• 대한중풍순환신경학회지
• /
• 제21권1호
• /
• pp.33-38
• /
• 2020

■ Objectives This case report is reported to show the effect of Ukgansan and Hwangnyeonhaedok-tang on a patient who complaining myoclonic seizure due to psychogenic non epileptic seizure, occurred after traumatic stress event. ■ Methods A female patients with myolconic seizure was treated with Ukgansan and Hwangnyeonhaedok-tang during 5 days. Then we assessed dyskinesia severity by AIMS(Abnormal Involuntary Movement Scale) every two days til discharge. ■ Results Seizure decreased two days after hospitalization, then disappeared third day. There was no recurrence till discharge. When she revisited outpatients clinic, there was no symptom. ■ Conclusion This case showed the effect of Ukgansan and Hwangnyeonhaedok-tang on psychogenic epileptic seizure.

• Journal of Korean Neurosurgical Society
• /
• 제65권3호
• /
• pp.415-421
• /
• 2022

Objective : Seizure recurrence after the first-ever seizure in patients with a supratentorial cerebral cavernous malformation (CCM) is almost certain, so the diagnosis and treatment of epilepsy is justified. The optimal method of management of these patients is still a matter of debate. The aim of our study was to identify factors associated with postoperative seizure control and assess the surgical morbidity rate. Methods : We retrospectively analysed 45 consecutive patients with a supratentorial CCM and symptomatic epilepsy in a single centre. Pre- and postoperative epidemiological data, seizure-related patient histories, neuroimaging results, surgery details and outcomes were obtained from hospital medical records. Seizure outcomes were assessed at least 12 months after surgery. Results : Thirty-five patients (77.8%) were seizure free at the long-term follow-up (Engel class I); six (13,3%) had rare, nocturnal seizures (Engel class II); and four (8.9%) showed meaningful improvement (Engel class III). In 15 patients (33%) in the Engel I group; it was possible to discontinue antiepileptic medication. Although there was not statistical significance, our results suggest that patients can benefit from early surgery. No deaths occurred in our study, and mild postoperative neurologic deficits were observed in two patients (4%) at the long-term follow-up. Conclusion : Surgical resection of CCMs should be considered in all patients with a supratentorial malformation and epilepsy due to the favourable surgical results in terms of the epileptic seizure control rate and low postoperative morbidity risk, despite the use of different predictors for the seizure outcome.

• Clinical and Experimental Pediatrics
• /
• 제48권9호
• /
• pp.920-923
• /
• 2005

Epilepsy is a neurological disorder from many molecular and biochemical responses. In the underlying mechanism, free radicals play an important role in seizure initiation and seizure-induced brain damage. Excessive production of oxygen free radicals and other radical species have been implicated in the development of seizures under pathological conditions and linked to seizure-induced neurodegeneration.

• Archives of Pharmacal Research
• /
• 제2권2호
• /
• pp.121-125
• /
• 1979

Piperine showed a central nervous system depressant activity which was characterized by the antagonistic effect against chemoshock seizure as well as potent muscular incoordination in mice.

• Clinical and Experimental Pediatrics
• /
• 제50권11호
• /
• pp.1097-1103
• /
• 2007

목 적 : 급성 증후성 경련이란 일시적인 중추 신경계 또는 전신적인 병태생리의 변화와 밀접히 연관되어 발생하는 경련으로 이와 달리 특별한 유발 인자 없이 발생하는 경련은 비유발성 경련으로 분류한다. 급성 증후성 경련이 추후에 비유발성 경련으로 이행할 수 있다는 문헌은 다수 보고되고 있으나 증후성 경련에서 비유발성 경련의 이행에 영향을 미치는 관련 인자들에 대한 자료는 미비한 실정이다. 이에 본 논문에서는 증후성 경련으로 입원한 환아들을 대상으로 지속적인 추적 관찰을 통해 비유발성 경련과 관련된 인자들에 대해 후향적으로 조사하였고, 이러한 관련 인자들과 비유발성 경련 이행 여부에 관해 통계적인 분석을 통해 그 유의성을 알아보고자 하였다. 방 법 : 급성 증후성 경련으로 진단된 환아들을 대상으로 최소 1년간의 추적 관찰을 통해 비유발성 경련으로의 이행 여부를 후향적으로 조사하였고, 이에 따른 관련 인자로써 호발 연령, 성별, 가족력, 경련의 유형, 발달 정도 등을 포함하여 다양한 원인들을 분류하고 뇌파 검사 및 뇌영상 검사 등의 결과를 조사하여 비유발성 경련과의 관계를 통계적으로 분석하였다. 결 과 : 급성 증후성 경련에서 비유발성 경련으로 이행하는 경우는 2-6세에 가장 호발하고 성별에 따른 차이는 없으며 뇌증과 중추 신경계 감염이 많은 원인을 차지한다. 비유발성 경련으로 이행하는 경우의 관련 인자로는 간질 지속 상태를 동반한 경우와 부분 발작의 경우에 통계적으로 유의한 차이를 보이며, 이외에 뇌파 검사와 뇌 영상검사에서 이상 소견을 보이는 경우에도 비유발성 경련으로 이행하는 데 있어 통계적으로 유의한 값을 보였다. 그러나 성별, 경련성 질환의 가족력, 발달 정도, 경련시의 각성 상태 등의 인자들과 비유발성 경련의 관계에는 통계적인 유의성을 갖지 못하였다. 결 론 : 급성 증후성 경련 환아들의 비유발성 경련 이행에 따른 관련 인자로는 경련의 지속 시간, 경련의 유형, 이상 뇌파 소견 및 이상 뇌 영상검사 소견을 들 수 있다. 따라서 이러한 인자들에 해당하는 경우에는 급성 증후성 경련의 치료 후에도 지속적인 추적 관찰을 통해 향후 발생할 수 있는 비유발성 경련에 대한 적절한 검사와 대처가 필요하다고 생각된다.

• 대한한방소아과학회지
• /
• 제16권1호
• /
• pp.75-80
• /
• 2002

A 10-year-old boy with a history of epileptic seizure for 3 years, showed ataxia and left side weakness. In Brain MRI, hemiatrophy of the right hemisphere was noted. So we considered that he had a cerebral hemiatrophy caused by continued epileptic seizure and treated him with herbal medicine, acupuncture and physical therapy. We report a case of a 10-year-old boy who showed symptoms of a cerebral hemiatrophy caused by maintained epileptic seizure.

• Journal of Korean Neurosurgical Society
• /
• 제62권3호
• /
• pp.336-343
• /
• 2019

Epilepsy surgery revealed dramatically improved seizure outcomes over medical therapy in drug-resistant epilepsy patients. Children with epilepsy, however, have multiple epileptic focuses which require multilobar resection for better seizure outcome. Multilobar resection has not only the several severe surgical complications, such as hydrocephalus and shunt-related craniosynostosis, due to intracranial volume reduction. Isolation method (disconnection surgery) was progressively studied over epileptic focus removal (resective surgery) for seizure control. This concept was first introduced for functional hemispherotomy, and its primary principle is to preserve the vital vascularized brain that is functionally disconnected from the contralateral healthy brain. Currently in most epilepsy centers, the predominant disconnection surgical methods, including functional hemispherotomy, are continually being refined and are showing excellent results. They allow the functional isolation of the hemisphere or multi-lobe, affected by severe epilepsy. This review describes recent findings concerning the indication, surgical technique, seizure outcome and complications in several disconnection surgeries including the functional hemispherotomy for refractory pediatric epilepsy.

• 동의생리병리학회지
• /
• 제21권1호
• /
• pp.328-332
• /
• 2007

Epilepsy is any of various neurological disorders characterized by sudden, recurring attacks of motor, sensory, or psychic malfunction with or without loss of consciousness or convulsive seizures. It could be divided into subcategories due to the international classification of epileptic seizure and the complex partial seizure, that is one of epileptic seizure subcategories, is characterized by elaborate and multiple sensory, motor, and/or psychic components accompanying the clouding of consciousness, prodrome, automatism, postictal confusion. This study reports a patient who was presumptive diagnosed as complex partial seizure by having the clouding of consciousness, prodrome, postictal confusion. We also diagnosed him as a ‘dianxian’ patient induced by sum deficiency of liver & kidney. This patient was treated by acupuncture to tonifying eum of liver & kidney and it achieved markedly improved symptoms.

• Child Health Nursing Research
• /
• 제12권3호
• /
• pp.417-425
• /
• 2006

Purpose: This study was done to investigate stress, coping and social support of mothers of children with seizure disorders, and to identify the relationship between these variables. Method: The participants were 105 mothers of children with seizure disorders. Data were collected through self-report questionnaires which were constructed to include stress, coping and social support. The data were analyzed using the SAS program. Result: Stress of mothers was significantly different according to number of times the child had been hospitalized and the mothers perception of the state of the child's health. Coping by mothers was significantly different according to religion, general health state and if mother knew the child's diagnosis. Social support for mothers was significantly different according to education level, monthly medical expenses and number of times the child had been hospitalized. Social support for mothers was correlated with stress and coping. Conclusion: The above findings indicate that coping in mothers of children with seizure disorder is related to social support. Therefore nursing interventions to reduce stress and improve coping should be provided for mothers of children with seizure disorder.

• Natural Product Sciences
• /
• 제16권2호
• /
• pp.99-106
• /
• 2010

This experiment was undertaken to investigate whether methanol extract of fruit peel of Dimocarpus longan Lour. (MEFL) protects against kainic acid (KA)-induced seizure. Oral administration of MEFL (1, 2 and 4 mg/kg) increased KA (50 mg/kg)-induced survival rate and latency of convulsion onset, and deceased seizure scores and weight loss induced by intraperitoneal (i.p) injection of KA in mice. In addition, MEFL protected against cell death in the hippocampus of rat brain after KA-administration as analyzed by using TUNEL assay in rats. MEFL also significantly blocked seizure-form of electroencephalogram (EEG) power spectra induced by KA in rats. MEFL also inhibited elevation of [$Ca^{2+}$]i and increased [$Cl^-$]i induced by KA in cultured neuronal cells. Therefore, it is suggested that MEFL protects against seizure induced by KA, decreasing [$Ca^{2+}$]i.