• Reproductive and Developmental Biology
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• v.36 no.1
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• pp.39-47
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• 2012

Ovarian cancer is the most lethal gynecological malignancy, and specific biomarkers are important needed to improve diagnosis, prognosis, and to forecast and monitor treatment efficiency. There are a lot of pathological factors, including reactive oxygen species (ROS), involved in the process of cancer initiation and progression. The oxidative modification of proteins by ROS is implicated in the etiology or progression of disorders and diseases. In this study, a labeling experiment with the thiol-modifying reagent biotinylated iodoacetamide (BIAM) revealed that a variety of proteins were differentially oxidized between normal and tumor tissues of ovarian cancer patients. To identify cysteine oxidation-sensitive proteins in ovarian cancer patients, we performed comparative analysis by nano-UPLC-$MS^E$ shotgun proteomics. We found oxidation-sensitive 22 proteins from 41 peptides containing cysteine oxidation. Using Ingenuity program, these proteins identified were established with canonical network related to cytoskeletal network, cellular organization and maintenance, and metabolism. Among oxidation-sensitive proteins, the modification pattern of Collagen alpha-1(VI) chain (COL6A1) was firstly confirmed between normal and tumor tissues of patients by 2-DE western blotting. This result suggested that COL6A1 might have cysteine oxidative modification in tumor tissue of ovarian cancer patients.

• Korean Journal of Child Studies
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• v.12 no.2
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• pp.111-129
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• 1991

The present study investigated how the inconsistency between episodes in a story affects judgment of the importance of a sentence. In experiment I, 120 college students read 4 stories containing 3 episodes and judged each of the sentences, one after another. The results of the importance rating showed that adult subjects were sensitive to inconsistency between episodes. The analysis of episodes revealed a significant difference between episodes in all of the 4 stories, with lowest importance ratings given to the inconsistent episodes. In experiment II, 220 children were sampled from a private school of middle S.E.S.Status. 2nd-, 4th- and 6th- graders read 2 stories, and judged the importance of the sentences. It was found that children were less sensitive to inconsistencies in a story than adults. Younger children had more difficulty in the integration of inconsistent information. Especially in the 2nd episode, the importance rating was affected by grade [F(2,2627)=195.52, p<.01], suggesting that 6th graders were more sensitive to inconsistencies than the younger children. In contrast to adults, 2nd graders gave high importance ratings to inconsistent sentences as well as to consistent sentences.

• Macromolecular Research
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• v.16 no.2
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• pp.169-177
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• 2008

This paper reports a facile synthesis of new water-soluble poly(ethylene oxide) (PEO)-based amphiphilic block copolymers showing pH sensitive phase transition behaviors. The copolymers were prepared by atom transfer radical polymerization (ATRP) of methacrylamide type of monomers carrying a sulfonamide group using a PEO-based macroinitiator and a Cu(I)Br/$Me_6TREN$ catalytic system in aqueous media. The resulting polymers were characterized by a combination of $^1H$-NMR, size exclusion chromatography, and UV/Visible spectrophotometeric analysis. The micellization of the block copolymers as a drug-loading mechanism in aqueous media using fluorescein salt was examined as a function of pH. The stable micelle formation and its loading efficacy suggest that the block copolymers can be used as precursors for drug-nanocontainers.

• Mass Spectrometry Letters
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• v.13 no.4
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• pp.158-165
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• 2022

Many therapeutic class drugs such as beta-blocker, corticosteroids, NSAIDs, etc are prohibited substances in the horse racing industry. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology makes it possible to isolate drugs from interference, enables various drug analyses in complex biological samples due to its sensitive sensitivity, and has been successfully applied to doping control. In this paper, we describe a rapid and sensitive method based on solid-phase extraction (SPE) using solid phase cartridge and LC-MS/MS to screen for different class's 35 drug targets in equine plasma. Plasma samples were pretreated by SPE with the NEXUS cartridge consisted non-polar carbon resin and minimum buffer solvent. Chromatographic separation of the analytes was performed on ACQUITY HSS C18 column (2.1 × 150 mm, 1.8 ㎛). The elution gradient was conducted with 5 mM ammonium formate (pH 3.0) in distilled water and 0.1% formic acid in acetonitrile at a flow rate of 0.25 mL/min. The selected reaction monitoring (SRM) mode was used for drug screening with multiple transitions in the positive ionization mode. The specificity, limit of detection, recovery, and stability was evaluated for validation. The method was found to be sensitive and reproducible for drug screening. The method was applied to plasma sample analysis for the proficiency test from the Association of Racing Chemist.

• The Journal of Bigdata
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• v.6 no.2
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• pp.161-168
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• 2021

In this study, we propose a cardiovascular disease prediction model using machine learning. First, a multidimensional analysis of various differences between the two groups is performed and the results are visualized. In particular, we propose a predictive model using cost-sensitive learning that can improve the sensitivity for cases where there is a high class imbalance between the normal and patient groups, such as diseases. In this study, a predictive model is developed using CART and XGBoost, which are representative machine learning technologies, and prediction and performance are compared for cardiovascular disease patient data. According to the study results, CART showed higher accuracy and specificity than XGBoost, and the accuracy was about 70% to 74%.

• Journal of Sensor Science and Technology
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• v.31 no.3
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• pp.151-155
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• 2022

In this paper, we present a highly-sensitive gate/body-tied (GBT) metal-oxide semiconductor field-effect transistor (MOSFET)-type photodetector using multi-finger structure whose photocurrent increases in proportion to the number of fingers. The drain current that flows through a MOSFET using multi-finger structure is proportional to the number of fingers. This study intends to confirm that the photocurrent of a GBT MOSFET-type photodetector that uses the proposed multi-finger structure is larger than the photocurrent per unit area of the existing GBT MOSFET-type photodetectors. Analysis and measurement of a GBT MOSFET-type photodetector that utilizes a multi-finger structure confirmed that photocurrent increases in ratio to the number of fingers. In addition, the characteristics of the photocurrent in relation to the optical power were measured. In order to determine the influence of the incident the wavelength of light, the photocurrent was recorded as the incident the wavelength of light varied over a range of 405 to 980 nm. A highly-sensitive GBT MOSFET-type photodetector with multi-finger structure was designed and fabricated by using the Taiwan semiconductor manufacturing company (TSMC) complementary metal-oxide-semiconductor (CMOS) 0.18 um 1-poly 6-metal process and its characteristics have been measured.

• Journal of the Korean Society for Precision Engineering
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• v.12 no.12
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• pp.53-63
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• 1995

In the analysis of metal forming problems, the explicit time integration finite element method, which does not have convergence problems, is frequently used. The present work is to assess the applicability of the explicit time integration finite element method to quasi-static metal forming problems. Compressing analyses of thin-walled tubes and solid cylinders are performed with different loading velocities. The computed buckled profiles of thin walled tubes are compared with the theoretical and experimental ones and it is found that at sufficiently low loading velocity, the explicit time integration finite element method accurately predict quasi-static buckled profiles. When loading volocity is increased, the computed buckled profiles of thin-walled tubes are very sensitive to loading velocity however the computed profiles of solid cylinders are less sensitive to loading velocity. In orther words, the geometrically self-constrained specimens like solid cylinders are less sensitive to loading velocity than the geometrically unconstrained specimens like thin-walled tubes. As a result, it is found that the geometrically self-constrained problems which include the greater part of metal forming problems can be efficiently analyzed with loading velocity control technique.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.43 no.2
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• pp.14-24
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• 2020

Google Trends is a useful tool not only for setting search periods, but also for providing search volume to specific countries, regions, and cities. Extant research showed that the big data from Google Trends could be used for an on-line market analysis of opinion sensitive products instead of an on-site survey. This study investigated the market share of tumor necrosis factor-alpha (TNF-α) inhibitor, which is in a great demand pharmaceutical product, based on big data analysis provided by Google Trends. In this case study, the consumer interest data from Google Trends were compared to the actual product sales of Top 3 TNF-α inhibitors (Enbrel, Remicade, and Humira). A correlation analysis and relative gap were analyzed by statistical analysis between sales-based market share and interest-based market share. Besides, in the country-specific analysis, three major countries (USA, Germany, and France) were selected for market share analysis for Top 3 TNF-α inhibitors. As a result, significant correlation and similarity were identified by data analysis. In the case of Remicade's biosimilars, the consumer interest in two biosimilar products (Inflectra and Renflexis) increased after the FDA approval. The analytical data showed that Google Trends is a powerful tool for market share estimation for biosimilars. This study is the first investigation in market share analysis for pharmaceutical products using Google Trends big data, and it shows that global and regional market share analysis and estimation are applicable for the interest-sensitive products.

• The Journal of Fisheries Business Administration
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• v.37 no.3 s.72
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• pp.65-83
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• 2006

This study is to obtain the order of the sensitivity of importing marine products with regard to non - economic aspects of considerations under the free - trade. Three criteria are extracted considering various aspects of Korean fishery society. They are the socio - economic, resource - environmental, and policy - appropriateness criterion. The Analytic Hierachy Process(AHP) is used to obtain the estimates of weights among these criteria. First of all, the weights between economic and non - economic in the first hierachy of sensitivity criteria turn out to be 83.3% and 16.7%. Second, the weights among three criteria in the non - economic aspect, the second hierachy, are following that the socio - economic criterion is 19.6%, resource - environmental 31.1%, and policy - appropriateness 49.3% respectively. 47 selected fishes are evaluated based on these three non - economic criteria using 9- point scales. The over - all order of sensitivity is a croaker, hairtail, flatfish, sea breams, and so forth in descending order. The least sensitive fish turns out to be an angler. In addition to the over - all order, the sensitivity based on the three specific non - economic aspects is also investigated. The most sensitive fish in terms of the socio - economic criterion is an hairtail while the least one is a filefish. The most sensitive fish in terms of the resource - environmental criterion is an abalone while the least one is an angler. Finally, the most sensitive fish in terms of the policy - appropriateness is a mackerel while the least one is a small octopus.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.35S no.9
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• pp.1-8
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• 1998

In this paper, we analyze the probability of soft handoff and hard handoff which served in DS-CDMA cellular system, and propose a new handoff control scheme. The object of proposed scheme is to reduce the hard handoff probability of delay sensitive calls which are very sensitive to transmission errors. In this scheme, if soft handoff is not possible, for a delay sensitive call, a delay insensitive call using the same frequency channel that a handoff call is using is handed off to one of other frequency channels and the traffic channel released by delay insensitive call's handoff is assigned to a delay sensitive call for soft handoff. A performance of the proposed scheme was evaluated through computer simulation.