on growth of juvenile parrot fish, Oplegnathus fasciatus. Two plicate groups of fish averaging 4.5 g were fed four experimental diets containing herb mixture (0 and 5 g/kg diet) at each of two lipid levels $(8\%\;and\;16\%)$ for 8 months from summer to spring (water temperature, $7.2-25.4^{\circ}C)$. Weight gain improved with increasing dietary lipid level or supplementation of herb mixture during the first 4 months feeding period. Weight gain of fish fed the diet containing $16\%$ lipid level was significantly higher (P<0.05) than that of fish fed the diet containing $8\%$ lipid level. Weight gain of fish fed the diet with herb mixture was significantly higher (P<0.05) than that of fish fed the diet without herb at the $16\%$ lipid level. Feed efficiency was influenced by dietary lipid level or herb mixture during the first 4 months. On the other hand, weight gain and feed efficiency were not affected by dietary lipid level and herb mixture after 4 months until end of feeing period. Survival of fish fed the diet containing $8\%$ lipid without supplementation of herb mixture was the lowest among the groups (P<0.05). Lipid contents of liver and viscera tended to increase with increasing dietary lipid level during the first 4 months feeding period, however muscle lipid content was not influenced by dietary lipid and herb. Total cholesterol of serum was influenced by dietary lipid level during the first 4 months feeding period. These results indicate that an increase of dietary lipid level from $8\%\;to\;16\%$ and supplementation of herb mixture can improve growth performance of juvenile parrot fish when water temperature is optimum for growth such as the summer season in Korea.

• Journal of Preventive Medicine and Public Health
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• 제24권4호
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• pp.516-530
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• 1991

일상생활을 통한 연섭취로 인한 고혈압 발생 가능성 및 이때 연이 혈압에 영향을 미칠 수 있는 기전을 밝히기 위한 연구의 일환으로 환자 대조군 연구를 실시하였다. 대상자로서 울산 및 그 인근지역의 직업적 연폭로 과거력이 없는 남자 근로자 중 고혈압 환자 72명, 대조군 69명을 선택하였다. 혈중 연과 혈장레닌활성도(Plasma renin activity, PRA)를 측정하였으며 동시에 흡연유무, 음주유무, 고혈압 가족력 유무를 확인하고 body mass index(BMI), 혈청 소디움, 포타시움, 이온화 칼슘, 크레아티닌 및 총 콜레스테롤을 측정하였다. 고혈압군의 혈중 연농도는 $19.8{\pm}5.5{\mu}g/dl$로서 대조군의 $12.5{\pm}4.7{\mu}g/dl$에 비해 유의하게 높았고(p<0.01) 또한 혈중 연의 고혈압발생에 대한 교차비(odds ratio)가 1.38로서 역시 유의하였다(p<0.01). PRA나 In(PRA)가 고혈압군과 대조군 사이에 유의한 차이가 없었으나 고혈압군에서 혈중 연농도가 증가함에 따라 PRA도 어느정도 증가하는 양상을 보였고(p<0.1), In(PHA)를 종속변수로 하는 중회귀분석을 실시하였을 때 혈중 연농도(회귀계수 ; 0.037)가 10% 수준에서 유의하였다. 본 연구를 통해 볼 때, 지금까지 알려진 정상치 범위 이내의 혈중 연과 고혈압 발생간의 인과 관계에 대해 계속 연구해 볼 필요성을 느끼며 이때 PRA의 변화가 작용 기전의 일부에 관여할 가능성이 있을 것으로 추측된다.

• 대한핵의학회지
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• 제26권2호
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• pp.257-264
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• 1992

Diagnostic approaches such as angiography, ultrasound, computed tomography and nuclear magnetic resonance have limitation for contributing to the early clinical diagnosis of atherosclerosis. Recently, $^{99m}Tc-labelled$ low density lipoprotein was developed to detect early atherosclerotic lesion by external imaging with gamma camera. To determine whether $^{99m}Tc-LDL$ scintigraphy can visualize the active atherosclerotic lesion, rabbits were injected with $^{99m}Tc-LDL$, 3 months after feeding dietary fat (lanolin) and we obtained following results. 1) Labelling efficiency of $^{99m}Tc-LDL$ was $79\sim88%$. 2) Biodistribution study of normal rabbits with $^{99m}Tc-LDL$ revealed the high activities in spleen, adrenal gland, liver, kidney which are major organs of high metabolic rate of LDL. 3) Three months after feeding lanolin, serum cholesterol was markedly increased from $74{\pm}17mg/dl$ to $979{\pm}153mg/dl$ and histologic study of aorta after sacrificing the rabbit demonstrated marked atherosclerotic changes. 4) Atherosclerotic lesion of abdominal aorta which was confirmed with histologic study could be demonstrated in $^{99m}Tc-LDL$ scintigraphy after feeding lanolin for 3 months. In conclusion, the results of this preliminary investigation suggest that it may be possible to image active atheromatous lesion with $^{99m}Tc-LDL$. It is anticipated that this promising agent may allow the in vivo monitoring of preclinical atherosclerotic lesions and may be useful to evaluate the metabolic pathway of LDL in humans.