• Korean Journal of Biological Psychiatry
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• v.14 no.1
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• pp.14-20
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• 2007

Objectives : The diagnosis of depression is based on a highly variable set of symptoms. Therefore, depression should not be viewed as a single disease, but a heterogenous syndrome comprised of different pathophysiologies. There are several subtypes of depression which were already incorporated in DSM-IV. This article provides a systematic review of pharmacological treatments of two recognized subtypes of depression-dysthymic disorder and atypical depression. Methods : Systematic search of relevant literatures on dysthymic disorder and atypical depression was performed by proposed search strategy of the Clinical Research Center for Depression of Korean Health 21 R&D Project. All identified literatures were carefully reviewed and classified according to SIGN grading system and summarized in a narrative manner. Results : For the treatment of dysthymic disorder and atypical depression, selective serotonin reuptake inhibitors( SSRIs) and moclobemide have more evidence than the other antidepressants. SSRIs and moclobemide showed superior tolerability than tricyclic antidepressants. Conclusions : The authors proposed treatment recommendations for dysthymic disorder and atypical depression by the methods of evidence-based medicine(EBM). However, guideline developing methods of EBM also have several inevitable limitations. Therefore, in the absence of clear and significant differences in efficacy, the choice of medication must be individualized for a particular patient based on psychiatrist's own clinical decision.

• Biomedical Science Letters
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• v.12 no.3
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• pp.139-143
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• 2006

Jopock (Jpk) has previously been ascertained that induces both bacterial and mammalian cell death. The Escherichia coli cells expressing Glutathion S-transferase (GST) fused Jpk showed elongated phenotype and inhibited cell growth which led eventual cell death. In an attempt to search the genetic suppressor of the lethal protein Jpk in bacterial cells, we constructed a unidirectional protein expression vector inserting tac promoter next to the C-terminus Jpk in pGEX-Jpk. The function of additional tac promoter was confirmed by substituting lac promoter in Plac-TOPO plasmid. The cells harboring plac- TOPO, which regulates $lacZ{\alpha}$ gene expression under lac promoter, formed blue colonies in 5-bromo-4-3 $indolyo-{\beta}-D-galactoside$ (X-gal) plate. When lac promoter was changed to tac promoter, same results were observed. Since the addition of tac promoter did not affect the toxic effect of Jpk, the pGEX-Jpk-ptac could be a useful vector for the screening of suppressor(s) for Jpk, in which GST-Jpk and a putative Jpk-suppressing protein are coexpressing from two unidirectional tac promoters, which response to the same inducer, $isopropyl-{\beta}-D-thiogalactopyranoside (IPTG)$.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.3C
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• pp.83-91
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• 2005

We analyze the performance of an adaptive hybrid search code acquisition algorithm for direct-sequence code division multiple access (DS-CDMA) systems under slowly-moving mobile environments. The code acquisition algorithm is designed to provide the desired feature of constant false alarm rate (CFAR) to cope with nonstationarity of the interference in CDMA forward links. An analytical expression for the mean acquisition time is first derived and the probabilities of detection, miss, and false alarm are then obtained for frequency-selective Rayleigh fading environments. The fading envelope of a received signal is assumed to be constant over the duration of post-detection integration (PDI), considering slow fading environments. Finally, the performance of the designed code acquisition algorithm shall be evaluated numerically to examine the effect of some design parameters such as the sub-window size, size of the PDI, decision threshold, and so on, considering cdma2000 environments.

• Proceedings of the IEEK Conference
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• 2004.06a
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• pp.147-150
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• 2004

In this paper, we propose a reduced-state sequence estimation (RSSE) for trellis coded modulation (TCM) in OFDM with two-stage IDFT/ DFTs, MMSE-LE, and interleaving on frequency selective Rayleigh fading channels. The Viterbi algorithm (VA) is used to search for the best path through the reduced-state trellis combined with equalization and TCM decoding. Computer simulations confirm the bit error probability of the proposed scheme.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.2 no.2
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• pp.115-121
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• 2002

This paper presents an evolutionary design of digital IIR filters using the genetic algorithm (GA) with modified genetic operators and real-valued encoding. Conventional digital IIR filter design methods involve algebraic transformations of the transfer function of an analog low-pass filter (LPF) that satisfies prescribed filter specifications. Other types of frequency-selective digital fillers as high-pass (HPF), band-pass (BPF), and band-stop (BSF) filters are obtained by appropriate transformations of a prototype low-pass filter. In the GA-based digital IIR filter design scheme, filter coefficients are represented as a set of real-valued genes in a chromosome. Each chromosome represents the structure and weights of an individual filter. GA directly finds the coefficients of the desired filter transfer function through genetic search fur given filter specifications of minimum filter order. Crossover and mutation operators are selected to ensure the stability of resulting IIR filters. Other types of filters can be found independently from the filter specifications, not from algebraic transformations.

• Journal of the Korean housing association
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• v.12 no.4
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• pp.19-31
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• 2001

The purpose of this study is to investigate the meaning and the function of the shared space in the existing multi-family housing through analyzing the reality and resident's requirement for it, and additionally to develop the research project to investigate its activation strategy. The method of this study was through analyzing the related literature and the existing study. The followings were found out from this study concerning the shared space: 1) Both the supplier and resident of multi-family housing started to recognize the importance of its role with relation to the quality of the home environment. 2) In residents' requirements for it, there was its common elements, and selective differences according to the size of housing, life cycle, and whether housewife has a job or not etc. 3) In order to activate the shared space, we need to search abut using behavior for that, its flexibility of housing regulations, and to develop an effective management program. Finally this study emphasized on the necessity of planning focused on the shared space for the community design in multi-family housing.

• Electronics and Telecommunications Trends
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• v.14 no.6 s.60
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• pp.9-21
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• 1999

최근 인터넷상에는 매일 방대한 양의 정보가 창출되어 유포되고 있으며, 수많은 정보 제공 사이트들이 늘고 있다. 이용자들은 필요한 정보를 찾고 활용하기 위해 야후(Yahoo), 알타비스타(AltaVista) 등 국외 검색엔진(search engine)들과 심마니, 미스 다찾니 등 국내 검색엔진 등 인터넷상에 운용되고 있는 이들 시스템들을 이용하고 있지만, 대부분의 시스템들은 자체 정보 제공보다는 로봇 에이전트를 이용하여 인터넷 사이트에 등록되어 있는 다양한 분야의 홈페이지 정보들을 수집/분석하여 관련 사이트를 연결해주는 방식의 메타 검색엔진들로서 불필요한 정보들까지 제공함에 따라 이용자들이 필요로 하는 정보를 찾기에는 너무 많은 노력과 시간을 소모하게 되는 문제점을 안고 있다. 이에 본 고에서는 형태소 분석 및 시소러스 사전을 이용하여 검색의 정확성 및 재현율 향상을 고려하고, 주제어 중심의 불리언 검색뿐만 아니라 하이퍼텍스트 기반의 주제어 카탈로그 검색, 각기 다른 사이트의 검색엔진들로부터 질의한 결과를 통합하여 제공하는 지능형 통합검색, 이용자 프로파일에 근거하여 최신 업데이트된 정보를 주기적으로 제공해주는 맞춤정보서비스(Selective Dissemination of Information Service: SDI) 등을 통합한 인터넷 기반의 한글 정보검색시스템의 구현에 대한 내용을 기술하고자 한다.

• Proceedings of the IEEK Conference
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• 1999.11a
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• pp.617-620
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• 1999

In this paper, a new autofocusing technique which is resistive to noise generated by the CCD of video cameras is proposed. In the proposed scheme, the frequency selective weighted median (FSWM) filter is utilized to estimate the degree of focus and the fast hill-climbing search (HCS) strategy is exploited to determine the best focused image. Since the FSWM filter can not only extract high frequency components from the image, but also eliminate impulsive noise, the proposed autofocusing method employing the FSWM criterion function can estimate the degree of focus precisely. Furthermore, the proposed real-time HCS algorithm enables the video camera to continuously focus on dynamic images. Experimental results demonstrate that the proposed technique outperforms existing techniques by enhancing the accuracy of the focus value of the video camera without the influence of noise.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.32B no.12
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• pp.1680-1686
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• 1995

GAs, effective stochastic search algorithms based on the model of natural evolution and genetics, have been successfully applied to various optimization problems. When population size is not large, GAs often suffer from the phenomenon of premature convergence in which all chromosomes in the population lose the diversity of genes before they find the optimal solution. In this paper, we propose that a new heuristic that maintains the diversity of genes by adding some chromosomes with random mutation and selective mutation into population during evolution. And population size changes dynamically with supplement of new chromosomes. Experimental results for several test functions show that when population size is rather small and the length of chromosome is not long, this method is effective.

• Biotechnology and Bioprocess Engineering:BBE
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• v.2 no.2
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• pp.105-108
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• 1997

A search was undertaken to screen microorganisms that produce an enzyme capable of deacylating glutary1-7-amincephalosporanic acid to 7-aminocephalosporanic acid in soil samples. The screening was carried out by preparing enrichment cultures containing glutary-7ACA and cephalosporin C as selective carbon sources. A non-${\beta}$-lactam model compound,, glutary-p-nitroanilide, was synthesized as a substrate suitable for the rapid screening of microorganisms isolated from the enrichment cultures. Two isolates exhibiting acylase activity, designated BY7.4 and BY8.1, were identified as strains of Pseudomonas species. Pseudomonas BY8.1 showed higher acylase activity toward G1-7ACA than Pseudomonas BY7.4. Environmental conditions for the optimal acylase activity of Pseudomonas BY8.1 were shown to be pH9 and 30$^{\circ}C$.