• Phonetics and Speech Sciences
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• v.12 no.1
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• pp.33-42
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• 2020

This study identified the substitution of /u/ for /o/ (e.g., pyəllo [pyəllu]) in Korean based on the speech corpus as a function of grammar items. Korean /o/ and /u/ share the vowel feature [+rounded], but are distinguished in terms of tongue height. However, researchers have reported that the merger of Korean /o/ and /u/ is in progress, making them indistinguishable. Thus, in this study, the frequency of the phonetic manifestation /u/ of the underlying form of /o/ for each grammar item was calculated in The Korean Corpus of Spontaneous Speech (Seoul Corpus 2015) which is a large corpus from a total of 40 speakers from Seoul or Gyeonggi-do. It was then confirmed that linking endings, particles, and adverbs ending with /o/ in the word-final position were substituted for /u/ approximately 50% of the stimuli, whereas, in nominal items, they were replaced at a frequency of less than 5%. The high rates of substitution were the special particle "-do[du]" (59.6%) and the linking ending "-go[gu]" (43.5%) among high-frequency items. Observing Korean pronunciation in real life provides deep insight into its theoretical implications in terms of speech recognition.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.197-197
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• 1998

Chronic electroconvulsive shock(ECS) was shown to Increase phosphatidylinositol-4,5-bisphosphate(PIP$_2$) breakdown and the activity of PLC with the accumulation of inositol-1,4,5-triphosphate(IP3). The purpose of the present study was to determine the effect of ECS on the expression of phospholipase C(PLC) isotypes in rat brain. Two groups of animals were prepared: sham and ECS treated groups. Rats in ECS treated groups received maximal ECS(70mA, 0.5second, 60㎐) by constant current stimulator through ear-clip to induce tonic extension seizures for 12 consecutive days. The expression of PLC isotypes in rat brain was determined by immunohistochemical procedure using sagital section of rat brain. The immunoreactivity of PLC${\beta}$1 was observed in corpus striatum, hippocampus, thalamus and that of PLC${\gamma}$1 in corpus striatum, hippocampus, thalamus, frontal cortex, parietooccipital cortex, limbic forebrain, pons, medulla, superior colliculus, inferior colliculus, rest of midbrain. The amount of PLC was analyzed by Western blot using antibodies against PLC${\beta}$1 and PLC${\gamma}$1. Chronic ECS reduced the immunoreactivity of PLC${\beta}$1 in corpus striatum, hippocampus, thalamus but had little effect on PLC${\gamma}$1. To quantify this change, quantitative Western blot using antibodies against PLC${\beta}$1 and PLC${\gamma}$1 was conducted. The immunoreactivity of PLC${\beta}$1 in ECS treated rat whole brain was decreased by 40 % in cytosolic fraction and 26 % in membrane fraction. This different effect of ECS on PLC isotypes may results from the difference of their activation mechanisms and the different effects of ECS on them. The results from the present study suggest that chronic ECS primalily affects neurotransmitter receptors related IP$_3$ signaling in rat brain.

• Language and Information
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• v.19 no.2
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• pp.19-36
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• 2015

The aim of this paper is to investigate the usage of Korean markers -(n)un and -i/ka in editorial texts focusing on information structure. Noun phrases ending with the markers -(n)un and -i/ka were annotated semi-automatically using a corpus obtained from an online newspaper. Two important factors to determine the choice of markers were examined with the annotated data: referential givenness/newness and position in a sentence. Referential givenness and newness were adopted as indicators of information structure, topic and focus respectively. In addition to quantitative analysis, qualitative analysis was conducted on the selected data. The results suggest that both the marker -(n)un and -i/ka could carry a topic and a focus reading. Sentence position also played a crucial role in determining the marker, and the marker -i/ka was used more frequently in a later position of a sentence than the marker -(n)un.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• v.55 no.8
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• pp.498-507
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• 2012

Background and Objectives We aimed to develop a Korean version of the velopharyngeal insufficiency (VPI) speech corpus system. Subjects and Method After developing a 3-channel simultaneous speech recording device capable of recording nasal/oral and normal compound speech separately, voice data were collected from VPI patients aged more than 10 years with/without the history of operation or prior speech therapy. This was compared to a control group for which VPI was simulated by using a french-3 nelaton tube inserted via both nostril through nasopharynx and pulling the soft palate anteriorly in varying degrees. The study consisted of three transcriptors: a speech therapist transcribed the voice file into text, a second transcriptor graded speech intelligibility and severity and the third tagged the types and onset times of misarticulation. The database were composed of three main tables regarding (1) speaker's demographics, (2) condition of the recording system and (3) transcripts. All of these were interfaced with the Praat voice analysis program, which enables the user to extract exact transcribed phrases for analysis. Results In the simulated VPI group, the higher the severity of VPI, the higher the nasalance score was obtained. In addition, we could verify the vocal energy that characterizes hypernasality and compensation in nasal/oral and compound sounds spoken by VPI patients as opposed to that characgerizes the normal control group. Conclusion With the Korean version of VPI speech corpus system, patients' common difficulties and speech tendencies in articulation can be objectively evaluated. Comparing these data with those of the normal voice, mispronunciation and dysarticulation of patients with VPI can be corrected.

• Proceedings of the Korean Information Science Society Conference
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• 2010.11a
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• pp.70-71
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• 2010

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.145.1-145.1
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• 2001

• Proceedings of the Korean Information Science Society Conference
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• 2010.06a
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• pp.90-91
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• 2010

• Korean Journal of Radiology
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• v.23 no.2
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• pp.226-236
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• 2022

Objective: This study aimed to explore the myelin volume change in patients with mild traumatic brain injury (mTBI) with post-concussion syndrome (PCS) using a multidynamic multiecho (MDME) sequence and automatic whole-brain segmentation. Materials and Methods: Forty-one consecutive mTBI patients with PCS and 29 controls, who had undergone MRI including the MDME sequence between October 2016 and April 2018, were included. Myelin volume fraction (MVF) maps were derived from the MDME sequence. After three dimensional T1-based brain segmentation, the average MVF was analyzed at the bilateral cerebral white matter (WM), bilateral cerebral gray matter (GM), corpus callosum, and brainstem. The Mann-Whitney U-test was performed to compare MVF and myelin volume between patients with mTBI and controls. Myelin volume was correlated with neuropsychological test scores using the Spearman rank correlation test. Results: The average MVF at the bilateral cerebral WM was lower in mTBI patients with PCS (median [interquartile range], 25.2% [22.6%-26.4%]) than that in controls (26.8% [25.6%-27.8%]) (p = 0.004). The region-of-interest myelin volume was lower in mTBI patients with PCS than that in controls at the corpus callosum (1.87 cm³ [1.70-2.05 cm³] vs. 2.21 cm³ [1.86-3.46 cm³]; p = 0.003) and brainstem (9.98 cm³ [9.45-11.00 cm³] vs. 11.05 cm³ [10.10-11.53 cm³]; p = 0.015). The total myelin volume was lower in mTBI patients with PCS than that in controls at the corpus callosum (0.45 cm³ [0.39-0.48 cm³] vs. 0.48 cm³ [0.45-0.54 cm³]; p = 0.004) and brainstem (1.45 cm³ [1.28-1.59 cm³] vs. 1.54 cm³ [1.42-1.67 cm³]; p = 0.042). No significant correlation was observed between myelin volume parameters and neuropsychological test scores, except for the total myelin volume at the bilateral cerebral WM and verbal learning test (delayed recall) (r = 0.425; p = 0.048). Conclusion: MVF quantified from the MDME sequence was decreased at the bilateral cerebral WM in mTBI patients with PCS. The total myelin volumes at the corpus callosum and brainstem were decreased in mTBI patients with PCS due to atrophic changes.

• Korean Journal of Veterinary Research
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• v.29 no.4
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• pp.589-599
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• 1989

A total of 13 synchronized dairy cattle(Holstein) were used to determine pregnancy rates in relation to plasma progesterone, estradiol-$17{\beta}$ levels and serum chemical values on the day of last $PGF_{2{\alpha}}$ injection and day of frozen/thawed bovine embryo transfer. The pregnancy rate of recipients with 1.0~4.0ng/ml of progesterone levels at the day of last $PGF_{2{\alpha}}$ injection was higher than that of recipients with below 1.0ng/ml or above 4.0ng/ml of progesterone levels. On the day of transfer, optimal progesterone levels were between 1.0ng/ml and 4.0ng/ml coinciding with a pregnancy rate of 88.9%. Pregnancy rate decreased when progesterone levels were below 1.0ng/ml(33.3%) or above 4.0ng/ml(0%). Corpus luteum grade did not affect pregnancy rate and this result revealed that manual palpation of corpus luteum was not valid criterion of corpus luteum function. Progesterone levels as well as pregnancy rate did not significantly differ whether the corpus luteum was on the right($1.62{\pm}1.33ng/ml$; 63.5%) or left ovary($1.99{\pm}0.61ng/ml$; 85.0%). Estradiol-$17{\beta}$ levels were not significantly different between pregnant and nonpregnant recipients, but estradiol-$17{\beta}$ levels($82.2{\pm}13.5$ VS. $72.3{\pm}10.1pg/ml$) were higher at below 1.0ng/ml of progesterone, and pregnancy rates(33.3 VS. 80%) tended to be lower than above 1.0ng/ml of progesterone. Total cholesterol levels on the day of last $PGF_{2{\alpha}}$ injection and day of transfer did not affect pregnancy rate. Calcium and inorganic phoshorus levels belonged to normal range in most of the recipients. These range did not affect pregnancy rate. In reviewing above results, plasma progesterone levels(1.0~4.0ng/ml) at the time of transfer are diagnostic value for screening recipients prior to transfer of frozen/thawed bovine embryos.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.12
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• pp.1711-1715
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• 2006

To predict the number of preantral (primordial, primary and secondary) follicles retrieved from bovine ovaries, we examined the relationship between morphological parameters of ovaries and number of preantral follicles retrieved mechanically. The preantral follicles were retrieved mechanically by slicing ovarian tissue and the influences of size of the ovaries, number of antral follicles, and presence of cystic follicle and corpus luteum on the retrieval were evaluated. Total 77 ovaries were used and significant (p<0.05) relationship was detected between the number of antral follicles and the presence of cystic follicles, and the retrieval number. More preantral follicles were retrieved from the ovaries having more than 20 antral follicles than those having less than 20 antral follicles (17,760${\pm}$5,637 vs. 3,689${\pm}$537) in the ovarian cortex. The retrieval number was significantly reduced in cystic ovaries compared with non-cystic ovaries (5,167${\pm}$825 vs. 20,631${\pm}$6,507). However, neither ovary size (<3.5, 3.5 to 4.0, 4.0 to 4.5 and >4.5 cm) nor the presence of corpus luteum affected the follicle retrieval. In conclusion, the number of preantral follicles retrieved from the ovaries can simply be predicted by the number of antral follicles and the presence of cystic follicles in the ovarian cortex.