• Journal of Medicine and Life Science
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• 제20권1호
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• pp.1-7
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• 2023

Transient receptor potential ankyrin 1 (TRPA1) receptors are major polymodal nociceptors that generate primary pain responses in the peripheral nerve endings of the dorsal root ganglion neurons. Recently, we reported that the activation of TRPA1 receptors by reactive oxygen species (ROS) signaling, which is triggered by Ca²⁺ influx through T-type Ca²⁺ channels, contributes to prolonged pain responses induced by jellyfish toxin. In this review, we focus on the characteristics of the TRPA1 receptor involved in intracellular signaling as a secondary pain modulator. Unlike other transient receptor potential receptors, TRPA1 receptors can induce membrane depolarization by ROS without exogenous stimuli in peripheral and central sensory neurons. Therefore, it is important to identify the functional characteristics of TRPA1 receptors to understand pain modulation under several pathogenic conditions such as neuropathic pain syndromes and autoimmune diseases, which are mediated by oxidative signaling to cause chronic pain in the sensory system.

• 한국측량학회지
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• 제27권2호
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• pp.249-260
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• 2009

공중 모니터링 시스템으로 획득된 센서 데이터의 georeferencing 정확도는 시스템에 탑재된 GPS/IMU의 성능에 크게 의존된다. 그러나 고성능이지만 고가인 GPS/IMU의 탑재는 전체 시스템의 개발비를 크게 증가시키는 문제를 야기한다. 이에 본 연구는 MEMS 형태의 저가 통합형 GPS/IMU를 탑재한 UAV 기반의 공중 모니터링 시스템으로부터 취득된 영상 및 GPS/IMU 데이터를 시뮬레이션하고, 시뮬레이션된 센서 데이터에 지상기준점을 사용하지 않고 aerial triangulation을 적용하여 영상 georeferencing을 수행한다. 영상 georeferencing의 결과를 분석하여 각 영상의 추정된 외부표정변수와 지상점 좌표의 정확도를 평가한다. Aerial triangulation 없이 direct georeferencing을 수행한 결과와 비교할 때 외부표정변수와 지상점 좌표의 RMSE가 90%이상 감소하였다. 본 연구를 통해 저가 실시간 공중 모니터링 시스템 개발의 높은 가능성을 확인할 수 있었다.

• 디자인학연구
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• 제20권3호
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• pp.39-48
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• 2007

본 논문은 도시환경의 공공사인시스템의 효율극대화를 위하여 안구운동을 측정하는 공학 심리적 또는 인지 과학적 실험을 통하여 안구운동과 가로세로의 시각흐름 그리고 유전된 문화적. 선험적 도식 그리고 대뇌의 시각 시스템의 차별을 탐색하였다. 따라서 EMR 관측실험과 bitmap counting 방법을 대입함으로서 가장 효율적인 시각디자인 측정을 구할 수 있는 algorithm을 도출하였다. 본 논문에서는 과학적인 실험 Data가 인간의 $\ulcorner$Schema$\lrcorner$ 와 $\ulcorner$Sensory Qualia$\lrcorner$ 에 의해, 차별화와 시각표집(Visual Sampling)의 가변성(Momentum)이 상존함을 알게 되었다.

• 한국실내디자인학회논문집
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• 제20권3호
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• pp.143-151
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• 2011

With today's new media environment throughout Ubiquitous information innovation, live and dynamic fluid space is being created by integrating organic integration between electronic space and physical space and transplanting intelligence to materials. In other words, perception occurs in fluid space itself in a new media environment so has complicatedly organic relationship with environment and humans. In addition, emotion, time and movement have actively attempted to enter the space so designs appealing to humans' emotions are made through stimulation of synaesthetic sensory organs. This can be understood in the same context that media is eventually expansion of human body. Fluid space has characteristics of a live organism with factors such as sensor, perception and behavior so it needs to interpret perceptual system relationally and synthetically through an organic study method. This study looks into characteristics of organic perceptual system in terms of the meaning that fluid space with movements have as the sensory-perceptive subject and accordingly makes the world more sufficient as the third space, prepares a possibility to get out of limited five senses, and will develop fluid space as the organic environment making stimulation by itself.

• The Journal of Korean Physical Therapy
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• 제13권1호
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• pp.219-227
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• 2001

Capsaicin. a vanillyl amide(8-methy1-N-vanilly1-6-nonenamide) with a molecular weight of 305.42, was substance, interrupting the pain conducting pathway Until recently the neurotoxic effects of Capsaicin to adult animals were thought to be limited to the peripheral nervous system. But several reports suggest the possibility of central nervous system changes after Capsaicin administration to the adult rat. Capsaicin desensitization is defined as long lasting, reversible suppression of sensory neuron activity. How fast and for how long the desensitization develops is related to the dose and time of exposure to Capsaicin, and the interval between consecutive dosing. In the long term Capsaicin treatment can lead to morphological degeneration and changes in some small sensory neurons, predominantly unmyelinated C fiber afferent nerve fibers. Clinical interest has recently been roused by evidence that Capsaicin's desensitizing action may be of therapeutic value and that an endogenous Capsaicin-1 ike substance may exist. This study summarizes the fundamental knowledge(mechanism, receptors, et al of Capsaicin) of Capsaicin for physical therapists.

• The Korean Journal of Physiology and Pharmacology
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• 제5권6호
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• pp.511-519
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• 2001

Nimopidine, one of dihydropyridine derivatives, has been widely used to pharmacologically identify L-type Ca currents. In this study, it was tested if nimodipine is a selective blocker for L-type Ca currents in sensory neurons and heterologous system. In mouse dorsal root ganglion neurons (DRG), low concentrations of nimodipine $(<10\;{\mu}M),$ mainly targeting L-type Ca currents, blocked high-voltage-activated calcium channel currents by ${\sim}38%.$ Interestingly, high concentrations of nimodipine $(>10\;{\mu}M)$ further reduced the 'residual' currents in DRG neurons from ${\alpha}_{1E}$ knock-out mice, after blocking L-, N- and P/Q-type Ca currents with $10\;{\mu}M$ nimodipine, $1\;{\mu}M\;{\omega}-conotoxin$ GVIA and 200 nM ${\omega-agatoxin$ IVA, indicating inhibitory effects of nimodipine on R-type Ca currents. Nimodipine $(>10\;{\mu}M)$ also produced the inhibition of both low-voltage-activated calcium channel currents in DRG neurons and ${\alpha}_{1B}\;and\;{\alpha}_{1E}$ subunit based Ca channel currents in heterologous system. These results suggest that higher nimodipine $(>10\;{\mu}M)$ is not necessarily selective for L-type Ca currents. While care should be taken in using nimodipine for pharmacologically defining L-type Ca currents from native macroscopic Ca currents, nimodipine $(>10\;{\mu}M)$ could be a useful pharmacological tool for characterizing R-type Ca currents when combined with toxins blocking other types of Ca channels.

• 복식문화연구
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• 제20권2호
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• pp.144-153
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• 2012

This study performed a simultaneous sensory evaluation and color measurement, targeting 136 female university students who live in the Dae-Jeon region. the study measured participants'facial coloration under the condition of available light between 11 AM and 3 PM from Spring (May) to Autumn (October) in 2009. For statistical analysis, descriptive statistics, a member variate analysis, and discriminant analysis were executed using SPSS version 18.0 of the statistics program. The results of this study are as follows. First, as a result of the sensory evaluation, the blue undertone well matched to face type was dominantly distributed among the female university student participants. Second, the forehead showed a type of yellowish coloration and was relatively dark to cheeks. However the cheek displayed a reddish coloration and was relatively bright compared to the forehead from an evaluation of a cheek and forehead color measurement. Third, due to the investigation the of facial coloration variable, a yellowish and reddish chromaticity on the cheek were evident as a variable of facial coloration, which has an influence on the classification of the types of facial color. As a result of the induced discriminant through these two color variables, the yellowish chromaticity appeared as a color variable to have a greater influence than the reddish chromaticity on the cheek.

• 한국식생활문화학회지
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• 제33권5호
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• pp.426-436
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• 2018

This study assessed effective strategies to reduce the sodium intake among consumers using pork cutlet sauce as a model food system. Original pork cutlet sauce and sodium-reduced sauce (29% reduced by a salt substitute) were analyzed to characterize the sensory properties using descriptive analysis. The effects of sodium-reduction of the sauce, consumer type (nutrition teachers vs. general consumers), information related to the sodium content, serving method, and consumer's health, taste and sodium-related attitudes on the consumer's preference, perception, and intake of the sauce were analyzed using a consumer test. In descriptive analysis, the original and sodium-reduced sauce showed similar sensory characteristics but did not differ in saltiness. In the consumer test, there were no significant differences in the overall preference levels between the two sauces. On the other hand, there were significant differences in preference and perception between nutrition teachers and general consumer groups, which were due largely to their age as well as the health and sodium-related attitudes and nutritional knowledge differences. Sodium-reduced information decreased the perceived saltiness intensity. In addition, reducing sodium intake by serving pork cutlet sauce in a bottle can be an effective strategy because this serving method increased the acceptance and induced the smaller intake of sauce.

• 대한두개안면성형외과학회지
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• 제21권6호
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• pp.380-383
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• 2020

Schwannomas, which originate from Schwann cells in the peripheral nervous system, are slowg-rowing and uncommon benign tumors. Most schwannomas (90%) occur in isolation, and multiple occurrences are a characteristic feature of neurofibromas. Schwannomas of the nose and nasal tip are particularly unusual. Although a few cases of schwannomas of the sinusoidal tract and nasal septum have been reported, schwannomas arising from the nasal dorsum area and tip are extremely rare. Sensory abnormalities are also a very rare symptom. We excised a schwannoma on the nasal dorsum through direct incision and a schwannoma on the nasal tip through open rhinoplasty. No postoperative complications involving recurrence, hematoma, or infection occurred. The possibility of neurological changes should be considered in cases of an abnormality in the peripheral nervous system. Schwannoma must be kept in mind as a possible cause of neurological changes localized to a specific dermatome, and should always be considered in the differential diagnosis of a mass on the nose.

• International Journal of Computer Science & Network Security
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• 제23권2호
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• pp.47-54
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• 2023

This article reviews recent advances and perspectives in neuroscience related to consciousness, cognition, and neural networks in the brain. The neural mechanisms underlying cognitive processes, such as perception, attention, memory, and decision-making, are explored. The article also examines how these processes give rise to our experience of consciousness. The implications of these findings for our understanding of the brain and its functions are presented, as well as potential applications of this knowledge in fields such as medicine, psychology, and artificial intelligence. Additionally, the article explores the concept of a quantum viewpoint concerning consciousness, cognition, and creativity and how incorporating DNA as a key element could reconcile classical and quantum perspectives on human behaviour, consciousness, and cognition, as explained by genomic psychological theory. Furthermore, the article explains how the human brain processes external stimuli through the sensory nervous system and how it can be simulated using an artificial neural network (ANN) consisting of one input layer, multiple hidden layers, and an output layer. The law of learning is also discussed, explaining how ANNs work and how the modification of weight values affects the output and input values. The article concludes with a discussion of future research directions in this field, highlighting the potential for further discoveries and advancements in our understanding of the brain and its functions.