• Title/Summary/Keyword: Selection signature

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Identification of Recently Selected Mutations Driven by Artificial Selection in Hanwoo (Korean Cattle)

  • Lim, Dajeong;Gondro, Cedric;Park, Hye Sun;Cho, Yong Min;Chai, Han Ha;Seong, Hwan Hoo;Yang, Bo Suk;Hong, Seong Koo;Chang, Won Kyung;Lee, Seung Hwan
    • Asian-Australasian Journal of Animal Sciences
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    • v.26 no.5
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    • pp.603-608
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    • 2013
  • Hanwoo have been subjected over the last seventy years to intensive artificial selection with the aim of improving meat production traits such as marbling and carcass weight. In this study, we performed a signature of selection analysis to identify recent positive selected regions driven by a long-term artificial selection process called a breeding program using whole genome SNP data. In order to investigate homozygous regions across the genome, we estimated iES (integrated Extended Haplotype Homozygosity SNP) for the each SNPs. As a result, we identified two highly homozygous regions that seem to be strong and/or recent positive selection. Five genes (DPH5, OLFM3, S1PR1, LRRN1 and CRBN) were included in this region. To go further in the interpretation of the observed signatures of selection, we subsequently concentrated on the annotation of differentiated genes defined according to the iES value of SNPs localized close or within them. We also described the detection of the adaptive evolution at the molecular level for the genes of interest. As a result, this analysis also led to the identification of OLFM3 as having a strong signal of selection in bovine lineage. The results of this study indicate that artificial selection which might have targeted most of these genes was mainly oriented towards improvement of meat production.

Multimodal Biometric Using a Hierarchical Fusion of a Person's Face, Voice, and Online Signature

  • Elmir, Youssef;Elberrichi, Zakaria;Adjoudj, Reda
    • Journal of Information Processing Systems
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    • v.10 no.4
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    • pp.555-567
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    • 2014
  • Biometric performance improvement is a challenging task. In this paper, a hierarchical strategy fusion based on multimodal biometric system is presented. This strategy relies on a combination of several biometric traits using a multi-level biometric fusion hierarchy. The multi-level biometric fusion includes a pre-classification fusion with optimal feature selection and a post-classification fusion that is based on the similarity of the maximum of matching scores. The proposed solution enhances biometric recognition performances based on suitable feature selection and reduction, such as principal component analysis (PCA) and linear discriminant analysis (LDA), as much as not all of the feature vectors components support the performance improvement degree.

Identification of genomic diversity and selection signatures in Luxi cattle using whole-genome sequencing data

  • Mingyue Hu;Lulu Shi;Wenfeng Yi;Feng Li;Shouqing Yan
    • Animal Bioscience
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    • v.37 no.3
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    • pp.461-470
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    • 2024
  • Objective: The objective of this study was to investigate the genetic diversity, population structure and whole-genome selection signatures of Luxi cattle to reveal its genomic characteristics in terms of meat and carcass traits, skeletal muscle development, body size, and other traits. Methods: To further analyze the genomic characteristics of Luxi cattle, this study sequenced the whole-genome of 16 individuals from the core conservation farm in Shandong region, and collected 174 published genomes of cattle for conjoint analysis. Furthermore, three different statistics (pi, Fst, and XP-EHH) were used to detect potential positive selection signatures related to selection in Luxi cattle. Moreover, gene ontology and Kyoto encyclopedia of genes and genomes pathway enrichment analyses were performed to reveal the potential biological function of candidate genes harbored in selected regions. Results: The results showed that Luxi cattle had high genomic diversity and low inbreeding levels. Using three complementary methods (pi, Fst, and XP-EHH) to detect the signatures of selection in the Luxi cattle genome, there were 2,941, 2,221 and 1,304 potentially selected genes identified, respectively. Furthermore, there were 45 genes annotated in common overlapping genomic regions covered 0.723 Mb, including PLAG1 zinc finger (PLAG1), dedicator of cytokinesis 3 (DOCK3), ephrin A2 (EFNA2), DAZ associated protein 1 (DAZAP1), Ral GTPase activating protein catalytic subunit alpha 1 (RALGAPA1), mediator complex subunit 13 (MED13), and decaprenyl diphosphate synthase subunit 2 (PDSS2), most of which were enriched in pathways related to muscle growth and differentiation and immunity. Conclusion: In this study, we provided a series of genes associated with important economic traits were found in positive selection regions, and a scientific basis for the scientific conservation and genetic improvement of Luxi cattle.

A Pre-processing Study to Solve the Problem of Rare Class Classification of Network Traffic Data (네트워크 트래픽 데이터의 희소 클래스 분류 문제 해결을 위한 전처리 연구)

  • Ryu, Kyung Joon;Shin, DongIl;Shin, DongKyoo;Park, JeongChan;Kim, JinGoog
    • KIPS Transactions on Software and Data Engineering
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    • v.9 no.12
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    • pp.411-418
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    • 2020
  • In the field of information security, IDS(Intrusion Detection System) is normally classified in two different categories: signature-based IDS and anomaly-based IDS. Many studies in anomaly-based IDS have been conducted that analyze network traffic data generated in cyberspace by machine learning algorithms. In this paper, we studied pre-processing methods to overcome performance degradation problems cashed by rare classes. We experimented classification performance of a Machine Learning algorithm by reconstructing data set based on rare classes and semi rare classes. After reconstructing data into three different sets, wrapper and filter feature selection methods are applied continuously. Each data set is regularized by a quantile scaler. Depp neural network model is used for learning and validation. The evaluation results are compared by true positive values and false negative values. We acquired improved classification performances on all of three data sets.

Advanced Feature Selection Method on Android Malware Detection by Machine Learning (악성 안드로이드 앱 탐지를 위한 개선된 특성 선택 모델)

  • Boo, Joo-hun;Lee, Kyung-ho
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.30 no.3
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    • pp.357-367
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    • 2020
  • According to Symantec's 2018 internet security threat report, The number of new mobile malware variants increased by 54 percent in 2017, as compared to 2016. And last year, there were an average of 24,000 malicious mobile applications blocked each day. Existing signature-based technologies of malware detection have limitations. So, malware detection technique through machine learning is being researched to detect malware variant. However, even in the case of applying machine learning, if the proper features of the malware are not properly selected, the machine learning cannot be shown correctly. We are focusing on feature selection method to find the features of malware variant in this research.

Characteristics of Signature Bonnie Cashin Designs

  • Kim, Injoo;Lee, Seung A;Sarofeen, George F.
    • International Journal of Costume and Fashion
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    • v.15 no.1
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    • pp.51-74
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    • 2015
  • The purpose of this exploratory research is to study Cashin's fashion philosophy and to draw her design characteristics through analysis of her work. As a result of this research, 76 garment pieces were selected from the 180 Bonnie Cashin collections at the University of Cincinnati to document and evaluate. The final selection includes: sixteen jackets, fifteen skirts, five pants, five tops, seven dresses, twenty five coats, and three capes. Bonnie Cashin specialized in practical and functional; yet innovative designs such as leather trimmed tweed Jackets/coats, canvas raincoats, suede leather coats, and ponchos. Her trademark elements include toggle closures, oversized pockets, her Noh coats, tweed suits, canvas raincoats, fringed suede dresses, funnel neck pullovers, jersey dresses, and ponchos. She emphasized function and comfort and she believed that a good design must also be practical. The examination of these 76 pieces from the University of Cincinnati's private Bonnie Cashin Collection brings to light Bonnie Cashin's creative design and what she represented in the development of American fashion design in the $20^{th}$ century.

A Study on An Enhancement Scheme of Privacy and Anonymity through Convergence of Security Mechanisms in Blockchain Environments (블록체인 환경에서 보안 기법들의 융합을 통한 프라이버시 및 익명성 강화 기법에 대한 연구)

  • Kang, Yong-Hyeog
    • Journal of the Korea Convergence Society
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    • v.9 no.11
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    • pp.75-81
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    • 2018
  • Anonymity and privacy issues are becoming important as all transactions in the blockchain are open to users. Public blockchains appear to guarantee anonymity by using public-key addresses on behalf of users, but they can weaken anonymity by tracking with various analytic techniques based on transaction graph. In this paper, we propose a scheme to protect anonymity and privacy by converging various security techniques such as k-anonymity, mixing, blind signature, multi-phase processing, random selection, and zero-knowledge proof techniques with incentive mechanism and contributor participation. Through performance analysis, our proposed scheme shows that it is difficult to invade privacy and anonymity through collusion attacks if the number of contributors is larger than that of conspirators.

Detection of copy number variation and selection signatures on the X chromosome in Chinese indigenous sheep with different types of tail

  • Zhu, Caiye;Li, Mingna;Qin, Shizhen;Zhao, Fuping;Fang, Suli
    • Asian-Australasian Journal of Animal Sciences
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    • v.33 no.9
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    • pp.1378-1386
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    • 2020
  • Objective: Chinese indigenous sheep breeds can be classified into the following three categories by their tail morphology: fat-tailed, fat-rumped and thin-tailed sheep. The typical sheep breeds corresponding to fat-tailed, fat-rumped, and thin-tailed sheep are large-tailed Han, Altay, and Tibetan sheep, respectively. Detection of copy number variation (CNV) and selection signatures provides information on the genetic mechanisms underlying the phenotypic differences of the different sheep types. Methods: In this study, PennCNV software and F-statistics (FST) were implemented to detect CNV and selection signatures, respectively, on the X chromosome in three Chinese indigenous sheep breeds using ovine high-density 600K single nucleotide polymorphism arrays. Results: In large-tailed Han, Altay, and Tibetan sheep, respectively, a total of six, four and 22 CNV regions (CNVRs) with lengths of 1.23, 0.93, and 7.02 Mb were identified on the X chromosome. In addition, 49, 34, and 55 candidate selection regions with respective lengths of 27.49, 16.47, and 25.42 Mb were identified in large-tailed Han, Altay, and Tibetan sheep, respectively. The bioinformatics analysis results indicated several genes in these regions were associated with fat, including dehydrogenase/reductase X-linked, calcium voltage-gated channel subunit alpha1 F, and patatin like phospholipase domain containing 4. In addition, three other genes were identified from this analysis: the family with sequence similarity 58 member A gene was associated with energy metabolism, the serine/arginine-rich protein specific kinase 3 gene was associated with skeletal muscle development, and the interleukin 2 receptor subunit gamma gene was associated with the immune system. Conclusion: The results of this study indicated CNVRs and selection regions on the X chromosome of Chinese indigenous sheep contained several genes associated with various heritable traits.

A whole genomic scan to detect selection signatures between Berkshire and Korean native pig breeds

  • Edea, Zewdu;Kim, Kwan-Suk
    • Journal of Animal Science and Technology
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    • v.56 no.7
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    • pp.23.1-23.7
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    • 2014
  • Background: Scanning of the genome for selection signatures between breeds may play important role in understanding the underlie causes for observable phenotypic variations. The discovery of high density single nucleotide polymorphisms (SNPs) provide a useful starting point to perform genome-wide scan in pig populations in order to identify loci/candidate genes underlie phenotypic variation in pig breeds and facilitate genetic improvement programs. However, prior to this study genomic region under selection in commercially selected Berkshire and Korean native pig breeds has never been detected using high density SNP markers. To this end, we have genotyped 45 animals using Porcine SNP60 chip to detect selection signatures in the genome of the two breeds by using the $F_{ST}$ approach. Results: In the comparison of Berkshire and KNP breeds using the FDIST approach, a total of 1108 outlier loci (3.48%) were significantly different from zero at 99% confidence level with 870 of the outlier SNPs displaying high level of genetic differentiation ($F_{ST}{\geq}0.490$). The identified candidate genes were involved in a wide array of biological processes and molecular functions. Results revealed that 19 candidate genes were enriched in phosphate metabolism (GO: 0006796; ADCK1, ACYP1, CAMK2D, CDK13, CDK13, ERN1, GALK2, INPP1; MAK, MAP2K5, MAP3K1, MAPK14, P14KB, PIK3C3, PRKC1, PTPRK, RNASEL, THBS1, BRAF, VRK1). We have identified a set of candidate genes under selection and have known to be involved in growth, size and pork quality (CART, AGL, CF7L2, MAP2K5, DLK1, GLI3, CA3 and MC3R), ear morphology and size (HMGA2 and SOX5) stress response (ATF2, MSRB3, TMTC3 and SCAF8) and immune response (HCST and RYR1). Conclusions: Some of the genes may be used to facilitate genetic improvement programs. Our results also provide insights for better understanding of the process and influence of breed development on the pattern of genetic variations.

Improved Network Intrusion Detection Model through Hybrid Feature Selection and Data Balancing (Hybrid Feature Selection과 Data Balancing을 통한 효율적인 네트워크 침입 탐지 모델)

  • Min, Byeongjun;Ryu, Jihun;Shin, Dongkyoo;Shin, Dongil
    • KIPS Transactions on Software and Data Engineering
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    • v.10 no.2
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    • pp.65-72
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    • 2021
  • Recently, attacks on the network environment have been rapidly escalating and intelligent. Thus, the signature-based network intrusion detection system is becoming clear about its limitations. To solve these problems, research on machine learning-based intrusion detection systems is being conducted in many ways, but two problems are encountered to use machine learning for intrusion detection. The first is to find important features associated with learning for real-time detection, and the second is the imbalance of data used in learning. This problem is fatal because the performance of machine learning algorithms is data-dependent. In this paper, we propose the HSF-DNN, a network intrusion detection model based on a deep neural network to solve the problems presented above. The proposed HFS-DNN was learned through the NSL-KDD data set and performs performance comparisons with existing classification models. Experiments have confirmed that the proposed Hybrid Feature Selection algorithm does not degrade performance, and in an experiment between learning models that solved the imbalance problem, the model proposed in this paper showed the best performance.