• 대한임상검사과학회지
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• 제37권3호
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• pp.212-215
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• 2005

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy in clinical practice, with a 0.1% life time risk in the general population. Conventional neurophysiological studies have been useful in the diagnosis of this condition, as have a number of more specialized procedures. Therefore, we evaluated the diagnostic sensitivities of several parameters in nerve conduction technique for CTS patients. We analyzed 100 patients (159 hands) who were diagnosed with CTS clinically and electrophysiolosically. Median motor and sensory nerve conduction velocities (MCV and SCV) with wrist, palm, and finger stimulation were performed in traditional methods. Sensitivities of each test were calculated and compared to normal control data. The sensitivities of existing nerve conduction method were noted in terminal latency on median nerve, 2nd finger-wrist segment, 3rd finger-wrist segment, palm-wrist segment and distoproximal ratio, as 72.96%, 92.45%, 94.34%, 94.97%, and 97.48%, respectively. In the early course of CTS, sensory nerve conductions in the median nerve are more valuable than motor nerve conduction. Sensory nerve conductions are usually affected before motor nerve conductions in CTS. In this study, we detected that slowing of median SCV was the most frequent in the distoproximal ratio.

• Annals of Clinical Neurophysiology
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• 제7권2호
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• pp.133-137
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• 2005

Underlying neuropathies combined with amyotrophic lateral sclerosis (ALS) cast doubt on the diagnosis of ALS when present. Abnormal sural nerve conductions were found in 3 patients with clinically definite ALS. Pathologically demyelinating, axonal, or vasculitic neuropathy was suggested respectively. High dose oral corticosteroid had no effect and clinical courses were deteriorating in all the patients. The causes of combined neuropathies were unclear. Possibility of direct consequence of ALS, concomitant neuropathies, or rare variants of ALS should be considered in these cases.

• Journal of Preventive Medicine and Public Health
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• 제28권4호
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• pp.899-910
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• 1995

1994년 1월 24일부터 동년 4월 8일까지 부산 메리놀병원 내과 및 신경과에서 당뇨병으로 진단되어 당뇨교실에서 치료를 받고 있는 입원 및 외래환자 67명(남37명, 여 30명 : 평균연령 $52.55{\pm}13.67$세)라 병력 및 이학적 소견상 말초신경에 이상이 없다고 진단된 직원 및 그 가족 53명(남 28명, 여 25명 : 평균연령 $45.75{\pm}12.21$세)을 대상으로 본 병원 신경생리검사실에서 가중침자감각역치와 감각신경전도검사를 측정한 결과는 다음과 같다. 1. 가중침자감각역치는 양측 손과 발의 측정한 모든 부위에서 당뇨병 환자 중 증상군, 무증상군 그리고 대조군간에 있어서 통계학적으로 유의한 차이를 나타냈는데, 대조군이 당뇨병 환자군보다 낮았고 당뇨병 환자 중 무증상군이 증상군보다 낮게 나타났다. 2. 당뇨병 환자에 있어서 가중침자감각역치는 증상군과 무증상군 모두 연령과 당뇨병유병기간과는 통계학적으로 유의한 상관관계를 나타내어 연령이 많고 유병기간이 길수록 가중침자감각역치는 높았으며 기타 체중, 신장 및 교육수준과는 유의한 상관성이 없었다. 3. 대조군에 있어서 가중침자감각역치는 연령과는 통계학적으로 유의한 상관관계를 나타냈고 교육수준과는 역상관관계를 나타내어 연령이 많고 교육수준이 낮을수록 가중침자감각역치는 높았으며 체중과 신장과는 유의한 상관성이 없었다. 4. 가중침자감각역치에 있어서 연령을 보정한 후의 각 부위별 세 군간의 차이는 우측 제5수지와 좌측 발에서는 세 군 서로 모두 통계학적으로 유의한 차이를 나타냈으나(p<0.05), 양측 제2수지와 좌측 제5수지 그리고 우측 발에서의 가중침자감각역치는 증상군과 대조군, 그리고 무증상군과 대조군간에서만 통계학적으로 유의한 차이를 나타내었다(p<0.05). 5. 각 부위별 가중침자감각역치와 감각신경의 전도 속도 및 활동전위 진폭과의 상관관계는 측정한 모든 부위에서 통계학적으로 유의한 상관관계를 나타냈다(p<0.05). 이상의 결과로 보아 감각신경 전도검사가 가중침자감각역치보다 정확한 검사이긴 하지만 가중침자감각역치는 말초감각장애 정도를 외래에서 신속히 알고 싶을 때나, 감각신경 전도검사가 불가능한 상황에서 매우 유용한 검사방법이라 생각된다.

• Annals of Clinical Neurophysiology
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• 제23권2호
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• pp.108-116
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• 2021

Background: Nitrous oxide (N₂O) is used in surgery and dentistry for its anesthetic and analgesic effects. However, neurological and psychiatric manifestations of N₂O abuse have been increasingly reported among Korean adults. The aim of this study was to demonstrate laboratory findings of N₂O abuse in Korean patients. Methods: Patients diagnosed with N₂O-induced neuropathy or myelopathy from August 2018 to December 2019 were enrolled. Their clinical presentations and laboratory and imaging findings were analyzed. Results: Sensory changes and limb weakness were present in nine of the enrolled patients. The laboratory findings revealed that seven patients had high homocysteine levels and five had high methylmalonic acid levels in their blood. Nerve conductions studies indicated that axonal neuropathy was present in four cases and longer F-wave and Hoffman's-reflex latencies were present in two cases. Signal changes in cervical spine imaging occurred in five patients, while two had normal results. Conclusions: Chronic N₂O abuse can cause neurological damage or psychiatric problems. Because N₂O is illegal for recreational use in Korea, patients tend to hide their history of use. Even though the spinal imaging results were normal, clinicians should consider the possibility of N₂O use, and further electrophysiological tests should be applied for precise evaluations.