• BMB Reports
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• v.51 no.1
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• pp.1-2
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• 2018

Positive selection on a new beneficial mutation generates a characteristic pattern of DNA sequence polymorphism when it reaches an intermediate allele frequency. On genome sequences of African Drosophila melanogaster, we detected such signatures of selection at 37 candidate loci and identified "sweeping haplotypes (SHs)" that are increasing or have increased rapidly in frequency due to hitchhiking. Based on geographic distribution of SH frequencies, we could infer whether selective sweeps occurred starting from de novo beneficial mutants under simple constant selective pressure. Single SHs were identified at more than half of loci. However, at many other loci, we observed multiple independent SHs, implying soft selective sweeps due to a high beneficial mutation rate or parallel evolution across space. Interestingly, SH frequencies were intermediate across multiple populations at about a quarter of the loci despite relatively low migration rates inferred between African populations. This invokes a certain form of frequency-dependent selection such as heterozygote advantage. At one locus, we observed a complex pattern of multiple independent that was compatible with recurrent frequency-dependent positive selection on new variants. In conclusion, genomic patterns of positive selection are very diverse, with equal contributions of hard and soft sweeps and a surprisingly large proportion of frequency-dependent selection in D. melanogaster populations.

• Journal of Industrial Technology
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• v.19
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• pp.217-226
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• 1999

A single phase to three phase power converter with cost effective and simple structure is proposed. The converter consists of rectifier and inverter. The rectifier is composed of a half wave rectifier, a dc link capacitor, and a current limiting inductor, and the inverter is of only two switches with PWM control. For negative sequence operation the inverter output voltage leads the line input by $60^{\circ}$, and for positive sequence operation the inverter output voltage leads by $60^{\circ}$. We can see that positive sequence operation shows higher output voltage, slight harmonic distortion(2%), and better performances such as high efficiency and high power factor. A mathematical model for system analysis is provided, and specifications for selection and control scheme both for start-up and for steady state are analyzed. comparison and operational limits of positive and negative sequence operation are performed, and simulations and experiments are executed to verify the proposed.

• Genomics & Informatics
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• v.9 no.4
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• pp.189-193
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• 2011

Simple sequence repeats (SSRs) are ubiquitous short tandem duplications found within eukaryotic genomes. Their length variability and abundance throughout the genome has led them to be widely used as molecular markers for crop-breeding programs, facilitating the use of marker-assisted selection as well as estimation of genetic population structure. Here, we report a software application, "SSR-Primer Generator " for SSR discovery, SSR-primer design, and homology-based search of in silico amplicons from a DNA sequence dataset. On submission of multiple FASTA-format DNA sequences, those analyses are batch processed in a Java runtime environment (JRE) platform, in a pipeline, and the resulting data are visualized in HTML tabular format. This application will be a useful tool for reducing the time and costs associated with the development and application of SSR markers.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.05
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• pp.42-44
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• 1995

The original DANTE sequence and its variations have limitation in excitation profile (a sinc function-like excitation) due to the finite duration of the DANTE pulsetrain. This sinc function-like selection profile excites only a small fraction of the spins in the pixel thereby results in poor signal to noise ratio (only about ${\sim}1%$ of normal MR imaging sequence). Therefore, this poor signal to noise ratio (SNR) has been the main drawback of the original DANTE sequence. To improve the signal to noise ratio, phases of individual RF pulses in the DANTE pulse train were modulated so that more spins in the object were excited ($1{\sim}3$). We have introduced a new FM (Frequency Modulation) DANTE sequence and analyzed the signal intensity and excitation profiles.

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.31-32
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• 2007

In this paper, a fault section detection method is proposed for ungrounded system in the case of a single line-to-ground fault. A conventional method is used for faulted feeder selection according to the angular relationship between zero-sequence currents of the feeders and zero-sequence voltage of the system. Fault section detection is based on the comparison of phase angle of zero-sequence current. Proposed method has been testified in a demo system by Matlab/Simulink simulations. Based on Distribution Automation System(DAS), Feeder Remote Terminal Unit(FRTU) is used to collect those necessary data, at present a demo system is under developing using Manufacturing Message Specification (MMS) in IEC61850 standard.

• Food Science and Biotechnology
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• v.27 no.6
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• pp.1755-1760
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• 2018

The objective of this study was to perform genetic diversity analysis of 13 strains isolated from South Korean foods by multilocus sequence typing (MLST). For typing, seven housekeeping loci (atpA, dnaA, dnaK, gyrB, pheS, pyrG, and rpoA) were selected, amplified and analyzed. Fifty-one polymorphic sites varying from 1 to 22 in each species were identified. Thirteen sequence types were generated with allele numbers ranged from 2 to 10. The overall relationship between strains was assessed by unweighted pair group method with arithmetic mean dendrogram and minimum spanning tree. In addition, combined spits tree analysis revealed intragenic recombination. No clear relationship was observed between the isolation sources and strains. The developed MLST scheme enhanced our knowledge of the population diversity of Leu. citreum strains and will be used further for the selection of industrially important strain.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.04a
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• pp.405-408
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• 2000

The objective of this paper is to develop a model to integrate process planning and resource planning through analysis of the machine tool selection and operations sequencing problem. The model is formulated as a travelling salesman problem with precedence relations. To solve our model, we also propose an efficient genetic algorithm based on topological sort concept.

• Proceedings of the KIEE Conference
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• 1996.11a
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• pp.175-178
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• 1996

Power system is becomming more and more complex and large. So system is stressed increasingly. This paper presents a method to select contingency ranking in power systems for EMS operation. Firstly, the proposed method is applied line outage using Thevenin equivalent circuit. Secondly, Contingency harmful to system is selected by loss variation between base case and fault. Thirdly, this paper prescribed simulated line sequence. Therefore this algorithm shows higher computation speed and effective memory use.

• Proceedings of the KIEE Conference
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• 2004.11c
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• pp.496-498
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• 2004

An action-selection-mechanism is proposed to deal with sequential behaviors, where associations between some of stimulus and behaviors will be learned by a shortest-path-finding-based reinforcement team ins technique. To be specific, we define behavioral motivation as a primitive node for action selection, and then sequentially construct a network with behavioral motivations. The vertical path of the network represents a behavioral sequence. Here, such a tree fur our proposed ASM can be newly generated and/or updated. whenever a new sequential behaviors is learned. To show the validity of our proposed ASM, some experimental results on a "pushing-box-into-a-goal task" of a mobile robot will be illustrated.

• Journal of Korean Institute of Industrial Engineers
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• v.15 no.2
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• pp.45-55
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• 1989

This paper deals with development of a computer-aided process selection and sequencing technique and its software for metal cutting processes of rotational parts. The process selection procedure consists of selection for proper machining operations and machine tools suitable for the selected operations. Machining operations are selected based on machining surface features and machine tools are selected by employing a conversion table which converts machining operations into machine tools. The process sequence is determined by the proper manipulation of the precedence relation matrix. A computer program for the proposed technique is developed by using Turbo-Pascal on IBM PC/AT compatible system. The proposed technique works well to real problems.