• 응용통계연구
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• 제34권3호
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• pp.439-447
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• 2021

범지구적 이상기후의 잦은 출현으로 기상 변화에 대한 관련 연구가 활발히 진행되고 있지만, 장기간 축적된 기상자료를 이용한 경향성 분석 연구는 부족하였다. 본 연구에서는 비모수적 분석방법을 이용해 40년간 종관기상관측장비(ASOS)로 부터 축적된 기온 시계열 자료의 경향성을 분석하였다. 남한지역의 연평균 기온과 계절별 평균기온 시계열 자료에 대한 Mann-Kendall 검정 결과 상승 경향성이 존재하는 것으로 나타났다. 또한 Pettitt 검정을 적용해 탐색된 변동점을 전후로 경향성의 정도를 파악할 수 있는 Sen's slope를 계산한 결과, 변동점 이후의 최근 자료에서 기온의 상승 경향성이 더욱 큰 것을 확인하였다.

• 한국수자원학회논문집
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• 제46권3호
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• pp.219-227
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• 2013

수문시계열 자료에 변동성, 도약성, 경향성, 주기성 등이 있으면 이러한 자료는 일반적으로 비정상성을 가지며, 특히 경향성 판단을 통한 다양한 방법들이 제시되어 왔다. 그러나 다양한 방법 간의 검정능력에 대한 평가는 많이 이루어지지 않았으며, 그로인해 동일 자료에 대한 다른 방법의 적용으로 반대의 결과가 나오는 경우도 발생하게 된다. 따라서 본 연구에서는 통계적 특성에 따른 경향성 분석의 변화를 파악하고, 경향성 분석방법 간의 검정능력을 파악해 보았다. 이를 위해 경향성 분석기법인 Mann-Kendall 검정, Hotelling-Pabst 검정, t 검정, Sen 검정을 적용하였으며 기울기, 표본크기, 표준편차에 따라 다양한 모의실험을 수행하였다. 그 결과 t 검정이 다른 검정에 비해 상대적으로 높은 검정력을 보였고, Mann-Kendall 검정, Hotelling-Pabst 검정, Sen 검정은 비슷한 결과를 보였다.

• Korean Journal of Radiology
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• 제22권6호
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• pp.959-969
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• 2021

Objective: This study aimed to evaluate the role of preoperative two-dimensional (2D) shear wave elastography (SWE) in assessing the stages of liver fibrosis in patients with suspected biliary atresia (BA) and compared its diagnostic performance with those of serum fibrosis biomarkers. Materials and Methods: This study was approved by the ethical committee, and written informed parental consent was obtained. Two hundred and sixteen patients were prospectively enrolled between January 2012 and October 2018. The 2D SWE measurements of 69 patients have been previously reported. 2D SWE measurements, serum fibrosis biomarkers, including fibrotic markers and biochemical test results, and liver histology parameters were obtained. 2D SWE values, serum biomarkers including, aspartate aminotransferase to platelet ratio index (APRi), and other serum fibrotic markers were correlated with the stages of liver fibrosis by METAVIR. Receiver operating characteristic (ROC) curves and area under the ROC (AUROC) curve analyses were used. Results: The correlation coefficient of 2D SWE value in correlation with the stages of liver fibrosis was 0.789 (p < 0.001). The cut-off values of 2D SWE were calculated as 9.1 kPa for F1, 11.6 kPa for F2, 13.0 kPa for F3, and 15.7 kPa for F4. The AUROCs of 2D SWE in the determination of the stages of liver fibrosis ranged from 0.869 to 0.941. The sensitivity and negative predictive value of 2D SWE in the diagnosis of ≥ F3 was 93.4% and 96.0%, respectively. The diagnostic performance of 2D SWE was superior to that of APRi and other serum fibrotic markers in predicting severe fibrosis and cirrhosis (all p < 0.005) and other serum biomarkers. Multivariate analysis showed that the 2D SWE value was the only statistically significant parameter for predicting liver fibrosis. Conclusion: 2D SWE is a more effective non-invasive tool for predicting the stage of liver fibrosis in patients with suspected BA, compared with serum fibrosis biomarkers.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5775-5781
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• 2013

Background: The gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is the most common type of neuroendocrine neoplasm. We summarized data in our centre to investigate the clinicopathological features, diagnostic methods, therapeutic approaches and prognosis for this neoplasm to increase knowledge of this disease in Asian populations. Method: A total of 122 patients treated at Sun Yet-san Memorial Hospital of Sun Yat-sen University between January 2000 and December 2011 were analyzed retrospectively. Results: Pancreas was the most common site of involvement (65/122, 53.3%); this disease has no special symptoms; positive rates of chromogranin A (CgA) and synaptophysin (Syn) were 81.1% and 87.7%, respectively. The positive rate of Syn had statistical difference among the three grades, but not CgA. Some 68 patients had G1 tumors, 32 G2 tumors and 22 G3 tumors, and Chi-square test showed that higher grading was correlated with worse prognosis (${\chi}^2=32.825$, P=0.0001). A total of 32 patients presented with distant metastasis, and 8 cases emerged during following up. Cox proportional hazards regression modeling showed that the tumor grade (P=0.01), lymphatic metastasis (P=0.025) and distant metastasis (P=0.031) were predictors of unfavorable prognosis. The overall 5-year survival rate was 39.6%, the 5-year survival rate of G1 was 55.7%, and the G2 and G3 were 34.2% and 0%, respectively. Conclusions: The incidence of gastroenteropancreatic neuroendocrine tumors has risen over the last 12 years. All grades of these diseases metastasize readily, and further research regarding the treatment of patients after radical surgery is needed to prolong disease-free survival.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4759-4763
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• 2013

Background: Prognostic factors of postoperative early and late recurrence in patients with hepatocellular carcinoma (HCC) undergoing curative resection remain to be clarified. The aim of this study was to identify risk factors for postoperative early (${\leq}$ 2 year) and late (> 2 year) intrahepatic recurrences in patients with single HCCs without macrovascular invasion. Methods: A total of 280 patients from December 2004 to December 2007 were retrospectively included in this study. Intrahepatic recurrence was classified into early (${\leq}$ 2 year) and late (> 2 year) and the Chi-Square test or Fisher's exact test and multivariate logistic regression analysis were performed to determine significant risk factors. Results: During the follow-up, 124 patients had intrahepatic recurrence, early and late in 82 and 42 patients, respectively. Multivariate logistic regression analysis showed that microvascular invasion (p=0.006, HR: 2.397, 95% CI: 1.290-4.451) was the only independent risk factor for early recurrence, while being female (p = 0.031, HR: 0.326, 95% CI: 0.118-0.901), and having a high degree of cirrhosis (P=0.001, HR: 2.483, 95% CI: 1.417-4.349) were independent risk factors for late recurrence. Conclusions: Early and late recurrence of HCC is linked to different risk factors in patients with single HCC without macrovascular invasion. This results suggested different emphases of strategies for prevent of recurrence after curative resection, more active intervention including adjuvant therapy, anti-cirrhosis drugs and careful follow-up being necessary for patients with relevant risk factors.

• 한국지하수토양환경학회지:지하수토양환경
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• 제14권5호
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• pp.41-50
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• 2009

제주도 지하수관측망의 지하수위 측정 자료에 대하여 모수 및 비모수 경향분석을 수행하였다. 분석대상은 2001년부터 1년 이상 관측된 관측정으로 총 106개 관측정 중 94개가 이에 해당된다. 모수분석은 일평균 및 월중앙값을 이용한 선형회귀분석을 실시하였으며 비모수분석은 월중앙값에 대해 Mann-Kendall trend test와 Sen's trend test를 적용하였다. 선형회귀분석 결과 일평균값에 대하여 58.5%가 감소경향을 나타났으며 월중앙간에 대해서는 79.8%가 감소하는 경향을 보였다. Mann-Kendall trend test와 Sen's trend test를 신뢰수준 95%와 99%로 실시한 결과 두 분석 모두 일치하는 결과를 보였다. 95% 신뢰수준에서는 32%가 감소경향을 보였으며 3%가 증가경향을 나타냈고, 나머지 65%는 경향성이 나타나지 않았다. 또 99%신뢰수준에서는 16%가 감소경향을 보였으며 2%가 증가경향을 나타냈고 그리고 나머지 82%에서는 경향성이 없는 것으로 나타났다. 수위하강이 우세하게 나타난 지역은 제주도 북서부 및 남서부의 해안지역으로 도시 및 관광지에서의 다량의 지하수 양수와 관련 있는 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8855-8859
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• 2014

Purpose: To investigate the impact of hyperglycemia during inductive treatment on the prognosis of acute lymphocytic leukemia (ALL) in children. Materials and Methods: Clinical data of 159 ALL childhood cases were reviewed. The patients were divided into the hyperglycemia group (fasting $glucose{\geq}126mg/dl$ and/or random blood $glucose{\geq}200mg/dl$) and the euglycemia group according to the blood glucose values. The X2 test was performed to compare the complete remission rates of the two groups, and Kaplan-Meier and log-rank tests were performed to compare the 5-year overall and relapse-free survival. Results: The incidence of hyperglycemia in the $age{\geq}10-year-old$ group was higher than the younger-age group (P=0.009). Values in the interim- and high-risk groups were higher than the standard-risk group (P=0.028), while there was no significant difference between genders (P=0.056). The complete remission rates of the 2 groups demonstrated no significant difference (P=0.134), while the 5-year OS of the hyperglycemia group was lower than in the euglycemia group ($83.8{\pm}6.0%$ vs $94.9{\pm}2.4%$, P=0.014). The 5 -year RFS was significantly lower than the euglycemia group ($62.9{\pm}8.7%$) vs $80.2{\pm}9.1%$, P<0.001). Conclusions: Children with $age{\geq}10year$ old, and in the middle- and high-risk groups appear prone to complicating hyperglycemia during inductive chemotherapy, associated with lower 5-year OS and RFS.

• 대한토목학회논문집
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• 제28권1B호
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• pp.65-77
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• 2008

본 연구에서는 지리 및 지형적 특성과 도시화에 따른 기후변화가 기준증발산량에 미치는 영향을 파악하기 위하여 FAO P-M 기준증발산식을 이용하여 연별 및 각 월별 기준증발산량과 기준증발산식의 에너지항 및 공기동력항 변화추세를 분석하였다. 추세분석을 위하여 전국 21개 연구지역에서 일별 기후자료를 수집하여 Spearman 순위상관분석, Sen분석(Sen's estimator of slope) 그리고 실제변화율분석과 선형회귀분석 등을 실시하였다. 또한 도시지역 특성에 따라 21개 연구지역을 군집화하였고, 각 군집에 따른 기준증발산과 기준증발산식의 에너지항 및 공기동력항의 변화를 분석하였다. 연구결과에 의하면 도시화정도는 기준증발산, 에너지항 및 공기동력항의 변화추세 및 크기에 밀접한 영향이 있으나, 변화추세 정도(Sen's slope)에는 큰 영향이 없는 것으로 나타났다. 에너지항의 경우 해안지역에서는 주로 증가추세를 보이는 반면, 내륙지역에서는 일부 월을 제외하고 감소추세를 보이고 있다. 또한 지역 경사도는 에너지항보다는 공기동력항 변화추세 정도(Sen's slope)에 더 큰 영향력을 보이는 것으로 판단된다. 공기동력항의 경우 해안 및 내륙지역에서 증가추세를 보이고 있고, 내륙지역이 해안지역보다 더 큰 공기동력항의 증가추세를 보이고 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.551-557
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• 2015

Background: Differentiating morphologic features based on hematoxylin-eosin (HE) staining is the most common method to classify pathological subtypes of non-small-cell lung cancer (NSCLC). However, its accuracy and inter-observer reproducibility in pathological diagnosis of poorly differentiated NSCLC remained to be improved. Materials and Methods: We attempted to explore the role of immunohistochemistry (IHC) staining in diagnosing pulmonary squamous cell carcinoma (SQCC) with poorly differentiated features by HE staining or with elevated serum adenocarcinoma-specific tumor markers (AD-TMs). We also compared the difference of epidermal growth factor receptor (EGFR) mutation rate between patients with confirmed SQCC and those with revised pathological subtype. Logistic regression analyses were used to test the association between different factors and diagnostic accuracy. Results: A total of 132 patients who met the eligible criteria and had adequate specimens for IHC confirmation were included. Pathological revised cases in poor differentiated subgroup, biopsy samples and high-level AD-TMs cases were more than those with high/moderate differentiation, surgical specimens and normal-level AD-TMs. Moreover, biopsy sample was a significant factor decreasing diagnostic accuracy of pathological subtype (OR, 4.037; 95% CI 1.446-11.267, p=0.008). Additionally, EGFR mutation rate was higher in patients with pathological diagnostic changes than those with confirmed SQCC (16.7% vs 4.4%, p=0.157). Conclusions: Diagnosis based on HE staining only might cause pathological misinterpretation in NSCLC patients with poor differentiation or high-level AD-TMs, especially those with biopsy samples. HE staining and IHC should be combined as pathological diagnostic standard. The occurrence of EGFR mutations in pulmonary SQCC might be overestimated.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2010년도 학술발표회
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• pp.1099-1103
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• 2010

본 연구에서는 기후변화로 인한 부산 강우특성을 고려하고 강수량의 증감을 알아보기 위하여 부산 기상청 지점의 강우 자료를 수집하고 분석하여 월, 계절, 연 평균강우와 지속시간별 연최대 강우량 및 강우강도(30 mm 이상)를 Trend 분석하였다. 분석기법은 T Test, Hotelling Pabst Test, Non Linear Test, Mann-Kendall Test, Sen Test이고 0.99, 0.95, 0.90의 유의수준별로 분석하였다. 분석된 결과는 1등급에서 4등급까지 등급화하고, 특히 Sen Test의 Slope는 빈도분석하여 등급화하였다.