• Title/Summary/Keyword: Sequence validation

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A Study on the Factors Affecting Knowledge Contribution and Knowledge Utilization in an Online Knowledge Network (온라인 지식네트워크 내에서의 지식기여 및 지식활용 활동에 영향을 미치는 요인)

  • Jung, Jae-Hwuen;Yang, Sung-Byung;Kim, Young-Gul
    • Journal of the Korean Operations Research and Management Science Society
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    • v.34 no.3
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    • pp.1-27
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    • 2009
  • Since online knowledge networks usually consist of a larger, loosely knit, and geographically distributed group of "strangers" who may not know each other very well, members may not willingly share their knowledge with others. In order to address this challenge, this study looks Into the factors that are expected to affect knowledge sharing in an online knowledge network. For empirical validation, we choose "the global network of Korean scientists and engineers (KOSEN)" as one of the best practices of online knowledge networks. By using the archival, network, and survey data, we validate two models of knowledge sharing in sequence (i.e., knowledge contribution and knowledge utilization models) and then discuss the results. The findings of this study show that individuals not only contribute but also utilize knowledge in an online knowledge network when they are structurally embedded and perceive a strong reciprocity. In the network. In addition, taking pleasure in helping is found to positively affect knowledge contribution, whereas perceiving usefulness is found to Influence knowledge utilization. Contributions of this study and future research opportunities are also discussed.

A New Integrated Software Development Environment Based on SDL, MSC, and CHILL for Large-scale Switching Systems

  • Lee, Dong-Gill;Lee, Joon-Kyung;Choi, Wan;Lee, Byung-Sun;Han, Chi-Moon
    • ETRI Journal
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    • v.18 no.4
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    • pp.265-286
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    • 1997
  • This paper presents a new software development environment that supports an integrated methodology for covering all phases of software development and gives integrated methods with tools for ITUT (Telecommunication Standardization Section of the International Telecommunication Union) languages. The design of the environment to improve software productivity and quality is based on five main concepts: 1) formal specifications based on SDL (Specification and Description Language) and MSC (Message Sequence Charts) in the design phase, 2) verification and validation of those designs by tools, 3) automatic code generation and a safe separate compilation scheme based on CHILL (CCITT High-Level Language) to facilitate programming-in-the-many and programming-in-the-large. 4) debugging of distributed real-time concurrent CHILL programs, and 5) simulation of application software for integrated testing on the host machine based on CHILL. The application results of the environment compared with other approaches show that the productivity is increased by 19 % because of decreasing implementation and testing cost, and the quality is increased by 83 % because of the formal specifications with its static and dynamic checking facilities.

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Partial AUC maximization for essential gene prediction using genetic algorithms

  • Hwang, Kyu-Baek;Ha, Beom-Yong;Ju, Sanghun;Kim, Sangsoo
    • BMB Reports
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    • v.46 no.1
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    • pp.41-46
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    • 2013
  • Identifying genes indispensable for an organism's life and their characteristics is one of the central questions in current biological research, and hence it would be helpful to develop computational approaches towards the prediction of essential genes. The performance of a predictor is usually measured by the area under the receiver operating characteristic curve (AUC). We propose a novel method by implementing genetic algorithms to maximize the partial AUC that is restricted to a specific interval of lower false positive rate (FPR), the region relevant to follow-up experimental validation. Our predictor uses various features based on sequence information, protein-protein interaction network topology, and gene expression profiles. A feature selection wrapper was developed to alleviate the over-fitting problem and to weigh each feature's relevance to prediction. We evaluated our method using the proteome of budding yeast. Our implementation of genetic algorithms maximizing the partial AUC below 0.05 or 0.10 of FPR outperformed other popular classification methods.

Crippling Test of Z-section Graphite/Epoxy Stringers (Z-단면 Graphite/Epoxy 스트링거의 크리플링 실험)

  • 최상민;권진희
    • Composites Research
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    • v.14 no.3
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    • pp.32-41
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    • 2001
  • Z-section composite stringers with various lengths and flange-widths are tested in axial compression for the validation of a finite element algorithm to calculate the buckling and crippling stresses of composite laminated stringers. The stacking sequence considered is $[{\pm}45/0/90]s$. Strain gages are attached to each specimen, and deflection and end-shortening are obtained by two LVDTs. The buckling load is determined from the load vs. strain response, load vs. end-shortening curves, and load vs. out-of-plane deflection curves. The ultimate stress after local buckling is used as the crippling stress. Comparison between finite element and experimental results shows good agreement in the local buckling and crippling stresses.

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Comparison and validation on shotcrete modelling method for the quantitative stability estimation of a tunnel (터널의 정량적 안정성 평가를 위한 숏크리트 모델링 방법 비교 검증에 관한 연구)

  • You, Kwang-Ho;Lee, Min-Ho;Park, Yeon-Jun
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.9 no.2
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    • pp.99-107
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    • 2007
  • A method was suggested by You et al. (2000) to calculate safety factor of a tunnel based on numerical analysis with the shear strength reduction technique. In the method, the shotcrete is assumed to fail when its stress exceeds the allowable stress. The proposed method had been steadily developed by You et al. (2005) and Han et al. (2006). In this study, the previous routine was corrected so that tunnel construction sequences could be considered in calculating the safety factor of a tunnel. In addition, a proper way to model shotcrete is to be suggested by comparing with the previous studies.

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The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigs

  • Jin, S.;Lee, J.B.;Kang, K.;Yoo, C.K.;Kim, B.M.;Park, H.B.;Lim, H.T.;Cho, I.C.;Maharani, D.;Lee, J.H.
    • Asian-Australasian Journal of Animal Sciences
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    • v.26 no.10
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    • pp.1374-1378
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    • 2013
  • Based on a quantitative traits locus (QTL) study using a $F_2$ intercross between Landrace and Korean native pigs, a significant QTL affecting teat numbers in SSC7 was identified. The strong positional candidate gene, TBC1D21, was selected due to its biological function for epithelial mesenchymal cell development. Sequence analysis revealed six single nucleotide polymorphisms (SNPs) in the TBC1D21 gene. Among these, two SNP markers, one silent mutation (SNP01) for g.13,050A>G and one missense mutation (SNP04) for c.829A>T (S277C), were genotyped and they showed significant associations with teat number traits (p value = 6.38E-05 for SNP01 and p value = 1.06E-07 for SNP04 with total teat numbers). Further functional validation of these SNPs could give valuable information for understanding the teat number variation in pigs.

Genetics of Fusarium Wilt Resistance in Pigeonpea (Cajanus cajan) and Efficacy of Associated SSR Markers

  • Singh, Deepu;Sinha, B.;Rai, V.P.;Singh, M.N.;Singh, D.K.;Kumar, R.;Singh, A.K.
    • The Plant Pathology Journal
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    • v.32 no.2
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    • pp.95-101
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    • 2016
  • Inheritance of resistance to Fusarium wilt (FW) disease caused by Fusarium udum was investigated in pigeonpea using four different long duration FW resistant genotypes viz., BDN-2004-1, BDN-2001-9, BWR-133 and IPA-234. Based on the $F_2$ segregation pattern, FW resistance has been reported to be governed by one dominant gene in BDN-2004-1 and BDN-2001-9, two duplicate dominant genes in BWR-133 and two dominant complimentary genes in resistance source IPA-234. Further, the efficacy of six simple sequence repeat (SSR) markers namely, ASSR-1, ASSR-23, ASSR-148, ASSR-229, ASSR-363 and ASSR-366 reported to be associated with FW resistance were also tested and concluded that markers ASSR-1, ASSR-23, ASSR-148 will be used for screening of parental genotypes in pigeonpea FW resistance breeding programs. The information on genetics of FW resistance generated from this study would be used, to introgress FW resistance into susceptible but highly adopted cultivars through marker-assisted backcross breeding and in conventional breeding programs.

Simultaneous diagnosis and differentiation of Mycoplasma hyopneumoniae and Mycoplasma hyorhinis infections by multiplex PCR (Mycoplasma hyopneumoniae와 Mycoplasma hyorhinis 동시 감별진단을 위한 다중진단 중합효소반응)

  • Hong, Sunhwa;Lee, Hyun-A;Kim, Dong-Woo;Kim, Tae-Wan;Kim, Okjin
    • Korean Journal of Veterinary Service
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    • v.37 no.4
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    • pp.247-252
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    • 2014
  • The economic impact of swine mycoplasma infection is high. An accurate diagnosis is often difficult and time consuming. We report the development and validation of an effective multiplex polymerase chain reaction (PCR) assay that detects Mycoplasma (M.) hyopneumoniae and M. hyorhinis. The multi detection of M. hyopneumoniae and M. hyorhinis primer set were employed to detect mycoplasma species and typing of the species was performed on the basis of sequence analysis of the PCR product. The target nucleic acid fragments were specifically amplified by M. hyopneumoniae and M. hyorhinis PCR with 16S ribosomal DNA primers. Single and mixed Mycoplasma species DNA templates were used to evaluate the specificity of the multiplex assay. The corresponding specific DNA products were amplified for each pathogen. The multiplex PCR assay provides a novel tool for simultaneous detection and differentiation of M. hyopneumoniae and M. hyorhinis.

Frequency variation in construction stages and model validation for steel buildings

  • Aras, Fuat
    • Steel and Composite Structures
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    • v.22 no.3
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    • pp.647-662
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    • 2016
  • This study aims to monitor the variation of modal frequencies of steel buildings during their construction sequence. In this respect, construction of a steel building is followed by vibration based measurements. The monitored building is a three-story educational building within a building group whose structural system consists of steel moment resisting steel frames and eccentric braces. Five different acceleration measurements in two perpendicular directions are taken on five different construction stages, starting from the erection of the columns and beams ending with the completion of the construction. The recorded measurements are transferred into frequency domain and the dominant frequencies for each case have been determined. The change in the dominant frequencies is evaluated with the existing construction stages and performed constructional works between the stages. The last measurement, performed on the building in service, revealed the first two dominant frequencies as mutual in X and Y direction, showing that these dynamic modes are torsional modes. This result is investigated by numerical analysis performed with finite element model of the building constructed for design purpose. Lower frequencies and different mode shapes are determined from numerical analysis. The reason of lower frequencies is discussed and the vibration survey is extended to determine the effects of an adjacent building. The results showed that the building is in strong relation with an adjoining building in spite of a designed construction joint.

An effective solution of electro-thermo-structural problem of uni-axially graded material

  • Murin, J.;Kutis, V.;Masny, M.
    • Structural Engineering and Mechanics
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    • v.28 no.6
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    • pp.695-713
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    • 2008
  • The aim of this contribution is to present a new link/beam finite element suitable for electrothermo-structural analysis of uni-axially graded materials. Continuous polynomial variation of geometry and material properties will be considered. The element matrix and relations for solution of Joule's heat (and its distribution to the element nodes) have been established in the sense of a sequence method of a coupled problem solution. The expression for the solution of nodal forces caused by a continuously distributed temperature field has also been derived. The theoretical part of this contribution is completed by numerical validation, which proves the high accuracy and effectiveness of the proposed element. The results of the performed experiments are compared with those obtained using the more expensive multiphysical link element and solid element of the FEM program Ansys. The proposed finite element could be used not only in the multiphysical analysis of the current paths and actuators but also in analysis of other 1D construction parts made of composite or uni-axially graded materials.