• Journal of Chest Surgery
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• v.32 no.11
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• pp.971-977
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• 1999

Background: Immunologic and inflammatory responses of cardiopulmonary bypass(CPB) influence postoperative mortality and morbidity with multiple organ injury. It has been reported that ischemia/reperfusion induced-myocardial injury during CPB is causative of release of inflammatory cytokines such as interleukin-6(IL-6) and tumor necrosis factor-$\alpha$ (TNF-$\alpha$). The purpose of this study was to detect the time course of the activated cytokine and troponin-T(TnT), and to examine the correlation between such parameters during CPB. Material and Method: The serial samples were collected from arterial blood via radial arterial catheter in 23 patients who are underwent open heart surgery (OHS) with CPB, the IL-6, TNF-$\alpha$ and TnT were checked. Result: \circled1 IL-6, TNF$\alpha$- and TnT concentration increased significantly during CPB with a peaking level of CPB-off (p 0.05). \circled2 IL-6 had highly positive correlation with aortic cross clamping time and total bypass time(r=0.80, 0.78; p 0.05, respectively). \circled3 There was no correlation among IL-6, TNF-$\alpha$ and TnT. Conclusion: In conclusion, these data showed that elevated production of serum IL-6 during CPB was attributable to ischemia/reperfusion induced-myocardial damage. IL-6 will become a new and sensitive biological marker in assessment of myocardial damage during OHS with CPB. However, further studies will be needed to apply IL-6 in more patient population.

• Journal of Ecology and Environment
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• v.35 no.4
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• pp.323-329
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• 2012

The Standardized Precipitation Index (SPI) is a widely used drought index to provide good estimations of the intensity, magnitude and spatial extent of droughts. The objective of this study was to analyze the spatial pattern of drought by SPI index. In this paper, the patterns of drought hazard in Iran are evaluated according to the data of 40 weather stations during 1967-2009. The influenced zone of each station was specified by the Thiessen method. It was attempted to make a new model of drought hazard using GIS. Three criteria for drought were studied and considered to define areas of vulnerability. Drought hazard criteria used in the present model included: maximum severity of drought in the period, trend of drought, and the maximum number of sequential arid years. Each of the vulnerability indicators were mapped and these as well as a final hazard map were classified into 5 hazard classes of drought: one, slight, moderate, severe and very severe. The final drought vulnerability map was prepared by overlaying three criteria maps in a GIS, and the final hazard classes were defined on the basis of hazard scores, which were determined according to the means of the main indicators. The final vulnerability map shows that severe hazard areas (43% of the country) which are observed in the west and eastern parts of country are much more widespread than areas under other hazard classes. Overall, approximately half of the country was determined to be under severe and very severe hazard classes for drought.

• Journal of Chest Surgery
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• v.53 no.6
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• pp.368-374
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• 2020

Background: The extracorporeal ventricular assist device (e-VAD) system is designed for left ventricular support using a permanent life support console. This study aimed to determine the impact of temporary e-VAD implantation bridging on posttransplant outcomes. Methods: We reviewed the clinical records of 6 patients with the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile 1, awaiting heart transplantation, who were provided with temporary e-VAD from 2018 to 2019. The circuit comprised a single centrifugal pump without an oxygenator. The e-VAD inflow cannula was inserted into the apex of the left ventricle, and the outflow cannula was positioned in the ascending aorta. The median follow-up duration was 8.4±6.9 months. Results: After e-VAD implantation, lactate dehydrogenase levels significantly decreased, and Sequential Organ Failure Assessment scores significantly improved. Bedside rehabilitation was possible in 5 patients. After a mean e-VAD support duration of 14.5±17.3 days, all patients were successfully bridged to transplantation. After transplantation, 5 patients survived for at least 6 months. Conclusion: e-VAD may reverse end-organ dysfunction and improve outcomes in INTERMACS I heart transplant patients.

• Fisheries and Aquatic Sciences
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• v.5 no.3
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• pp.219-228
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• 2002

Based on the five-year (October 1992 through September 1997) Topex/Poseidon altimeter measurements, we describe the statistical characteristics of the eddy variability in the East Sea in terms of sea surface height anomaly, slope variability, and eddy kinetic energy (EKE). The sea surface height anomalies in the East Sea are produced with standard corrections from Topex/Poseidon measurements. In order to eliminate the high frequency noise in the sea surface height anomaly data, the alongtrack height anomaly data was filtered by about 40 km low-pass Lanczos filter based on Strub et al. (1997) and Kelly et a1. (1998). We find that there exists a distinct spatial contrast of high eddy variability in the south and low eddy energy in the north, bordering the Polar Front. In the northwestern area $(north\;of\;39^{\circ}N\;and\;west\;of\;133^{\circ}E)$ from the Polar Front where the eddies frequently appear, the EKE is also considerabel. The high kinetic energy in the southern East Sea reveals a close connection with the paths of the Tsushima Warm Current, suggesting that the high variability in the south is mainly generated by the baroclinic instability process of the Tsushima Warm Current. This finding is supported by other studies (Fu and Zlontnicki, 1989; Stammer, 1997) wh.ch have shown the strong eddy energy coupled in the major current system. The monthly variation of the EKE in both areas of high and low eddy variability shows a strong seasonality of a high eddy kinetic energy from October to February and a relatively low one from March to September. The sequential pattern of wind stress curl shows resemblance with those of monthly and seasonal EKE and the two sequences have a correlation of 0.82 and 0.67, respectively, providing an evidence that wind stress curl can be the possible forcing for the monthly and seasonal variation of the EKE in the East Sea. The seasonality of the EKE also seems to correlate with the seasonality of the Tsushima Warm Current. There also exists the large spatial and interannual variabilities in the EKE.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.16 no.3
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• pp.281-290
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• 2003

Co Evolutionary Structural Design(CESD) Framework is presented, which can deal with the load design and structural topology design simultaneously. The load design here is the exploration algorithm that finds the critical load patterns of the given structure. In general, the load pattern is a crucial factor in determining the structural topology and being selected from the experts어 intuition and experience. However, if any of the critical load patterns would be excluded during the process of problem formation, the solution structure might show inadequate performance under the load pattern. Otherwise if some reinforcement method such as safety factor method would be utilized, the solution structure could result in inefficient conservativeness. On the other hand, the CESD has the ability of automatically finding the most critical load patterns and can help the structural solution evolve into the robust design. The CESD is made up of a load design discipline and a structural topology design discipline both of which have the fully coupled relation each other. This coupling is resolved iteratively until the resultant solution can resist against all the possible load patterns and both disciplines evolve into the solution structure with the mutual help or competition. To verify the usefulness of this approach, the 10 bar truss and the jacket type offshore structure are presented. SORA(Sequential Optimization & Reliability Assessment) is adopted in CESD as a probabilistic optimization methodology, and its usefulness in decreasing the computational cost is verified also.

• Tuberculosis and Respiratory Diseases
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• v.79 no.3
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• pp.158-164
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• 2016

Background: One to three percent of cases of acute tuberculosis (TB) require monitoring in the intensive care unit (ICU). The purpose of this study is to establish and determine the mortality rate and discuss the causes of high mortality in these cases, and to evaluate the clinical and laboratory findings of TB patients admitted to the pulmonary ICU. Methods: The data of patients admitted to the ICU of Yedikule Chest Diseases and Chest Surgery Education and Research Hospital due to active TB were retrospectively evaluated. Demographic characteristics, medical history, and clinical and laboratory findings were evaluated. Results: Thirty-five TB patients (27 males) with a median age of 47 years were included, of whom 20 died within 30 days (57%). The Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores were significantly higher, and albumin and $PaO_2/FIO_2$ levels were significantly lower, and shock, multiple organ failure, the need for invasive mechanical ventilation and drug resistance were more common in the patients who died. The mortality risk was 7.58 times higher in the patients requiring invasive mechanical ventilation. The SOFA score alone was a significant risk factor affecting survival. Conclusion: The survival rate is low in cases of tuberculosis treated in an ICU. The predictors of mortality include the requirement of invasive mechanical ventilation and multiple organ failure. Another factor specific to TB patients is the presence of drug resistance, which should be taken seriously in countries where there is a high incidence of the disease. Finding new variables that can be established with new prospective studies may help to decrease the high mortality rate.

• The Korean Journal of Nuclear Medicine
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• v.19 no.1
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• pp.73-75
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• 1985

Acute transient synovitis of the hip presents clinically pain and limping. But in the majority of the cases, definite positive findings are not manifest in roentgenogram in its early phase. However radionuclide bone imaging combines with the assessment of vascularization and bone tracer uptake is of great value in solving this diagnostic problem. The materials for this study consisted of 29 children with acute transient synovitis of the hip, characterized by symptoms and physical signs of an arthritis, negative X-ray findings and disappearance of all symptoms and signs within a short period of time. They were twenty males and 9 females and age ranged from 1 to 12 years. We took pelvic reontgenogram in AP and frog-leg views. After intravenous bolus injection of 10 to 15 mCi of $^{99m}Tc-methylene$ diphosphonate, 24 sequential image of the pelvis was taken at 2-second interval for blood flow study. The scintigrams were made using a gamma camera with high resolution parallel hole collimator. Blood pool imaging was obtained at 2 minutes after tracer administration. After 3 hours, static images were taken and then closeup image of the hip using pin-hole collimator was followed. The results were as follows: 1) Bone scintigram was much more sensitive than conventional roentgenogram in diagnosis of acute transient synovitis of the hip. 2) Three-phase imagings showed increased vascular activities in blood pool scintigrams in 96%. 3) Pin-hole imaging showed increased tracer uptake in the regional bones of the hip, par ticularly in the medial aspect of femoral head and acetabulum. 4) We confirmed that three-phase imaging reinforced with pin-hole technique were very useful in diagnose of acute transient synovitis of the hip.

• Journal of Korean society of Dental Hygiene
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• v.16 no.6
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• pp.931-941
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• 2016

Objectives: The purpose of this study was to examine the association between depression and poor oral health in Korean elderly using Korean version of the Patient Health Questionnaire-9 (PHQ-9) for assessment of depressive symptoms. Methods: This study used the data from Korean National Health and Nutrition Examination Survey (KNHANES VI-2). The study included 1,454 elderly Korean aged over 65. Variables included demographic characteristics (gender, age), socioeconomic factor (income, education), systemic diseases, oral health related factor (tooth brush, dental products), health related factor (alcohol drinking, smoking), and depression. Logistic regression analysis was used as sequential models. Effects were quantified as odds ratios (OR) and 95% confidence intervals (CI). Results: From frequency analysis, being female, primary school or less, non-alcohol drinking, poor oral health were significantly related to depression. In the multiple logistic regression model, depression was significantly associated with poor oral health (OR=1.96, CI=1.15-3.53) after adjustment for other covariates including demographic characteristics, socioeconomic factor, systemic diseases, oral health related factor, and health related factor (OR=1.91, CI=1.13-3.27). Conclusions: Depression had an influence on the poor oral health after adjustment as confounding variable in the elderly. It should be focused on the health promotion for the elderly vulnerable to depression and poor oral health. The development of the mental health and oral health should be established.

• Journal of Korean Society on Water Environment
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• v.29 no.5
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• pp.681-690
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• 2013

Watershed models have been increasingly used to support an integrated management of land and water, non-point source pollutants, and implement total daily maximum load policy. However, these models demand a great amount of input data, process parameters, a proper calibration, and sometimes result in significant uncertainty in the simulation results. For this reason, uncertainty analysis is necessary to minimize the risk in the use of the models for an important decision making. The objectives of this study were to evaluate three different uncertainty analysis algorithms (SUFI-2: Sequential Uncertainty Fitting-Ver.2, GLUE: Generalized Likelihood Uncertainty Estimation, ParaSol: Parameter Solution) that used to analyze the sensitivity of the SWAT(Soil and Water Assessment Tool) parameters and auto-calibration in a watershed, evaluate the uncertainties on the simulations of runoff and sediment load, and suggest alternatives to reduce the uncertainty. The results confirmed that the parameters which are most sensitive to runoff and sediment simulations were consistent in three algorithms although the order of importance is slightly different. In addition, there was no significant difference in the performance of auto-calibration results for runoff simulations. On the other hand, sediment calibration results showed less modeling efficiency compared to runoff simulations, which is probably due to the lack of measurement data. It is obvious that the parameter uncertainty in the sediment simulation is much grater than that in the runoff simulation. To decrease the uncertainty of SWAT simulations, it is recommended to estimate feasible ranges of model parameters, and obtain sufficient and reliable measurement data for the study site.

• The Journal of Korean Physical Therapy
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• v.30 no.5
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• pp.193-198
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• 2018

Purpose: The purpose of this study was to analysis of effectiveness between cognitive function assessment scores and gaming cognitive rehabilitation system in children with intellectual impairment. Methods: Five children (male=5, $age=10.00{\pm}0.80$) with intellectual impairment participated in this study and were randomly assigned to the experiment that played (received) gaming cognitive rehabilitation system (Neuroworld). The children were applied 2 times a week for 30 minutes during 3 months. The children were assessed K-WSIC-VI (Korean-Wechsler intelligence scale for children-fourth edition) and recorded that gained score in gaming cognitive rehabilitation system before and after intervention. K-WSIC-VI contained five primary index scores: verbal comprehension index, visual spatial index, fluid reasoning index, working memory index, and processing speed index. Gaming cognitive rehabilitation system scoring was composed visual recall, target recall, sequence recall, selective attention, continuous attention, and exploration. Results: In the intelligence quotient (IQ) of K-WSIC-VI, there were significant increased in all children. The visual recall item was highest effective in all children. However, sequential recall showed the lowest improvement in all children. The performance speed of selective attention item was decreased, this means that children's skills have improved. Also, their ability to explore has improved significantly. Conclusion: In conclusion, gaming cognitive rehabilitation system was significant effectiveness in cognitive function in some categories for children with intellectual impairment. However, the visual recall and performance speed don't represent of all cognitive function. Therefore, further studies will need to verify by applying more subject and longer duration.